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1. 发明授权

US06929239B1 Microfluid system for reactions and transfers 失效
标题翻译：用于反应和转移的微流体系统
公开(公告)号：US06929239B1
公开(公告)日：2005-08-16
申请号：US09786617
申请日：1999-09-08
申请人： Bruno Colin , Cécile Paris , Jacques Dachaud , Pierre Imbaud
发明人： Bruno Colin , Cécile Paris , Jacques Dachaud , Pierre Imbaud
IPC分类号： G01N1/00 , B01J19/00 , B01L3/00 , C12Q1/68 , F15C3/00 , F16K1/14 , F16K1/16 , F16K11/00
CPC分类号： F16K99/0001 , B01L3/502738 , B01L2300/0819 , B01L2300/0887 , B01L2300/123 , B01L2400/0605 , B01L2400/0638 , F16K99/0015 , F16K99/0023 , F16K2099/0071
摘要： The invention concerns a device for performing a reaction or at least two reactions in parallel or in series, and for transferring a fluid flow, consisting of. an upper surface (2) and a lower surface (3) mutually linked by an edge (4); at least a duct (5) wherein a fluid flow (F1) can be generated by means transferring at least one sample (6) to be treated and/or analysed, and at least a valve (8) incorporated in each duct (4) for directing each sample (6) thereby controlling the transfers, reactions and analyses in the device. Each valve (8) consists of two means (9 and 10) integral with the device, the first means (9) being mobile between an inoperative position wherein the fluid transfer (6) is possible and an active position wherein said transfer cannot take place, and the second means (10) being mobile between a position wherein it is not in contact with said first means (9) and an active position wherein it deforms the first means (9) and it is activated by an actuator external to the device.
摘要翻译：本发明涉及一种用于并行或串联地进行反应或至少两个反应的装置，并用于传送由以下组成的流体流。由边缘（4）相互连接的上表面（2）和下表面（3）; 至少一个管道（5），其中可以通过传送至少一个待处理和/或分析的样品（6）的装置产生流体流（F 1），以及至少一个结合在每个管道（4）中的阀门），用于引导每个样品（6），从而控制装置中的转移，反应和分析。每个阀（8）由与装置成一体的两个装置（9和10）组成，第一装置（9）可移动在不可操作的位置，其中流体传送（6）是可能的，并且其中所述传送不能发生的活动位置，并且所述第二装置（10）在其不与所述第一装置（9）接触的位置和其中使所述第一装置（9）变形并且由所述装置外部的致动器启动的活动位置之间可移动。

2. 发明申请

US20050019900A1 Device for the capacitive measuring of a fill level 审中-公开
标题翻译：用于电容式测量的装置
公开(公告)号：US20050019900A1
公开(公告)日：2005-01-27
申请号：US10498810
申请日：2002-12-18
申请人： Patrick Broyer , Pierre Imbaud
发明人： Patrick Broyer , Pierre Imbaud
IPC分类号： B01L3/00 , C12M1/34 , G01F23/26 , G01N27/22 , G01N33/483 , G01N35/10 , G01N37/00 , G01N11/00 , G01N33/487
CPC分类号： B01L3/502 , B01L2200/143 , B01L2300/0645 , B01L2300/0816 , B01L2300/0864 , G01F23/263 , G01N35/1016
摘要： A method of controlling the presence or absence of a volume of liquid in a container or of controlling the filling of a container with a liquid volume. A channel passes through the container and channel opens into a shaft which collects all or part of the liquid. The channel(s) and shaft(s) form a fluidic network. Implementation of the method includes: detecting the capacity, or another related parameter, such as the relative permittivity of the air present in the container, the oscillation frequency or the voltage, at each shaft before the liquid is injected; detecting the capacity, or another related parameter, at each shaft after the liquid has been injected; determining the capacitive variation, or a variation in a related parameter, at each shaft; and deducing the quantity of liquid present at each reaction shaft. The invention is particularly suitable for use in the field of diagnosis.
摘要翻译：控制容器中存在或不存在液体的方法或控制具有液体容积的容器的填充的方法。通道通过容器并且通道打开成收集全部或部分液体的轴。通道和轴形成流体网络。该方法的实现包括：在注入液体之前，检测在容器内存在的空气的相对介电常数，振荡频率或电压等容量或相关参数; 在注入液体之后，在每个轴处检测容量或另一相关参数; 确定每个轴处的电容变化或相关参数的变化; 并推导每个反应轴上存在的液体量。本发明特别适用于诊断领域。

3. 发明授权

US06994314B2 Valves activated by electrically active polymers or by shape-memory materials, device containing same and method for using same 失效
标题翻译：通过电活性聚合物或形状记忆材料活化的阀，含有该活性聚合物的装置及其使用方法
公开(公告)号：US06994314B2
公开(公告)日：2006-02-07
申请号：US10433261
申请日：2001-11-30
申请人： Francis Garnier , Bernard Mandrand , Patrick Broyer , Pierre Imbaud
发明人： Francis Garnier , Bernard Mandrand , Patrick Broyer , Pierre Imbaud
IPC分类号： F16K31/02
CPC分类号： F16K99/0001 , B81B3/0035 , C08L2201/12 , F04B53/1067 , F16K99/0015 , F16K99/0038 , F16K99/0044 , F16K99/0049 , F16K2099/0084
摘要： This invention concerns a valve (2), with at least one channel (3) running through it, allowing a fluid (F3) to be directed by transfer means within a device (1), the device (1) featuring at least one face (4), possibly flat, the valve (2) consisting of a film (7 or 16), flexible and/or which can be deformed, fixed on all or part of the face (4) of said device (1), and a film actuator (7), which enables said valve (2) to be activated or deactivated, this actuator consisting of an electrical power source.It also consists of a test sample card (1) equipped with at least one valve (2), and a process for actuating the valve (2), as described above.The invention is particularly applicable in the field of diagnosis.
摘要翻译：本发明涉及一种阀（2），其中至少一个通道（3）穿过其中，允许流体（F 3）由装置（1）内的转移装置引导，装置（1）具有至少一个由所述装置（1）的全部或部分表面（4）固定的柔性和/或可变形的膜（7或16）构成的阀门（2）可能是平的，以及能够使所述阀（2）被启动或停用的薄膜致动器（7），所述致动器由电源组成。

4. 发明授权

US5902746A Assembly for treating a sample in a liquid medium, in particular a biological material 失效
标题翻译：用于在液体介质，特别是生物材料中处理样品的装置
公开(公告)号：US5902746A
公开(公告)日：1999-05-11
申请号：US849515
申请日：1997-06-09
申请人： Bruno Colin , Bernard Mandrand , Pierre Imbaud
发明人： Bruno Colin , Bernard Mandrand , Pierre Imbaud
IPC分类号： G01N1/10 , B01L7/00 , C12M1/00 , C12N15/10 , G01N1/00 , G01N1/28 , G01N33/483 , C12M1/42
CPC分类号： G01N35/1097 , B01L7/52 , C12N15/1003
摘要： An assembly for treating a sample in a liquid medium, in particular a biological material, includes an essentially static permanently active module, closed off by a chamber from the outside. The assembly includes a disposable outer container holding the sample to be treated, for example an inoculum of a cell culture. The disposable outer container can be connected to the main outlet of a treatment circuit. Another disposable outer container is provided for analyzing the nucleic fraction obtained in the treatment circuit. This container can be connected to the main outlet of the treatment circuit and comprises various reagents and means for analyzing the nucleic fraction. Constituents of the assembly can act as a heat source when connected to an electrical current.
摘要翻译： PCT No.PCT / FR96 / 01635 Sec。 371日期：1997年6月9日 102（e）1997年6月9日PCT PCT 1996年10月18日PCT公布。出版物WO97 / 日期1997年5月1日用于处理液体介质，特别是生物材料中的样品的组件包括基本上静态的永久有效的模块，其被来自外部的室封闭。该组件包括容纳待处理样品的一次性外容器，例如细胞培养物的接种物。一次性外容器可连接到治疗电路的主出口。提供另一个一次性外容器用于分析在治疗电路中获得的核心部分。该容器可以连接到处理回路的主出口，并且包括用于分析核心部分的各种试剂和方法。当连接到电流时，组件的组成可以作为热源。

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