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    • 8. 发明授权
    • Anti-corrosion formulation for toothpastes
    • 牙膏防腐配方
    • US4309409A
    • 1982-01-05
    • US120012
    • 1980-02-08
    • Miguel Coll-PalagosFrances C. Benkwitt
    • Miguel Coll-PalagosFrances C. Benkwitt
    • A61K8/21A61K8/22A61K8/24A61K8/27A61Q11/00A61K7/16
    • A61Q11/00A61K8/21A61K8/24A61K8/27A61K2800/526
    • A formulation which consists essentially of from about 20%, by weight, to about 87%, by weight, zinc oxide, from about 13% to about 80%, by weight of a selected type of acidic pH adjuster, and from about 0% to about 7%, by weight, of trimagnesium phosphate, when incorporated in fluorine-containing toothpaste formulations which also contain at least one compound selected from the group consisting of an insoluble alkali metal metaphosphate and calcium pyrophosphate, yields a smooth paste having a pH of from about 5.5 to about 6.8 which will not corrode the inside of unlined aluminum tubes containing such a formulation. When the components of the formulation are based on the weight of the entire toothpaste formulation, said zinc oxide can be present at from about 0.05% to about 2.0%, the acidic pH adjuster can be present at from about 0.05% to about 3.0%, and the trimagnesium phosphate can be present at from about 0% to about 0.5%.
    • 基本上由约20重量%至约87重量%的氧化锌,约13重量%至约80重量%的选定类型的酸性pH调节剂和约0重量% 至约7重量%的磷酸三钙,当掺入还含有至少一种选自不溶性碱金属偏磷酸盐和焦磷酸钙的化合物的含氟牙膏配方中时,得到pH为 约5.5至约6.8,其不会腐蚀含有这种制剂的无衬里铝管的内部。 当制剂的组分基于整个牙膏制剂的重量时,所述氧化锌可以以约0.05%至约2.0%存在,酸性pH调节剂可以以约0.05%至约3.0%存在, 并且磷酸三钙可以以约0%至约0.5%存在。