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    • 6. 发明申请
    • Human chemotactic cytokine I polypeptides
    • 人类趋化性细胞因子I多肽
    • US20050069945A1
    • 2005-03-31
    • US10994821
    • 2004-11-23
    • Jian NiGuo-Liang YuPedro AlfonsoReiner GentzJeffrey Su
    • Jian NiGuo-Liang YuPedro AlfonsoReiner GentzJeffrey Su
    • C07H21/04C07K14/52C12P21/02C12Q1/68
    • C07K14/52C07H21/04
    • Human chemotactic cytokine I polypeptides and DNA (RNA) encoding such chemotactic cytokines and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemotactic cytokines for the treatment of leukemia, tumors, chronic infections, auto-immune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemotactic cytokines and their use as a therapeutic to treat rheumatoid arthritis, auto-immune and chronic and acute inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding the chemotactic cytokines and for detecting altered levels of the polypeptide in a host.
    • 公开了人类趋化性细胞因子I多肽和编码这种趋化性细胞因子的DNA(RNA)以及通过重组技术产生此类多肽的方法。 还公开了利用这种趋化性细胞因子治疗白血病,肿瘤,慢性感染,自身免疫疾病,纤维化病症,伤口愈合和牛皮癣的方法。 还公开了抗这种趋化性细胞因子的拮抗剂及其作为治疗类风湿性关节炎,自身免疫,慢性和急性炎性和感染性疾病,过敏反应,前列腺素不依赖性发烧和骨髓衰竭的治疗剂的用途。 还公开了用于检测与核酸序列中的突变和多肽的改变的浓度相关的疾病的诊断测定。 还公开了用于检测编码趋化性细胞因子的多核苷酸中的突变并用于检测宿主中多肽的改变水平的诊断测定。