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1. 发明授权

US08880160B2 Optimization of LV and RV lead placement based on electrical delays 有权
标题翻译：基于电气延迟优化LV和RV导线放置
公开(公告)号：US08880160B2
公开(公告)日：2014-11-04
申请号：US13552996
申请日：2012-07-19
申请人： Shibaji Shome , Pramodsingh Hirasingh Thakur , Yinghong Yu , Keith L. Herrmann , Aaron R. McCabe , Jiang Ding
发明人： Shibaji Shome , Pramodsingh Hirasingh Thakur , Yinghong Yu , Keith L. Herrmann , Aaron R. McCabe , Jiang Ding
IPC分类号： A61N1/05 , A61N1/368 , A61N1/39 , A61B5/0456 , A61B5/04 , A61N1/37 , A61N1/372
CPC分类号： A61B5/0456 , A61B5/04012 , A61N1/3684 , A61N1/3686 , A61N1/3702 , A61N1/37247 , A61N1/3918
摘要： A system comprises a cardiac signal sensing and a processing circuit. The cardiac signal sensing circuit senses a first cardiac signal segment that includes a QRS complex and a second cardiac signal segment that includes a fiducial indicative of local ventricular activation. The processor circuit includes a site activation timer circuit configured to determine a time duration between a fiducial of the QRS complex of the first cardiac signal segment and the fiducial of the second cardiac signal segment. The processor circuit is configured to generate, using the determined time duration, an indication of optimality of placement of one or more electrodes for delivering therapy and provide the indication to at least one of a user or process.
摘要翻译：一种系统包括心脏信号感测和处理电路。心脏信号感测电路感测包括QRS复合物的第一心脏信号片段和包括指示局部心室激活的基准的第二心脏信号片段。处理器电路包括站点激活定时器电路，其被配置为确定第一心脏信号段的QRS复合体的基准点与第二心脏信号段的基准点之间的持续时间。处理器电路被配置为使用所确定的持续时间来生成用于递送治疗的一个或多个电极的放置的最佳化的指示，并向至少一个用户或过程提供指示。

2. 发明授权

US08821404B2 Cardiac decompensation detection using multiple sensors 有权
标题翻译：使用多个传感器进行心脏代偿失调检测
公开(公告)号：US08821404B2
公开(公告)日：2014-09-02
申请号：US13324174
申请日：2011-12-13
申请人： Pramodsingh Hirasingh Thakur , Abhilash Patangay
发明人： Pramodsingh Hirasingh Thakur , Abhilash Patangay
IPC分类号： A61B5/02 , A61B5/08 , A61B5/053 , A61N1/365 , A61B5/03
CPC分类号： A61B5/0538 , A61B5/036 , A61B5/0809 , A61N1/36521 , A61N1/36535 , G06F19/00
摘要： Physiological data, such as thoracic impedance data, can be obtained over a first time window to establish a baseline, or can be used to form one or more data clusters. Additional physiological data, such as thoracic impedance test data acquired over a later time window, can be obtained and compared to the baseline or data clusters to determine an indication of worsening heart failure. In an example, a quantitative attribute of one or more data clusters can be monitored and used to provide an indication of worsening heart failure. A posture discrimination metric can be obtained, such as using the physiological data obtained over the first time window. The additional physiological data, such as can be obtained over a second time window, can be compared to the posture discrimination metric to provide a patient posture status.
摘要翻译：可以在第一时间窗口中获得诸如胸部阻抗数据的生理数据以建立基线，或者可以用于形成一个或多个数据簇。可以获得额外的生理数据，例如在稍后时间窗口上获取的胸部阻抗测试数据，并与基线或数据簇进行比较，以确定心脏衰竭恶化的指示。在一个示例中，可以监视一个或多个数据集群的定量属性并用于提供恶化的心力衰竭的指示。可以获得姿势辨别度量，例如使用在第一时间窗口中获得的生理数据。可以将诸如在第二时间窗口上获得的附加生理数据与姿势辨别度量进行比较以提供患者姿势状态。

3. 发明申请

US20120310101A1 WIDE QRS DETECTOR 有权
标题翻译：宽QRS检测器
公开(公告)号：US20120310101A1
公开(公告)日：2012-12-06
申请号：US13472563
申请日：2012-05-16
申请人： Abhilash Patangay , Shibaji Shome , Pramodsingh Hirasingh Thakur , Dan Li , Stevens L. Martin
发明人： Abhilash Patangay , Shibaji Shome , Pramodsingh Hirasingh Thakur , Dan Li , Stevens L. Martin
IPC分类号： A61B5/0472
CPC分类号： A61B5/0472 , A61B5/0031 , A61B5/0452 , A61B5/7239 , A61N1/3627 , A61N1/36507 , A61N1/37
摘要： A system comprises a cardiac signal sensing circuit and a processor circuit. To detect a QRS duration, the processor circuit determines an isoelectric amplitude value of the cardiac signal segment, identifies a time where the cardiac signal segment amplitude deviates from the first isoelectric amplitude value by a specified threshold deviation value as a Q time, determines an isoelectric value time after the determined maxima and minima times that the cardiac signal segment returns to the same or a different isoelectric amplitude value, identifies a time that follows both the determined maxima and minima times and precedes the isoelectric value time as an S time, wherein the cardiac signal segment amplitude at the identified S time satisfies a specified amplitude change criterion from an isoelectric amplitude value, and determines a time duration of the QRS complex in the cardiac signal segment using the identified Q and S times.
摘要翻译：一种系统包括心脏信号感测电路和处理器电路。为了检测QRS持续时间，处理器电路确定心脏信号片段的等电位振幅值，将心脏信号片段振幅与第一等电位振幅值偏离指定阈值偏差值的时间作为Q时间，确定等电点确定心脏信号段返回到相同或不同等电位振幅值的确定最大值和最小值之后的值时间，识别在确定的最大值和最小值时间之后的时间，并且在等电点时间之前等于S时间，其中在所识别的S时刻的心脏信号段振幅满足来自等电位振幅值的规定的振幅变化标准，并且使用所识别的Q和S倍来确定心脏信号段中的QRS复合物的持续时间。

4. 发明申请

US20110295084A1 INTEGRATING DEVICE-BASED SENSORS AND BEDSIDE BIOMARKER ASSAYS TO DETECT WORSENING HEART FAILURE 有权
标题翻译：集成基于设备的传感器和双面生物标记测试以检测心脏衰竭
公开(公告)号：US20110295084A1
公开(公告)日：2011-12-01
申请号：US13118932
申请日：2011-05-31
申请人： Pramodsingh Hirasingh Thakur , Abhilash Patangay , Craig Stolen , Timothy Meyer
发明人： Pramodsingh Hirasingh Thakur , Abhilash Patangay , Craig Stolen , Timothy Meyer
IPC分类号： A61B5/00
CPC分类号： A61B5/0205 , A61B5/0022 , A61B5/0031 , A61B5/02 , A61B5/08 , A61B7/00 , A61B2505/07 , A61N1/3627 , A61N1/36521 , A61N1/3702 , A61N1/37258 , G06F19/00
摘要： Physiological sensor data can be combined with external biomarker assays, such as a bedside assay for B-type natriuretic peptide (BNP), to improve the sensitivity and specificity of heart failure detection.
摘要翻译：生理传感器数据可与外部生物标志物检测结合，如B型利尿钠肽（BNP）的床边检测，以提高心力衰竭检测的灵敏度和特异性。

5. 发明申请

US20130190636A1 OPTIMIZATION OF LV AND RV LEAD PLACEMENT BASED ON ELECTRICAL DELAYS 有权
标题翻译：基于电延迟优化LV和RV导线放置
公开(公告)号：US20130190636A1
公开(公告)日：2013-07-25
申请号：US13552996
申请日：2012-07-19
申请人： Shibaji Shome , Pramodsingh Hirasingh Thakur , Yinghong Yu , Keith L. Herrmann , Aaron R. McCabe , Jiang Ding
发明人： Shibaji Shome , Pramodsingh Hirasingh Thakur , Yinghong Yu , Keith L. Herrmann , Aaron R. McCabe , Jiang Ding
IPC分类号： A61B5/0456 , A61B5/04
CPC分类号： A61B5/0456 , A61B5/04012 , A61N1/3684 , A61N1/3686 , A61N1/3702 , A61N1/37247 , A61N1/3918
摘要： A system comprises a cardiac signal sensing and a processing circuit. The cardiac signal sensing circuit senses a first cardiac signal segment that includes a QRS complex and a second cardiac signal segment that includes a fiducial indicative of local ventricular activation. The processor circuit includes a site activation timer circuit configured to determine a time duration between a fiducial of the QRS complex of the first cardiac signal segment and the fiducial of the second cardiac signal segment. The processor circuit is configured to generate, using the determined time duration, an indication of optimality of placement of one or more electrodes for delivering therapy and provide the indication to at least one of a user or process.
摘要翻译：一种系统包括心脏信号感测和处理电路。心脏信号感测电路感测包括QRS复合物的第一心脏信号片段和包括指示局部心室激活的基准的第二心脏信号片段。处理器电路包括站点激活定时器电路，其被配置为确定第一心脏信号段的QRS复合体的基准点与第二心脏信号段的基准点之间的持续时间。处理器电路被配置为使用所确定的持续时间来生成用于递送治疗的一个或多个电极的放置的最佳化的指示，并向至少一个用户或过程提供指示。

6. 发明申请

US20130165755A1 PHYSIOLOGICAL STATUS INDICATOR APPARATUS AND METHOD 有权
标题翻译：生理状态指示器和方法
公开(公告)号：US20130165755A1
公开(公告)日：2013-06-27
申请号：US13725675
申请日：2012-12-21
申请人： Pramodsingh Hirasingh Thakur , John D. Hatlestad , Ramesh Wariar , Viktoria A. Averina , Lynne E. Swanson
发明人： Pramodsingh Hirasingh Thakur , John D. Hatlestad , Ramesh Wariar , Viktoria A. Averina , Lynne E. Swanson
IPC分类号： A61B5/0205 , A61N1/365 , A61B5/053
CPC分类号： A61B5/053 , A61B5/686 , A61B5/72
摘要： A processor circuit can be configured to obtain a first multidimensional vector. The first multidimensional vector can include dimensions corresponding to respective first conductivity characteristics obtained from different implantable electrode configurations associated with a subject. The processor circuit can also be configured to obtain a second multidimensional vector or vector space. The second multidimensional vector or vector space can include dimensions corresponding to respective second conductivity characteristics obtained from such different electrode configurations associated with the same or a different subject. The processor circuit can also provide a physiological status indicator that can be obtained at least in part by performing a vector comparison of the first multidimensional vector to the second multidimensional vector space or vector.
摘要翻译：处理器电路可以被配置为获得第一多维向量。第一多维向量可以包括对应于从与对象相关联的不同可植入电极配置获得的各自的第一导电特性的尺寸。处理器电路还可以被配置为获得第二多维向量或向量空间。第二多维向量或向量空间可以包括对应于从与相同或不同对象相关联的这种不同电极配置获得的各自的第二导电特性的尺寸。处理器电路还可以提供至少部分地通过执行第一多维向量与第二多维向量空间或向量的向量比较来获得的生理状态指示符。

7. 发明申请

US20130116578A1 RISK STRATIFICATION BASED HEART FAILURE DETECTION ALGORITHM 有权
标题翻译：基于风险分析的心脏失效检测算法
公开(公告)号：US20130116578A1
公开(公告)日：2013-05-09
申请号：US13726786
申请日：2012-12-26
申请人： Qi An , Pramodsingh Hirasingh Thakur , Viktoria A. Averina , Yi Zhang , Robert J. Sweeney
发明人： Qi An , Pramodsingh Hirasingh Thakur , Viktoria A. Averina , Yi Zhang , Robert J. Sweeney
IPC分类号： A61B5/0205
CPC分类号： A61B5/0205 , A61B5/0031 , A61B5/02007 , A61B5/024 , A61B5/0816 , A61B5/4842 , A61B5/7275 , A61N1/37282 , G06F19/00 , G06Q10/00 , G06Q50/22 , G16H50/20 , G16H50/30 , G16H50/50
摘要： A system comprises a risk analysis module and a worsening heart failure (WHF) detection module. The risk analysis module measures at least one first physiological parameter of a subject using a physiological sensor of an ambulatory medical device, and determines a heart failure (HF) risk score for the subject according to the at least one measured first physiological parameter. The HF risk score indicates susceptibility of the subject to experiencing a HF event. The WHF detection module measures at least one second physiological parameter of the subject using the same or different physiological sensor, and generates an indication of prediction that the subject will experience a WHF event when the at least one second physiological parameter satisfies a WHF detection algorithm. The risk analysis module adjusts generation of the indication by the WHF detection algorithm according to the determined HF risk score.
摘要翻译：系统包括风险分析模块和恶化心力衰竭（WHF）检测模块。风险分析模块使用移动医疗装置的生理传感器测量受试者的至少一个第一生理参数，并且根据至少一个测量的第一生理参数确定受试者的心力衰竭（HF）风险评分。 HF风险评分表示受试者经历HF事件的易感性。 WHF检测模块使用相同或不同的生理传感器测量受试者的至少一个第二生理参数，并且当至少一个第二生理参数满足WHF检测算法时，生成预测对象将经历WHF事件的指示。风险分析模块根据确定的HF风险评分调整WHF检测算法生成指示。

8. 发明申请

US20120157864A1 CARDIAC DECOMPENSATION DETECTION USING MULTIPLE SENSORS 有权
标题翻译：使用多个传感器的心脏分解检测
公开(公告)号：US20120157864A1
公开(公告)日：2012-06-21
申请号：US13324174
申请日：2011-12-13
申请人： Pramodsingh Hirasingh Thakur , Abhilash Patangay
发明人： Pramodsingh Hirasingh Thakur , Abhilash Patangay
IPC分类号： A61B5/02
CPC分类号： A61B5/0538 , A61B5/036 , A61B5/0809 , A61N1/36521 , A61N1/36535 , G06F19/00
摘要： Physiological data, such as thoracic impedance data, can be obtained over a first time window to establish a baseline, or can be used to form one or more data clusters. Additional physiological data, such as thoracic impedance test data acquired over a later time window, can be obtained and compared to the baseline or data clusters to determine an indication of worsening heart failure. In an example, a quantitative attribute of one or more data clusters can be monitored and used to provide an indication of worsening heart failure. A posture discrimination metric can be obtained, such as using the physiological data obtained over the first time window. The additional physiological data, such as can be obtained over a second time window, can be compared to the posture discrimination metric to provide a patient posture status.
摘要翻译：可以在第一时间窗口中获得诸如胸部阻抗数据的生理数据以建立基线，或者可以用于形成一个或多个数据簇。可以获得额外的生理数据，例如在稍后时间窗口上获取的胸部阻抗测试数据，并与基线或数据簇进行比较，以确定心脏衰竭恶化的指示。在一个示例中，可以监视一个或多个数据集群的定量属性并用于提供恶化的心力衰竭的指示。可以获得姿势辨别度量，例如使用在第一时间窗口中获得的生理数据。可以将诸如在第二时间窗口上获得的附加生理数据与姿势辨别度量进行比较以提供患者姿势状态。

9. 发明授权

US09713432B2 Wide QRS detector 有权
公开(公告)号：US09713432B2
公开(公告)日：2017-07-25
申请号：US13472563
申请日：2012-05-16
申请人： Abhilash Patangay , Shibaji Shome , Pramodsingh Hirasingh Thakur , Dan Li , Stevens L. Martin
发明人： Abhilash Patangay , Shibaji Shome , Pramodsingh Hirasingh Thakur , Dan Li , Stevens L. Martin
IPC分类号： A61B5/0472 , A61B5/0452 , A61B5/00 , A61N1/362 , A61N1/365 , A61N1/37
CPC分类号： A61B5/0472 , A61B5/0031 , A61B5/0452 , A61B5/7239 , A61N1/3627 , A61N1/36507 , A61N1/37
摘要： A system comprises a cardiac signal sensing circuit and a processor circuit. To detect a QRS duration, the processor circuit determines an isoelectric amplitude value of the cardiac signal segment, identifies a time where the cardiac signal segment amplitude deviates from the first isoelectric amplitude value by a specified threshold deviation value as a Q time, determines an isoelectric value time after the determined maxima and minima times that the cardiac signal segment returns to the same or a different isoelectric amplitude value, identifies a time that follows both the determined maxima and minima times and precedes the isoelectric value time as an S time, wherein the cardiac signal segment amplitude at the identified S time satisfies a specified amplitude change criterion from an isoelectric amplitude value, and determines a time duration of the QRS complex in the cardiac signal segment using the identified Q and S times.

10. 发明授权

US08858448B2 Monitoring projections along principal components of multiple sensors as an indicator of worsening heart failure 有权
标题翻译：根据多个传感器的主要组件监测预测作为心力衰竭恶化的指标
公开(公告)号：US08858448B2
公开(公告)日：2014-10-14
申请号：US13325120
申请日：2011-12-14
申请人： Pramodsingh Hirasingh Thakur , Abhilash Patangay , Ramesh Wariar , John D. Hatlestad , Yi Zhang
发明人： Pramodsingh Hirasingh Thakur , Abhilash Patangay , Ramesh Wariar , John D. Hatlestad , Yi Zhang
IPC分类号： A61B5/02 , A61B5/11 , A61B5/0205 , A61B5/042 , A61B5/00 , A61B7/02 , A61B5/08 , A61N1/362 , A61B7/04 , A61N1/37 , A61B5/053
CPC分类号： A61B5/042 , A61B5/0205 , A61B5/053 , A61B5/0809 , A61B5/1107 , A61B5/6869 , A61B5/7253 , A61B7/023 , A61B7/04 , A61B2562/0219 , A61N1/3627 , A61N1/37
摘要： A device can include at least a first physiologic sensor circuit configured to provide a first physiologic signal, a second physiologic sensor circuit configured to provide a second physiologic signal, and a processor circuit. The processor circuit includes a principal component analysis circuit configured to represent data determined from the at least first and second physiologic sensor circuits as at least first and second axes, respectively, in a multidimensional space, determine one or more principal components in the multidimensional space, determine a quantitative attribute of the first and the second physiologic signals using at least one of the determined principal components or a projection of the data along the at least one determined principal component, and provide an indication of heart failure status according to the quantitative attribute to at least one of a user or a process.
摘要翻译：装置可以包括至少第一生理传感器电路，其被配置为提供第一生理信号，被配置为提供第二生理信号的第二生理传感器电路和处理器电路。处理器电路包括主分量分析电路，其被配置为将表示从至少第一和第二生理传感器电路确定的数据分别表示为多维空间中的至少第一和第二轴，确定多维空间中的一个或多个主要分量，使用确定的主成分中的至少一个或沿着至少一个确定的主成分的数据的投影来确定第一和第二生理信号的定量属性，并且根据定量属性提供心力衰竭状态的指示至少一个用户或进程。

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