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1. 发明申请

US20120064631A1 METHOD FOR AMPLIFICATION AND HIGH-LEVEL EXPRESSION OF TARGET GENE IN MAMMALIAN CELL, AND KIT FOR ACHIEVING THE METHOD 审中-公开
标题翻译：用于在马马里亚细胞中靶向靶基因扩增和高水平表达的方法和用于实现方法的试剂盒
公开(公告)号：US20120064631A1
公开(公告)日：2012-03-15
申请号：US13260192
申请日：2010-03-24
申请人： Noriaki Shimizu
发明人： Noriaki Shimizu
IPC分类号： C12N15/85 , C12N5/10
CPC分类号： C12P21/02 , C12N15/79 , C12N15/85 , C12N2510/02 , C12N2800/208 , C12N2820/80 , C12N2830/46
摘要： The present invention provides novel means for amplifying a target gene outside a chromosome of the mammalian cell with a high probability in amplifying a target gene with use of IR/MAR plasmid, to further improve a high-level gene amplification system. The present invention is a method of amplifying a target gene outside a chromosome of a mammalian cell, and includes the step of transferring, concurrently to a mammalian cell, (i) a vector including (a) a mammalian replication initiation region functioning in a mammalian cell and (b) a nuclear matrix attachment region functioning in a mammalian cell, (ii) a target gene, and (iii) a polynucleotide including a telomere repetitive sequence.
摘要翻译：本发明提供了利用IR / MAR质粒扩增目标基因的高可能性来扩增哺乳动物细胞染色体外的靶基因以进一步改进高水平基因扩增系统的新手段。本发明是扩增哺乳动物细胞染色体外的靶基因的方法，包括同时向哺乳动物细胞转移的步骤，（i）载体，其包含（a）在哺乳动物中起作用的哺乳动物复制起始区细胞和（b）在哺乳动物细胞中起作用的核基质附着区，（ii）靶基因，和（iii）包含端粒重复序列的多核苷酸。

2. 发明授权

US07960187B2 Recovery processing method to be adopted in substrate processing apparatus, substrate processing apparatus and program 有权
标题翻译：在基板处理装置，基板处理装置和程序中采用的恢复处理方法
公开(公告)号：US07960187B2
公开(公告)日：2011-06-14
申请号：US12048129
申请日：2008-03-13
申请人： Noriaki Shimizu
发明人： Noriaki Shimizu
IPC分类号： H01L21/00
CPC分类号： G05B19/4067 , G05B2219/32231 , G05B2219/37224 , G05B2219/50102 , G05B2219/50104 , H01L21/67276
摘要： The present invention provides a recovery processing method to restore the substrate processing apparatus to an operating state after correcting an abnormality having occurred in the substrate processing apparatus in operation and having resulted in a stop in the operation, comprising a substrate retrieval step in which substrate salvage processing is first executed for a wafer W left in a chamber in the substrate processing apparatus in correspondence to the extent to which the wafer has been processed at the time of the operation stop and the substrate having undergone the substrate salvage processing is then retrieved into the cassette storage container and an apparatus internal state restoration step in which the states inside the individual chambers of the substrate processing apparatus are restored.
摘要翻译：本发明提供一种恢复处理方法，用于在操作中校正在基板处理装置中发生的异常并且导致操作停止之后将基板处理装置恢复到操作状态，包括基板回收步骤，其中基板回收首先对于在基板处理装置的室中留下的晶片W进行处理，对应于在操作停止时晶片已被处理的程度，然后将经过基板补救处理的基板检索到盒式存储容器和装置内部状态恢复步骤，其中恢复基板处理装置的各个室内的状态。

3. 发明申请

US20080223298A1 RECOVERY PROCESSING METHOD TO BE ADOPTED IN SUBSTRATE PROCESSING APPARATUS, SUBSTRATE PROCESSING APPARATUS AND PROGRAM 有权
标题翻译：在基板处理装置中采用的恢复处理方法，基板处理装置和程序
公开(公告)号：US20080223298A1
公开(公告)日：2008-09-18
申请号：US12048129
申请日：2008-03-13
申请人： Noriaki SHIMIZU
发明人： Noriaki SHIMIZU
IPC分类号： B05C11/00 , C23F1/08 , H01L21/66
CPC分类号： G05B19/4067 , G05B2219/32231 , G05B2219/37224 , G05B2219/50102 , G05B2219/50104 , H01L21/67276
摘要： The present invention provides a recovery processing method to restore the substrate processing apparatus to an operating state after correcting an abnormality having occurred in the substrate processing apparatus in operation and having resulted in a stop in the operation, comprising a substrate retrieval step in which substrate salvage processing is first executed for a wafer W left in a chamber in the substrate processing apparatus in correspondence to the extent to which the wafer has been processed at the time of the operation stop and the substrate having undergone the substrate salvage processing is then retrieved into the cassette storage container and an apparatus internal state restoration step in which the states inside the individual chambers of the substrate processing apparatus are restored.
摘要翻译：本发明提供了一种恢复处理方法，用于在操作中校正在基板处理装置中发生的异常并且导致操作停止之后将基板处理装置恢复到操作状态，包括基板回收步骤，其中基板回收首先对于在基板处理装置的室中留下的晶片W进行处理，对应于在操作停止时晶片已被处理的程度，然后将经过基板补救处理的基板检索到盒式存储容器和装置内部状态恢复步骤，其中恢复基板处理装置的各个室内的状态。

4. 发明授权

US07409253B2 System and method for processing a substrate and program therefor 有权
标题翻译：用于处理衬底的系统和方法及其程序
公开(公告)号：US07409253B2
公开(公告)日：2008-08-05
申请号：US10825323
申请日：2004-04-16
申请人： Noriaki Shimizu , Kimihiro Fukasawa , Kazuhiro Kanaya , Jun Shoji
发明人： Noriaki Shimizu , Kimihiro Fukasawa , Kazuhiro Kanaya , Jun Shoji
IPC分类号： G06F19/00 , G05B11/01 , G05B19/42
CPC分类号： G05B19/0426 , G05B2219/32096 , G05B2219/45031
摘要： A substrate processing system allows to reduce the number of works that should be done by a software engineer. The system 100 includes a substrate processing apparatus 101; a substrate processing controller 102 for controlling the substrate processing apparatus 101; and a server 103 for storing therein commands, i.e., instructional statements, for defining an operation of each device. The substrate processing controller 102 has a RAM 105 serving as a work space for creating a macro file corresponding to each of processes divided from the whole substrate processing or for changing the content of a macro file; and an executor 108 composed of, e.g., CPU for executing a process sequence macro obtained by a combination of the created macro files. The user creates a macro file describing a sequential operation of each process or changes the content of a macro file by arranging the stored commands.
摘要翻译：基板处理系统允许减少软件工程师应该做的工作数量。系统100包括基板处理装置101; 用于控制基板处理装置101的基板处理控制器102; 以及用于存储用于定义每个设备的操作的命令（即，指令语句）的服务器103。基板处理控制器102具有作为用于创建对应于从整个基板处理划分的每个处理或用于改变宏文件的内容的宏文件的工作空间的RAM 105; 以及由例如CPU构成的执行器108，用于执行通过所创建的宏文件的组合而获得的处理序列宏。用户创建描述每个进程的顺序操作的宏文件，或者通过排列所存储的命令来改变宏文件的内容。

5. 发明申请

US20050124084A1 Substrate processing apparatus, control method for the apparatus, and program for implementing the method 有权
标题翻译：基板处理装置，装置的控制方法和实现该方法的程序
公开(公告)号：US20050124084A1
公开(公告)日：2005-06-09
申请号：US10984982
申请日：2004-11-10
申请人： Noriaki Shimizu , Masahiro Numakura
发明人： Noriaki Shimizu , Masahiro Numakura
IPC分类号： H01L21/02 , H01L21/00 , H01L21/66 , C23C16/00 , G01R31/26
CPC分类号： H01L21/67294 , H01L21/67276 , Y10S414/135
摘要： A substrate processing apparatus, according to which inspection of various devices in the substrate processing apparatus can be carried out with improved reliability, while reducing the burden on a user. A processing chamber processes semiconductor wafers therein. A transfer chamber transfers the semiconductor wafers. A FOUP (front opening unified pod) houses a plurality of dummy wafers for inspection of the processing chamber or the transfer chamber. A CPU causes an HDD (hard disk drive) to store a housing state relating to the arrangement of the dummy wafers in the FOUP before replacement of dummy wafers in the FOUP and that after the replacement as dummy wafer setup information.
摘要翻译：一种基板处理装置，根据该基板处理装置，可以在提高可靠性的同时进行基板处理装置中的各种装置的检查，同时减轻用户的负担。处理室在其中处理半导体晶片。传送室传送半导体晶片。 FOUP（前开口统一吊舱）容纳多个用于检查处理室或传送室的虚拟晶片。在更换FOUP中的虚拟晶片之前，将HDD（硬盘驱动器）存储在与FOUP中的虚设晶片的布置有关的壳体状态，以及在替换之后的虚拟晶片设置信息。

6. 发明授权

US06745341B1 Information processing apparatus having fault detection for multiplex storage devices 失效
标题翻译：具有用于多路存储装置的故障检测的信息处理装置
公开(公告)号：US06745341B1
公开(公告)日：2004-06-01
申请号：US09452092
申请日：1999-11-30
申请人： Shinichi Onitsuka , Toshinori Hiraishi , Akihiko Hisada , Noriaki Shimizu , Noboru Izumi
发明人： Shinichi Onitsuka , Toshinori Hiraishi , Akihiko Hisada , Noriaki Shimizu , Noboru Izumi
IPC分类号： G06F1100
CPC分类号： G06F11/2097 , G06F9/462 , G06F9/4812 , G06F9/485 , G06F11/2069 , G06F11/2094 , G06F2209/481
摘要： An information processing apparatus having a plurality of CPUs has increased reliability. When one of storage devices suffers a fault, a corresponding control device indicates the fault to other control devices, so that all the control devices can recognize the fault. When either one of the CPUs has accessed the storage device, the control device indicates the occurrence of the fault to the CPU. Upon reception of the indication of the occurrence of the fault, the CPU changes the storage device for an active system, if necessary, according to predetermined rules. The same processing is performed when other CPUs have accessed the storage device. As a result, when all the CPUs have accessed the storage device, the setting up of the active system is completed.
摘要翻译：具有多个CPU的信息处理装置具有增加的可靠性。当其中一个存储设备出现故障时，对应的控制设备将其故障指示给其他控制设备，以便所有控制设备能够识别出故障。当任一个CPU访问存储设备时，控制设备指示CPU发生故障。在接收到故障发生的指示时，如果需要，CPU根据预定的规则改变活动系统的存储设备。当其他CPU访问存储设备时，执行相同的处理。结果，当所有CPU都访问存储设备时，完成主动系统的设置。

7. 发明授权

US06312908B1 Method for isolation of extrachromosomal amplified genes 失效
标题翻译：分离染色体外扩增基因的方法
公开(公告)号：US06312908B1
公开(公告)日：2001-11-06
申请号：US09519931
申请日：2000-03-07
申请人： Geoffrey M. Wahl , Noriaki Shimizu
发明人： Geoffrey M. Wahl , Noriaki Shimizu
IPC分类号： C12Q168
CPC分类号： C12Q1/6806 , C12N15/1003 , C12Q1/6886
摘要： The present invention provides a method for the isolation of extrachromosomal amplified nucleic acids that are associated with a cell proliferative disorder. Isolation and further identification of such genes is critical for diagnosis, prognosis, and course of therapy.
摘要翻译：本发明提供了分离与细胞增殖性病症相关的染色体外扩增核酸的方法。这些基因的分离和进一步鉴定对于诊断，预后和治疗过程至关重要。

8. 发明授权

US6033849A Method for isolation of extrachromosomal amplified genes 失效
公开(公告)号：US6033849A
公开(公告)日：2000-03-07
申请号：US704391
申请日：1996-08-26
申请人： Geoffrey M. Wahl , Noriaki Shimizu
发明人： Geoffrey M. Wahl , Noriaki Shimizu
IPC分类号： C12N15/10 , C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6806 , C12N15/1003 , C12Q1/6886
摘要： The present invention provides a method for the isolation of extrachromosomal amplified nucleic acids that are associated with a cell proliferative disorder. Isolation and further identification of such genes is critical for diagnosis, prognosis, and course of therapy.

9. 发明授权

US08771983B2 Method and kit for expressing protein under regulation of the expression from repeated sequence formed by gene amplification, and transformant 有权
标题翻译：用于通过基因扩增形成的重复序列表达调控表达蛋白质的方法和试剂盒，以及转化体
公开(公告)号：US08771983B2
公开(公告)日：2014-07-08
申请号：US11889512
申请日：2007-08-14
申请人： Noriaki Shimizu
发明人： Noriaki Shimizu
IPC分类号： C12N15/85 , C12N15/87 , C12N15/90 , C12N15/113 , C12N5/16
CPC分类号： C12N15/67 , C12N15/85 , C12N2810/85 , C12N2820/85 , C12P21/02
摘要： A method is disclosed for releasing the transcriptional regulation caused by a repeated sequence in a gene, a kit therefor and so on to thereby establish a system capable of producing a protein in a large amount. At least one embodiment of the method can be achieved by any one or more of the following methods: (a) in the amplification of a gene encoding a target protein, co-amplifying a polynucleotide of 10 kbp or more such as a λ-phage DNA or an insulator sequence; (b) selecting by culturing cells having undergone gene amplification in media containing a drug with a gradual increase in concentration; (c) elevating the promoter activity of inducing the expression of a gene encoding a target protein; (d) excising an amplified gene region from a chromosome with the use of Cre-LoxP System; (e) treating cells having undergone gene amplification with 5-aza-2′-deoxycytidine to thereby lower the methylation degree of DNA; and (f) selecting the mammalian cells having undergone gene amplification on double minute chromosomes.
摘要翻译：公开了一种用于释放由基因中的重复序列引起的转录调控的方法，其用于其的试剂盒等，从而建立能够大量产生蛋白质的系统。该方法的至少一个实施方案可以通过以下任何一种或多种方法来实现：（a）扩增编码靶蛋白的基因，共扩增10kbp以上的多核苷酸，例如λ噬菌体 DNA或绝缘子序列; （b）通过培养在具有逐渐增加浓度的药物的培养基中培养经历基因扩增的细胞进行选择; （c）提高诱导编码靶蛋白的基因表达的启动子活性; （d）使用Cre-LoxP系统从染色体切除扩增的基因区域; （e）处理已经用5-氮杂-2'-脱氧胞苷进行基因扩增的细胞，从而降低DNA的甲基化程度; 和（f）选择在双分子染色体上经历基因扩增的哺乳动物细胞。

10. 发明授权

US06483312B2 Cylinder discrimination device and cylinder discrimination method of engine 有权
标题翻译：发动机缸体识别装置和气缸鉴别方法
公开(公告)号：US06483312B2
公开(公告)日：2002-11-19
申请号：US09789569
申请日：2001-02-22
申请人： Hirokazu Shimizu , Noriaki Shimizu
发明人： Hirokazu Shimizu , Noriaki Shimizu
IPC分类号： F02P1700
CPC分类号： F02D41/009 , F02D41/222 , F02D2041/227 , G01M15/06
摘要： An internal combustion engine is equipped with a plurality of cam sensors that output cylinder discrimination signals during every uneven crank angle interval, and specific cylinders are discriminated based on said cylinder discrimination signals output from said plurality of cam sensors. Based on the discrimination result of said specific cylinder and said cylinder discrimination signals from cam sensors, the cylinders other than said specific cylinders are discriminated.
摘要翻译：内燃机配备有多个凸轮传感器，其在每个不均匀曲柄角间隔期间输出气缸鉴别信号，并且基于从所述多个凸轮传感器输出的所述气缸鉴别信号来辨别特定气缸。基于所述特定气缸的鉴别结果和来自凸轮传感器的气缸鉴别信号，区分除所述特定气缸以外的气缸。

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