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1. 发明授权

US07074891B2 Leukocyte stimulating peptides 失效
标题翻译：白细胞刺激肽
公开(公告)号：US07074891B2
公开(公告)日：2006-07-11
申请号：US10774147
申请日：2004-02-05
申请人： Sung-Ho Ryu , Yoe-Sik Bae , Eun-Young Park , Pann-Ghill Suh
发明人： Sung-Ho Ryu , Yoe-Sik Bae , Eun-Young Park , Pann-Ghill Suh
IPC分类号： C07K7/06 , C07K7/08
CPC分类号： C07K7/06 , A61K38/00
摘要： The present application describes peptides that stimulate arachidonic acid release in target cells. The application also discloses peptides that cause intracellular calcium release.
摘要翻译：本申请描述了刺激靶细胞中花生四烯酸释放的肽。本申请还公开了引起细胞内钙释放的肽。

2. 发明授权

US08859496B2 Pharmaceutical composition using connective-tissue growth factor 有权
标题翻译：使用结缔组织生长因子的药物组合物
公开(公告)号：US08859496B2
公开(公告)日：2014-10-14
申请号：US13642143
申请日：2011-02-21
申请人： Sung Ho Ryu , Pann-Ghill Suh , Mi-Sook Lee , Wan-Uk Kim
发明人： Sung Ho Ryu , Pann-Ghill Suh , Mi-Sook Lee , Wan-Uk Kim
IPC分类号： A61K38/18
CPC分类号： A61K38/18
摘要： This disclosure relates to an angiogenesis-related pharmaceutical composition using connective tissue growth factor, more particularly to a pharmaceutical composition for promoting angiogenesis containing the connective tissue growth factor or a pharmaceutical composition for inhibiting angiogenesis containing at least one selected from the group consisting of polypeptide, antibody and a compound binding to connective tissue growth factor. The fragment of connective tissue growth factor protein, which was found out in the present invention, is a binding region to FPRL1, effectively induces FPRL1-specific ERK phosphorylation, activates FPRL1 to increase intracellular Ca2+ concentration, and finally, effectively induces angiogenesis, and thus, the fragment of connective tissue growth factor may be useful for a pharmaceutical composition for promoting angiogenesis, while polypeptide, antibody or a compound binding to the fragment of connective tissue growth factor protein may be useful for a pharmaceutical composition for inhibiting angiogenesis.
摘要翻译：本公开涉及使用结缔组织生长因子的血管生成相关药物组合物，更具体地涉及用于促进含有结缔组织生长因子的血管生成的药物组合物或用于抑制血管生成的药物组合物，其含有选自多肽，抗体和与结缔组织生长因子结合的化合物。在本发明中发现的结缔组织生长因子蛋白的片段是与FPRL1的结合区域，有效诱导FPRL1特异性ERK磷酸化，激活FPRL1以增加细胞内Ca2 +浓度，最终有效诱导血管生成，因此结缔组织生长因子的片段可用于促进血管发生的药物组合物，而多肽，抗体或结合组织生长因子蛋白的片段的化合物可用于抑制血管生成的药物组合物。

3. 发明授权

US08278263B2 Method of regulating mammalian target-of-rapamycin activity by interaction between phospholipase D and raptor 失效
标题翻译：通过磷脂酶D和猛禽相互作用调节哺乳动物雷帕霉素活性的方法
公开(公告)号：US08278263B2
公开(公告)日：2012-10-02
申请号：US12374262
申请日：2007-08-03
申请人： Sung-Ho Ryu , Pann-Ghill Suh , Sang-Hoon Ha , Do-Hyung Kim , Il-Shin Kim , Jung-Hwan Kim , Mi-Nam Lee , Hyun-Ju Lee , Jong Heon Kim , Sung-Key Jang , Tae-Hoon Lee
发明人： Sung-Ho Ryu , Pann-Ghill Suh , Sang-Hoon Ha , Do-Hyung Kim , Il-Shin Kim , Jung-Hwan Kim , Mi-Nam Lee , Hyun-Ju Lee , Jong Heon Kim , Sung-Key Jang , Tae-Hoon Lee
IPC分类号： A61K38/02
CPC分类号： A61K38/1709 , C07K14/4702 , C12N9/20 , C12Y301/04004 , G01N33/5011 , G01N2333/9121 , G01N2333/916
摘要： The present invention relates to a method of regulating mammalian target-of-rapamycin (mTOR) by regulating a phospholipase D (PLD) activity that generates a complex with mTOR. Further, the present invention also relates to a method of screening inhibitors of mTOR, and a method and a composition for treating mTOR-related metabolic diseases by inhibiting mTOR.
摘要翻译：本发明涉及通过调节与mTOR产生复合物的磷脂酶D（PLD）活性来调节哺乳动物雷帕霉素靶（mTOR）的方法。此外，本发明还涉及一种筛选mTOR抑制剂的方法，以及通过抑制mTOR来治疗mTOR相关代谢疾病的方法和组合物。

4. 发明申请

US20060166888A1 LEUKOCYTE STIMULATING PEPTIDES 有权
标题翻译：白蛋白刺激肽
公开(公告)号：US20060166888A1
公开(公告)日：2006-07-27
申请号：US11277343
申请日：2006-03-23
申请人： Sung-Ho Ryu , Yoe-Sik Bae , Eun-Young Park , Pann-Ghill Suh
发明人： Sung-Ho Ryu , Yoe-Sik Bae , Eun-Young Park , Pann-Ghill Suh
IPC分类号： A61K38/10 , A61K38/08 , C07K7/08 , C07K7/06 , C12P21/06
CPC分类号： C07K7/06 , A61K38/00
摘要： The present application describes peptides that stimulate arachidonic acid release in target cells. The application also discloses peptides that cause intracellular calcium release.
摘要翻译：本申请描述了刺激靶细胞中花生四烯酸释放的肽。本申请还公开了引起细胞内钙释放的肽。

5. 发明授权

US06887484B2 Vaccine composition containing a promoter peptide 有权
标题翻译：含有启动子肽的疫苗组合物
公开(公告)号：US06887484B2
公开(公告)日：2005-05-03
申请号：US10209802
申请日：2002-07-31
申请人： Yoe-Sik Bae , Youn-Dong Kim , You-Suk Seo , Young-Chul Sung , Pann-Ghill Suh , Sung-Ho Ryu , Taehoon Lee
发明人： Yoe-Sik Bae , Youn-Dong Kim , You-Suk Seo , Young-Chul Sung , Pann-Ghill Suh , Sung-Ho Ryu , Taehoon Lee
IPC分类号： A61K39/29 , C07K14/18 , A61K45/00 , A61K33/00 , A61K39/12 , A61K39/02
CPC分类号： C07K14/005 , A61K39/12 , A61K39/29 , A61K2039/545 , A61K2039/55505 , A61K2039/575 , C07K2319/00 , C12N2770/24222 , C12N2770/24234 , Y02A50/466
摘要： A vaccine having a good vaccination effect, which comprises an antigen; a peptide selected from the group consisting of a peptide having the amino acid sequence of SEQ ID NO: 1, a peptide having the amino acid sequence of SEQ ID NO: 2, and a peptide derived from a peptide having the amino acid sequence of SEQ ID NO: 1 or SEQ ID NO: 2; and an immune activator.
摘要翻译：具有良好疫苗接种效果的疫苗，其包含抗原; 选自具有SEQ ID NO：1的氨基酸序列的肽，具有SEQ ID NO：2的氨基酸序列的肽和源自SEQ ID NO：2的氨基酸序列的肽的肽的肽 ID NO：1或SEQ ID NO：2; 和免疫激活剂。

6. 发明授权

US08017572B2 Immune-modulating peptide 有权
标题翻译：免疫调节肽
公开(公告)号：US08017572B2
公开(公告)日：2011-09-13
申请号：US12246229
申请日：2008-10-06
申请人： Sung-Ho Ryu , Pann-Ghill Suh , Yoe-Sik Bae , Ji-Young Song
发明人： Sung-Ho Ryu , Pann-Ghill Suh , Yoe-Sik Bae , Ji-Young Song
IPC分类号： A61K38/08 , C07K7/06
CPC分类号： A61K38/08 , C07K7/06
摘要： Disclosed are peptides having SEQ ID NOs: 1 to 24 that induce superoxide generation by human monocytes or neutrophils; that induce an intracellular calcium increase by human peripheral blood monocytes or neutrophils; binds to formyl peptide receptor or formyl peptide receptor-like 1; that induce chemotactic migration of human monocytes or neutrophils in vitro; that induce degranulation in formyl peptide receptor expressing cells or formyl peptide receptor-like 1 expressing cells; that stimulate extracellular signal regulated protein kinase phosphorylation via activation of formyl peptide receptor or formyl peptide receptor-like 1; or that stimulate Akt phosphorylation via activation of formyl peptide receptor or formyl peptide receptor-like 1.
摘要翻译：公开了具有SEQ ID NO：1至24的肽，其诱导人单核细胞或嗜中性粒细胞产生超氧化物; 其诱导人外周血单核细胞或嗜中性粒细胞的细胞内钙增加; 结合甲酰肽受体或甲酰肽受体样1; 在体外诱导人单核细胞或嗜中性粒细胞趋化迁移; 其在表达甲酰基肽受体的细胞或甲酰肽受体样1表达细胞中诱导脱颗粒; 通过激活甲酰肽受体或甲酰肽受体样1刺激细胞外信号调节蛋白激酶磷酸化; 或通过激活甲酰肽受体或甲酰肽受体样1来刺激Akt磷酸化。

7. 发明授权

US07951779B2 Method of protecting cells against damage and pharmaceutical composition comprising leumorphin 有权
标题翻译：保护细胞免受损伤的方法和包含leumorphin的药物组合物
公开(公告)号：US07951779B2
公开(公告)日：2011-05-31
申请号：US11482480
申请日：2006-07-06
申请人： Byoung Dae Lee , SooMi Kim , Eun-Mi Hur , Yong-Soo Park , Yun-Hee Kim , Taehoon Lee , Kyong-Tai Kim , Pann-Ghill Suh , Sung Ho Ryu
发明人： Byoung Dae Lee , SooMi Kim , Eun-Mi Hur , Yong-Soo Park , Yun-Hee Kim , Taehoon Lee , Kyong-Tai Kim , Pann-Ghill Suh , Sung Ho Ryu
IPC分类号： A61K38/33
CPC分类号： A61K38/33
摘要： The present invention relates to a method of protecting cells against damage caused at least in part by apoptosis, comprising administering to subjects a therapeutic dose of leumorphin having cytoprotective activity, and a pharmaceutical composition comprising an effective amount of leumorphin having a cytoprotective activity.
摘要翻译：本发明涉及一种保护细胞免受至少部分通过细胞凋亡引起的损伤的方法，包括向受试者施用具有细胞保护活性的治疗剂量的亮氨酸，以及包含有效量的具有细胞保护活性的亮氨酸的药物组合物。

8. 发明申请

US20100120662A1 Glucose uptake modulator and method for treating diabetes or diabetic complications 审中-公开
标题翻译：葡萄糖摄取调节剂和治疗糖尿病或糖尿病并发症的方法
公开(公告)号：US20100120662A1
公开(公告)日：2010-05-13
申请号：US12657083
申请日：2010-01-13
申请人： Kyung-Moo Yea , Jae-Yoon Kim , Jong-Hyun Kim , Byoung-Dae Lee , Seung-Je Lee , Tae-Hoon Lee , Pann-Ghill Suh , Sung-Ho Ryu
发明人： Kyung-Moo Yea , Jae-Yoon Kim , Jong-Hyun Kim , Byoung-Dae Lee , Seung-Je Lee , Tae-Hoon Lee , Pann-Ghill Suh , Sung-Ho Ryu
IPC分类号： A61K38/28 , A61K31/661 , A61K38/16 , A61P3/10
CPC分类号： A61K31/7032 , A61K38/2228 , A61K38/28 , A61K2300/00
摘要： The present invention relates to an glucose uptake modulator, a pharmaceutical composition comprising the glucose uptake modulator, and a method of treating a diabetes or diabetic complications in a mammal in need thereof, which comprises administering to said mammal an effecting amount of a glucose uptake modulator.
摘要翻译：本发明涉及葡萄糖摄取调节剂，包含葡萄糖摄取调节剂的药物组合物和治疗有此需要的哺乳动物的糖尿病或糖尿病并发症的方法，其包括对所述哺乳动物施用有效量的葡萄糖摄取调节剂。

9. 发明申请

US20090312250A1 EPIDERMAL GROWTH FACTOR INCREASING INSULIN SECRETION AND LOWERING BLOOD GLUCOSE 审中-公开
标题翻译：生长因子增加胰岛素分泌和降低血糖
公开(公告)号：US20090312250A1
公开(公告)日：2009-12-17
申请号：US12373691
申请日：2007-07-16
申请人： Sung-Ho Ryu , Hye-Young Lee , Kyung-Moo Yea , Byoung-Dae Lee , Young-Chan Chae , Hyeon-Soo Kim , Seon-Hee Kim , Pann-Ghill Suh
发明人： Sung-Ho Ryu , Hye-Young Lee , Kyung-Moo Yea , Byoung-Dae Lee , Young-Chan Chae , Hyeon-Soo Kim , Seon-Hee Kim , Pann-Ghill Suh
IPC分类号： A61K38/18
CPC分类号： A61K38/1808
摘要： The present inventors show that a brief exposure to EGF stimulates insulin secretion glucose-independently via a Ca2+ influx- and PLD2-dependent mechanism. Furthermore, the present invention shows that EGF is a novel secretagogue that lowers plasma glucose levels in normal and diabetic mice, suggesting the potential for EGF treatment in diabetes.
摘要翻译：本发明人表明，EGF的短暂暴露通过Ca2 +流入和PLD2依赖性机制独立地刺激胰岛素分泌葡萄糖。此外，本发明显示EGF是降低正常糖尿病小鼠血浆葡萄糖水平的新型促分泌素，表明在糖尿病中EGF治疗的潜力。

10. 发明申请

US20090304667A1 Method of Regulating Mammalian Target-of-Rapamycin Activity by Interaction Between Phospholipase D and RHEB 失效
标题翻译：通过磷脂酶D和RHEB之间的相互作用调节哺乳动物雷帕霉素目标的方法
公开(公告)号：US20090304667A1
公开(公告)日：2009-12-10
申请号：US12374239
申请日：2007-08-03
申请人： Sung-Ho Ryu , Pann-Ghill Suh , Sang-Hoon Ha , Mi-Nam Lee , Hyun-Ju Lee , II-Shin Kim , Do-Hyung Kim , Tae-Hoon Lee
发明人： Sung-Ho Ryu , Pann-Ghill Suh , Sang-Hoon Ha , Mi-Nam Lee , Hyun-Ju Lee , II-Shin Kim , Do-Hyung Kim , Tae-Hoon Lee
IPC分类号： A61K38/46 , A61K38/16 , G01N33/567 , G01N33/574
CPC分类号： C12Q1/485 , A61K38/00 , C12N9/16 , C12Q1/34 , G01N2333/9121 , G01N2333/916
摘要： The present invention relates to method of regulating mammalian target-of-rapamycin (mTOR) based on a novel finding of a regulating mechanism of mTOR by a phospholipase D (PLD), and Ras homolog enriched in brain (Rheb). Further, the present invention also relates to a method of screening inhibitors of mTOR, and a method and a composition for treating mTOR-related metabolic diseases by inhibitin mTOR.
摘要翻译：本发明涉及基于由磷脂酶D（PLD）和富含脑（Rheb）的Ras同源物的mTOR调节机制的新发现调节哺乳动物雷帕霉素靶（mTOR）的方法。此外，本发明还涉及一种筛选mTOR抑制剂的方法，以及通过抑制mTOR治疗mTOR相关代谢疾病的方法和组合物。

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