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1. 发明授权

US07108867B2 Process for preparing particles 失效
标题翻译：制备颗粒的方法
公开(公告)号：US07108867B2
公开(公告)日：2006-09-19
申请号：US10250868
申请日：2002-01-21
申请人： Goran Eric Sundholm , Mustafa Demirbuker , Saeed Moshashaee
发明人： Goran Eric Sundholm , Mustafa Demirbuker , Saeed Moshashaee
IPC分类号： A61K9/14 , A61K9/16 , A61K38/00 , A61K38/28 , B01J13/00
CPC分类号： A61K38/28 , A61K9/1688 , A61K31/167 , A61K31/575 , A61K31/58 , B01D11/0411 , Y10S977/773 , A61K2300/00
摘要： A process for preparing particles of a substance, such as a protein or polypeptide, comprising: (a) preparing a first liquid comprising water, the substance and a modulator, wherein the modulator has a solubility in water which decreases with increasing temperature; and (b) contacting the first liquid with a second liquid comprising a fluid gas and an organic solvent using an anti-solvent fluid gas technique under conditions of temperature and pressure which result in the precipitation of particles comprising the substance, wherein the temperature of the first liquid is at or above the cloud point temperature of the first liquid when the first liquid contacts the second liquid. Also claimed are particles obtained according to the process and compositions containing the particles.
摘要翻译：一种制备物质如蛋白质或多肽的颗粒的方法，包括：（a）制备包含水，所述物质和调节剂的第一液体，其中所述调节剂在水中具有随温度升高而降低的溶解度; 和（b）使用反溶剂流体气体技术在温度和压力的条件下使第一液体与包含流体气体和有机溶剂的第二液体接触，导致包含物质的颗粒的沉淀，其中当第一液体接触第二液体时，第一液体处于或高于第一液体的浊点温度。还要求保护的是根据该方法获得的颗粒和含有颗粒的组合物。

2. 发明申请

US20070116650A1 Device, method and use for the formation of small particles 有权
标题翻译：用于形成小颗粒的装置，方法和用途
公开(公告)号：US20070116650A1
公开(公告)日：2007-05-24
申请号：US10583489
申请日：2004-12-20
申请人： Mustafa Demirbuker
发明人： Mustafa Demirbuker
IPC分类号： A61K9/14
CPC分类号： A61K9/1688 , B01F5/0663 , B01F5/068 , B01J2/04
摘要： The invention relates to a device for producing small particles of a certain substance. The device includes first inlet means (4) for a solution or a suspension containing the substance and second inlet means (3) for an atomizing agent. The device further includes mixing means (12) for the solution and the atomizing agent and outlet means (13) for the particles. First (9, 10) and second (14, 11) conduit means are provided from the first (4) and second (3) inlet means respectively to the mixing means (12). According to the invention the first (9, 10) and second (14, 11) conduit means meet each other at the mixing means (12) at an angle of at least 30o. The invention also relates to a corresponding method and to use of the device and the method as well as to particles obtained by the method.
摘要翻译：本发明涉及一种用于生产某种物质的小颗粒的装置。该装置包括用于溶液或包含物质的悬浮液的第一入口装置（4）和用于雾化剂的第二入口装置（3）。该装置还包括用于溶液的混合装置（12）和用于颗粒的雾化剂和出口装置（13）。第一（9,10）和第二（14,11）导管装置分别从第一（4）和第二（3）入口装置提供到混合装置（12）。根据本发明，第一（9,10）和第二（14,11）管道装置在混合装置（12）处以至少30°的角度彼此相遇。本发明还涉及相应的方法以及使用该装置和方法以及通过该方法获得的颗粒。

3. 发明申请

US20100308484A1 Method and Arrangement for the Production of Particles 有权
标题翻译：颗粒生产方法与布置
公开(公告)号：US20100308484A1
公开(公告)日：2010-12-09
申请号：US12745072
申请日：2008-12-01
申请人： Mustafa Demirbuker
发明人： Mustafa Demirbuker
IPC分类号： B29B9/00
CPC分类号： B01J2/06 , A61K9/1688 , B01J2/04 , B01J4/002 , B01J19/26
摘要： A method for producing particles, from a substance, having predetermined size and/or morphology characteristics. The method consists of mixing within a spray nozzle a solution stream containing the substance in dissolved or dispersed form with a supercritical fluid stream. Spraying the mixture through a nozzle into a particle collecting chamber and there separating the particles. The characteristic feature is an additional step, providing a make-up agent (modifier) to the fluid stream, possibly combined with recycling of the fluid and/or performing the method essentially simultaneously in several spray nozzles. Additional features are also a production system comprising functions for performing the method above and the introduction of the make-up agent, recycling of the fluid and performing several runs essentially simultaneously in the same production system. Also a pharmaceutical formulation in which particles produced according to the method has been used for its manufacture.
摘要翻译：从具有预定尺寸和/或形态特征的物质制备颗粒的方法。该方法包括在喷雾喷嘴内混合含有溶解或分散形式的物质与超临界流体流的溶液流。将混合物通过喷嘴喷射到颗粒收集室中，并分离颗粒。该特征是额外的步骤，为流体流提供补充剂（改性剂），可能与流体的再循环相结合，和/或在几个喷嘴中基本上同时进行该方法。附加特征也是包括用于执行上述方法的功能和补充剂的引入，流体的再循环以及在同一生产系统中基本上同时执行几个运行的功能的生产系统。还有一种药物制剂，其中根据该方法生产的颗粒已被用于其制造。

4. 发明授权

US07829123B2 Process 失效
标题翻译：处理
公开(公告)号：US07829123B2
公开(公告)日：2010-11-09
申请号：US11521631
申请日：2006-09-15
申请人： Goran Eric Sundholm , Mustafa Demirbuker , Saeed Moshashaee
发明人： Goran Eric Sundholm , Mustafa Demirbuker , Saeed Moshashaee
IPC分类号： A61K9/14 , A61K9/16 , A61K38/00 , A61K38/28 , B01J2/04 , B01J13/00
CPC分类号： A61K38/28 , A61K9/1688 , A61K31/167 , A61K31/575 , A61K31/58 , B01D11/0411 , Y10S977/773 , A61K2300/00
摘要： A process for preparing particles of a substance, such as a protein or polypeptide, comprising: (a) preparing a first liquid comprising water, the substance and a modulator, wherein the modulator has a solubility in water which decreases with increasing temperature; and (b) contacting the first liquid with a second liquid comprising a fluid gas and an organic solvent using an anti-solvent fluid gas technique under conditions of temperature and pressure which result in the precipitation of particles comprising the substance, wherein the temperature of the first liquid is at or above the cloud point temperature of the first liquid when the first liquid contacts the second liquid. Also claimed are particles obtained according to the process and compositions containing the particles.
摘要翻译：一种制备物质如蛋白质或多肽的颗粒的方法，包括：（a）制备包含水，所述物质和调节剂的第一液体，其中所述调节剂在水中具有随温度升高而降低的溶解度; 和（b）使用反溶剂流体气体技术在温度和压力的条件下使第一液体与包含流体气体和有机溶剂的第二液体接触，导致包含物质的颗粒的沉淀，其中当第一液体接触第二液体时，第一液体处于或高于第一液体的浊点温度。还要求保护的是根据该方法获得的颗粒和含有颗粒的组合物。

5. 发明申请

US20070009604A1 Process 失效
标题翻译：处理
公开(公告)号：US20070009604A1
公开(公告)日：2007-01-11
申请号：US11521631
申请日：2006-09-15
申请人： Goran Sundholm , Mustafa Demirbuker , Saeed Moshashaee
发明人： Goran Sundholm , Mustafa Demirbuker , Saeed Moshashaee
IPC分类号： A61K38/28 , A61K31/573 , B29B9/00 , A61K9/14
CPC分类号： A61K38/28 , A61K9/1688 , A61K31/167 , A61K31/575 , A61K31/58 , B01D11/0411 , Y10S977/773 , A61K2300/00
摘要： A process for preparing particles of a substance, such as a protein or polypeptide, comprising: (a) preparing a first liquid comprising water, the substance and a modulator, wherein the modulator has a solubility in water which decreases with increasing temperature; and (b) contacting the first liquid with a second liquid comprising a fluid gas and an organic solvent using an anti-solvent fluid gas technique under conditions of temperature and pressure which result in the precipitation of particles comprising the substance, wherein the temperature of the first liquid is at or above the cloud point temperature of the first liquid when the first liquid contacts the second liquid. Also claimed are particles obtained according to the process and compositions containing the particles.
摘要翻译：一种制备物质如蛋白质或多肽的颗粒的方法，包括：（a）制备包含水，所述物质和调节剂的第一液体，其中所述调节剂在水中的溶解度随温度升高而降低; 和（b）使用反溶剂流体气体技术在温度和压力的条件下使第一液体与包含流体气体和有机溶剂的第二液体接触，导致包含物质的颗粒的沉淀，其中当第一液体接触第二液体时，第一液体处于或高于第一液体的浊点温度。还要求保护的是根据该方法获得的颗粒和含有颗粒的组合物。

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