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1. 发明授权

US07841824B2 Method for transferring magnetic samples from a source to a target 失效
标题翻译：将磁性样本从源传输到目标的方法
公开(公告)号：US07841824B2
公开(公告)日：2010-11-30
申请号：US12454227
申请日：2009-05-14
申请人： Hans-Jörg Zobel , Gerard William Leeman , Amir Porat , Moshe Gombinsky
发明人： Hans-Jörg Zobel , Gerard William Leeman , Amir Porat , Moshe Gombinsky
IPC分类号： G01N33/497
CPC分类号： B01L3/0217 , B01L2200/0657 , B01L2300/0829 , B01L2400/043 , B03C1/0332 , B03C1/288 , B03C1/30 , B03C2201/18 , B03C2201/26 , G01N35/109 , G01N2035/0474
摘要： A control system for transferring a sample from a source vessel to a target vessel generally includes a vessel unit, a primary transfer unit, an x-drive, a y-drive, a z-drive and a control unit for controlling the drives. The vessel unit includes a support plate for supporting the source vessel and the target vessel thereon and the transfer unit includes at least one transfer device for transferring the sample from the source vessel to the target vessel. The x-, y- and z-drives reciprocally translate one of the support plate and the transfer device in a respective x-direction, y-direction and z-direction, wherein the x, y and z directions define a three axis Cartesian coordinate system.
摘要翻译：用于将样品从源容器传送到目标容器的控制系统通常包括容器单元，一次传送单元，x驱动器，y驱动器，z驱动器和用于控制驱动器的控制单元。容器单元包括用于在其上支撑源容器和目标容器的支撑板，并且转移单元包括用于将样品从源容器转移到目标容器的至少一个转移装置。 x，y和z驱动器在相应的x方向，y方向和z方向上将支撑板和传送装置中的一个相互平移，其中x，y和z方向限定三轴笛卡尔坐标系统。

2. 发明申请

US20090297327A1 Apparatus and method for transferring samples from a source to a target 失效
标题翻译：将样本从源传送到目标的装置和方法
公开(公告)号：US20090297327A1
公开(公告)日：2009-12-03
申请号：US12454227
申请日：2009-05-14
申请人： Hans-Jorg Zobel , Gerard William Leeman , Amir Porat , Moshe Gombinsky
发明人： Hans-Jorg Zobel , Gerard William Leeman , Amir Porat , Moshe Gombinsky
IPC分类号： B65G49/00
CPC分类号： B01L3/0217 , B01L2200/0657 , B01L2300/0829 , B01L2400/043 , B03C1/0332 , B03C1/288 , B03C1/30 , B03C2201/18 , B03C2201/26 , G01N35/109 , G01N2035/0474
摘要： A control system for transferring a sample from a source vessel to a target vessel generally includes a vessel unit, a primary transfer unit, an x-drive, a y-drive, a z-drive and a control unit for controlling the drives. The vessel unit includes a support plate for supporting the source vessel and the target vessel thereon and the transfer unit includes at least one transfer device for transferring the sample from the source vessel to the target vessel. The x-, y- and z-drives reciprocally translate one of the support plate and the transfer device in a respective x-direction, y-direction and z-direction, wherein the x, y and z directions define a three axis Cartesian coordinate system.
摘要翻译：用于将样品从源容器传送到目标容器的控制系统通常包括容器单元，一次传送单元，x驱动器，y驱动器，z驱动器和用于控制驱动器的控制单元。容器单元包括用于在其上支撑源容器和目标容器的支撑板，并且转移单元包括用于将样品从源容器转移到目标容器的至少一个转移装置。 x，y和z驱动器在相应的x方向，y方向和z方向上将支撑板和传送装置中的一个相互平移，其中x，y和z方向限定三轴笛卡尔坐标系统。

3. 发明授权

US06409925B1 Device and system for transfer of material 失效
标题翻译：用于材料转移的装置和系统
公开(公告)号：US06409925B1
公开(公告)日：2002-06-25
申请号：US09601741
申请日：2000-08-07
申请人： Moshe Gombinsky , Anna Khatskina
发明人： Moshe Gombinsky , Anna Khatskina
IPC分类号： B01D3506
CPC分类号： G01N35/1074 , B01J19/0046 , B01J2219/00315 , B01J2219/00468 , B01J2219/005 , B01J2219/00585 , B01J2219/0059 , B01J2219/00592 , B01J2219/00596 , B01J2219/00722 , B01J2219/00725 , B03C1/0332 , B03C1/284 , B03C1/286 , B03C1/288 , B03C2201/18 , B03C2201/26 , C40B40/06 , C40B40/10 , C40B60/14 , G01N35/0098 , G01N35/1065 , G01N35/1072
摘要： The invention concerns a device for collection of magnetic particles. The invention further concerns a system for transfer of material from a plurality of source vessels to a plurality of target vessels, the device comprising a plurality of collecting members each of which can be manipulated independently. The invention further concerns a method for detection of biological entities being fluorescent label, wherein the entities are bound to magnetic particles. The fluorescent emission is concentrated by clustering the magnetic particles utilizing magnetic force.
摘要翻译：本发明涉及用于收集磁性颗粒的装置。本发明还涉及一种用于将材料从多个源容器传送到多个靶容器的系统，该装置包括多个收集构件，每个收集构件可独立地操作。本发明还涉及用于检测作为荧光标记的生物实体的方法，其中所述实体与磁性颗粒结合。通过利用磁力聚集磁性颗粒来浓缩荧光发射。

4. 发明授权

US07597520B2 Apparatus and method for transferring samples from a source to a target 失效
标题翻译：将样本从源传送到目标的装置和方法
公开(公告)号：US07597520B2
公开(公告)日：2009-10-06
申请号：US11311558
申请日：2005-12-19
申请人： Hans-Jörg Zobel , Gerard William Leeman , Amir Porat , Moshe Gombinsky
发明人： Hans-Jörg Zobel , Gerard William Leeman , Amir Porat , Moshe Gombinsky
IPC分类号： G01N37/497
CPC分类号： G01N35/10 , B03C1/286 , G01N35/04
摘要： A transfer unit for transferring a sample from a source vessel to a target vessel. The transfer unit includes a transfer device having a pin tip with a central bore terminating at a bottom wall, an actuating element movably disposed in the pin tip bore, an actuator rod for moving the actuating element and a compensating device connected between the actuating element and the actuator rod. The actuator rod moves the actuating element between a first position adjacent the tip bottom wall and a second position away from the bottom wall. Movement of the actuating element causes a sample in proximity to the pin tip to be alternately collected and released from the pin tip. Such movement also defines a stroke length for the actuator rod, wherein the compensating device compensates for any variations in the actuator rod stroke length. The transfer unit further includes a tip ejector for removing the disposable tips from the transfer device and a tip loading station for applying the tips to the transfer device.
摘要翻译：用于将样品从源容器转移到目标容器的转移单元。传送单元包括具有销末端的传送装置，其中心孔终止在底壁处，可移动地设置在销尖孔中的致动元件，用于移动致动元件的致动杆和连接在致动元件和执行器杆。致动器杆将致动元件移动到与尖端底壁相邻的第一位置和远离底壁的第二位置之间。致动元件的运动导致靠近销尖的样品交替地从销尖收集和释放。这种运动还限定了致动器杆的行程长度，其中补偿装置补偿致动器杆行程长度中的任何变化。传送单元还包括用于从传送装置移除一次性尖端的尖端喷射器和用于将尖端施加到传送装置的尖端装载站。

5. 发明申请

US20070172941A1 Disposable vessels or tips having ultra-thin areas therein, and methods for manufacture of same 审中-公开
标题翻译：具有超薄区域的一次性容器或尖端及其制造方法
公开(公告)号：US20070172941A1
公开(公告)日：2007-07-26
申请号：US11338891
申请日：2006-01-25
申请人： Amir Porat , Moshe Gombinsky , Agmon Porat
发明人： Amir Porat , Moshe Gombinsky , Agmon Porat
IPC分类号： C12M3/00
CPC分类号： B01L3/508 , B01L3/5082 , B01L3/5085 , B01L2300/0829 , B01L2300/0851
摘要： The invention discloses disposable polymeric vessels or tip products, having a thin area upon at least a portion of the vessel or tip, for use in medical and scientific laboratories. The thin area has a thickness of less than 100 microns. Examples of such products are test-tubes, microtubes and multiwell plates. The thin area is transparent, and is advantageous for performance of optical assays, and in performance of attraction and transfer of magnetic particles. Methods for manufacturing the polymeric vessel and tip products are disclosed.
摘要翻译：本发明公开了一种在医疗和科学实验室中使用的在容器或尖端的至少一部分上具有薄区域的一次性聚合物容器或尖端产品。薄区域的厚度小于100微米。这些产品的实例是试管，微管和多孔板。薄区域是透明的，并且对于光学测定的性能以及磁性颗粒的吸引和转移的性能是有利的。公开了制造聚合物容器和尖端产品的方法。

6. 发明申请

US20060144169A1 Combinatorial pipettor device 失效
标题翻译：组合移液器装置
公开(公告)号：US20060144169A1
公开(公告)日：2006-07-06
申请号：US11029013
申请日：2005-01-05
申请人： Amir Porat , Moshe Gombinsky
发明人： Amir Porat , Moshe Gombinsky
IPC分类号： G01N1/14
CPC分类号： B01L3/0217 , B01L3/021 , B01L2200/0657 , Y10T436/2575
摘要： A combinatorial pipettor device for the collection of a sample adapted for use with different size microtiter plates. The device comprises an upper plate having first and second halves, each half independently movable between an upper and a lower position, and a lower plate having tip connectors for the attachment of collecting tips. Also included are sample collector members having proximal ends and distal ends and a mechanism for moving at least one half of the upper plate between the upper and lower positions. Proximal ends of the sample collector members are held by the upper plate and distal ends of the sample collector members are engagable with the lower plate such that when at least one half of the upper plate is moved from the upper to the lower position, the corresponding sample collector members are lowered, thereby facilitating collection of a sample into a tip attached to one of the connectors.
摘要翻译：用于收集适于与不同尺寸微量滴定板一起使用的样品的组合移液器装置。该装置包括具有第一和第二半部的上板，每个半部可独立地在上部和下部位置之间移动，下部板具有用于附接收集尖端的尖端连接器。还包括具有近端和远端的样本收集器构件和用于在上位置和下位置之间移动上板的至少一半的机构。样品收集器构件的近端由上板保持，并且样品收集器构件的远端可与下板接合，使得当上板的至少一半从上位移到下位时，相应的样品收集器构件被降低，从而便于将样品收集到连接到一个连接器的尖端中。

7. 发明授权

US5395498A Method for separating biological macromolecules and means therfor 失效
标题翻译：分离生物大分子的方法和方法
公开(公告)号：US5395498A
公开(公告)日：1995-03-07
申请号：US970081
申请日：1992-11-02
申请人： Moshe Gombinsky , Adi Se-Lavan Lev
发明人： Moshe Gombinsky , Adi Se-Lavan Lev
IPC分类号： G01N27/447 , C25B7/00
CPC分类号： G01N27/44726
摘要： Macromolecules from a sample are electrophoresed and the obtained electrophoretogram is contacted with a planar matrix of magnetic particles. The magnetic particles having binding specificity to one or more specific species of biological macromolecules, whereby the one or more specific macromolecules bind to the particles in the matrix. The particles can then be collected on the basis of their magnetic properties and the bound macromolecules can then be separated from the particles.
摘要翻译：将来自样品的大分子进行电泳，并将获得的电泳图与磁性颗粒的平面基质接触。磁性颗粒对一种或多种特定种类的生物大分子具有结合特异性，由此一种或多种特异性大分子与基质中的颗粒结合。然后可以基于它们的磁性来收集颗粒，然后将结合的大分子与颗粒分离。

8. 发明授权

US07534081B2 Apparatus and method for transferring samples from a source to a target 失效
公开(公告)号：US07534081B2
公开(公告)日：2009-05-19
申请号：US11135962
申请日：2005-05-24
申请人： Hans-Jörg Zobel , Gerard William Leeman , Amir Porat , Moshe Gombinsky
发明人： Hans-Jörg Zobel , Gerard William Leeman , Amir Porat , Moshe Gombinsky
IPC分类号： G01N33/497
CPC分类号： B01L3/0217 , B01L2200/0657 , B01L2300/0829 , B01L2400/043 , B03C1/0332 , B03C1/288 , B03C1/30 , B03C2201/18 , B03C2201/26 , G01N35/109 , G01N2035/0474
摘要： A control system for transferring a sample from a source vessel to a target vessel generally includes a vessel unit, a primary transfer unit, an x-drive, a y-drive, a z-drive and a control unit for controlling the drives. The vessel unit includes a support plate for supporting the source vessel and the target vessel thereon and the transfer unit includes at least one transfer device for transferring the sample from the source vessel to the target vessel. The x-, y- and z-drives reciprocally translate one of the support plate and the transfer device in a respective x-direction, y-direction and z-direction, wherein the x, y and z directions define a three axis Cartesian coordinate system.

9. 发明授权

US07219567B2 Combinatorial pipettor device 失效
标题翻译：组合移液器装置
公开(公告)号：US07219567B2
公开(公告)日：2007-05-22
申请号：US11029013
申请日：2005-01-05
申请人： Amir Porat , Moshe Gombinsky
发明人： Amir Porat , Moshe Gombinsky
IPC分类号： G01N1/14
CPC分类号： B01L3/0217 , B01L3/021 , B01L2200/0657 , Y10T436/2575
摘要： A combinatorial pipettor device for the collection of a sample adapted for use with different size microtiter plates. The device comprises an upper plate having first and second halves, each half independently movable between an upper and a lower position, and a lower plate having tip connectors for the attachment of collecting tips. Also included are sample collector members having proximal ends and distal ends and a mechanism for moving at least one half of the upper plate between the upper and lower positions. Proximal ends of the sample collector members are held by the upper plate and distal ends of the sample collector members are engagable with the lower plate such that when at least one half of the upper plate is moved from the upper to the lower position, the corresponding sample collector members are lowered, thereby facilitating collection of a sample into a tip attached to one of the connectors.
摘要翻译：用于收集适于与不同尺寸微量滴定板一起使用的样品的组合移液器装置。该装置包括具有第一和第二半部的上板，每个半部可独立地在上部和下部位置之间移动，下部板具有用于附接收集尖端的尖端连接器。还包括具有近端和远端的样本收集器构件和用于在上位置和下位置之间移动上板的至少一半的机构。样品收集器构件的近端由上板保持，并且样品收集器构件的远端可与下板接合，使得当上板的至少一半从上位移到下位时，相应的样品收集器构件被降低，从而便于将样品收集到连接到一个连接器的尖端中。

10. 发明申请

US20060269385A1 Apparatus and method for transferring samples from a source to a target 失效
公开(公告)号：US20060269385A1
公开(公告)日：2006-11-30
申请号：US11135962
申请日：2005-05-24
申请人： Hans-Jorg Zobel , Gerard Leeman , Amir Porat , Moshe Gombinsky
发明人： Hans-Jorg Zobel , Gerard Leeman , Amir Porat , Moshe Gombinsky
IPC分类号： B65B21/02
CPC分类号： B01L3/0217 , B01L2200/0657 , B01L2300/0829 , B01L2400/043 , B03C1/0332 , B03C1/288 , B03C1/30 , B03C2201/18 , B03C2201/26 , G01N35/109 , G01N2035/0474
摘要： A control system for transferring a sample from a source vessel to a target vessel generally includes a vessel unit, a primary transfer unit, an x-drive, a y-drive, a z-drive and a control unit for controlling the drives. The vessel unit includes a support plate for supporting the source vessel and the target vessel thereon and the transfer unit includes at least one transfer device for transferring the sample from the source vessel to the target vessel. The x-, y- and z-drives reciprocally translate one of the support plate and the transfer device in a respective x-direction, y-direction and z-direction, wherein the x, y and z directions define a three axis Cartesian coordinate system.

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