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1. 发明申请

US20070225680A1 GUIDING CATHETER WITH CHEMICALLY SOFTENED DISTAL PORTION AND METHOD OF MAKING SAME 审中-公开
标题翻译：引导式导管，具有化学干燥的远端部分及其制造方法
公开(公告)号：US20070225680A1
公开(公告)日：2007-09-27
申请号：US11277051
申请日：2006-03-21
申请人： James Biggins
发明人： James Biggins
IPC分类号： A61M25/00 , B32B37/00
CPC分类号： B29C71/0009 , A61L29/06 , A61L29/141 , A61M25/0009 , A61M25/0012 , A61M25/0045 , A61M25/005 , A61M25/0054 , A61M25/0069 , A61M25/0662 , A61M2025/0081 , B29L2031/7542 , C08L77/00
摘要： A guiding catheter for placement in a patient's vessel. The catheter includes an elongate hollow shaft with open proximal and distal ends and a bore extending there through. The catheter shaft includes an inner liner, a metallic reinforcement layer overlying the inner liner, and a unitary outer jacket covering the reinforcement layer. A distal portion of the outer jacket of the catheter shaft is chemically softened to be more flexible than a proximal portion of the outer jacket. A connector fitting is mounted at the proximal end of the shaft in communication with the bore and a distal tip is attached to the distal end of the shaft. A method of manufacturing the guiding catheter is also disclosed.
摘要翻译：用于放置在患者血管中的引导导管。导管包括具有开放的近端和远端的细长空心轴和在其上延伸的孔。导管轴包括内衬，覆盖内衬的金属加强层和覆盖加强层的整体外护套。导管轴的外护套的远端部分被化学软化以比外护套的近端部分更柔韧。连接器配件安装在与孔连通的轴的近端处，并且远侧末端附接到轴的远端。还公开了一种制造引导导管的方法。

2. 发明申请

US20110060398A1 ENDOPROSTHESIS WITH FILAMENT REPOSITIONING OR RETRIEVAL MEMBER AND GUARD STRUCTURE 有权
标题翻译：具有光纤记录或检索成员和保护结构的内窥镜
公开(公告)号：US20110060398A1
公开(公告)日：2011-03-10
申请号：US12872298
申请日：2010-08-31
申请人： Srinath Tupil , James Biggins , William Bertolino
发明人： Srinath Tupil , James Biggins , William Bertolino
IPC分类号： A61F2/82
CPC分类号： A61F2/88 , A61F2/07 , A61F2/86 , A61F2/90 , A61F2002/072 , A61F2002/075 , A61F2002/9505 , A61F2002/9511 , A61F2002/9528 , A61F2002/9534 , A61F2220/0058 , A61F2220/0075 , A61F2230/0078 , A61F2250/0039
摘要： An endoprosthesis includes a stent structure having an elongate member longitudinal portions of which overlap to define the crossover structures. The stent structure may also include loop structures, which are contiguous with the crossover structures, through which a filament extends. A guard structure is secured to the stent structure and located adjacent to the crossover structures to obstruct displacement of the filament between the longitudinal portions of the elongate member of the crossover structures. A method for operating the endoprosthesis includes displacing the loop structures toward one another along the filament to displaced positions relative to the suture structure for reducing the respective profiles of the stent structure and patch structure.
摘要翻译：内假体包括具有细长构件的支架结构，其长度部分重叠以限定交叉结构。支架结构还可以包括与交叉结构邻接的环结构，细丝延伸穿过该结构。保护结构被固定到支架结构并且位于交叉结构附近以阻止细丝在交叉结构的细长构件的纵向部分之间的移位。用于操作内用假体的方法包括将所述环结构相对于所述细丝相互朝向彼此移动以相对于所述缝合线结构移位以减少所述支架结构和贴片结构的相应轮廓。

3. 发明授权

US08961501B2 Method for applying flowable hydrogels to a cornea 有权
标题翻译：将可流动水凝胶应用于角膜的方法
公开(公告)号：US08961501B2
公开(公告)日：2015-02-24
申请号：US12884466
申请日：2010-09-17
申请人： Peter Jarrett , Rami El Hayek , Michael Bassett , James Biggins
发明人： Peter Jarrett , Rami El Hayek , Michael Bassett , James Biggins
IPC分类号： A61B18/18 , A61F2/00 , A61K9/00 , A61K9/06 , A61K47/34
CPC分类号： A61K9/0048 , A61K9/06 , A61K47/34
摘要： Materials and methods of treating an eye with a hydrogel formed on the eye. Embodiments are provided that include post-keratectomy bandages. A method of treating a patient by application of a hydrogel bandage to a cornea by providing a first hydrogel precursor in a dry form immobilized in a first deposit at a first location in a well, providing a second hydrogel precursor in a dry form immobilized in a second deposit at a second location in the well, mixing the deposits together to form a mixture, and transferring at least some of the mixture to the cornea, with the mixture forming a covalently crosslinked hydrogel on the cornea.
摘要翻译：用眼睛上形成的水凝胶治疗眼睛的材料和方法。提供了包括后角膜切除术绷带的实施例。一种通过将水凝胶绷带应用于角膜来治疗患者的方法，该方法通过在第一位置上提供固定在第一沉积物中的以干燥形式固定的第一水凝胶前体，提供固定在孔中的干燥形式的第二水凝胶前体第二次沉积在井的第二位置，将沉积物混合在一起形成混合物，并将至少一些混合物转移到角膜，混合物在角膜上形成共价交联的水凝胶。

4. 发明授权

US08784473B2 Endoprosthesis with filament repositioning or retrieval member and guard structure 有权
标题翻译：具有细丝重新定位或取回构件和保护结构的内置假体
公开(公告)号：US08784473B2
公开(公告)日：2014-07-22
申请号：US12872298
申请日：2010-08-31
申请人： Srinath Tupil , James Biggins , William Bertolino
发明人： Srinath Tupil , James Biggins , William Bertolino
IPC分类号： A61F2/88
CPC分类号： A61F2/88 , A61F2/07 , A61F2/86 , A61F2/90 , A61F2002/072 , A61F2002/075 , A61F2002/9505 , A61F2002/9511 , A61F2002/9528 , A61F2002/9534 , A61F2220/0058 , A61F2220/0075 , A61F2230/0078 , A61F2250/0039
摘要： An endoprosthesis includes a stent structure having an elongate member longitudinal portions of which overlap to define the crossover structures. The stent structure may also include loop structures, which are contiguous with the crossover structures, through which a filament extends. A guard structure is secured to the stent structure and located adjacent to the crossover structures to obstruct displacement of the filament between the longitudinal portions of the elongate member of the crossover structures. A method for operating the endoprosthesis includes displacing the loop structures toward one another along the filament to displaced positions relative to the suture structure for reducing the respective profiles of the stent structure and patch structure.
摘要翻译：内假体包括具有细长构件的支架结构，其长度部分重叠以限定交叉结构。支架结构还可以包括与交叉结构邻接的环结构，细丝延伸穿过该结构。保护结构被固定到支架结构并且位于交叉结构附近以阻止细丝在交叉结构的细长构件的纵向部分之间的移位。用于操作内用假体的方法包括将所述环结构相对于所述细丝相互朝向彼此移动以相对于所述缝合线结构移位以减少所述支架结构和贴片结构的相应轮廓。

5. 发明申请

US20120071865A1 FLOWABLE HYDROGELS FOR CONTROL OF CELL IN-MIGRATION 有权
标题翻译：用于控制细胞迁移的可流动水凝胶
公开(公告)号：US20120071865A1
公开(公告)日：2012-03-22
申请号：US12884466
申请日：2010-09-17
申请人： Peter Jarrett , Rami El Hayek , Michael Bassett , James Biggins
发明人： Peter Jarrett , Rami El Hayek , Michael Bassett , James Biggins
IPC分类号： A61B18/20 , A61P27/02 , A61P29/00 , A61K9/00
CPC分类号： A61K9/0048 , A61K9/06 , A61K47/34
摘要： Materials and methods of treating an eye with a hydrogel formed on the eye. Embodiments are provided that include post-keratectomy bandages.
摘要翻译：用眼睛上形成的水凝胶治疗眼睛的材料和方法。提供了包括后角膜切除术绷带的实施例。

6. 发明申请

US20070244413A1 Medical guidewire tip construction 审中-公开
标题翻译：医疗导丝尖端施工
公开(公告)号：US20070244413A1
公开(公告)日：2007-10-18
申请号：US11403043
申请日：2006-04-12
申请人： James Biggins
发明人： James Biggins
IPC分类号： A61M25/00
CPC分类号： A61M25/09 , A61M25/0054 , A61M2025/09083 , A61M2025/09175
摘要： A medical guidewire having a core-to-tip construction that includes a core wire region surrounded by a flexible coil. The core wire having a distal tip segment that includes a proximal flat drop axially separated from a distal flat drop by a cylindrical or frusto-conical linking portion. The proximal and distal flat drops each having a pair of parallel planar surfaces, wherein the planar surfaces of the proximal flat drop are at an angle to the planar surfaces of the distal flat drop. The tip construction provides improved flexibility while maintaining columnar strength and providing excellent torsional characteristics.
摘要翻译：一种医疗用导线，其具有芯 - 尖端结构，其包括被柔性线圈围绕的芯线区域。芯线具有远侧末端段，其包括通过圆柱形或截头圆锥形连接部分从远端平坦液滴轴向分离的近侧平坦液滴。近端和远端扁平液滴各自具有一对平行的平坦表面，其中近端平坦液滴的平坦表面与远端平坦液滴的平面表面成一角度。尖端结构提供了改善的灵活性，同时保持柱状强度并提供优异的扭转特性。

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