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1. 发明授权

US08278263B2 Method of regulating mammalian target-of-rapamycin activity by interaction between phospholipase D and raptor 失效
标题翻译：通过磷脂酶D和猛禽相互作用调节哺乳动物雷帕霉素活性的方法
公开(公告)号：US08278263B2
公开(公告)日：2012-10-02
申请号：US12374262
申请日：2007-08-03
申请人： Sung-Ho Ryu , Pann-Ghill Suh , Sang-Hoon Ha , Do-Hyung Kim , Il-Shin Kim , Jung-Hwan Kim , Mi-Nam Lee , Hyun-Ju Lee , Jong Heon Kim , Sung-Key Jang , Tae-Hoon Lee
发明人： Sung-Ho Ryu , Pann-Ghill Suh , Sang-Hoon Ha , Do-Hyung Kim , Il-Shin Kim , Jung-Hwan Kim , Mi-Nam Lee , Hyun-Ju Lee , Jong Heon Kim , Sung-Key Jang , Tae-Hoon Lee
IPC分类号： A61K38/02
CPC分类号： A61K38/1709 , C07K14/4702 , C12N9/20 , C12Y301/04004 , G01N33/5011 , G01N2333/9121 , G01N2333/916
摘要： The present invention relates to a method of regulating mammalian target-of-rapamycin (mTOR) by regulating a phospholipase D (PLD) activity that generates a complex with mTOR. Further, the present invention also relates to a method of screening inhibitors of mTOR, and a method and a composition for treating mTOR-related metabolic diseases by inhibiting mTOR.
摘要翻译：本发明涉及通过调节与mTOR产生复合物的磷脂酶D（PLD）活性来调节哺乳动物雷帕霉素靶（mTOR）的方法。此外，本发明还涉及一种筛选mTOR抑制剂的方法，以及通过抑制mTOR来治疗mTOR相关代谢疾病的方法和组合物。

2. 发明授权

US6161390A Ice maker assembly in refrigerator and method for controlling the same 有权
标题翻译：冰箱制冰机总成及其控制方法
公开(公告)号：US6161390A
公开(公告)日：2000-12-19
申请号：US392449
申请日：1999-09-09
申请人： Il Shin Kim
发明人： Il Shin Kim
IPC分类号： F25C1/10 , F25C1/04 , F25C5/18 , F25C5/06
CPC分类号： F25C5/187 , F25C1/04 , F25C2305/022
摘要： Ice maker assembly in a refrigerator and method for controlling the same, which can make a stable ice checkup step, the ice maker assembly including a driving means for generating a rotating force, an ice tray connected to the driving means for being rotated by the rotating force from the driving means to transfer ice to an underlying ice container, an ice checkup lever connected to the driving means for conducting an ice checkup step in which an amount of ice in the ice container is detected, and movement transmission means for transmission of a rotating force of the ice tray to the ice checkup lever, wherein, when the ice checkup lever starts the ice checkup step, the ice tray is rotated by a preset angle at first, to transmit a rotating force of the ice tray generated by the rotation to the ice checkup lever, which is a movement transfer means, so that the ice checkup lever makes an initial movement by a preset angle.
摘要翻译：制冰机中的制冰机组件及其控制方法，其可以进行稳定的冰测试步骤，所述制冰机组件包括用于产生旋转力的驱动装置，连接到所述驱动装置的冰盘，以通过所述旋转来自驱动装置的用于将冰传送到下面的冰容器的力;冰检查杆，连接到用于进行冰检验步骤的驱动装置，其中检测到冰容器中的冰量;以及运动传递装置，冰盘的旋转力与冰检查杠杆的关系，其中，当冰检查杆开始冰检验步骤时，冰盘首先旋转预设角度，以传递由旋转产生的冰盘的旋转力作为移动传递装置的冰检查杆，使得冰检查杆以预设的角度进行初始移动。

3. 发明授权

US08168177B2 Method of regulating mammalian target-of-rapamycin activity by interaction between phospholipase D and Rheb 失效
标题翻译：通过磷脂酶D和Rheb之间的相互作用调节哺乳动物雷帕霉素活性的方法
公开(公告)号：US08168177B2
公开(公告)日：2012-05-01
申请号：US12374239
申请日：2007-08-03
申请人： Sung-Ho Ryu , Pann-Ghill Suh , Sang-Hoon Ha , Mi-Nam Lee , Hyun-Ju Lee , Il-Shin Kim , Do-Hyung Kim , Tae-Hoon Lee
发明人： Sung-Ho Ryu , Pann-Ghill Suh , Sang-Hoon Ha , Mi-Nam Lee , Hyun-Ju Lee , Il-Shin Kim , Do-Hyung Kim , Tae-Hoon Lee
IPC分类号： A61K38/46 , C12N9/14
CPC分类号： C12Q1/485 , A61K38/00 , C12N9/16 , C12Q1/34 , G01N2333/9121 , G01N2333/916
摘要： The present invention relates to method of regulating mammalian target-of-rapamycin (mTOR) based on a novel finding of a regulating mechanism of mTOR by a phospholipase D (PLD), and Ras homolog enriched in brain (Rheb). Further, the present invention also relates to a method of screening inhibitors of mTOR, and a method and a composition for treating mTOR-related metabolic diseases by inhibiting mTOR.
摘要翻译：本发明涉及基于由磷脂酶D（PLD）和富含脑（Rheb）的Ras同源物的mTOR调节机制的新发现调节哺乳动物雷帕霉素靶（mTOR）的方法。此外，本发明还涉及一种筛选mTOR抑制剂的方法，以及通过抑制mTOR来治疗mTOR相关代谢疾病的方法和组合物。

4. 发明申请

US20100184636A1 Method of Regulating Mammalian Target-of-Rapamycin Activity by Interaction Between Phospholipase D and Raptor 失效
标题翻译：通过磷脂酶D和猛禽相互作用调节哺乳动物雷帕霉素目标的方法
公开(公告)号：US20100184636A1
公开(公告)日：2010-07-22
申请号：US12374262
申请日：2007-08-03
申请人： Sung-Ho Ryu , Pann-Ghill Suh , Sang-Hoon Ha , Do-Hyung Kim , Il-Shin Kim , Jung-Hwan Kim , Mi-Nam Lee , Hyun-Ju Lee , Jong-Heon Kim , Sung-Key Jang , Tae-Hoon Lee
发明人： Sung-Ho Ryu , Pann-Ghill Suh , Sang-Hoon Ha , Do-Hyung Kim , Il-Shin Kim , Jung-Hwan Kim , Mi-Nam Lee , Hyun-Ju Lee , Jong-Heon Kim , Sung-Key Jang , Tae-Hoon Lee
IPC分类号： A61K38/02 , A61P35/00 , A61P3/04 , A61P3/10 , C07K2/00 , C12Q1/02
CPC分类号： A61K38/1709 , C07K14/4702 , C12N9/20 , C12Y301/04004 , G01N33/5011 , G01N2333/9121 , G01N2333/916
摘要： The present invention relates to a method of regulating mammalian target-of-rapamycin (mTOR) by regulating a phospholipase D (PLD) activity that generates a complex with mTOR. Further, the present invention also relates to a method of screening inhibitors of mTOR, and a method and a composition for treating mTOR-related metabolic diseases by inhibiting mTOR.
摘要翻译：本发明涉及通过调节与mTOR产生复合物的磷脂酶D（PLD）活性来调节哺乳动物雷帕霉素靶（mTOR）的方法。此外，本发明还涉及一种筛选mTOR抑制剂的方法，以及通过抑制mTOR来治疗mTOR相关代谢疾病的方法和组合物。

5. 发明申请

US20090151367A1 REFRIGERATOR 有权
标题翻译：冰箱
公开(公告)号：US20090151367A1
公开(公告)日：2009-06-18
申请号：US12362591
申请日：2009-01-30
申请人： Il-Shin KIM , Seon-Il YU , Kun-Jun SEOK , Yong-Chol KWON
发明人： Il-Shin KIM , Seon-Il YU , Kun-Jun SEOK , Yong-Chol KWON
IPC分类号： F25C1/00 , F25C5/18
CPC分类号： F25C1/24 , B67D1/0858 , F25C1/04 , F25C5/185 , F25C5/22 , F25C2400/10 , F25C2400/14 , F25C2500/02 , F25D11/022 , F25D23/02 , F25D23/126 , F25D2323/021 , F25D2400/06 , Y10S277/921 , Y10T29/53 , Y10T137/0318
摘要： According to one aspect, there is provided a refrigerator including a refrigerating chamber formed at a relatively upper portion of a refrigerator body and a freezing chamber formed at a relatively lower portion of the refrigerator body, which comprises an ice-making chamber which is partitioned in the refrigerating chamber by insulating walls and includes an icemaker for making ice and an ice storage for storing the ice made in the icemaker. The temperature in the refrigerating chamber can be accurately controlled, the loss of cold air can be minimized and the structures for supplying water into the icemaker and the dispenser can be simplified.
摘要翻译：根据一方面，提供一种冰箱，其包括形成在冰箱主体的相对上部的冷藏室和形成在冰箱主体的相对较低部分处的冷冻室，该冷冻室包括分隔成的制冰室冷藏室由绝热壁组成，并包括用于制冰的制冰机和用于储存在制冰机中制冰的冰存储器。可以精确地控制冷藏室中的温度，可以最小化冷空气的损失，并且可以简化用于向制冰机和分配器供水的结构。

6. 发明申请

US20060218961A1 Refrigerator 有权
公开(公告)号：US20060218961A1
公开(公告)日：2006-10-05
申请号：US10549934
申请日：2004-03-26
申请人： Il-Shin Kim , Seon-Il Yu , Kun-Jun Seok , Yong-Chol Kwon
发明人： Il-Shin Kim , Seon-Il Yu , Kun-Jun Seok , Yong-Chol Kwon
IPC分类号： F25C5/18 , F25D11/02
CPC分类号： F25C1/24 , B67D1/0858 , F25C1/04 , F25C5/185 , F25C5/22 , F25C2400/10 , F25C2400/14 , F25C2500/02 , F25D11/022 , F25D23/02 , F25D23/126 , F25D2323/021 , F25D2400/06 , Y10S277/921 , Y10T29/53 , Y10T137/0318
摘要： In the related art refrigerator, its structure for supplying water to a dispenser and water tank was complicated. In addition, since an icemaker is installed in a refrigerating chamber of the refrigerator, there is a problem in that the water supplied into the icemaker is frozen. Furthermore, if the icemaker is installed in the freezing chamber of the refrigerator in which the refrigerating chamber is formed at a lower portion thereof and a refrigerating chamber is formed at an upper portion thereof, there is another problem in that it is difficult to control the temperature in the refrigerating chamber or ice-making capability of the icemaker is lowered. The present invention is directed to a refrigerator. According to an aspect of the present invention for solving the above problems, there is provided a refrigerator including a refrigerating chamber formed at a relatively upper portion of a refrigerator body and a freezing chamber formed at a relatively lower portion of the refrigerator body, which comprises an ice-making chamber which is partitioned in the refrigerating chamber by means of insulating walls and includes an icemaker for making ice and an ice storage for storing the ice made in the icemaker, a first heat exchanger for generating cold air to regulate the temperature in the ice-making chamber, and a second heat exchanger for generating cold air to regulate the temperature in the freezing and refrigerating chambers, wherein the first and second heat exchanger are components of a heat exchange cycle. According to the refrigerator of the present invention so configured, there are advantages in that the temperature in the refrigerating chamber can be accurately controlled, the loss of cold air can be minimized and the structures for supplying water into the icemaker and the dispenser can be simplified.

7. 发明授权

US07484382B2 Refrigerator 有权
标题翻译：冰箱
公开(公告)号：US07484382B2
公开(公告)日：2009-02-03
申请号：US10549934
申请日：2004-03-26
申请人： Il-Shin Kim , Seon-Il Yu , Kun-Jun Seok , Yong-Chol Kwon
发明人： Il-Shin Kim , Seon-Il Yu , Kun-Jun Seok , Yong-Chol Kwon
IPC分类号： F25C1/12
CPC分类号： F25C1/24 , B67D1/0858 , F25C1/04 , F25C5/185 , F25C5/22 , F25C2400/10 , F25C2400/14 , F25C2500/02 , F25D11/022 , F25D23/02 , F25D23/126 , F25D2323/021 , F25D2400/06 , Y10S277/921 , Y10T29/53 , Y10T137/0318
摘要： The present invention is directed to a refrigerator. According to an aspect of the present invention, there is provided a refrigerator including a refrigerating chamber formed at a relatively upper portion of a refrigerator body and a freezing chamber formed at a relatively lower portion of the refrigerator body, which comprises an ice-making chamber which is partitioned in the refrigerating chamber by means of insulating walls and includes an icemaker for making ice and an ice storage for storing the ice made in the icemaker, a first heat exchanger for generating cold air to regulate the temperature in the ice-making chamber, and a second heat exchanger for generating cold air to regulate the temperature in the freezing and refrigerating chambers, wherein the first and second heat exchangers are components of a heat exchange cycle. There are advantages in that the temperature in the refrigerating chamber can be accurately controlled, the loss of cold air can be minimized and the structures for supplying water into the icemaker and the dispenser can be simplified.
摘要翻译：本发明涉及一种冰箱。根据本发明的一个方面，提供了一种冰箱，其包括形成在冰箱主体的相对上部的冷藏室和形成在冰箱主体的相对较低部分处的冷冻室，该冷冻室包括制冰室其通过绝缘壁在制冷室中分隔，并且包括用于制冰的制冰机和用于储存在制冰机中制成的冰的冰储存器，用于产生冷空气以调节制冰室中的温度的第一热交换器以及用于产生冷空气以调节冷冻和冷藏室中的温度的第二热交换器，其中第一和第二热交换器是热交换循环的组成部分。具有能够精确控制冷藏室内的温度的优点，能够使冷空气的损失最小化，能够简化向制冰机和分配器供水的结构。

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