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1. 发明授权

US5853980A Black creek canal hantavirus and related methods 失效
标题翻译：黑河运河汉族病毒及相关方法
公开(公告)号：US5853980A
公开(公告)日：1998-12-29
申请号：US792055
申请日：1997-02-03
申请人： Pierre E. Rollin , Luanne Elliott , Thomas G. Ksiazek , Stuart T. Nichol , Sergey Morzunov , Eugeny Ravkov
发明人： Pierre E. Rollin , Luanne Elliott , Thomas G. Ksiazek , Stuart T. Nichol , Sergey Morzunov , Eugeny Ravkov
IPC分类号： C12N7/00 , G01N33/569 , C12Q1/70 , A61K39/12 , C07H21/04 , C12Q1/68
CPC分类号： C12N7/00 , G01N33/56983 , C12N2760/12011
摘要： The present invention relates to the discovery and isolation of a novel hantavirus designated the Black Creek Canal hantavirus. In particular, the present invention relates to nucleic acids of the newly discovered virus and to nucleic acid reagents (primers and probes), purified polypeptides and antibodies for use in methods of detection and prevention of infection by the virus. A vaccine or purified immunogenic polypeptide of the Black Creek Canal hantavirus in a pharmaceutically acceptable carrier is provided. A vector comprising the nucleic acids of the invention is provided. A method of detecting the presence of a hantavirus in a subject comprising contacting an antibody-containing sample from the subject with a purified polypeptide of the invention and detecting the reaction of the polypeptide and the antibody is provided. A method of detecting the presence of the Black Creek Canal hantavirus is provided comprising reverse transcribing viral RNA to synthesize a complementary DNA sequence followed by amplifying the DNA using primers which are selective for the Black Creek Canal hantavirus and detecting the presence of amplification, thereby indicating presence of the Black Creek Canal hantavirus in the sample.
摘要翻译：本发明涉及发现和分离命名为黑溪运河汉坦病毒的新型汉坦病毒。特别地，本发明涉及新发现的病毒的核酸和涉及用于检测和预防病毒感染的方法的核酸试剂（引物和探针），纯化多肽和抗体。提供了黑色河运河汉坦病毒在药学上可接受的载体中的疫苗或纯化的免疫原性多肽。提供了包含本发明的核酸的载体。检测受试者汉坦病毒存在的方法，包括使来自受试者的含抗体样品与本发明的纯化多肽接触并检测多肽和抗体的反应。提供了检测黑河运河汉坦病毒存在的方法，其包括逆转录病毒RNA以合成互补DNA序列，然后使用对黑溪运河汉坦病毒有选择性的引物扩增DNA并检测扩增的存在，由此表明样本中黑溪运河汉坦病毒的存在。

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