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1. 发明申请

US20090173892A1 IMAGING OF BIOLOGICAL SAMPLES 失效
标题翻译：生物样本的成像
公开(公告)号：US20090173892A1
公开(公告)日：2009-07-09
申请号：US12159790
申请日：2007-01-19
申请人： Patrick Courtney , Paul Orange , Janet Park , Claire Hooper
发明人： Patrick Courtney , Paul Orange , Janet Park , Claire Hooper
IPC分类号： G01T1/10 , G01J1/58
CPC分类号： G01N33/582 , G01N21/6408 , G01N21/6428 , G01N21/6458 , G01N33/5005
摘要： Methods and apparatus relating to the imaging of biological samples are provided. More particularly, they relate to the detection of light emanating from fluorescent species present in a sample in order to study the structure and dynamics of such a sample. Such a method of analysis comprises irradiating the sample with a pulse of excitation energy causing fluorescent species in the sample to fluoresce; detecting light emanating from the sample during a predetermined period of time after the pulse; generating and storing data recording at least the wavelength of the detected light against time; and analysing the data with reference to the respective lifetimes of the fluorescent species to detect the presence of the respective emissions from three or more different fluorescent species which emit light simultaneously during at least part of said predetermined period, which are indistinguishable from each other on the basis of their wavelength or lifetime alone.
摘要翻译：提供了与生物样品成像有关的方法和设备。更具体地，它们涉及从存在于样品中的荧光物质发出的光的检测，以便研究这种样品的结构和动力学。这种分析方法包括用激发能量的脉冲照射样品中的荧光物质发荧光; 在脉冲之后的预定时间段内检测从样品发出的光; 生成和存储至少记录检测到的光的波长的数据; 并且参考荧光物质的相应寿命来分析数据，以检测来自三个或更多个在所述预定时间段的至少部分期间同时发光的三种或更多种不同荧光物质的各自发射的存在，所述荧光物质在它们的波长或寿命的基础。

2. 发明申请

US20090298114A1 APPARATUS AND METHODS FOR IMAGING AND MODIFICATION OF BIOLOGICAL SAMPLES 审中-公开
标题翻译：生物样品成像和修改的装置和方法
公开(公告)号：US20090298114A1
公开(公告)日：2009-12-03
申请号：US12162444
申请日：2007-02-28
申请人： Patrick Courtney , Alistair Fitch
发明人： Patrick Courtney , Alistair Fitch
IPC分类号： C12Q1/02 , C12N13/00 , C12M3/00
CPC分类号： G01N21/6458 , G01N21/6408
摘要： This invention relates to enrichment of a biological sample comprising a plurality of cells to assist further analysis thereof. It provides a technique comprising the steps of: (a) providing a sample comprising a plurality of cells which include a photosensitive compound that can be induced by light irradiation to inactivate or kill at least part of the respective cell; (b) acquiring an image of at least a portion of the sample; (c) identifying cells of interest in the sample image; (d) selecting cells other than the cells identified in step (c); and (e) irradiating only those cells selected in step (d) with a light beam so as induce the photosensitive compound therein to inactivate or kill at least part of those cells, and thereby enrich the sample with respect to the cells of interest for further analysis.
摘要翻译：本发明涉及包含多个细胞的生物样品的富集以辅助其进一步分析。它提供了一种技术，其包括以下步骤：（a）提供包含多个细胞的样品，所述细胞包括可通过光照射诱导的光敏化合物，以灭活或杀死相应细胞的至少一部分; （b）获取所述样品的至少一部分的图像; （c）识别样本图像中感兴趣的细胞; （d）选择除步骤（c）中鉴定的细胞以外的细胞; 和（e）仅用光束照射步骤（d）中选择的那些细胞，以便诱导其中的光敏化合物灭活或杀死这些细胞的至少一部分，从而使样品相对于感兴趣的细胞富集进一步分析。

3. 发明授权

US07521696B2 Method and apparatus for analyzing a dynamic sample 有权
标题翻译：用于分析动态样本的方法和装置
公开(公告)号：US07521696B2
公开(公告)日：2009-04-21
申请号：US11718788
申请日：2005-12-21
申请人： Patrick Courtney , Robert Hoult , Alistair Fitch , Steve Bush , Shab Ladha , Colin Blackmore
发明人： Patrick Courtney , Robert Hoult , Alistair Fitch , Steve Bush , Shab Ladha , Colin Blackmore
IPC分类号： G01N21/64
CPC分类号： G01N33/582 , G01N21/6428 , G01N21/6456
摘要： A method of analysing a sample of biological material including components (2a to 2d) tagged with respective fluorescent labels (4a to 4d), comprises the steps of identifying a specific labeled component (2d) to be monitored, and irradiating with an energy beam at least one region (8) of the sample which substantially surrounds said specific component. The energy beam modifies the optical properties of labels in the region (8) such that they are distinguishable from the label (4d) associated with said specific component (2d). This assists the tracking of a specific component of interest as it moves through a sample. Apparatus for carrying out the method is also described.
摘要翻译：一种分析生物材料样品的方法，包括用各自的荧光标记（4a至4d）标记的成分（2a至2d），包括鉴定待监测的特异性标记组分（2d）和用能量束照射的步骤所述样品的至少一个区域（8）基本上围绕所述特定组分。能量束修改区域（8）中的标签的光学特性，使得它们与与所述特定部件（2d）相关联的标签（4d）区分开。这有助于跟踪特定的感兴趣的组件，因为它通过一个样本。还描述了用于执行该方法的装置。

4. 发明申请

US20060124870A1 Imaging 有权
标题翻译：成像
公开(公告)号：US20060124870A1
公开(公告)日：2006-06-15
申请号：US10531007
申请日：2003-10-15
申请人： Fedja Bobanovic , John Phillips , Shab Ladha , Patrick Courtney
发明人： Fedja Bobanovic , John Phillips , Shab Ladha , Patrick Courtney
IPC分类号： G21G4/00
CPC分类号： G02B21/0044 , G02B21/0064 , G02B21/0076 , G02B21/008
摘要： A method of imaging light from a specimen in which excitation light passes to the specimen via a scanning system and light emitted by luminescence of the specimen passes in another direction via the scanning system to an image capture device having a sensor having discrete spatially distinct light sensitive regions. The scanning system is operated so as to scan the whole of an area of interest of the specimen, and the excitation light and/or the image capture device are controlled so that light emitted from the specimen is only incident on the image capture device sensor for a specific time period equal to that required for scanning the whole of the area of interest n times (where n is a whole number equal to or greater than 1). The scanning system is a confocal system, and in one example comprises a rotating Nipkow disc scanner and the pattern of openings in the disc is such that rotation of the disc through A° results in scanning the whole of the area of interest and the said specific time period is selected to correspond to nA° of disc rotation. Apparatus for performing the method to produce a video signal for creating an image in a display device or for processing and analysis by a computer, includes control means adapted to control the excitation light and/or the image capture device so that light from the specimen is incident on the image capture device for the specific period of time, and the image capture device is a CCD camera.
摘要翻译：一种对来自试样的光进行成像的方法，其中激发光通过扫描系统传递到样本，并且通过扫描系统的发光发射的光通过扫描系统的另一方向到具有离散空间上不同光敏感的传感器的图像捕获装置地区。操作扫描系统以扫描样本的整个感兴趣区域，并且控制激发光和/或图像捕获装置，使得从样本发射的光仅入射到图像捕获装置传感器上与扫描整个感兴趣区域n次（其中n是等于或大于1的整数）所需的特定时间段相等。扫描系统是共焦系统，并且在一个示例中包括旋转的Nipkow盘扫描器，并且盘中的开口图案使得盘通过A°的旋转导致扫描感兴趣的整个区域，并且所述特定选择时间段以对应于盘旋转的nA°。用于执行产生用于在显示装置中创建图像或由计算机进行处理和分析的视频信号的方法的装置包括适于控制激发光和/或图像捕获装置的控制装置，使得来自标本的光为在特定时间段内对图像捕获装置发生事件，并且图像捕获装置是CCD照相机。

5. 发明授权

US10429304B2 Apparatus and methods for imaging and modification of biological samples 有权
公开(公告)号：US10429304B2
公开(公告)日：2019-10-01
申请号：US12162444
申请日：2007-02-28
申请人： Patrick Courtney , Alistair Fitch
发明人： Patrick Courtney , Alistair Fitch
IPC分类号： C12Q1/02 , G01N21/64
摘要： This invention relates to enrichment of a biological sample comprising a plurality of cells to assist further analysis thereof. It provides a technique comprising the steps of: (a) providing a sample comprising a plurality of cells which include a photosensitive compound that can be induced by light irradiation to inactivate or kill at least part of the respective cell; (b) acquiring an image of at least a portion of the sample; (c) identifying cells of interest in the sample image; (d) selecting cells other than the cells identified in step (c); and (e) irradiating only those cells selected in step (d) with a light beam so as induce the photosensitive compound therein to inactivate or kill at least part of those cells, and thereby enrich the sample with respect to the cells of interest for further analysis.

6. 发明授权

US09012868B2 Fluorescence microscopy methods and apparatus 有权
标题翻译：荧光显微镜方法和仪器
公开(公告)号：US09012868B2
公开(公告)日：2015-04-21
申请号：US13143563
申请日：2010-01-14
申请人： Patrick Courtney , Alois Renn
发明人： Patrick Courtney , Alois Renn
IPC分类号： G01N21/64 , G02B21/00
CPC分类号： G01N21/6458 , G01N21/6428 , G01N2021/6441 , G01N2021/6478 , G02B21/0044 , G02B21/0076
摘要： Methods and apparatus are provided concerning the control of photobleaching of fluorescent labels during the study of samples by fluorescence microscopy. A method is described for operating fluorescence microscopy apparatus to analyse a sample (114), the apparatus including input, processing, sample irradiating and detection arrangements (110, 112; 104; 100; 122), and the method including the steps of: receiving parameters in the processing arrangement via the input arrangement, wherein the parameters relate to an experiment to be conducted using the apparatus and include at least one parameter relating to a fluorescent label present in the sample; and determining with the processing arrangement an excitation procedure to be carried out during the experiment having regard to the inputted parameters and the rate of photobleaching of the fluorescent label desired during the experiment. Furthermore, confocal fluorescence microscopy apparatus is described which comprises an optical arrangement in the light path from an excitation energy source to a sample which acts to adjust the intensity profile of the light beam across its width so as to be more evenly distributed than a Gaussian profile and/or includes a spinning disk, wherein the rotational speed of the disk is variable under the control of a processing arrangement of the apparatus.
摘要翻译：提供了通过荧光显微镜在样品研究过程中控制荧光标记光漂白的方法和装置。描述了一种用于操作荧光显微镜装置以分析样品（114）的方法，所述样品（114）包括输入，处理，样品照射和检测装置（110,112; 104; 100; 122），并且所述方法包括以下步骤：接收经由输入装置的处理装置中的参数，其中参数涉及要使用该装置进行的实验，并且包括与存在于样品中的荧光标签有关的至少一个参数; 并且在实验过程中，利用处理装置确定要在实验期间执行的激励程序，该激励程序考虑到在实验期间期望的输入参数和荧光标签的漂白速率。此外，描述了共焦荧光显微镜装置，其包括从激发能量源到样品的光路中的光学装置，其用于调整光束在其宽度上的强度分布，以便比高斯分布更均匀地分布和/或包括旋转盘，其中盘的旋转速度在设备的处理装置的控制下是可变的。

7. 植物专利

USPP24595P2 Scaevola plant named ‘Kingscawite’ 有权
标题翻译： Scaevola植物名为“金斯卡威”
公开(公告)号：USPP24595P2
公开(公告)日：2014-07-01
申请号：US13507862
申请日：2012-08-02
申请人： Patrick Courtney
发明人： Patrick Courtney
IPC分类号： A01H5/00
CPC分类号： A01H5/02
摘要： A new and distinct cultivar of Scaevola plant named ‘Kingscawite’, characterized by its white-colored flowers, medium green-colored foliage, and vigorous, mounded-spreading growth habit, is disclosed.
摘要翻译：披露了一种新颖而独特的Scaevola植物名为“金丝雀”的品种，其特征是其白色花朵，中等绿色叶子，蓬勃发展的茁壮成长习惯。

8. 发明授权

US07906768B2 Imaging of biological samples 失效
标题翻译：生物样品成像
公开(公告)号：US07906768B2
公开(公告)日：2011-03-15
申请号：US12159790
申请日：2007-01-19
申请人： Patrick Courtney , Paul Orange , Janet Park , Claire Hooper
发明人： Patrick Courtney , Paul Orange , Janet Park , Claire Hooper
IPC分类号： G01J1/58
CPC分类号： G01N33/582 , G01N21/6408 , G01N21/6428 , G01N21/6458 , G01N33/5005
摘要： Methods and apparatus relating to the imaging of biological samples are provided. More particularly, they relate to the detection of light emanating from fluorescent species present in a sample in order to study the structure and dynamics of such a sample. Such a method of analysis comprises irradiating the sample with a pulse of excitation energy causing fluorescent species in the sample to fluoresce; detecting light emanating from the sample during a predetermined period of time after the pulse; generating and storing data recording at least the wavelength of the detected light against time; and analysing the data with reference to the respective lifetimes of the fluorescent species to detect the presence of the respective emissions from three or more different fluorescent species which emit light simultaneously during at least part of said predetermined period, which are indistinguishable from each other on the basis of their wavelength or lifetime alone.
摘要翻译：提供了与生物样品成像有关的方法和设备。更具体地，它们涉及从存在于样品中的荧光物质发出的光的检测，以便研究这种样品的结构和动力学。这种分析方法包括用激发能量的脉冲照射样品中的荧光物质发荧光; 在脉冲之后的预定时间段内检测从样品发出的光; 生成和存储至少记录检测到的光的波长的数据; 并且参考荧光物质的相应寿命来分析数据，以检测来自三个或更多个不同荧光物质的各自发射的存在，所述荧光物质在所述预定时间段的至少部分期间同时发光，所述不同荧光物质在它们的波长或寿命的基础。

9. 发明授权

US07671345B2 Method of analysing a sample and apparatus therefor 有权
标题翻译：分析样品及其设备的方法
公开(公告)号：US07671345B2
公开(公告)日：2010-03-02
申请号：US11658829
申请日：2005-08-17
申请人： Colin Blackmore , Patrick Courtney , Alistair Fitch , Shab Ladha
发明人： Colin Blackmore , Patrick Courtney , Alistair Fitch , Shab Ladha
IPC分类号： G01J1/58
CPC分类号： G01N21/6458 , G01N21/6428 , G01N21/645 , G01N33/5005 , G01N33/582 , G01N2021/6432
摘要： A method for performing photo-modification of a biological sample, the method comprising: (a) irradiating the sample; (b) detecting one or more signals based on the irradiated sample; (c) using one or more processor means to analyze the detected signals and determine one or more irradiation parameters, and, (d) returning to (a) conditioned on the irradiation parameters. Thus modifications may be determined and executed interactively as an experiment progresses, and therefore directed towards specific structures and/or events identified as of particular interest in the course of the experiment.
摘要翻译：一种用于对生物样品进行光修饰的方法，所述方法包括：（a）照射样品; （b）基于被照射样品检测一个或多个信号; （c）使用一个或多个处理器装置来分析检测到的信号并确定一个或多个照射参数，以及（d）返回（a）对照射参数进行调节。因此，随着实验的进行，可以交互地确定和执行修改，并因此针对在实验过程中特别感兴趣的特定结构和/或事件。

10. 发明申请

US20080229289A1 Bitmapped Data String Conversions 审中-公开
标题翻译：位图数据字符串转换
公开(公告)号：US20080229289A1
公开(公告)日：2008-09-18
申请号：US11685521
申请日：2007-03-13
申请人： George M. Nauman , Brent Adkisson , Francis Patrick Courtney , Renee Lutzen
发明人： George M. Nauman , Brent Adkisson , Francis Patrick Courtney , Renee Lutzen
IPC分类号： G06F9/45
CPC分类号： H03M7/30
摘要： A method for converting bitmapped messages in one codeset into a message of another codesets is disclosed. In one step a bitmapped message is parsed into a bitmapped field and a data field. The binary representation of the bitmapped field is used to determine which data elements are present within the data field and the length of the data elements. The data elements may then be converted into a new codeset.
摘要翻译：公开了将一个代码集中的位图消息转换成另一代码集的消息的方法。在一个步骤中，位图消息被解析为位图字段和数据字段。位图字段的二进制表示用于确定数据字段中存在哪些数据元素以及数据元素的长度。然后可以将数据元素转换成新的代码集。

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