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1. 发明授权

US09572660B2 Prosthetic heart valves 有权
标题翻译：假心脏瓣膜
公开(公告)号：US09572660B2
公开(公告)日：2017-02-21
申请号：US12451678
申请日：2008-06-04
申请人： Peter N. Braido , Yousef F. Alkhatib
发明人： Peter N. Braido , Yousef F. Alkhatib
IPC分类号： A61F2/82 , A61F2/24 , A61L27/36 , A61L27/54
CPC分类号： A61F2/2418 , A61F2210/0076 , A61F2220/0016 , A61F2220/0075 , A61F2230/0054 , A61F2230/008 , A61L27/3604 , A61L27/54
摘要： A prosthetic heart valve (10) (e.g., a prosthetic aortic valve) is designed to be somewhat circumferentially collapsible and then re-expandable. The collapsed condition may be used for less invasive delivery of the valve into a patient. When the valve reaches the implant site in the patient, it re-expands to normal operating size, and also to engage surrounding tissue of the patient. The valve includes a stent portion (200) and a ring portion (100) that is substantially concentric with the stent portion but downstream from the stent portion in the direction of blood flow through the implanted valve. When the valve is implanted, the stent portion engages the patient's tissue at or near the native valve annulus, while the ring portion engages tissue downstream from the native valve site (e.g., the aorta).
摘要翻译：假体心脏瓣膜（10）（例如，假体主动脉瓣）被设计成有些周向可折叠并且然后再膨胀。折叠状态可以用于将瓣膜侵入性较差的患者。当阀门到达病人的植入部位时，它会重新扩大到正常的操作大小，并且还可以接合病人的周围组织。所述阀包括支架部分（200）和环状部分（100），所述支架部分（100）与所述支架部分基本上同心，但在所述支架部分的下游沿着通过所述植入瓣膜的血流方向。当植入瓣膜时，支架部分在天然瓣膜环处或附近接合患者组织，而环部分接合自然瓣膜部位（例如，主动脉）下游的组织。

2. 发明授权

US08425593B2 Collapsible prosthetic heart valves 有权
标题翻译：可折叠假体心脏瓣膜
公开(公告)号：US08425593B2
公开(公告)日：2013-04-23
申请号：US12733759
申请日：2008-09-26
申请人： Peter N. Braido , Andrea L. McCarthy , Rubem L. Figueiredo , Julia A. Neuman
发明人： Peter N. Braido , Andrea L. McCarthy , Rubem L. Figueiredo , Julia A. Neuman
IPC分类号： A61F2/24
CPC分类号： A61F2/2409 , A61F2/2403 , A61F2/2412 , A61F2/2415 , A61F2/2418 , A61F2/2433 , A61F2/89 , A61F2220/0008 , A61F2220/0075 , A61F2230/0006 , A61F2230/0054 , A61F2230/0069
摘要： Prosthetic heart valves, which are collapsible to a relatively small circumferential size for less invasive delivery into a patient and which then re-expand to operating size at an implant site in the patient, include a collapsible/expandable stent-like supporting structure and various components of flexible, sheet-like material that are attached to the supporting structure. For example, these sheet-like other components may include prosthetic valve leaflets, layers of buffering material, cuff material, etc. Improved structures and techniques are provided for securing such other components to the stent-like supporting structure of the valve.
摘要翻译：假体心脏瓣膜可折叠到相对较小的圆周尺寸以便较少侵入性地输送到患者体内，然后在患者的植入部位再扩张至操作尺寸，包括可折叠/可扩张的支架状支撑结构和各种部件柔性的片状材料，其附接到支撑结构。例如，这些片状的其他部件可以包括假体瓣膜小叶，缓冲材料层，袖带材料等。提供了改进的结构和技术，用于将这些其它部件固定到瓣膜的支架状支撑结构上。

3. 发明申请

US20100160832A1 APPARATUS AND METHOD FOR MEASURING BLOOD VESSELS 有权
标题翻译：用于测量血液容器的装置和方法
公开(公告)号：US20100160832A1
公开(公告)日：2010-06-24
申请号：US12340382
申请日：2008-12-19
申请人： Peter N. Braido
发明人： Peter N. Braido
IPC分类号： A61B5/107
CPC分类号： A61B5/1076 , A61B5/02007 , A61B5/6876 , A61B5/6884
摘要： An apparatus comprising a blood vessel measuring device is disclosed. The blood vessel measuring device may comprise a handle. A measuring member may be attached to the handle. The measuring member may be dimensioned to wrap around a blood vessel to measure a size of the blood vessel. The blood vessel measuring device may comprise an extension, and a first end of the extension may be attached to the handle. The blood vessel measuring device may comprise a connector attached to a second end of the extension. A method is also disclosed. The method may comprise inserting a measuring device into an incision in a patient. The measuring device may comprise a measuring member. The method may also comprise wrapping the measuring member around a blood vessel of the patient and measuring a dimension of the blood vessel with the measuring member.
摘要翻译：公开了一种包括血管测量装置的装置。血管测量装置可以包括手柄。测量构件可以附接到手柄。测量构件的尺寸可以围绕血管包围以测量血管的尺寸。血管测量装置可以包括延伸部，并且延伸部的第一端可以附接到手柄。血管测量装置可以包括连接到延伸部的第二端的连接器。还公开了一种方法。该方法可以包括将测量装置插入患者的切口中。测量装置可以包括测量构件。该方法还可以包括将测量构件缠绕在患者的血管周围并用测量构件测量血管的尺寸。

4. 发明授权

US08808356B2 Collapsible and re-expandable prosthetic heart valve cuff designs and complementary technological applications 有权
标题翻译：可折叠和可重新扩张的假体心脏瓣膜袖口设计和补充技术应用
公开(公告)号：US08808356B2
公开(公告)日：2014-08-19
申请号：US12737256
申请日：2009-07-15
申请人： Peter N. Braido , Paul E. Ashworth , Julia A. Neuman
发明人： Peter N. Braido , Paul E. Ashworth , Julia A. Neuman
IPC分类号： A61F2/06 , A61F2/24
CPC分类号： A61F2/2409 , A61F2/01 , A61F2/2412 , A61F2/2418 , A61F2/243 , A61F2/2433 , A61F2/2436 , A61F2/2442 , A61F2/246 , A61F2/2466 , A61F2210/0014 , A61F2220/0008 , A61F2220/0016 , A61F2220/0075 , A61F2230/0054 , A61F2230/0069 , A61F2250/0039 , A61F2250/0069
摘要： A prosthetic heart valve is provided with a cuff having features which promote sealing with the native tissues even where the native tissues are irregular. The cuff may include a portion adapted to bear on the LVOT when the valve is implanted in a native aortic valve. The valve may include elements for biasing the cuff outwardly with respect to the stent body when the stent body is in an expanded condition. The cuff may have portions of different thickness distributed around the circumference of the valve in a pattern matching the shape of the opening defined by the native tissue. All or part of the cuff may be movable relative to the stent during implantation.
摘要翻译：假体心脏瓣膜设置有具有促进与天然组织密封的特征的袖带，即使天然组织是不规则的。当瓣膜植入天然主动脉瓣中时，套囊可以包括适于承受LVOT的部分。当支架主体处于膨胀状态时，阀可以包括用于相对于支架主体向外偏压套囊的元件。袖带可以具有以与由天然组织限定的开口的形状相匹配的图案围绕阀的圆周分布的不同厚度的部分。在植入期间，全部或部分袖带可相对于支架移动。

5. 发明授权

US08728012B2 Apparatus and method for measuring blood vessels 有权
标题翻译：血管测量装置及方法
公开(公告)号：US08728012B2
公开(公告)日：2014-05-20
申请号：US12340382
申请日：2008-12-19
申请人： Peter N. Braido
发明人： Peter N. Braido
IPC分类号： A61B5/117 , A61B5/103 , A61B1/00 , G01B3/10
CPC分类号： A61B5/1076 , A61B5/02007 , A61B5/6876 , A61B5/6884
摘要： An apparatus comprising a blood vessel measuring device is disclosed. The blood vessel measuring device may comprise a handle. A measuring member may be attached to the handle. The measuring member may be dimensioned to wrap around a blood vessel to measure a size of the blood vessel. The blood vessel measuring device may comprise an extension, and a first end of the extension may be attached to the handle. The blood vessel measuring device may comprise a connector attached to a second end of the extension. A method is also disclosed. The method may comprise inserting a measuring device into an incision in a patient. The measuring device may comprise a measuring member. The method may also comprise wrapping the measuring member around a blood vessel of the patient and measuring a dimension of the blood vessel with the measuring member.
摘要翻译：公开了一种包括血管测量装置的装置。血管测量装置可以包括手柄。测量构件可以附接到手柄。测量构件的尺寸可以围绕血管包围以测量血管的尺寸。血管测量装置可以包括延伸部，并且延伸部的第一端可以附接到手柄。血管测量装置可以包括连接到延伸部的第二端的连接器。还公开了一种方法。该方法可以包括将测量装置插入患者的切口中。测量装置可以包括测量构件。该方法还可以包括将测量构件缠绕在患者的血管周围并用测量构件测量血管的尺寸。

6. 发明申请

US20110098800A1 AXIALLY ANCHORING COLLAPSIBLE AND RE-EXPANDABLE PROSTHETIC HEART VALVES FOR VARIOUS DISEASE STATES 有权
标题翻译：对各种疾病状态进行轴向锚定和可再膨胀的预防心脏瓣膜
公开(公告)号：US20110098800A1
公开(公告)日：2011-04-28
申请号：US12737254
申请日：2009-07-15
申请人： Peter N. Braido , Julia A. Neuman , Thomas M. Benson
发明人： Peter N. Braido , Julia A. Neuman , Thomas M. Benson
IPC分类号： A61F2/82 , A61F2/24
CPC分类号： A61F2/2412 , A61F2/2418 , A61F2220/0016 , A61F2220/0075 , A61F2230/0054 , A61F2230/008
摘要： A stent (10) for use in a prosthetic heart valve has an annulus section (12) adapted for placement within the leaflets and annulus of the native heart valve. The annulus section has latch members (50) adapted to engage the leaflets of the native heart valve when prosthetic valve is implanted in the native valve. The latch members may hold the leaflets in engagement with the annulus section, and help to retain the prosthetic valve in position. The annulus section may have a non-circular cross-sectional shape.
摘要翻译：用于假体心脏瓣膜的支架（10）具有适于放置在天然心脏瓣膜的瓣叶和环状物中的环形部分（12）。环形部分具有闩锁构件（50），当人工瓣膜植入天然瓣膜时，该构件适于接合天然心脏瓣膜的小叶。闩锁构件可以将小叶保持与环形部分接合，并且有助于将假体瓣保持在适当位置。环形部分可以具有非圆形横截面形状。

7. 发明申请

US20100168839A1 PROSTHETIC HEART VALVES 有权
标题翻译：先天性心脏瓣膜
公开(公告)号：US20100168839A1
公开(公告)日：2010-07-01
申请号：US12451678
申请日：2008-06-04
申请人： Peter N. Braido , Yousef F. Alkhatib
发明人： Peter N. Braido , Yousef F. Alkhatib
IPC分类号： A61F2/82 , A61F2/24
CPC分类号： A61F2/2418 , A61F2210/0076 , A61F2220/0016 , A61F2220/0075 , A61F2230/0054 , A61F2230/008 , A61L27/3604 , A61L27/54
摘要： A prosthetic heart valve (10) (e.g., a prosthetic aortic valve) is designed to be somewhat circumferentially collapsible and then re-expandable. The collapsed condition may be used for less invasive delivery of the valve into a patient. When the valve reaches the implant site in the patient, it re-expands to normal operating size, and also to engage surrounding tissue of the patient. The valve includes a stent portion (200) and a ring portion (100) that is substantially concentric with the stent portion but downstream from the stent portion in the direction of blood flow through the implanted valve. When the valve is implanted, the stent portion engages the patient's tissue at or near the native valve annulus, while the ring portion engages tissue downstream from the native valve site (e.g., the aorta).
摘要翻译：假体心脏瓣膜（10）（例如，假体主动脉瓣）被设计成有些周向可折叠并且然后再膨胀。折叠状态可以用于将瓣膜侵入性较差的患者。当阀门到达病人的植入部位时，它会重新扩大到正常的操作大小，并且还可以接合病人的周围组织。所述阀包括支架部分（200）和环状部分（100），所述支架部分（100）与所述支架部分基本上同心，但在所述支架部分的下游沿着通过所述植入瓣膜的血流方向。当植入瓣膜时，支架部分在天然瓣膜环处或附近接合患者组织，而环部分接合自然瓣膜部位（例如，主动脉）下游的组织。

8. 发明申请

US20100161040A1 CARDIOVASCULAR VALVE AND VALVE HOUSING APPARATUSES AND SYSTEMS 有权
标题翻译：心脏瓣膜和阀门壳体设备和系统
公开(公告)号：US20100161040A1
公开(公告)日：2010-06-24
申请号：US12340189
申请日：2008-12-19
申请人： Peter N. Braido , Yousef F. Alkhatib
发明人： Peter N. Braido , Yousef F. Alkhatib
IPC分类号： A61F2/24
CPC分类号： A61B17/11 , A61B5/1076 , A61B17/00234 , A61B17/1152 , A61B17/32002 , A61B17/32053 , A61B2017/00252 , A61B2017/00349 , A61B2017/00778 , A61B2017/1107 , A61B2017/1132 , A61B2017/1135 , A61B2090/061 , A61F2/06 , A61F2/064 , A61F2/24 , A61F2/2403 , A61F2/2409 , A61F2/2412 , A61F2/2418 , A61F2/2475 , A61F2002/068 , A61F2002/30714 , A61F2250/0089 , A61M1/10 , A61M1/1008 , A61M1/1096 , A61M1/12 , A61M27/006
摘要： A cardiovascular valve assembly is disclosed including a housing assembly comprising a first portion and a second portion removably attached to the first portion. A valve may be positioned within the housing assembly. The valve, which may be a mechanical valve, a biological tissue valve, or a polymeric valve, may be structured to allow fluid to flow through the housing assembly in a single direction. In certain embodiments, the valve assembly may further include at least one coupling structure provided on the second portion and at least one aperture defined in the first portion, with the aperture structured to receive the coupling structure to couple the first portion to the second portion. Corresponding systems incorporating cardiovascular valve assemblies are also disclosed.
摘要翻译：公开了一种心血管瓣膜组件，其包括壳体组件，壳体组件包括可拆卸地附接到第一部分的第一部分和第二部分。阀可以定位在壳体组件内。可以构造阀，其可以是机械阀，生物组织阀或聚合物阀，以允许流体沿单个方向流过壳体组件。在某些实施例中，阀组件还可以包括设置在第二部分上的至少一个联接结构和限定在第一部分中的至少一个孔，其中孔被构造成接收联接结构以将第一部分耦合到第二部分。还公开了包含心血管阀组件的相应系统。

9. 发明申请

US20100160939A1 SYSTEMS, APPARATUSES, AND METHODS FOR CARDIOVASCULAR CUTTING DEVICES AND VALVES 审中-公开
标题翻译：用于心脏切割装置和阀的系统，装置和方法
公开(公告)号：US20100160939A1
公开(公告)日：2010-06-24
申请号：US12340431
申请日：2008-12-19
申请人： Peter N. Braido
发明人： Peter N. Braido
IPC分类号： A61B17/32
CPC分类号： A61B17/32053 , A61B2017/00252 , A61B2017/1107 , A61B2017/1135
摘要： A system comprising a tube with a first end dimension to be positioned against a cardiovascular organ. The system may comprise a cutting member adapted to cut an opening in the cardiovascular organ. The system may also comprise a first valve positioned inside the tube. The first valve may be adapted to open to allow the cutting member to pass through the first valve to the cardiovascular organ. The first valve may be adapted to close after the cardiovascular coring device is retracted through the first valve. A cardiovascular coring apparatus is also disclosed. The cardiovascular coring apparatus may comprise a cutting member, a tissue retraction member, and a valve positioned inside the cutting member. A method for inserting a cutting member through a valve is disclosed. A method for inserting a tissue retraction member through a valve in a cutting member is also disclosed.
摘要翻译：一种系统，其包括具有第一端尺寸以便抵靠心血管器官定位的管。该系统可以包括适于切割心血管器官中的开口的切割构件。该系统还可以包括位于管内的第一阀。第一阀可以适于打开以允许切割构件穿过第一阀到达心血管器官。第一阀可适于在心血管取芯装置通过第一阀回缩之后关闭。还公开了一种心血管取芯装置。心血管取芯装置可以包括切割构件，组织缩回构件和定位在切割构件内部的阀。公开了一种通过阀插入切割构件的方法。还公开了一种通过切割构件中的阀将组织缩回构件插入的方法。

10. 发明授权

US09566146B2 Cardiovascular valve and valve housing apparatuses and systems 有权
标题翻译：心血管阀和阀门外壳设备和系统
公开(公告)号：US09566146B2
公开(公告)日：2017-02-14
申请号：US12340189
申请日：2008-12-19
申请人： Peter N. Braido , Yousef F. Alkhatib
发明人： Peter N. Braido , Yousef F. Alkhatib
IPC分类号： A61F2/24 , A61F2/06 , A61B17/11 , A61B17/115 , A61B17/3205 , A61M1/10 , A61B17/32 , A61B17/00 , A61F2/30
CPC分类号： A61B17/11 , A61B5/1076 , A61B17/00234 , A61B17/1152 , A61B17/32002 , A61B17/32053 , A61B2017/00252 , A61B2017/00349 , A61B2017/00778 , A61B2017/1107 , A61B2017/1132 , A61B2017/1135 , A61B2090/061 , A61F2/06 , A61F2/064 , A61F2/24 , A61F2/2403 , A61F2/2409 , A61F2/2412 , A61F2/2418 , A61F2/2475 , A61F2002/068 , A61F2002/30714 , A61F2250/0089 , A61M1/10 , A61M1/1008 , A61M1/1096 , A61M1/12 , A61M27/006
摘要： A cardiovascular valve assembly is disclosed including a housing assembly comprising a first portion and a second portion removably attached to the first portion. A valve may be positioned within the housing assembly. The valve, which may be a mechanical valve, a biological tissue valve, or a polymeric valve, may be structured to allow fluid to flow through the housing assembly in a single direction. In certain embodiments, the valve assembly may further include at least one coupling structure provided on the second portion and at least one aperture defined in the first portion, with the aperture structured to receive the coupling structure to couple the first portion to the second portion. Corresponding systems incorporating cardiovascular valve assemblies are also disclosed.
摘要翻译：公开了一种心血管瓣膜组件，其包括壳体组件，壳体组件包括可拆卸地附接到第一部分的第一部分和第二部分。阀可以定位在壳体组件内。可以构造阀，其可以是机械阀，生物组织阀或聚合物阀，以允许流体沿单个方向流过壳体组件。在某些实施例中，阀组件还可以包括设置在第二部分上的至少一个联接结构和限定在第一部分中的至少一个孔，其中孔被构造成接收联接结构以将第一部分耦合到第二部分。还公开了包含心血管阀组件的相应系统。

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