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    • 3. 发明授权
    • Method for manufacturing organic EL device
    • 制造有机EL器件的方法
    • US06659827B2
    • 2003-12-09
    • US09931244
    • 2001-08-17
    • Seon-Hee Kim
    • Seon-Hee Kim
    • H01J924
    • H01L27/3283H01L51/56
    • The present invention discloses a method for manufacturing an organic EL device on a transparent substrate including a display region and a non-display region, the display region having pixel regions, includes forming first electrodes, and first and second leads on the transparent substrate, the first electrode spaced apart from each other, connected with the first leads, and formed on the display region, the first and second leads formed on the non-display region. Then, a photoresist layer is deposited over the whole surface of the transparent substrate while covering the first electrode. A first mask and a second mask are aligned on the front side and the back side of the transparent substrate. An insulating layer and partition walls are formed on a region of the display region other than the pixel regions and an EL light-emitting layer is formed on the pixel regions. Finally, second electrodes are formed on the EL light-emitting layer. The second electrode is spaced apart from each other and perpendicular to the first electrode and connected with the second lead.
    • 本发明公开了一种在包括显示区域和非显示区域的透明基板上制造有机EL器件的方法,具有像素区域的显示区域包括形成第一电极,以及在透明基板上的第一和第二引线, 第一电极彼此间隔开,与第一引线连接,并且形成在显示区域上,形成在非显示区域上的第一和第二引线。 然后,在覆盖第一电极的同时,在透明基板的整个表面上沉积光致抗蚀剂层。 第一掩模和第二掩模在透明基板的正面和背面对准。 在除了像素区域之外的显示区域的区域上形成绝缘层和分隔壁,并且在像素区域上形成EL发光层。 最后,在EL发光层上形成第二电极。 第二电极彼此间隔开并垂直于第一电极并与第二引线相连。
    • 6. 发明申请
    • Immunosuppressive exosomes
    • 免疫抑制外来体
    • US20060116321A1
    • 2006-06-01
    • US11173339
    • 2005-07-01
    • Paul RobbinsSeon-Hee KimPeter Wehling
    • Paul RobbinsSeon-Hee KimPeter Wehling
    • A61K38/20A61K38/17
    • A61K39/0008A61K35/15A61K35/16A61K2039/55555
    • The present invention relates to methods and compositions for use in mediating an immunosuppressive reaction. The compositions of the invention comprise exosomes having immunosuppressive activity. Such exosomes may be derived from a variety of different cell types, including antigen presenting cells such as dendritic cells and macrophages. Prior to isolation of exosomes, the cells may be genetically engineered to express molecules capable of enhancing the immunosuppressive activity of said exosomes and/or may be exposed to one or more agents, such as cytokines or cytokine inhibitors, which are also capable of enhancing the immunosuppressive activity of exosomes. The present invention also relates to the use of such exosomes for the treatment of diseases and disorders associated with undesirable activation of the immune system. The present invention also includes exosomes isolated directly from serum that have been shown to be immunosuppressive.
    • 本发明涉及用于介导免疫抑制反应的方法和组合物。 本发明的组合物包含具有免疫抑制活性的外来体。 这样的外来体可以衍生自各种不同的细胞类型,包括抗原呈递细胞例如树突状细胞和巨噬细胞。 在分离外来体之前,细胞可以被遗传工程化以表达能够增强所述外来体的免疫抑制活性的分子和/或可以暴露于一种或多种如细胞因子或细胞因子抑制剂的试剂,其还能够增强 外来体的免疫抑制活性。 本发明还涉及这种外来体用于治疗与不期望的免疫系统活化相关的疾病和病症的用途。 本发明还包括已经显示为免疫抑制的直接从血清分离的外来体。