专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US08853371B2 Process for preparing unaggregated antibody Fc domains 有权
标题翻译：制备未聚集抗体Fc结构域的方法
公开(公告)号：US08853371B2
公开(公告)日：2014-10-07
申请号：US11875243
申请日：2007-10-19
申请人： Pedro Alfonso , Michael Capaldi , Dennis Dong , Thomas R. Gervais , Joshua Goldstein , Allen B. Magill , Nicole Quinlan , Deepak Saini
发明人： Pedro Alfonso , Michael Capaldi , Dennis Dong , Thomas R. Gervais , Joshua Goldstein , Allen B. Magill , Nicole Quinlan , Deepak Saini
IPC分类号： C07K17/00 , B01D15/38 , C07K1/22 , A61K39/395
CPC分类号： A61K39/39591 , B01D15/3809 , C07K1/22 , C07K2317/52 , C07K2319/30
摘要： Methods useful for producing a solution of purified Fc peptide chains are disclosed. The methods employ protein A chromatography to separate high molecular weight, aggregated peptide chains comprising antibody Fc domains from lower molecular weight unaggregated peptide chains that also comprise antibody Fc domains. The solutions of purified Fc peptide chains obtained by the methods of the invention contain less than 5% aggregate and greater than 70% of the Fc peptide chains subjected to purification.
摘要翻译：公开了可用于产生纯化的Fc肽链溶液的方法。该方法采用蛋白A色谱分离从包含抗体Fc结构域的低分子量未聚集肽链分离包含抗体Fc结构域的高分子量聚集肽链。通过本发明方法获得的纯化的Fc肽链的溶液含有少于5％的聚集体和大于70％的经过纯化的Fc肽链。

2. 外观设计

USD701505S1 Storage device carrier 有权
标题翻译：存储设备载体
公开(公告)号：USD701505S1
公开(公告)日：2014-03-25
申请号：US29411581
申请日：2012-01-24
申请人： Kevin Terwilliger , Pedro Alfonso , Richard Crisp , Robert Moser
设计人： Kevin Terwilliger , Pedro Alfonso , Richard Crisp , Robert Moser

3. 外观设计

USD593563S1 Bezel for information handling system housing 有权
公开(公告)号：USD593563S1
公开(公告)日：2009-06-02
申请号：US29326154
申请日：2008-10-13
申请人： Pedro Alfonso , Donald C. Guthan, Jr.
设计人： Pedro Alfonso , Donald C. Guthan, Jr.

4. 外观设计

USD593101S1 Bezel for tape storage rack system 有权
标题翻译：磁带存储机架系统的挡板
公开(公告)号：USD593101S1
公开(公告)日：2009-05-26
申请号：US29320172
申请日：2008-06-23
申请人： Pedro Alfonso , Yinggang Du
设计人： Pedro Alfonso , Yinggang Du

5. 发明申请

US20050157455A1 Information handling system product badge orientation system and method 有权
标题翻译：信息处理系统产品徽章定位系统及方法
公开(公告)号：US20050157455A1
公开(公告)日：2005-07-21
申请号：US10760818
申请日：2004-01-20
申请人： David Hernandez , Pedro Alfonso , Bradley Jackson , Kenneth Musgrave
发明人： David Hernandez , Pedro Alfonso , Bradley Jackson , Kenneth Musgrave
IPC分类号： G06F1/16 , H05K5/00 , H05K5/02 , H05K7/00
CPC分类号： H05K5/0243
摘要： A product badge coupled to a product, such as an information handling system, has a manually-selectable orientation to allow the orientation of the product badge to change for adapting to changes in the orientation of the product. A product badge support rotationally couples the product badge to the product for user selection of a desired orientation of product information, such as a manufacturer logo or a product identification number. Manual activation to change product badge orientation includes pushing the product badge into the product badge support to engage opposing cams, pushing the product badge edge to rotate the product badge to an opposing side having product information of another orientation, and pushing the product badge to activate a retention mechanism for release and retention of a selected of plural clips.
摘要翻译：耦合到产品（例如信息处理系统）的产品徽章具有手动可选择的方向，以允许产品徽章的定向改变以适应产品的取向的变化。产品徽章支持将产品徽章旋转耦合到产品，以便用户选择所需的产品信息方向，例如制造商标识或产品标识号。手动激活以更改产品徽章的方向包括将产品徽章推入产品徽章支持以吸引相对的凸轮，推动产品徽章边缘将产品徽章旋转到具有另一方向的产品信息的对方，并推动产品徽章激活用于释放和保持所选择的多个夹子的保持机构。

6. 发明申请

US20050069945A1 Human chemotactic cytokine I polypeptides 审中-公开
标题翻译：人类趋化性细胞因子I多肽
公开(公告)号：US20050069945A1
公开(公告)日：2005-03-31
申请号：US10994821
申请日：2004-11-23
申请人： Jian Ni , Guo-Liang Yu , Pedro Alfonso , Reiner Gentz , Jeffrey Su
发明人： Jian Ni , Guo-Liang Yu , Pedro Alfonso , Reiner Gentz , Jeffrey Su
IPC分类号： C07H21/04 , C07K14/52 , C12P21/02 , C12Q1/68
CPC分类号： C07K14/52 , C07H21/04
摘要： Human chemotactic cytokine I polypeptides and DNA (RNA) encoding such chemotactic cytokines and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemotactic cytokines for the treatment of leukemia, tumors, chronic infections, auto-immune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemotactic cytokines and their use as a therapeutic to treat rheumatoid arthritis, auto-immune and chronic and acute inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding the chemotactic cytokines and for detecting altered levels of the polypeptide in a host.
摘要翻译：公开了人类趋化性细胞因子I多肽和编码这种趋化性细胞因子的DNA（RNA）以及通过重组技术产生此类多肽的方法。还公开了利用这种趋化性细胞因子治疗白血病，肿瘤，慢性感染，自身免疫疾病，纤维化病症，伤口愈合和牛皮癣的方法。还公开了抗这种趋化性细胞因子的拮抗剂及其作为治疗类风湿性关节炎，自身免疫，慢性和急性炎性和感染性疾病，过敏反应，前列腺素不依赖性发烧和骨髓衰竭的治疗剂的用途。还公开了用于检测与核酸序列中的突变和多肽的改变的浓度相关的疾病的诊断测定。还公开了用于检测编码趋化性细胞因子的多核苷酸中的突变并用于检测宿主中多肽的改变水平的诊断测定。

7. 发明授权

US6029580A Hanging support basket for computers 失效
标题翻译：挂电脑支撑篮
公开(公告)号：US6029580A
公开(公告)日：2000-02-29
申请号：US112925
申请日：1998-07-09
申请人： Pedro Alfonso , Bryan Byle
发明人： Pedro Alfonso , Bryan Byle
IPC分类号： F16M13/00
CPC分类号： F16M13/02 , A47B2097/006 , F16M2200/02 , Y10S248/918
摘要： A computer user station includes a support member. A monitor and a keyboard are supported on a first surface of the support member. A computer chassis is mounted in a frame. The frame includes a mounting portion attached for mounting the computer chassis to a second surface of the support member in a suspended position. A security portion of the frame secures the frame to the computer chassis. The security portion also functions as a back support for a back surface of the computer chassis which is cradled in the frame in a tilted-back position.
摘要翻译：计算机用户站包括支持构件。显示器和键盘支撑在支撑构件的第一表面上。计算机机架安装在框架中。该框架包括安装部分，该安装部分附接用于将悬挂位置的计算机机架安装到支撑构件的第二表面。框架的安全部分将框架固定到计算机机箱。安全部分还用作后倾位置的框架内的计算机机箱的后表面的后支撑。

8. 外观设计

USD660841S1 Storage device housing 有权
标题翻译：存储设备外壳
公开(公告)号：USD660841S1
公开(公告)日：2012-05-29
申请号：US29399454
申请日：2011-08-15
申请人： Pedro Alfonso , Robert Moser , Yinggang Du
设计人： Pedro Alfonso , Robert Moser , Yinggang Du

9. 发明申请

US20090171072A1 Process for Preparing Unaggregated Antibody FC Domains 有权
标题翻译：制备未分类抗体FC域的方法
公开(公告)号：US20090171072A1
公开(公告)日：2009-07-02
申请号：US11875243
申请日：2007-10-19
申请人： Pedro Alfonso , Michael Capaldi , Dennis Dong , Thomas R. Gervais , Joshua Goldstein , Allen B. Magill , Nicole Quinlan , Deepak Saini
发明人： Pedro Alfonso , Michael Capaldi , Dennis Dong , Thomas R. Gervais , Joshua Goldstein , Allen B. Magill , Nicole Quinlan , Deepak Saini
IPC分类号： C07K16/00
CPC分类号： A61K39/39591 , B01D15/3809 , C07K1/22 , C07K2317/52 , C07K2319/30
摘要： Methods useful for producing a solution of purified Fc peptide chains are disclosed. The methods employ protein A chromatography to separate high molecular weight, aggregated peptide chains comprising antibody Fc domains from lower molecular weight unaggregated peptide chains that also comprise antibody Fc domains. The solutions of purified Fc peptide chains obtained by the methods of the invention contain less than 5% aggregate and greater than 70% of the Fc peptide chains subjected to purification.
摘要翻译：公开了可用于产生纯化的Fc肽链溶液的方法。该方法采用蛋白A色谱分离从包含抗体Fc结构域的低分子量未聚集肽链分离包含抗体Fc结构域的高分子量聚集肽链。通过本发明方法获得的纯化的Fc肽链的溶液含有少于5％的聚集体和大于70％的经过纯化的Fc肽链。

10. 外观设计

USD593100S1 Bezel for rack storage system 有权
标题翻译：机架存储系统的挡板
公开(公告)号：USD593100S1
公开(公告)日：2009-05-26
申请号：US29320171
申请日：2008-06-23
申请人： Pedro Alfonso , Yinggang Du
设计人： Pedro Alfonso , Yinggang Du

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式