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1. 发明授权

US07776521B1 Coronavirus isolated from humans 有权
标题翻译：从人类分离的冠状病毒
公开(公告)号：US07776521B1
公开(公告)日：2010-08-17
申请号：US11748359
申请日：2007-05-14
申请人： Paul A. Rota , Larry J. Anderson , William J. Bellini , Michael D. Bowen , Cara Carthel Burns , Raymond Campagnoli , Qi Chen , James A. Comer , Byron T. Cook , Shannon L. Emery , Dean D. Erdman , Cynthia S. Goldsmith , Jeanette Guarner , Charles D. Humphrey , Joseph P. Icenogle , Thomas G. Ksiazek , Richard F. Meyer , Stephan S. Monroe , William Allan Nix , M. Steven Oberste , Christopher D. Paddock , Teresa C. T. Peret , Pierre E. Rollin , Mark A. Pallansch , Anthony Sanchez , Wun-Ju Shieh , Suxiang Tong , Sherif R. Zaki
发明人： Paul A. Rota , Larry J. Anderson , William J. Bellini , Michael D. Bowen , Cara Carthel Burns , Raymond Campagnoli , Qi Chen , James A. Comer , Byron T. Cook , Shannon L. Emery , Dean D. Erdman , Cynthia S. Goldsmith , Jeanette Guarner , Charles D. Humphrey , Joseph P. Icenogle , Thomas G. Ksiazek , Richard F. Meyer , Stephan S. Monroe , William Allan Nix , M. Steven Oberste , Christopher D. Paddock , Teresa C. T. Peret , Pierre E. Rollin , Mark A. Pallansch , Anthony Sanchez , Wun-Ju Shieh , Suxiang Tong , Sherif R. Zaki
IPC分类号： C12Q1/70 , C07H21/00 , C12N15/50
CPC分类号： C07K14/005 , A61K39/12 , A61K39/215 , C12N7/00 , C12N2770/20021 , C12N2770/20022 , C12N2770/20034
摘要： Disclosed herein is a newly isolated human coronavirus (SARS-CoV), the causative agent of severe acute respiratory syndrome (SARS). Also provided are the nucleic acid sequence of the SARS-CoV genome and the amino acid sequences of the SARS-CoV open reading frames, as well as methods of using these molecules to detect a SARS-CoV and detect infections therewith. Immune stimulatory compositions are also provided, along with methods of their use.
摘要翻译：本文公开了新分离的人冠状病毒（SARS-CoV），严重急性呼吸综合征（SARS）的致病因子。还提供了SARS-CoV基因组的核酸序列和SARS-CoV开放阅读框的氨基酸序列，以及使用这些分子检测SARS-CoV并检测其感染的方法。还提供免疫刺激组合物及其使用方法。

2. 发明授权

US07220852B1 Coronavirus isolated from humans 有权
标题翻译：从人类分离的冠状病毒
公开(公告)号：US07220852B1
公开(公告)日：2007-05-22
申请号：US10822904
申请日：2004-04-12
申请人： Paul A. Rota , Larry J. Anderson , William J. Bellini , Cara Carthel Burns , Raymond Campagnoli , Qi Chen , James A. Comer , Shannon L. Emery , Dean D. Erdman , Cynthia S. Goldsmith , Charles D. Humphrey , Joseph P. Icenogle , Thomas G. Ksiazek , Stephan S. Monroe , William Allan Nix , M. Steven Oberste , Teresa C. T. Peret , Pierre E. Rollin , Mark A. Pallansch , Anthony Sanchez , Suxiang Tong , Sherif R. Zaki
发明人： Paul A. Rota , Larry J. Anderson , William J. Bellini , Cara Carthel Burns , Raymond Campagnoli , Qi Chen , James A. Comer , Shannon L. Emery , Dean D. Erdman , Cynthia S. Goldsmith , Charles D. Humphrey , Joseph P. Icenogle , Thomas G. Ksiazek , Stephan S. Monroe , William Allan Nix , M. Steven Oberste , Teresa C. T. Peret , Pierre E. Rollin , Mark A. Pallansch , Anthony Sanchez , Suxiang Tong , Sherif R. Zaki
IPC分类号： C12N15/50 , C12N7/00
CPC分类号： C07K14/005 , A61K39/12 , A61K39/215 , C12N7/00 , C12N2770/20021 , C12N2770/20022 , C12N2770/20034
摘要： Disclosed herein is a newly isolated human coronavirus (SARS-CoV), the causative agent of severe acute respiratory syndrome (SARS). Also provided are the nucleic acid sequence of the SARS-CoV genome and the amino acid sequences of the SARS-CoV open reading frames, as well as methods of using these molecules to detect a SARS-CoV and detect infections therewith. Immune stimulatory compositions are also provided, along with methods of their use.
摘要翻译：本文公开了新分离的人冠状病毒（SARS-CoV），严重急性呼吸综合征（SARS）的致病因子。还提供了SARS-CoV基因组的核酸序列和SARS-CoV开放阅读框的氨基酸序列，以及使用这些分子检测SARS-CoV并检测其感染的方法。还提供免疫刺激组合物及其使用方法。

3. 发明授权

US06620913B1 Polypeptides of a novel hantavirus 失效
标题翻译：新型汉坦病毒的多肽
公开(公告)号：US06620913B1
公开(公告)日：2003-09-16
申请号：US10125631
申请日：2002-04-18
申请人： Stuart T. Nichol , Christina F. Spiropoulou , Thomas G. Ksiazek , Pierre E. Rollin
发明人： Stuart T. Nichol , Christina F. Spiropoulou , Thomas G. Ksiazek , Pierre E. Rollin
IPC分类号： C07K100
CPC分类号： C07K14/005 , A61K39/00 , C12N7/00 , C12N2760/12121 , C12N2760/12122 , C12Q1/702
摘要： The present invention relates to the discovery of a novel Hantavirus. In particular, the present invention relates to nucleic acids of the newly discovered virus and to nucleic acid reagents and antibodies for use in methods of detection and prevention of infection by the virus.
摘要翻译：本发明涉及一种新型汉坦病毒的发现。特别地，本发明涉及新发现的病毒的核酸和用于检测和预防病毒感染的方法中的核酸试剂和抗体。

4. 发明授权

US5853980A Black creek canal hantavirus and related methods 失效
标题翻译：黑河运河汉族病毒及相关方法
公开(公告)号：US5853980A
公开(公告)日：1998-12-29
申请号：US792055
申请日：1997-02-03
申请人： Pierre E. Rollin , Luanne Elliott , Thomas G. Ksiazek , Stuart T. Nichol , Sergey Morzunov , Eugeny Ravkov
发明人： Pierre E. Rollin , Luanne Elliott , Thomas G. Ksiazek , Stuart T. Nichol , Sergey Morzunov , Eugeny Ravkov
IPC分类号： C12N7/00 , G01N33/569 , C12Q1/70 , A61K39/12 , C07H21/04 , C12Q1/68
CPC分类号： C12N7/00 , G01N33/56983 , C12N2760/12011
摘要： The present invention relates to the discovery and isolation of a novel hantavirus designated the Black Creek Canal hantavirus. In particular, the present invention relates to nucleic acids of the newly discovered virus and to nucleic acid reagents (primers and probes), purified polypeptides and antibodies for use in methods of detection and prevention of infection by the virus. A vaccine or purified immunogenic polypeptide of the Black Creek Canal hantavirus in a pharmaceutically acceptable carrier is provided. A vector comprising the nucleic acids of the invention is provided. A method of detecting the presence of a hantavirus in a subject comprising contacting an antibody-containing sample from the subject with a purified polypeptide of the invention and detecting the reaction of the polypeptide and the antibody is provided. A method of detecting the presence of the Black Creek Canal hantavirus is provided comprising reverse transcribing viral RNA to synthesize a complementary DNA sequence followed by amplifying the DNA using primers which are selective for the Black Creek Canal hantavirus and detecting the presence of amplification, thereby indicating presence of the Black Creek Canal hantavirus in the sample.
摘要翻译：本发明涉及发现和分离命名为黑溪运河汉坦病毒的新型汉坦病毒。特别地，本发明涉及新发现的病毒的核酸和涉及用于检测和预防病毒感染的方法的核酸试剂（引物和探针），纯化多肽和抗体。提供了黑色河运河汉坦病毒在药学上可接受的载体中的疫苗或纯化的免疫原性多肽。提供了包含本发明的核酸的载体。检测受试者汉坦病毒存在的方法，包括使来自受试者的含抗体样品与本发明的纯化多肽接触并检测多肽和抗体的反应。提供了检测黑河运河汉坦病毒存在的方法，其包括逆转录病毒RNA以合成互补DNA序列，然后使用对黑溪运河汉坦病毒有选择性的引物扩增DNA并检测扩增的存在，由此表明样本中黑溪运河汉坦病毒的存在。

5. 发明申请

US20150218525A1 HUMAN EBOLA VIRUS SPECIES AND COMPOSITIONS AND METHODS THEREOF 有权
标题翻译：人类EBOLA病毒物种及其组合物及其方法
公开(公告)号：US20150218525A1
公开(公告)日：2015-08-06
申请号：US14694036
申请日：2015-04-23
申请人： Jonathan S. Towner , Stuart T. Nichol , James A. Comer , Thomas G. Ksiazek , Pierre E. Rollin
发明人： Jonathan S. Towner , Stuart T. Nichol , James A. Comer , Thomas G. Ksiazek , Pierre E. Rollin
IPC分类号： C12N7/00 , C12Q1/70 , G01N33/569 , C07K14/005
CPC分类号： C12N7/00 , A61K39/00 , A61K39/12 , A61K2039/5254 , A61K2039/5256 , A61K2039/53 , A61K2039/542 , A61K2039/543 , C07K14/005 , C07K16/10 , C07K2317/76 , C12N2760/14121 , C12N2760/14134 , C12N2760/14143 , C12N2760/14145 , C12N2810/6072 , C12Q1/701 , G01N33/56983 , G01N2333/08
摘要： Compositions and methods including and related to the Ebola Bundibugyo virus (EboBun) are provided. Compositions are provided that are operable as immunogens to elicit and immune response or protection from EboBun challenge in a subject such as a primate. Inventive methods are directed to detection and treatment of EboBun infection.
摘要翻译：提供包括埃博拉病毒（EboBun）的组合物和方法。提供了可作为免疫原起作用的组合物，以在诸如灵长类动物的受试者中引发和免疫应答或免受EboBun攻击的保护。本发明的方法涉及EboBun感染的检测和治疗。

6. 发明申请

US20120251502A1 Human Ebola Virus Species and Compositions and Methods Thereof 审中-公开
标题翻译：人埃博拉病毒种及其组成及方法
公开(公告)号：US20120251502A1
公开(公告)日：2012-10-04
申请号：US13125890
申请日：2009-10-26
申请人： Jonathan S. Towner , Stuart T. Nichol , James A. Comer , Thomas G. Ksiazek , Pierre E. Rollin
发明人： Jonathan S. Towner , Stuart T. Nichol , James A. Comer , Thomas G. Ksiazek , Pierre E. Rollin
IPC分类号： A61K35/76 , C07H21/04 , C12N7/04 , C07K14/08 , A61K38/02 , A61K31/7088 , C07K7/06 , C07K7/08 , C12N7/00 , C07H21/02
CPC分类号： C12N7/00 , A61K39/00 , A61K39/12 , A61K2039/5254 , A61K2039/5256 , A61K2039/53 , A61K2039/542 , A61K2039/543 , C07K14/005 , C07K16/10 , C07K2317/76 , C12N2760/14121 , C12N2760/14134 , C12N2760/14143 , C12N2760/14145 , C12N2810/6072 , C12Q1/701 , G01N33/56983 , G01N2333/08
摘要： Compositions and methods including and related to the Ebola Bundibugyo virus (EboBun) are provided. Compositions are provided that are operable as immunogens to elicit and immune response or protection from EboBun challenge in a subject such as a primate. Inventive methods are directed to detection and treatment of EboBun infection.
摘要翻译：提供包括埃博拉病毒（EboBun）的组合物和方法。提供了可作为免疫原起作用的组合物，以在诸如灵长类动物的受试者中引发和免疫应答或免受EboBun攻击的保护。本发明的方法涉及EboBun感染的检测和治疗。

7. 发明授权

US5945277A Strain of hantavirus nucleotide sequences thereof related probes, primers and vectors, and methods for detection 失效
标题翻译：其汉坦病毒核苷酸序列的应变相关探针，引物和载体以及检测方法
公开(公告)号：US5945277A
公开(公告)日：1999-08-31
申请号：US657641
申请日：1996-05-30
申请人： Stuart T. Nichol , Christina F. Spiropoulou , Thomas G. Ksiazek , Pierre E. Rollin
发明人： Stuart T. Nichol , Christina F. Spiropoulou , Thomas G. Ksiazek , Pierre E. Rollin
IPC分类号： A61K39/00 , C07K14/175 , C12N7/00 , C12N15/40 , C12Q1/70 , C07H21/04 , C12P19/34 , C12Q1/68
CPC分类号： C07K14/005 , C12N7/00 , C12Q1/702 , A61K39/00 , C12N2760/12121 , C12N2760/12122
摘要： The present invention relates to the discovery of a novel Hantavirus. In particular, the present invention relates to nucleic acids of the newly discovered virus and to nucleic acid reagents and antibodies for use in methods of detection and prevention of infection by the virus.
摘要翻译：本发明涉及一种新型汉坦病毒的发现。特别地，本发明涉及新发现的病毒的核酸和用于检测和预防病毒感染的方法中的核酸试剂和抗体。

8. 发明授权

US5916754A Bayou hantavirus and related methods 失效
标题翻译： Bayou汉坦病毒及相关方法
公开(公告)号：US5916754A
公开(公告)日：1999-06-29
申请号：US390888
申请日：1995-02-17
申请人： Stuart T. Nichol , Sergey Morzunov , Thomas G. Ksiazek , Pierre E. Rollin , Christina F. Spiropoulou
发明人： Stuart T. Nichol , Sergey Morzunov , Thomas G. Ksiazek , Pierre E. Rollin , Christina F. Spiropoulou
IPC分类号： A61K38/00 , A61K39/00 , A61P31/12 , C07K14/175 , A61K39/12 , A61K39/42 , C07H21/04
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , C12N2760/12122
摘要： The present invention relates to the discovery and isolation of a novel hantavirus designated the Bayou hantavirus. In particular, the present invention relates to nucleic acids of the newly discovered virus and to nucleic acid reagents (primers and probes), purified polypeptides and antibodies for use in methods of detection and prevention of infection by the virus. A vaccine or purified immunogenic polypeptide of the Bayou hantavirus in a pharmaceutically acceptable carrier is provided. A vector comprising the nucleic acids of the invention is provided. A method of detecting the presence of a hantavirus in a subject comprising contacting an antibody-containing sample from the subject with a purified polypeptide of the invention and detecting the reaction of the polypeptide and the antibody is provided. A method of detecting the presence of the Bayou hantavirus is provided comprising reverse transcribing viral RNA to synthesize a complementary DNA sequence followed by amplifying the DNA using primers which are selective for the Bayou hantavirus and detecting the presence of amplification, thereby indicating presence of the Bayou hantavirus in the sample.
摘要翻译：本发明涉及发现和分离命名为巴约汉坦病毒的新型汉坦病毒。特别地，本发明涉及新发现的病毒的核酸和涉及用于检测和预防病毒感染的方法的核酸试剂（引物和探针），纯化多肽和抗体。提供了在药学上可接受的载体中的Bayou汉坦病毒的疫苗或纯化的免疫原性多肽。提供了包含本发明的核酸的载体。检测受试者汉坦病毒存在的方法，包括使来自受试者的含抗体样品与本发明的纯化多肽接触并检测多肽和抗体的反应。提供了检测Bayou汉坦病毒存在的方法，其包括逆转录病毒RNA以合成互补DNA序列，然后使用对Bayou汉坦病毒选择性的引物扩增DNA并检测扩增的存在，从而指示Bayou的存在样本中的汉坦病毒。

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