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1. 发明授权

US08961501B2 Method for applying flowable hydrogels to a cornea 有权
标题翻译：将可流动水凝胶应用于角膜的方法
公开(公告)号：US08961501B2
公开(公告)日：2015-02-24
申请号：US12884466
申请日：2010-09-17
申请人： Peter Jarrett , Rami El Hayek , Michael Bassett , James Biggins
发明人： Peter Jarrett , Rami El Hayek , Michael Bassett , James Biggins
IPC分类号： A61B18/18 , A61F2/00 , A61K9/00 , A61K9/06 , A61K47/34
CPC分类号： A61K9/0048 , A61K9/06 , A61K47/34
摘要： Materials and methods of treating an eye with a hydrogel formed on the eye. Embodiments are provided that include post-keratectomy bandages. A method of treating a patient by application of a hydrogel bandage to a cornea by providing a first hydrogel precursor in a dry form immobilized in a first deposit at a first location in a well, providing a second hydrogel precursor in a dry form immobilized in a second deposit at a second location in the well, mixing the deposits together to form a mixture, and transferring at least some of the mixture to the cornea, with the mixture forming a covalently crosslinked hydrogel on the cornea.
摘要翻译：用眼睛上形成的水凝胶治疗眼睛的材料和方法。提供了包括后角膜切除术绷带的实施例。一种通过将水凝胶绷带应用于角膜来治疗患者的方法，该方法通过在第一位置上提供固定在第一沉积物中的以干燥形式固定的第一水凝胶前体，提供固定在孔中的干燥形式的第二水凝胶前体第二次沉积在井的第二位置，将沉积物混合在一起形成混合物，并将至少一些混合物转移到角膜，混合物在角膜上形成共价交联的水凝胶。

2. 发明申请

US20100209478A1 DRUG DELIVERY THROUGH HYDROGEL PLUGS 有权
标题翻译：药物通过HYDROGEL PLUG递送
公开(公告)号：US20100209478A1
公开(公告)日：2010-08-19
申请号：US12704692
申请日：2010-02-12
申请人： Amarpreet S. Sawhney , Peter Jarrett , Michael Bassett , Charles Blizzard
发明人： Amarpreet S. Sawhney , Peter Jarrett , Michael Bassett , Charles Blizzard
IPC分类号： A61F2/14 , A61K31/437 , A61K31/135 , A61P27/02 , A61P27/06 , B29B9/06
CPC分类号： A61K9/0051 , A61B17/12099 , A61B17/12159 , A61B17/1219 , A61F9/00772 , A61F2250/0067 , A61K31/135 , A61K31/437
摘要： An embodiment is a medical prosthesis for blocking or reducing tear flow through a punctum or canaliculus of a human eye and delivering a drug to the eye that comprises a dehydrated covalently crosslinked synthetic hydrophilic polymer hydrogel with dimensions to pass through a puncta lacrimali, with the dehydrated hydrogel absorbing physiological water to swell to at least 1 mm in cross-sectional width and conformably fit a canaliculus, with the hydrogel comprising a therapeutic agent dispersed through the hydrogel for release to an eye, with the hydrogel having a water content of at least about 50% by weight or volume when allowed to fully hydrate in vitro in physiological saline.
摘要翻译：一个实施方案是用于阻断或减少穿过人眼的泪点或泪管的泪液的药物假体，并将药物递送到眼睛，所述药物包括脱水的共价交联的合成亲水性聚合物水凝胶，其尺寸通过泪点，脱水水凝胶吸收生理水以横截面宽度膨胀至至少1mm，并且顺应地配合小孔，其中水凝胶包含分散在水凝胶中的治疗剂以释放至眼睛，水凝胶的水含量至少约为当在生理盐水中体外充分水合时，其重量为50％或体积。

3. 发明申请

US20100170384A1 LOCKING DEVICE 审中-公开
标题翻译：锁定设备
公开(公告)号：US20100170384A1
公开(公告)日：2010-07-08
申请号：US12601945
申请日：2008-05-27
申请人： Peter Jarrett
发明人： Peter Jarrett
IPC分类号： F15B15/19
CPC分类号： F15B15/19
摘要： A pyrotechnic releasable locking device for maintaining a first and a second member of a structure in a fixed relationship. The locking device comprises a body for locating on or within the first member of the structure such that, in use, a part of the body protrudes into the second member of the structure. The pyrotechnic compound is located on or within the body and a channel is located in the interior of the body and runs between the pyrotechnic compound and an exterior surface of the part of the body that, in use, protrudes into a recess in the second member of the structure. When the pyrotechnic compound is ignited the combustion gases travel along the channel into the recess of the second member of the structure, and the resultant gas pressure forces the body out of the recess thereby releasing the second member of the structure.
摘要翻译：一种用于将固定关系中的结构的第一和第二构件保持的烟火释放式锁定装置。锁定装置包括用于定位在结构的第一构件上或内部的主体，使得在使用中，主体的一部分突出到结构的第二构件中。烟火化合物位于身体内部或内部，并且通道位于身体的内部，并且在烟火化合物与身体部分的外表面之间延伸，在使用中，该烟道气化合物与外部部分在第二部件的结构。当烟火化合物被点燃时，燃烧气体沿着通道行进到结构的第二构件的凹部中，并且所产生的气体压力迫使身体离开凹槽，从而释放结构的第二构件。

4. 发明申请

US20050281866A1 Adherent polymeric compositions 审中-公开
标题翻译：粘附聚合物组合物
公开(公告)号：US20050281866A1
公开(公告)日：2005-12-22
申请号：US11136328
申请日：2005-05-23
申请人： Peter Jarrett , Kenneth Messier , Robert Miller , C. Philbrook , Hildegard Kramer , J. Kablik , Erika Johnston , Luis Avila , Arthur Coury
发明人： Peter Jarrett , Kenneth Messier , Robert Miller , C. Philbrook , Hildegard Kramer , J. Kablik , Erika Johnston , Luis Avila , Arthur Coury
IPC分类号： A61L15/16 , A61L24/00 , A61L24/04 , A61L27/34 , A61L31/06 , A61L31/10
CPC分类号： A61L31/06 , A61L24/0042 , A61L24/043 , A61L27/34 , A61L31/10 , C08L71/02
摘要： Described herein are adhesive polymeric compositions and methods for using the compositions. The composition are adherent to the applied surface. The compositions, in certain embodiments, are biodegradable and biocompatible, and can be designed with selected properties of compliancy and elasticity for different surgical and therapeutic applications. The adherent polymeric compositions comprise a polymerized macromer network and an additive mixed or entangled in the polymerized macromer. The additive is bonded to a surface by at least one covalent bond or by secondary interactions and is not covalently bonded to the polymerized macromer network. Alternatively, the additive is bonded to the surface by at least one covalent bond and is also bonded to the macromer network. The disclosed compositions can be used as an improved barrier, coating or drug delivery system that due to the additive is highly adherent to an applied surface. The compositions of the present invention are typically non-toxic, water miscible and have adaptable characteristics depending on the macromers and additives used. For example, specific macromers can be used for targeted bioresorption rate and/or degradation rate of the applied composition.
摘要翻译：本文描述的是粘合聚合物组合物和使用该组合物的方法。组合物附着在所施加的表面上。在某些实施方案中，组合物是可生物降解的和生物相容的，并且可以设计成具有针对不同手术和治疗应用的选择性的适应性和弹性。粘附的聚合物组合物包含聚合的大分子单体网络和在聚合的大分子单体中混合或缠结的添加剂。添加剂通过至少一个共价键或通过二次相互作用结合到表面上，并且不共价键合到聚合的大分子单体网络上。或者，添加剂通过至少一个共价键与表面键合，并且也结合到大分子单体网络上。所公开的组合物可以用作改进的屏障，涂层或药物递送系统，由于添加剂与施加的表面高度粘附。根据所使用的大分子单体和添加剂，本发明的组合物通常是无毒的，水可混溶的并具有适应性的特性。例如，特定的大分子单体可用于所应用组合物的靶向生物再吸收速率和/或降解速率。

5. 发明申请

US20130071462A1 Drug Delivery Systems and Applications 审中-公开
标题翻译：药物输送系统和应用
公开(公告)号：US20130071462A1
公开(公告)日：2013-03-21
申请号：US13234428
申请日：2011-09-16
申请人： Peter Jarrett , Rami El-Hayek , Amarpreet S. Sawhney
发明人： Peter Jarrett , Rami El-Hayek , Amarpreet S. Sawhney
IPC分类号： A61K9/14 , A61P27/02 , A61K38/38
CPC分类号： A61K9/0024 , A61K9/06 , A61K9/5015 , A61K38/00
摘要： Certain embodiments of the invention include medical materials and methods comprising a biodegradable hydrophilic hydrogel comprising dispersed lipophilic particles that comprise a therapeutic agent, wherein the lipophilic particles have a low water solubility in physiological saline at physiological temperature.
摘要翻译：本发明的某些实施方案包括包含可生物降解的亲水性水凝胶的医学材料和方法，其包含包含治疗剂的分散的亲脂性颗粒，其中所述亲脂性颗粒在生理温度下在生理盐水中具有低水溶性。

6. 发明授权

US10226417B2 Drug delivery systems and applications 有权
公开(公告)号：US10226417B2
公开(公告)日：2019-03-12
申请号：US13234428
申请日：2011-09-16
申请人： Peter Jarrett , Rami El-Hayek , Amarpreet S. Sawhney , Sarah Guedez
发明人： Peter Jarrett , Rami El-Hayek , Amarpreet S. Sawhney , Sarah Guedez
IPC分类号： A61K9/14 , A61K9/00 , A61K9/06 , A61K9/50 , A61K38/00
摘要： Certain embodiments of the invention include medical materials and methods comprising a biodegradable hydrophilic hydrogel comprising dispersed lipophilic particles that comprise a therapeutic agent, wherein the lipophilic particles have a low water solubility in physiological saline at physiological temperature.

7. 发明申请

US20120071865A1 FLOWABLE HYDROGELS FOR CONTROL OF CELL IN-MIGRATION 有权
标题翻译：用于控制细胞迁移的可流动水凝胶
公开(公告)号：US20120071865A1
公开(公告)日：2012-03-22
申请号：US12884466
申请日：2010-09-17
申请人： Peter Jarrett , Rami El Hayek , Michael Bassett , James Biggins
发明人： Peter Jarrett , Rami El Hayek , Michael Bassett , James Biggins
IPC分类号： A61B18/20 , A61P27/02 , A61P29/00 , A61K9/00
CPC分类号： A61K9/0048 , A61K9/06 , A61K47/34
摘要： Materials and methods of treating an eye with a hydrogel formed on the eye. Embodiments are provided that include post-keratectomy bandages.
摘要翻译：用眼睛上形成的水凝胶治疗眼睛的材料和方法。提供了包括后角膜切除术绷带的实施例。

8. 发明授权

US08409606B2 Drug delivery through hydrogel plugs 有权
标题翻译：通过水凝胶塞送药
公开(公告)号：US08409606B2
公开(公告)日：2013-04-02
申请号：US12704692
申请日：2010-02-12
申请人： Amarpreet S. Sawhney , Peter Jarrett , Michael Bassett , Charles Blizzard
发明人： Amarpreet S. Sawhney , Peter Jarrett , Michael Bassett , Charles Blizzard
IPC分类号： A61F2/00 , B29B9/06 , A01N43/42 , A01N37/08 , A61K31/44 , A61K31/215
CPC分类号： A61K9/0051 , A61B17/12099 , A61B17/12159 , A61B17/1219 , A61F9/00772 , A61F2250/0067 , A61K31/135 , A61K31/437
摘要： An embodiment is a medical prosthesis for blocking or reducing tear flow through a punctum or canaliculus of a human eye and delivering a drug to the eye that comprises a dehydrated covalently crosslinked synthetic hydrophilic polymer hydrogel with dimensions to pass through a puncta lacrimali, with the dehydrated hydrogel absorbing physiological water to swell to at least 1 mm in cross-sectional width and conformably fit a canaliculus, with the hydrogel comprising a therapeutic agent dispersed through the hydrogel for release to an eye, with the hydrogel having a water content of at least about 50% by weight or volume when allowed to fully hydrate in vitro in physiological saline.
摘要翻译：一个实施方案是用于阻断或减少穿过人眼的泪点或泪管的泪液的药物假体，并将药物递送到眼睛，该药物包括脱水的共价交联的合成亲水性聚合物水凝胶，其尺寸通过泪点，脱水水凝胶吸收生理水以横截面宽度膨胀至至少1mm，并且顺应地配合小孔，其中水凝胶包含分散在水凝胶中的治疗剂以释放至眼睛，水凝胶的水含量至少约为当在生理盐水中体外充分水合时，其重量为50％或体积。

9. 发明申请

US20060093648A1 Hydrogels for orthopedic repair 审中-公开
标题翻译：用于整形外科修复的水凝胶
公开(公告)号：US20060093648A1
公开(公告)日：2006-05-04
申请号：US11301055
申请日：2005-12-12
申请人： Arthur Coury , Stephen Goodrich , Hildegard Kramer , Luis Avila , John Traverse , Peter Jarrett
发明人： Arthur Coury , Stephen Goodrich , Hildegard Kramer , Luis Avila , John Traverse , Peter Jarrett
IPC分类号： A61F2/00 , A61K47/48 , C08F4/28
CPC分类号： A61K9/06
摘要： Hydrogels intended for orthopedic applications, including repair and regeneration of cartilage, bone, joint surfaces and related tissues, must possess greater strength and toughness than hydrogels used in soft tissue repair. A hydrogel formulation is provided which has high strength, toughness, a suitable mechanical modulus and low equilibrium hydration. It may also have controlled porosity or degradation time. It can be made to polymerize in situ with high (“good” to “excellent”) adherence to target tissue or surfaces. A preferred formulation for forming such gels comprises 40 to 80% by weight of a low-molecular weight polar monomer and 30 to 10% of a hydrophilic macromeric crosslinker.
摘要翻译：用于矫形应用的水凝胶，包括软骨，骨，关节表面和相关组织的修复和再生，必须具有比在软组织修复中使用的水凝胶更大的强度和韧性。提供了具有高强度，韧性，合适的机械模量和低平衡水合的水凝胶制剂。它也可能具有受控的孔隙率或降解时间。它可以使得在目标组织或表面上具有高（“良好”至“优异”）粘附的原位聚合。用于形成这种凝胶的优选制剂包含40至80重量％的低分子量极性单体和30至10重量％的亲水性大分子交联剂。

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