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1. 发明授权

US06319515B1 Isosorbide dinitrate-containing patch 有权
标题翻译：含硝酸异山梨酯的补片
公开(公告)号：US06319515B1
公开(公告)日：2001-11-20
申请号：US09142492
申请日：1998-09-08
申请人： Osafumi Hidaka , Satoshi Murakami , Yoshifusa Tachimori , Michisuke Ohe
发明人： Osafumi Hidaka , Satoshi Murakami , Yoshifusa Tachimori , Michisuke Ohe
IPC分类号： A61F1300
CPC分类号： A61K9/703 , A61K9/7053 , A61K9/7061 , A61K31/34 , Y10S514/947
摘要： The present invention relates to an isosorbide dinitrate-containing patch, in which an adhesive layer comprising an adhesive composition is formed on a flexible support, and the adhesive composition consists of an acrylic-based adhesive (A), a polyvinyl acetate-based adhesive (B), a plasticizing component (C) and isosorbide dinitrate (D), and satisfies the following weight ratios (1) through (3) of each of the components: (1) A:B=70:30 to 10:90, (2) the weight ratio of the component C based on the adhesive composition is 10 to 40% by weight, and (3) the weight ratio of the component D based on the adhesive composition is 20 to 35% by weight. Provided is a patch excellent in percutaneous absorption, handleability, resistance to skin irritation, sustained release, adhesivity, etc.
摘要翻译：本发明涉及含有硝酸异山梨酯的贴剂，其中在柔性载体上形成包含粘合剂组合物的粘合剂层，并且粘合剂组合物由丙烯酸类粘合剂（A），聚乙酸乙烯酯类粘合剂 B），增塑组分（C）和硝酸异山梨酯（D），并且满足下列各组分的重量比（1）至（3）：（1）A：B = 70:30至10:90，（2）基于粘合剂组合物的组分C的重量比为10〜40重量％，（3）基于粘合剂组合物的组分D的重量比为20〜35重量％。提供的是经皮吸收，操作性，抗皮肤刺激，持续释放，粘合等优异的贴剂

2. 发明授权

US06294045B1 Plaster agent and method of preparing same 失效
标题翻译：石膏剂及其制备方法
公开(公告)号：US06294045B1
公开(公告)日：2001-09-25
申请号：US08392399
申请日：1995-02-22
申请人： Osafumi Hidaka , Michisuke Ohe , Osam Magoshi , Toshiyuki Kato , Tomoki Sakai
发明人： Osafumi Hidaka , Michisuke Ohe , Osam Magoshi , Toshiyuki Kato , Tomoki Sakai
IPC分类号： C09J500
CPC分类号： A61K9/703 , A61K9/7061
摘要： A plaster agent comprising a water impermeable or water semipermeable film (layer a), one tackifier layer (layer b) laminated on one surface of said layer a, and another tackifier layer (layer d) laminated on said layer b through an intermediary knitted fabric having a weight per unit area of 10 to 100 g/m2 (layer c) comprising hollow fibers having pores extending therethrough in the outer peripheral direction and containing substantially no medicine internally thereof, and at least one of said layer b and said layer d containing a vaporizable or non-vaporizable medicine.
摘要翻译：包含不透水或水半透膜（a层），层压在所述层a的一个表面上的一个增粘剂层（层b）和通过中间编织物层压在所述层b上的另一增粘剂层（层d）的石膏剂每单位面积重量为10〜100g / m 2（层c），包含中空纤维，该中空纤维具有在外周方向上延伸穿过的孔，并且其内部基本上不含药物，并且所述层b和所述层d中的至少一个含有可蒸发或不可蒸发的药物。

3. 发明授权

US5225199A Pharmaceutical plasters 失效
标题翻译：制药膏药
公开(公告)号：US5225199A
公开(公告)日：1993-07-06
申请号：US778819
申请日：1991-12-24
申请人： Osafumi Hidaka , Satoshi Murakami
发明人： Osafumi Hidaka , Satoshi Murakami
IPC分类号： A61F13/00 , A61F13/02 , A61K9/70
CPC分类号： A61K9/703 , A61F13/00063 , A61F13/0206 , A61F13/0223 , A61F13/0226 , A61F13/023 , A61F13/0253 , A61F13/0256 , A61K9/7061 , A61K9/7084 , A61F2013/00663 , A61F2013/00868 , A61F2013/00906
摘要： A plaster comprising the film layer which is composed of a film having 0.5 to 4.9 .mu.m thickness, 8 to 85 g/mm strengths, respectively in the two directions intersecting substantially at right angle, 30 to 150% elongations, respectively in the two directions intersecting at right angle, and 1.0 to 5.0 ratio between the two direction elongations (wherein the smaller elongation is used as the denominator, when the ratios of the elongations in the 2 directions are different) and an adhesive layer (a) which contains a transdermally absorbable drug and is laminated on one surface of said film layer in 2 to 60 .mu.m thickness enables transdermal absorption of a clinically effective amount of a drug with skin rashes reduced. Additionally, a backing sheet may be preferably provided, for example, the plaster made of said film layer (3) and said adhesive layer (a) (4) is press-bonded via an adhesive layer (b) (2) to a backing sheet (1) and a release film (5) to give a plaster of improved handleability.

4. 发明授权

US06497897B2 Plaster agent and method of preparing same 失效
公开(公告)号：US06497897B2
公开(公告)日：2002-12-24
申请号：US09939705
申请日：2001-08-28
申请人： Osafumi Hidaka , Michisuke Ohe , Osam Magoshi , Toshiyuki Kato , Tomoki Sakai
发明人： Osafumi Hidaka , Michisuke Ohe , Osam Magoshi , Toshiyuki Kato , Tomoki Sakai
IPC分类号： A61F1300
CPC分类号： A61K9/703 , A61K9/7061
摘要： A plaster agent comprising a water impermeable or water semipermeable film (layer a), one tackifier layer (layer b) laminated on one surface of said layer a, and another tackifier layer (layer d) laminated on said layer b through an intermediary knitted fabric having a weight per unit area of 10 to 100 g/m2 (layer c) comprising hollow fibers having pores extending therethrough in the outer peripheral direction and containing substantially no medicine internally thereof, and at least one of said layer b and said layer d containing a vaporizable or non-vaporizable medicine.

5. 发明授权

US07223418B2 Stretchable patch 失效
标题翻译：伸缩补丁
公开(公告)号：US07223418B2
公开(公告)日：2007-05-29
申请号：US09959420
申请日：2001-03-05
申请人： Osafumi Hidaka , Akiko Ohata
发明人： Osafumi Hidaka , Akiko Ohata
IPC分类号： A61F2/00
CPC分类号： A61K9/7053 , A61K9/7061
摘要： A stretch plaster comprising a support membrane having a thickness of 1 to 50 μm and a drug containing adhesive layer having a thickness of 3 to 400 μm, wherein(i) the support membrane comprising a copolymer of 0 to 90% by weight of vinyl acetate, 10 to 97% by weight of alkyl (meth)acrylate having 3 to 14 of a mean carbon number of alkyl group and 0 to 15% by weight of (meth)acrylic acid,(ii) the copolymer is cross-linked by polyvalent metal such as aluminum or a poly-functional chain compound, wherein the cross-linking ratio is 20% or more of the theoretical total number of carboxyl group of the copolymer when the polymer is cross-linked by the polyvalent metal such as aluminum, and is 1 to 10% expressed by copolymerized ratio of the poly-functional chain compound when the copolymer is cross-linked by poly-functional chain compound, (iii) the support membrane has 150 g or less of self adhesion shown by an adhesion between the support membranes and (iv) the support membrane has 70% or more of an elasticity recovery when it stretches 10% of itself.
摘要翻译：一种拉伸膏药，其特征在于，包括厚度为1〜50μm的支撑膜和厚度为3〜400μm的药物的粘合剂层，其中，（i）所述支撑膜包含0〜90重量％的乙酸乙烯酯，10〜97重量％的烷基平均碳数为3〜14的（甲基）丙烯酸烷基酯和（甲基）丙烯酸为0〜15重量％的（甲基）丙烯酸酯，（ii）共聚物通过多价交联而交联金属如铝或多官能链化合物，其中当聚合物通过多价金属如铝交联时，交联比为共聚物的理论总羧基的20％或更多，并且当通过多官能链化合物交联共聚物时，多官能链化合物的共聚比例为1〜10％，（iii）支撑膜具有150g以下的自粘合性，支撑膜和（iv）支撑膜具有70％或更多的弹性恢复，当它伸展自身的10％。

6. 发明授权

US07074421B2 Member for application of ointment and ointment patch employing the same 失效
标题翻译：用于使用相同的软膏和软膏补丁的成员
公开(公告)号：US07074421B2
公开(公告)日：2006-07-11
申请号：US10031409
申请日：2001-06-05
申请人： Susumu Maruo , Osafumi Hidaka
发明人： Susumu Maruo , Osafumi Hidaka
IPC分类号： A01N25/34 , A61K9/00 , A61K9/70 , A61L15/16
CPC分类号： A61K9/7023
摘要： An ointment patch includes a support, an ointment, and optionally, a separator. In this ointment patch, the ointment is coated on one surface of the support in an amount of 0.1 mg to 200 mg per 1 cm2 of the support, and the support has a thickness of 1 μm to 2000 μm and 50% modulus of 5 g/cm to 600 g/cm.
摘要翻译：软膏补片包括支持物，软膏和任选的分离器。在这种软膏贴剂中，软膏以0.1mg至200mg / 1cm 2的载体涂覆在载体的一个表面上，并且载体的厚度为1μm至2000μm 妈妈和50％模量为5g / cm 3至600g / cm 3。

7. 发明授权

US07056527B2 Patches containing buprenorphine hydrochloride 失效
公开(公告)号：US07056527B2
公开(公告)日：2006-06-06
申请号：US09959117
申请日：2001-02-22
申请人： Susumu Maruo , Osafumi Hidaka , Satoshi Murakami
发明人： Susumu Maruo , Osafumi Hidaka , Satoshi Murakami
IPC分类号： A61K9/00 , A61K9/70 , A61F13/00 , A61F13/02
CPC分类号： A61K9/7061 , A61K9/0014 , A61K31/485 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/26
摘要： A patch comprising an adhesive layer formed on one surface of a flexible support, wherein said adhesive layer containing a drug, an absorption enhancer and an adhesive comprising; (i) said drug is buprenorphine hydrochloride and/or buprenorphine, and (ii) said absorption enhancer is a mixture of polyoxyethylene sorbitan mono fatty acid ester having 6 to 20 of oxyethylene units and 12 to 18 of carbon number of fatty acid ester, and at least one selected from the group consisting of liquid higher fatty acid ester, 60 to 180 of molecular weight of liquid poly hydric alcohol, lactic acid and triacetin, and (iii) said adhesive is an acrylic-based adhesive.

8. 发明授权

US5336210A Plaster agent 失效
标题翻译：石膏剂
公开(公告)号：US5336210A
公开(公告)日：1994-08-09
申请号：US7830
申请日：1993-01-22
申请人： Osafumi Hidaka , Michisuke Ohe , Osam Magoshi , Toshiyuki Kato , Tomoki Sakai
发明人： Osafumi Hidaka , Michisuke Ohe , Osam Magoshi , Toshiyuki Kato , Tomoki Sakai
IPC分类号： A61K9/70 , A61F13/00
CPC分类号： A61K9/703 , A61K9/7061 , A61K9/7092
摘要： A plaster agent comprising a water impermeable or water semipermeable film (layer a), one tackifier layer (layer b) laminated on one surface of said layer a, and another tackifier layer (layer d) laminated on said layer b through an intermediary knitted fabric having a weight per unit area of 10 to 100 g/m.sup.2 (layer c) comprising hollow fibers having pores extending therethrough in the outer peripheral direction and containing substantially no medicine internally thereof, and at least one of said layer b and said layer d containing a vaporizable or non-vaporizable medicine.
摘要翻译：包含不透水或水半透膜（a层），层压在所述层a的一个表面上的一个增粘剂层（层b）和通过中间编织物层压在所述层b上的另一增粘剂层（层d）的石膏剂每单位面积重量为10〜100g / m 2（层c），包含中空纤维，该中空纤维具有在外周方向上延伸穿过的孔，并且其内部基本上不含药物，并且所述层b和所述层d中的至少一个含有可蒸发或不可蒸发的药物。

9. 发明授权

US4990340A Sustained release pharmaceutical preparation 失效
标题翻译：持续释放药物制剂
公开(公告)号：US4990340A
公开(公告)日：1991-02-05
申请号：US522493
申请日：1990-05-14
申请人： Osafumi Hidaka , Tomoki Sakai
发明人： Osafumi Hidaka , Tomoki Sakai
IPC分类号： A61K9/00 , A61K9/70
CPC分类号： A61K9/703 , A61K9/7084
摘要： A sustained release pharmaceutical preparation for percutaenous administration use mainly composed of a drug layer which is a layer made to contain drugs, to have no adhesiveness to the skin, but to be used in contact with the skin.

10. 发明授权

US4801458A Sustained release pharmaceutical plaster 失效
标题翻译：持续释放药用石膏
公开(公告)号：US4801458A
公开(公告)日：1989-01-31
申请号：US17946
申请日：1987-02-24
申请人： Osafumi Hidaka , Tomoki Sakai , Toyoaki Sakano
发明人： Osafumi Hidaka , Tomoki Sakai , Toyoaki Sakano
IPC分类号： A61K9/70 , A61K9/00
CPC分类号： A61K9/0092 , A61K9/703 , A61K9/7084
摘要： A sustained release pharmaceutical plaster which is characterized in that it is a pharmaceutical preparation mainly composed of an adhesive compound layer and a supporter which supports the adhesive compound layer, inside of which there is an arrangement of hollow fibers, that have radially arranged open pores, with their tubular hollows filled with medicines.
摘要翻译： PCT No.PCT / JP86 / 00317 Sec。 371日期1987年2月24日 102（e）1987年2月24日PCT PCT。1986年6月23日PCT公布。第WO87 / 00046号公报日本1987年1月15日。一种缓释药用石膏，其特征在于，它是一种主要由粘合剂化合物层和支持物构成的药物制剂，其中粘合剂化合物层的内部具有中空纤维的布置，具有径向布置的开孔，其管状中空填充药物。

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