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1. 发明授权

US06319515B1 Isosorbide dinitrate-containing patch 有权
标题翻译：含硝酸异山梨酯的补片
公开(公告)号：US06319515B1
公开(公告)日：2001-11-20
申请号：US09142492
申请日：1998-09-08
申请人： Osafumi Hidaka , Satoshi Murakami , Yoshifusa Tachimori , Michisuke Ohe
发明人： Osafumi Hidaka , Satoshi Murakami , Yoshifusa Tachimori , Michisuke Ohe
IPC分类号： A61F1300
CPC分类号： A61K9/703 , A61K9/7053 , A61K9/7061 , A61K31/34 , Y10S514/947
摘要： The present invention relates to an isosorbide dinitrate-containing patch, in which an adhesive layer comprising an adhesive composition is formed on a flexible support, and the adhesive composition consists of an acrylic-based adhesive (A), a polyvinyl acetate-based adhesive (B), a plasticizing component (C) and isosorbide dinitrate (D), and satisfies the following weight ratios (1) through (3) of each of the components: (1) A:B=70:30 to 10:90, (2) the weight ratio of the component C based on the adhesive composition is 10 to 40% by weight, and (3) the weight ratio of the component D based on the adhesive composition is 20 to 35% by weight. Provided is a patch excellent in percutaneous absorption, handleability, resistance to skin irritation, sustained release, adhesivity, etc.
摘要翻译：本发明涉及含有硝酸异山梨酯的贴剂，其中在柔性载体上形成包含粘合剂组合物的粘合剂层，并且粘合剂组合物由丙烯酸类粘合剂（A），聚乙酸乙烯酯类粘合剂 B），增塑组分（C）和硝酸异山梨酯（D），并且满足下列各组分的重量比（1）至（3）：（1）A：B = 70:30至10:90，（2）基于粘合剂组合物的组分C的重量比为10〜40重量％，（3）基于粘合剂组合物的组分D的重量比为20〜35重量％。提供的是经皮吸收，操作性，抗皮肤刺激，持续释放，粘合等优异的贴剂

2. 发明授权

US06497897B2 Plaster agent and method of preparing same 失效
公开(公告)号：US06497897B2
公开(公告)日：2002-12-24
申请号：US09939705
申请日：2001-08-28
申请人： Osafumi Hidaka , Michisuke Ohe , Osam Magoshi , Toshiyuki Kato , Tomoki Sakai
发明人： Osafumi Hidaka , Michisuke Ohe , Osam Magoshi , Toshiyuki Kato , Tomoki Sakai
IPC分类号： A61F1300
CPC分类号： A61K9/703 , A61K9/7061
摘要： A plaster agent comprising a water impermeable or water semipermeable film (layer a), one tackifier layer (layer b) laminated on one surface of said layer a, and another tackifier layer (layer d) laminated on said layer b through an intermediary knitted fabric having a weight per unit area of 10 to 100 g/m2 (layer c) comprising hollow fibers having pores extending therethrough in the outer peripheral direction and containing substantially no medicine internally thereof, and at least one of said layer b and said layer d containing a vaporizable or non-vaporizable medicine.

3. 发明授权

US5336210A Plaster agent 失效
标题翻译：石膏剂
公开(公告)号：US5336210A
公开(公告)日：1994-08-09
申请号：US7830
申请日：1993-01-22
申请人： Osafumi Hidaka , Michisuke Ohe , Osam Magoshi , Toshiyuki Kato , Tomoki Sakai
发明人： Osafumi Hidaka , Michisuke Ohe , Osam Magoshi , Toshiyuki Kato , Tomoki Sakai
IPC分类号： A61K9/70 , A61F13/00
CPC分类号： A61K9/703 , A61K9/7061 , A61K9/7092
摘要： A plaster agent comprising a water impermeable or water semipermeable film (layer a), one tackifier layer (layer b) laminated on one surface of said layer a, and another tackifier layer (layer d) laminated on said layer b through an intermediary knitted fabric having a weight per unit area of 10 to 100 g/m.sup.2 (layer c) comprising hollow fibers having pores extending therethrough in the outer peripheral direction and containing substantially no medicine internally thereof, and at least one of said layer b and said layer d containing a vaporizable or non-vaporizable medicine.
摘要翻译：包含不透水或水半透膜（a层），层压在所述层a的一个表面上的一个增粘剂层（层b）和通过中间编织物层压在所述层b上的另一增粘剂层（层d）的石膏剂每单位面积重量为10〜100g / m 2（层c），包含中空纤维，该中空纤维具有在外周方向上延伸穿过的孔，并且其内部基本上不含药物，并且所述层b和所述层d中的至少一个含有可蒸发或不可蒸发的药物。

4. 发明授权

US06294045B1 Plaster agent and method of preparing same 失效
标题翻译：石膏剂及其制备方法
公开(公告)号：US06294045B1
公开(公告)日：2001-09-25
申请号：US08392399
申请日：1995-02-22
申请人： Osafumi Hidaka , Michisuke Ohe , Osam Magoshi , Toshiyuki Kato , Tomoki Sakai
发明人： Osafumi Hidaka , Michisuke Ohe , Osam Magoshi , Toshiyuki Kato , Tomoki Sakai
IPC分类号： C09J500
CPC分类号： A61K9/703 , A61K9/7061
摘要： A plaster agent comprising a water impermeable or water semipermeable film (layer a), one tackifier layer (layer b) laminated on one surface of said layer a, and another tackifier layer (layer d) laminated on said layer b through an intermediary knitted fabric having a weight per unit area of 10 to 100 g/m2 (layer c) comprising hollow fibers having pores extending therethrough in the outer peripheral direction and containing substantially no medicine internally thereof, and at least one of said layer b and said layer d containing a vaporizable or non-vaporizable medicine.
摘要翻译：包含不透水或水半透膜（a层），层压在所述层a的一个表面上的一个增粘剂层（层b）和通过中间编织物层压在所述层b上的另一增粘剂层（层d）的石膏剂每单位面积重量为10〜100g / m 2（层c），包含中空纤维，该中空纤维具有在外周方向上延伸穿过的孔，并且其内部基本上不含药物，并且所述层b和所述层d中的至少一个含有可蒸发或不可蒸发的药物。

5. 发明授权

US4414254A Selective light-transmitting laminated structure 失效
标题翻译：选择性透光层压结构
公开(公告)号：US4414254A
公开(公告)日：1983-11-08
申请号：US333774
申请日：1981-12-23
申请人： Kaoru Iwata , Toshio Nishihara , Michisuke Ohe , Yoichi Saito , Akihiro Horike
发明人： Kaoru Iwata , Toshio Nishihara , Michisuke Ohe , Yoichi Saito , Akihiro Horike
IPC分类号： B05D5/06 , B32B7/12 , E06B3/24 , B32B27/40
CPC分类号： B05D5/06 , B32B7/12 , Y10T428/24975 , Y10T428/31583 , Y10T428/31605 , Y10T428/31678 , Y10T428/31681 , Y10T428/31699 , Y10T428/31786 , Y10T428/31935
摘要： In a selective light-transmitting laminated structure comprising (a) a laminate composed of a transparent substrate and formed on at least one surface of the substrate, a thin metallic layer and/or a thin metal oxide layer, if required in combination with a thin film layer having a high refractive index, and (b) a protective layer composed mainly of a polymer having structural units of the general formula ##STR1## wherein R represents a hydrogen atom or a methyl group, as main structural units, the improvement wherein a urethan linkage exists in the interface between the laminate (a) and the protective layer (b).
摘要翻译：在一种选择性透光层压结构中，包括（a）由透明基底构成并且形成在基底的至少一个表面上的层压体，薄金属层和/或薄金属氧化物层，如果需要，与薄的具有高折射率的膜层，和（b）主要由具有通式（I）的结构单元的聚合物组成的保护层，其中R表示氢原子或甲基作为主要结构单元，其中在层压体（a）和保护层（b）之间的界面中存在氨基甲酸酯键。

6. 发明授权

US5762954A Isosorbide dinitrate-containing patch using a mixed adhesive 失效
标题翻译：含有硝酸异山梨酯的贴剂使用混合粘合剂
公开(公告)号：US5762954A
公开(公告)日：1998-06-09
申请号：US700418
申请日：1996-08-28
申请人： Takao Fujii , Makoto Iwata , Minoru Furuya , Michisuke Ohe
发明人： Takao Fujii , Makoto Iwata , Minoru Furuya , Michisuke Ohe
IPC分类号： A61K9/70 , A61K31/34 , A61F13/02
CPC分类号： A61K9/7053 , A61K31/34 , A61K9/7069
摘要： The present invention provides an ISDN-containing patch that causes minimal occurrence of skin rash and has excellent percutaneous absorption and adhesive strength. The present invention discloses an isorbide dinitrate-containing patch comprising: an adhesive layer formed on a flexible support, wherein said layer comprises an adhesive composition containing adhesive and isosorbide dinitrate, the adhesive being composed of silicone-based adhesive (A) and polyvinyl acetate-based adhesive (B), their weight ratio being A:B=85:15 to 15:85, and the weight ratio of isosorbide dinitrate (C) to the adhesives (A+B) being (A+B):C=90:10 to 60:40.
摘要翻译： PCT No.PCT / JP95 / 00318 Sec。 371日期：1996年8月28日 102（e）日期1996年8月28日PCT提交1995年2月28日PCT公布。公开号WO95 / 22970 日期1995年8月31日本发明提供了一种含有皮肤斑块的皮肤，其皮肤皮疹发生率最低，具有优异的经皮吸收和粘合强度。本发明公开了一种含有硝酸异硼酸盐的贴剂，包括：形成在柔性载体上的粘合剂层，其中所述层包含含有粘合剂和硝酸异山梨酯的粘合剂组合物，所述粘合剂由硅氧烷基粘合剂（A）和聚乙酸乙烯酯 - （B），它们的重量比为A:B = 85:15至15:85，硝酸异山梨酯（C）与粘合剂（A + B）的重量比为（A + B）：C = 90 ：10到60:40。

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