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1. 发明申请

US20120157864A1 CARDIAC DECOMPENSATION DETECTION USING MULTIPLE SENSORS 有权
标题翻译：使用多个传感器的心脏分解检测
公开(公告)号：US20120157864A1
公开(公告)日：2012-06-21
申请号：US13324174
申请日：2011-12-13
申请人： Pramodsingh Hirasingh Thakur , Abhilash Patangay
发明人： Pramodsingh Hirasingh Thakur , Abhilash Patangay
IPC分类号： A61B5/02
CPC分类号： A61B5/0538 , A61B5/036 , A61B5/0809 , A61N1/36521 , A61N1/36535 , G06F19/00
摘要： Physiological data, such as thoracic impedance data, can be obtained over a first time window to establish a baseline, or can be used to form one or more data clusters. Additional physiological data, such as thoracic impedance test data acquired over a later time window, can be obtained and compared to the baseline or data clusters to determine an indication of worsening heart failure. In an example, a quantitative attribute of one or more data clusters can be monitored and used to provide an indication of worsening heart failure. A posture discrimination metric can be obtained, such as using the physiological data obtained over the first time window. The additional physiological data, such as can be obtained over a second time window, can be compared to the posture discrimination metric to provide a patient posture status.
摘要翻译：可以在第一时间窗口中获得诸如胸部阻抗数据的生理数据以建立基线，或者可以用于形成一个或多个数据簇。可以获得额外的生理数据，例如在稍后时间窗口上获取的胸部阻抗测试数据，并与基线或数据簇进行比较，以确定心脏衰竭恶化的指示。在一个示例中，可以监视一个或多个数据集群的定量属性并用于提供恶化的心力衰竭的指示。可以获得姿势辨别度量，例如使用在第一时间窗口中获得的生理数据。可以将诸如在第二时间窗口上获得的附加生理数据与姿势辨别度量进行比较以提供患者姿势状态。

2. 发明授权

US09713432B2 Wide QRS detector 有权
公开(公告)号：US09713432B2
公开(公告)日：2017-07-25
申请号：US13472563
申请日：2012-05-16
申请人： Abhilash Patangay , Shibaji Shome , Pramodsingh Hirasingh Thakur , Dan Li , Stevens L. Martin
发明人： Abhilash Patangay , Shibaji Shome , Pramodsingh Hirasingh Thakur , Dan Li , Stevens L. Martin
IPC分类号： A61B5/0472 , A61B5/0452 , A61B5/00 , A61N1/362 , A61N1/365 , A61N1/37
CPC分类号： A61B5/0472 , A61B5/0031 , A61B5/0452 , A61B5/7239 , A61N1/3627 , A61N1/36507 , A61N1/37
摘要： A system comprises a cardiac signal sensing circuit and a processor circuit. To detect a QRS duration, the processor circuit determines an isoelectric amplitude value of the cardiac signal segment, identifies a time where the cardiac signal segment amplitude deviates from the first isoelectric amplitude value by a specified threshold deviation value as a Q time, determines an isoelectric value time after the determined maxima and minima times that the cardiac signal segment returns to the same or a different isoelectric amplitude value, identifies a time that follows both the determined maxima and minima times and precedes the isoelectric value time as an S time, wherein the cardiac signal segment amplitude at the identified S time satisfies a specified amplitude change criterion from an isoelectric amplitude value, and determines a time duration of the QRS complex in the cardiac signal segment using the identified Q and S times.

3. 发明授权

US08858448B2 Monitoring projections along principal components of multiple sensors as an indicator of worsening heart failure 有权
标题翻译：根据多个传感器的主要组件监测预测作为心力衰竭恶化的指标
公开(公告)号：US08858448B2
公开(公告)日：2014-10-14
申请号：US13325120
申请日：2011-12-14
申请人： Pramodsingh Hirasingh Thakur , Abhilash Patangay , Ramesh Wariar , John D. Hatlestad , Yi Zhang
发明人： Pramodsingh Hirasingh Thakur , Abhilash Patangay , Ramesh Wariar , John D. Hatlestad , Yi Zhang
IPC分类号： A61B5/02 , A61B5/11 , A61B5/0205 , A61B5/042 , A61B5/00 , A61B7/02 , A61B5/08 , A61N1/362 , A61B7/04 , A61N1/37 , A61B5/053
CPC分类号： A61B5/042 , A61B5/0205 , A61B5/053 , A61B5/0809 , A61B5/1107 , A61B5/6869 , A61B5/7253 , A61B7/023 , A61B7/04 , A61B2562/0219 , A61N1/3627 , A61N1/37
摘要： A device can include at least a first physiologic sensor circuit configured to provide a first physiologic signal, a second physiologic sensor circuit configured to provide a second physiologic signal, and a processor circuit. The processor circuit includes a principal component analysis circuit configured to represent data determined from the at least first and second physiologic sensor circuits as at least first and second axes, respectively, in a multidimensional space, determine one or more principal components in the multidimensional space, determine a quantitative attribute of the first and the second physiologic signals using at least one of the determined principal components or a projection of the data along the at least one determined principal component, and provide an indication of heart failure status according to the quantitative attribute to at least one of a user or a process.
摘要翻译：装置可以包括至少第一生理传感器电路，其被配置为提供第一生理信号，被配置为提供第二生理信号的第二生理传感器电路和处理器电路。处理器电路包括主分量分析电路，其被配置为将表示从至少第一和第二生理传感器电路确定的数据分别表示为多维空间中的至少第一和第二轴，确定多维空间中的一个或多个主要分量，使用确定的主成分中的至少一个或沿着至少一个确定的主成分的数据的投影来确定第一和第二生理信号的定量属性，并且根据定量属性提供心力衰竭状态的指示至少一个用户或进程。

4. 发明授权

US08602996B2 Integrating device-based sensors and bedside biomarker assays to detect worsening heart failure 有权
标题翻译：整合基于装置的传感器和床旁生物标志物检测以检测恶化的心力衰竭
公开(公告)号：US08602996B2
公开(公告)日：2013-12-10
申请号：US13118932
申请日：2011-05-31
申请人： Pramodsingh Hirasingh Thakur , Abhilash Patangay , Craig Stolen , Timothy Meyer
发明人： Pramodsingh Hirasingh Thakur , Abhilash Patangay , Craig Stolen , Timothy Meyer
IPC分类号： A61B5/02
CPC分类号： A61B5/0205 , A61B5/0022 , A61B5/0031 , A61B5/02 , A61B5/08 , A61B7/00 , A61B2505/07 , A61N1/3627 , A61N1/36521 , A61N1/3702 , A61N1/37258 , G06F19/00
摘要： Devices and methods for improving the sensitivity and specificity of heart failure (HF) detection are described. The devices and methods can detect a HF status such as using physiological sensor data and external biomarker assays. An apparatus can comprise ambulatory physiological sensors that can provide a first HF status indicator and a second HF status indicator to a user. An external biomarker sensor can provide an amount of a biomarker present, such as an assay for B-type natriuretic peptide (BNP), which provides information about HF status. A processor circuit can switch from a first HF detection mode to a second detection mode such as in response to the information from the biomarker sensor. The first detection mode can detect HF status using the first HF status indicator, and the second detection mode can detect HF status using the second HF status indicator. The second detection mode can have a higher specificity than the first detection mode.
摘要翻译：描述了用于改善心力衰竭（HF）检测的灵敏度和特异性的装置和方法。设备和方法可以检测HF状态，例如使用生理传感器数据和外部生物标志物测定。装置可以包括可向用户提供第一HF状态指示符和第二HF状态指示符的动态生理传感器。外部生物标志物传感器可以提供一定量的存在的生物标志物，例如提供关于HF状态的信息的B型利尿钠肽（BNP）的测定。处理器电路可以从第一HF检测模式切换到第二检测模式，例如响应于来自生物标志物传感器的信息。第一检测模式可以使用第一HF状态指示器检测HF状态，第二检测模式可以使用第二HF状态指示器检测HF状态。第二检测模式可以具有比第一检测模式更高的特异性。

5. 发明申请

US20120157799A1 USING DEVICE BASED SENSORS TO CLASSIFY EVENTS AND GENERATE ALERTS 审中-公开
标题翻译：使用基于设备的传感器进行分类事件和生成警报
公开(公告)号：US20120157799A1
公开(公告)日：2012-06-21
申请号：US13331288
申请日：2011-12-20
申请人： Abhilash Patangay , Pramodsingh Hirasingh Thakur , Yi Zhang
发明人： Abhilash Patangay , Pramodsingh Hirasingh Thakur , Yi Zhang
IPC分类号： A61B5/00 , A61B5/0205
CPC分类号： A61B5/0031 , A61B5/0215 , A61B5/029 , A61B5/042 , A61B5/0537 , A61B5/0538 , A61B5/4842 , A61B5/686 , A61B7/00 , A61B2562/06
摘要： The present subject matter includes apparatus, methods and device-readable media for using impedance and heart sounds to classify events and alerts. An apparatus can include a processor circuit configured to receive a physiological indication, classify the indication, and generate a multi-dimensional heart failure decompensation status indication. A method can include obtaining a physiological indication, classifying the indication and generating a multi-dimensional heart failure decompensation status indication. A device-readable medium can include instructions that, when performed by the device can obtain a physiological indication, classify the indication, and generate a multi-dimensional heart failure decompensation status alert.
摘要翻译：本主题包括用于使用阻抗和心脏声音对事件和警报进行分类的装置，方法和设备可读介质。一种装置可以包括配置成接收生理指示，对该指示进行分类并产生多维心力衰竭失代偿状态指示的处理器电路。方法可以包括获得生理指示，分类指示并产生多维心力衰竭失代偿状态指示。设备可读介质可以包括指令，当由设备执行时可以获得生理指示，对指示进行分类，并产生多维心力衰竭失代偿状态警报。

6. 发明申请

US20110098771A1 MULTIPLE VECTOR FLUID LOCALIZATION 有权
标题翻译：多个矢量流体定位
公开(公告)号：US20110098771A1
公开(公告)日：2011-04-28
申请号：US12912219
申请日：2010-10-26
申请人： Pramodsingh Hirasingh Thakur , Abhilash Patangay , Kent Lee
发明人： Pramodsingh Hirasingh Thakur , Abhilash Patangay , Kent Lee
IPC分类号： A61N1/37
CPC分类号： A61B5/4878 , A61B5/01 , A61B5/053 , A61B5/0537 , A61B5/0538 , A61B5/4836 , A61B5/4875 , A61B5/6869 , A61B5/7282 , A61B5/74 , A61N1/3627 , A61N1/36521 , A61N1/3702
摘要： A differential or relative measurement between an orthogonal measurement vector and another measurement vector can be used to determine the location where fluid accumulation is occurring or the local change in such fluid accumulation. This can help diagnose or treat infection or hematoma or seroma at a pocket of an implanted cardiac rhythm management device, other implanted medical device, or prosthesis. It can also help diagnose or treat pulmonary edema, pneumonia, pulmonary congestion, pericardial effusion, pericarditis, pleural effusion, hemodilution, or another physiological condition.
摘要翻译：可以使用正交测量矢量和另一测量矢量之间的差分或相对测量来确定发生流体积聚的位置或这种液体积聚中的局部变化。这可以帮助诊断或治疗植入式心律管理装置，其他植入的医疗装置或假体的口袋上的感染或血肿或血清。它还可以帮助诊断或治疗肺水肿，肺炎，肺部充血，心包积液，心包炎，胸腔积液，血液稀释或其他生理条件。

7. 发明授权

US09332924B2 Posture detection using thoracic impedance 有权
标题翻译：姿势检测采用胸部阻抗
公开(公告)号：US09332924B2
公开(公告)日：2016-05-10
申请号：US13324201
申请日：2011-12-13
申请人： Pramodsingh Hirasingh Thakur , Abhilash Patangay
发明人： Pramodsingh Hirasingh Thakur , Abhilash Patangay
IPC分类号： A61B5/053 , A61B5/0205 , A61B5/11 , A61B5/00 , A61B5/103 , A61N1/365
CPC分类号： A61B5/0538 , A61B5/0205 , A61B5/103 , A61B5/1116 , A61B5/686 , A61B5/6869 , A61B2560/0462 , A61N1/36521 , A61N1/36535 , G06F19/00
摘要： Physiological data, such as thoracic impedance data, can be obtained over a first time window to establish a baseline, or can be used to form one or more data clusters. Additional physiological data, such as thoracic impedance test data acquired over a later time window, can be obtained and compared to the baseline or data clusters to determine an indication of worsening heart failure. In an example, a quantitative attribute of one or more data clusters can be monitored and used to provide an indication of worsening heart failure. A posture discrimination metric can be obtained, such as using the physiological data obtained over the first time window. The additional physiological data, such as can be obtained over a second time window, can be compared to the posture discrimination metric to provide a patient posture status.
摘要翻译：可以在第一时间窗口中获得诸如胸部阻抗数据的生理数据以建立基线，或者可以用于形成一个或多个数据簇。可以获得额外的生理数据，例如在稍后时间窗口上获取的胸部阻抗测试数据，并与基线或数据簇进行比较，以确定心脏衰竭恶化的指示。在一个示例中，可以监视一个或多个数据集群的定量属性并用于提供恶化的心力衰竭的指示。可以获得姿势辨别度量，例如使用在第一时间窗口中获得的生理数据。可以将诸如在第二时间窗口上获得的附加生理数据与姿势辨别度量进行比较以提供患者姿势状态。

8. 发明授权

US09066659B2 Transient sensor response to posture as a measure of patient status 有权
标题翻译：瞬态传感器对姿势的响应作为患者状态的度量
公开(公告)号：US09066659B2
公开(公告)日：2015-06-30
申请号：US13437318
申请日：2012-04-02
申请人： Pramodsingh Hirasingh Thakur , Abhilash Patangay , John D. Hatlestad , Kenneth C. Beck
发明人： Pramodsingh Hirasingh Thakur , Abhilash Patangay , John D. Hatlestad , Kenneth C. Beck
IPC分类号： A61B5/0205 , A61B5/00 , A61B5/11 , G06F19/00 , A61N1/365
CPC分类号： A61B5/0205 , A61B5/0031 , A61B5/02405 , A61B5/076 , A61B5/1116 , A61B5/1118 , A61B5/4836 , A61B5/4848 , A61B5/686 , A61B5/7246 , A61B5/7275 , A61B5/742 , A61B2560/0462 , A61B2562/0219 , A61N1/36535 , G06F19/34 , G16H20/40
摘要： Patient posture information can be received, such as to indicate a change in patient posture by at least a threshold amount. A transient response signal indicative of a change in a physiological parameter can be received at multiple instances near a change in patient posture. Waveform morphology features can be extracted from a transient response signal and used to provide an indication of a cardiac status, such as a heart failure status.
摘要翻译：可以接收患者姿势信息，例如指示患者姿势的变化至少阈值量。可以在患者姿势变化附近的多个实例处接收表示生理参数变化的瞬时响应信号。可以从瞬态响应信号中提取波形形态特征，并用于提供心脏状态的指示，例如心力衰竭状态。

9. 发明授权

US08900140B2 Multiple vector fluid localization 有权
标题翻译：多向量流体定位
公开(公告)号：US08900140B2
公开(公告)日：2014-12-02
申请号：US12912219
申请日：2010-10-26
申请人： Pramodsingh Hirasingh Thakur , Abhilash Patangay , Kent Lee
发明人： Pramodsingh Hirasingh Thakur , Abhilash Patangay , Kent Lee
IPC分类号： A61B5/00 , A61N1/37 , A61B5/053 , A61N1/365 , A61N1/362
CPC分类号： A61B5/4878 , A61B5/01 , A61B5/053 , A61B5/0537 , A61B5/0538 , A61B5/4836 , A61B5/4875 , A61B5/6869 , A61B5/7282 , A61B5/74 , A61N1/3627 , A61N1/36521 , A61N1/3702
摘要： A differential or relative measurement between an orthogonal measurement vector and another measurement vector can be used to determine the location where fluid accumulation is occurring or the local change in such fluid accumulation. This can help diagnose or treat infection or hematoma or seroma at a pocket of an implanted cardiac rhythm management device, other implanted medical device, or prosthesis. It can also help diagnose or treat pulmonary edema, pneumonia, pulmonary congestion, pericardial effusion, pericarditis, pleural effusion, hemodilution, or another physiological condition.
摘要翻译：可以使用正交测量矢量和另一测量矢量之间的差分或相对测量来确定发生流体积聚的位置或这种液体积聚中的局部变化。这可以帮助诊断或治疗植入式心律管理装置，其他植入的医疗装置或假体的口袋上的感染或血肿或血清。它还可以帮助诊断或治疗肺水肿，肺炎，肺部充血，心包积液，心包炎，胸腔积液，血液稀释或其他生理条件。

10. 发明申请

US20120157858A1 MONITORING PROJECTIONS ALONG PRINCIPAL COMPONENTS OF MULTIPLE SENSORS AS AN INDICATOR OF WORSENING HEART FAILURE 有权
标题翻译：监测多个传感器主要成分作为心脏衰竭指标的预测
公开(公告)号：US20120157858A1
公开(公告)日：2012-06-21
申请号：US13325120
申请日：2011-12-14
申请人： Pramodsingh Hirasingh Thakur , Abhilash Patangay , Ramesh Wariar , John D. Hatlestad , Yi Zhang
发明人： Pramodsingh Hirasingh Thakur , Abhilash Patangay , Ramesh Wariar , John D. Hatlestad , Yi Zhang
IPC分类号： A61B5/0205 , A61B5/02
CPC分类号： A61B5/042 , A61B5/0205 , A61B5/053 , A61B5/0809 , A61B5/1107 , A61B5/6869 , A61B5/7253 , A61B7/023 , A61B7/04 , A61B2562/0219 , A61N1/3627 , A61N1/37
摘要： A device can include at least a first physiologic sensor circuit configured to provide a first physiologic signal, a second physiologic sensor circuit configured to provide a second physiologic signal, and a processor circuit. The processor circuit includes a principal component analysis circuit configured to represent data determined from the at least first and second physiologic sensor circuits as at least first and second axes, respectively, in a multidimensional space, determine one or more principal components in the multidimensional space, determine a quantitative attribute of the first and the second physiologic signals using at least one of the determined principal components or a projection of the data along the at least one determined principal component, and provide an indication of heart failure status according to the quantitative attribute to at least one of a user or a process.
摘要翻译：设备可以包括至少第一生理传感器电路，其被配置为提供第一生理信号，被配置为提供第二生理信号的第二生理传感器电路和处理器电路。处理器电路包括主分量分析电路，其被配置为将表示从至少第一和第二生理传感器电路确定的数据分别表示为多维空间中的至少第一和第二轴，确定多维空间中的一个或多个主要分量，使用确定的主成分中的至少一个或沿着至少一个确定的主成分的数据的投影来确定第一和第二生理信号的定量属性，并且根据定量属性提供心力衰竭状态的指示至少一个用户或进程。

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