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1. 发明授权

US5032354A Method for producing a metallic sintered body 失效
标题翻译：金属烧结体的制造方法
公开(公告)号：US5032354A
公开(公告)日：1991-07-16
申请号：US573767
申请日：1990-08-28
申请人： Michio Nakanishi , Takuya Miho
发明人： Michio Nakanishi , Takuya Miho
IPC分类号： B22F3/02 , B22F1/00 , C08K3/08
CPC分类号： B22F1/0059 , C08K3/08
摘要： A composition for producing a metallic sintered body consisting essentially of a mixture of a powdered metal having an average particle size of not more than 50 microns with a lactone resin having a relative viscosity value in the range of from 1.15 to 3.20 is disclosed.The composition has excellent properties such as mechanical strength of a green body thereof, and only a short time being necessary for removal or elimination of binder in comparison with conventional sintering compositions.Furthermore, the binder in the present composition is substantially composed of a single component; accordingly, manufacturing process control can be simplified by use of the lactone resin.Furthermore, a method for producing a metallic sintered body using such composition is also disclosed.

2. 发明授权

US4200560A Process for preparing water-soluble alkyd resins 失效
标题翻译：制备水溶性醇酸树脂的方法
公开(公告)号：US4200560A
公开(公告)日：1980-04-29
申请号：US895560
申请日：1978-04-12
申请人： Masyoshi Kubo , Michio Nakanishi , Shoji Watanabe
发明人： Masyoshi Kubo , Michio Nakanishi , Shoji Watanabe
IPC分类号： C08G63/42 , C08G63/48 , C09D167/00 , C08L67/08 , C08G63/22 , C08L67/02
CPC分类号： C08G63/42 , C08G63/48 , C08K5/34 , C09D167/00 , Y10T428/31794
摘要： A process for preparing a water-soluble alkyd resin, which comprises(1) reacting(i) at least one of(a) a 1,2-epoxyalkane containing 6 to 28 carbon atoms,(b) a straight-chain internal epoxyalkane containing 6 to 20 carbon atoms,(c) a mixture of one or more of the 1,2-epoxyalkane (a) and/or the internal epoxyalkane (b), or(d) a mixture of one or more of the 1,2-epoxyalkane (a) and/or the internal epoxyalkane (b) and an unsaturated fatty acid containing 12 to 18 carbon atoms in a molar ratio of about 4:1 to about 2:1 of the 1,2-epoxyalkane (a) and/or the internal epoxyalkane (b) to the unsaturated fatty acid;with(ii) at least one of(a') an aromatic carboxyl compound selected from the group consisting essentially of phthalic anhydride, isophthalic acid, terephthalic acid, an ester of isophthalic acid and an ester of terephthalic acid,(b') a mixture of two or more of the aromatic carboxyl compounds (a'), or(c') a mixture of one or more of the aromatic carboxylic compounds (a') and an aliphatic dicarboxylic acid having 3 or more carbon atoms or an anhydride thereof; and(iii) a polyhydric alcohol containing 2 to 10 carbon atomsto form a polyester containing hydroxyl groups and having an acid value of about 5 or less, a hydroxyl value of about 40 to about 200 and an average molecular weight of about 600 to about 2,500;(2) reacting the hydroxyl groups of the polyester with an aromatic polycarboxylic acid anhydride to adjust the acid value of the polyester to about 25 to about 80 and form a carboxyl group-containing alkyd resin; and(3) neutralizing the carboxyl group-containing alkyd resin with a base.
摘要翻译：一种制备水溶性醇酸树脂的方法，其包括（1）（i）使（a）含有6至28个碳原子的1,2-环氧烷烃中的至少一种（b）直链内部环氧烷烃 6至20个碳原子，（c）1,2-环氧烷烃（a）和/或内部环氧烷烃（b）中的一种或多种的混合物，或（d）1,2 - 环氧烷烃（a）和/或内部环氧烷烃（b）和含有12至18个碳原子的不饱和脂肪酸，其摩尔比约为1,2-环氧烷（a）的约4:1至约2:1，和 /或内部环氧烷烃（b）与不饱和脂肪酸反应; 与（ii）至少一种（a'）芳族羧基化合物，其选自基本上由邻苯二甲酸酐，间苯二甲酸，对苯二甲酸，间苯二甲酸的酯和对苯二甲酸的酯，（b'）混合物的芳族羧酸化合物（a'）或（c'）中的一种或多种芳族羧酸化合物（a'）和具有3个或更多个碳原子的脂族二羧酸或其酸酐的混合物; 和（iii）含有2至10个碳原子的多元醇，以形成含羟基并具有约5或更小的酸值，约40至约200的羟基值和约600至约平均分子量的聚酯 2,500; （2）使聚酯的羟基与芳族多羧酸酐反应，将聚酯的酸值调节至约25〜约80，形成含羧基的醇酸树脂; 和（3）用碱中和含羧基的醇酸树脂。

3. 发明授权

US3978071A Substituted phenylalkanoic acids and derivatives 失效
标题翻译：取代的苯基链烷酸及其衍生物
公开(公告)号：US3978071A
公开(公告)日：1976-08-31
申请号：US486728
申请日：1974-07-08
申请人： Michio Nakanishi , Tomio Muro , Tohru Nakao , Kiyoshi Ogawa
发明人： Michio Nakanishi , Tomio Muro , Tohru Nakao , Kiyoshi Ogawa
IPC分类号： C07D471/04 , C07D487/04 , C07D513/04
CPC分类号： C07D513/04 , C07D471/04 , C07D487/04
摘要： Substituted phenylalkanoic acids and derivatives thereof of the formula: ##SPC1##Wherein each of R.sup.1 and R.sup.2 is a hydrogen atom or an alkyl group having 1 to 4 carbon atoms; each of X.sup.1 and X.sup.2 is a hydrogen atom, a halogen atom, an alkyl group having 1 to 4 carbon atoms or an alkoxy group having 1 to 4 carbon atoms; Y is COOH, COOR (wherein R is an alkyl group having 1 to 4 carbon atoms), CONH.sub.2, CSNH.sub.2, CN or COZ--A--N(R.sup.3)(R.sup.4) (wherein Z is an oxygen atom or an imino group, A is an alkylene group having 2 to 4 carbon atoms and each of R.sup.3 and R.sup.4 is a hydrogen atom or an alkyl group having 1 to 4 carbon atoms, or R.sup.3 and R.sup.4 together with the adjacent nitrogen atom form a saturated heterocycle selected from pyrrolidine, piperidine, morpholine, piperazine and piperazine substituted by an alkyl group having 1 to 4 carbon atoms at the 4-position; and ring P represents a pyridine ring, a pyrimidine ring or a thiazole ring; and pharmaceutically acceptable salts thereof are useful as analgesics, anti-pyrestics and anti-inflammatory agents.
摘要翻译：取代的苯基链烷酸及其下式的衍生物：

4. 发明授权

US4016276A Treatment of liver dysfunction with 2-amino-6-benzyl-3-ethoxycarbonyl-4,5,6,7-tetrahydro-thieno[2,3-c]pyridi ne hydrochloride 失效
标题翻译：用2-氨基-6-苄基-3-乙氧基羰基-4,5,6,7-四氢噻吩并[8，2,3-c]吡啶盐酸盐处理肝功能障碍
公开(公告)号：US4016276A
公开(公告)日：1977-04-05
申请号：US569118
申请日：1975-04-17
申请人： Toshihiro Kobayakawa , Hiroshi Yasuda , Kazuhiro Goto , Michio Nakanishi
发明人： Toshihiro Kobayakawa , Hiroshi Yasuda , Kazuhiro Goto , Michio Nakanishi
IPC分类号： C07D495/04 , A61K31/435 , A61P1/16
CPC分类号： A61K31/435
摘要： Pharmaceutical compositions containing 2-amino-6-benzyl-3-ethoxycarbonyl-4,5,6,7-tetrahydro-thieno[2,3-c]pyridine hydrochloride and a method of using such compositions in treatment of liver dysfunction in mammals are disclosed.
摘要翻译：含有2-氨基-6-苄基-3-乙氧基羰基-4,5,6,7-四氢 - 噻吩并[2,3-c]吡啶盐酸盐的药物组合物和使用这些组合物治疗哺乳动物肝脏功能障碍的方法被披露。

5. 发明授权

US3974168A Tricycle substituted acetones 失效
标题翻译：三轮车替代丙酮
公开(公告)号：US3974168A
公开(公告)日：1976-08-10
申请号：US503207
申请日：1974-09-04
申请人： Michio Nakanishi , Takanori Oe , Mineo Tsuruda
发明人： Michio Nakanishi , Takanori Oe , Mineo Tsuruda
IPC分类号： C07D471/04 , C07D491/04 , C07D491/052 , C07D495/04 , C07D487/00
CPC分类号： C07D471/04 , C07D491/04 , C07D495/04 , Y10S514/916
摘要： Compounds of the formula: ##SPC1##WhereinOf X.sup.1 and X.sup.2 is a hydrogen atom, a halogen atom or an alkyl group having 1 to 4 carbon atoms;R.sup.1 is a hydrogen atom, an alkyl group having 1 to 4 carbon atoms, an alkenyl group having 2 to 4 carbon atoms, an alkynyl group having 2 to 4 carbon atoms or a group -B.sup.1 -R.sup.3 (wherein B.sup.1 is an alkylene group having 1 to 4 carbon atoms, and R.sup.3 is a carboxyl group, an alkoxycarbonyl group in which the alkoxy moiety has 1 to 4 carbon atoms, an alkoxy group having 1 to 4 carbon atoms or a di-alkyl-amino group in which each alkyl moiety has 1 to 4 carbon atoms);R.sup.2 is an alkyl group having 1 to 4 carbon atoms or a group -B.sup.2 -R.sup.4 (wherein B.sup.2 is an alkylene group having 2 to 4 carbon atoms, and R.sup.4 is a carboxyl group or a di-alkyl-amino group in which each alkyl moiety has 1 to 4 carbon atoms);A is a methylene group or a carbonyl group;Y is an oxygen atom, a sulfur atom or an alkyl-imino group in which the alkyl moiety has 1 to 4 carbon atoms; andRing P is a pyridine ring; andPharmaceutically acceptable salts thereof are disclosed.They are useful as anti-inflammatory agents, analgesics, antipyretics and antirheumatics.
摘要翻译：下式的化合物：

6. 发明授权

US5158963A 1-4-dihydropyridine derivative, process for preparing the same and pharmaceutical composition containing the same 失效
标题翻译： 1-4-二氢吡啶衍生物，其制备方法和含有它们的药物组合物
公开(公告)号：US5158963A
公开(公告)日：1992-10-27
申请号：US557816
申请日：1990-07-26
申请人： Michio Nakanishi , Katsuhiro Uchida , Terutake Nakagawa , Kiyoharu Ukai , Michiko Nagahara , Jun Nakano , Kazuhiko Kimura
发明人： Michio Nakanishi , Katsuhiro Uchida , Terutake Nakagawa , Kiyoharu Ukai , Michiko Nagahara , Jun Nakano , Kazuhiko Kimura
IPC分类号： C07D211/90
CPC分类号： C07D211/90
摘要： A 1,4-dihydropyridine derivative having the formula (I): ##STR1## wherein X is oxygen atom or nitrogen atom; when X is oxygen atom, R.sup.1 is hydrogen atom, a lower alkyl group, a lower cycloalkyl group, a lower alkenyl group or magnesium atom, when X is nitrogen atom, X-R.sup.1 group is NH.sub.2, NHR.sup.1', NR.sup.1' R.sup.1" or ##STR2## in which R.sup.1' is a lower alkyl group or a lower alkoxyalkyl group, R.sup.1" is a lower alkyl group and n is an integer of 2 to 6; R.sup.2 is a lower alkyl group, a lower cycloalkyl group or a lower alkoxyalkyl group and R.sup.3 is a lower alkyl group, formyl group, dimethoxymethyl group, cyano group or amino group, when X is oxygen atom and R.sup.1 is hydrogen atom or magnesium atom, R.sup.3 is methyl group, when X is nitrogen atom, R.sup.3 is methyl group, or a pharmaceutically acceptable salt thereof, some processes for preparing the same and a pharmaceutical composition containing the same. According to the present invention, a superior cerebral function improver can be provided.

7. 发明授权

US4968739A Composition and method for producing a metallic sintered body 失效
标题翻译：用于制造金属烧结体的组合物和方法
公开(公告)号：US4968739A
公开(公告)日：1990-11-06
申请号：US442756
申请日：1989-11-29
申请人： Michio Nakanishi , Takuya Miho
发明人： Michio Nakanishi , Takuya Miho
IPC分类号： B22F3/02 , B22F1/00 , C08K3/08
CPC分类号： B22F1/0059 , C08K3/08
摘要： A composition for producing a metallic sintered body consisting essentially of a mixture of a powered metal having an average particle size of not more than 50 microns with a lactone resin having a relative viscosity value in the range of from 1.15 to 3.20 is disclosed.The composition has excellent properties such as mechanical strength of a green body thereof, and only a short time being necessary for removal or elimination of binder in comparison with conventional sintering compositions.Furthermore, the binder in the present composition is substantially composed of a single component; accordingly, manufacturing process control can be simplified by use of the lactone resin.Furthermore, a method for producing a metallic sintered body using such composition is also disclosed.

8. 发明授权

US4010184A Thienodiazepines 失效
标题翻译：噻吩二氮
公开(公告)号：US4010184A
公开(公告)日：1977-03-01
申请号：US453117
申请日：1974-03-20
申请人： Michio Nakanishi , Kazuhiko Araki , Tetsuya Tahara , Masami Shiroki
发明人： Michio Nakanishi , Kazuhiko Araki , Tetsuya Tahara , Masami Shiroki
IPC分类号： C07D495/04 , C07D333/24
CPC分类号： C07D495/04
摘要： Thienodiazepines of the formula: ##STR1## wherein Ar is mono- or di-substituted phenyl [the substituents(s) being H, halogen, C.sub.1.sub.-4 alkyl or C.sub.1.sub.-4 alkoxy] or pyridyl; R.sup.1 is H or C.sub.1.sub.-4 alkyl; R.sup.2 is H, halogen or C.sub.1.sub.-4 alkyl; or R.sup.1 and R.sup.2 combinedly form -(CH.sub.2).sub.4 -; each of R.sup.3 and R.sup.4 is C.sub.1.sub.-4 alkyl, or R.sup.3 and R.sup.4 together with the adjacent nitrogen atom form a heterocyclic group; A is C.sub.2.sub.-4 alkylene; and n is an integer of zero and 1; and pharmaceutically acceptable acid addition salts thereof are disclosed. They are useful as analgesics.
摘要翻译：其中Ar是单取代或二取代的苯基[取代基是H，卤素，C 1-4烷基或C 1-4烷氧基]或吡啶基; R1是H或C1-4烷基; R2是H，卤素或C1-4烷基; 或R 1和R 2结合形成 - （CH 2）4 - ; R 3和R 4各自为C 1-4烷基，或者R 3和R 4与相邻的氮原子一起形成杂环基; A是C 2-4亚烷基; 并且n是0和1的整数; 及其药学上可接受的酸加成盐。它们作为止痛剂是有用的。

9. 发明授权

US4511687A Polycaprolactone composition 失效
标题翻译：聚己内酯组合物
公开(公告)号：US4511687A
公开(公告)日：1985-04-16
申请号：US383054
申请日：1982-05-28
申请人： Michio Nakanishi , Naoki Nakashima
发明人： Michio Nakanishi , Naoki Nakashima
IPC分类号： C08L67/04 , C09J167/04 , C08L93/04
CPC分类号： C08L67/04 , C09J167/04
摘要： A synthetic resin composition comprises (A) 100 parts by weight of polycaprolactone and (B-1) 10 to 70 parts by weight of a thermoplastic resin and 1 to 30 parts by weight of a tackifier, or (B-2) 10 to 70 parts by weight of a chlorinated polyolefin.
摘要翻译：合成树脂组合物包含（A）100重量份的聚己内酯和（B-1）10〜70重量份的热塑性树脂和1〜30重量份的增粘剂，或（B-2）10〜70 重量份的氯化聚烯烃。

10. 发明授权

US3965111A Triazolothienodiazepine compounds 失效
标题翻译：三唑并噻吩并二氮杂类化合物
公开(公告)号：US3965111A
公开(公告)日：1976-06-22
申请号：US301910
申请日：1972-10-30
申请人： Michio Nakanishi , Kazuhiko Araki , Tetsuya Tahara , Masami Shiroki
发明人： Michio Nakanishi , Kazuhiko Araki , Tetsuya Tahara , Masami Shiroki
IPC分类号： A61K31/55 , A61P23/00 , A61P25/08 , A61P25/20 , C07D495/04 , C07D495/14
CPC分类号： C07D495/04 , C07D495/14
摘要： Triazolothienodiazepine compounds of the formula; ##SPC1##Wherein X is a member selected from the group consisting of a hydrogen atom, a methyl group, a methoxy group and a trifluoromethyl group; each of R.sup.1 and R.sup.2 is a member selected from the group consisting of a hydrogen atom and an alkyl group having 1 to 4 carbon atoms, or R.sup.1 and R.sup.2 together can form a tetramethylene group, i.e.--(CH.sub.2).sub.4 --; R is a member selected from the group consisting of a hydrogen atom, an alkyl group having 1 to 4 carbon atoms, --CONHR.sup.3 (R.sup.3 being an alkyl group having 1 to 4 carbon atoms) and -alk-N(R.sup. 4)(R.sup.5) (each of R.sup.4 and R.sup.5 being a member selected from the group consisting of a hydrogen atom and an alkyl group having 1 to 4 carbon atoms, or R.sup.4 and R.sup.5 and N can form a heterocyclic ring; and alk being an alkylene group having 2 to 4 carbon atoms); and Z is a member selected from the group consisting of an oxygen atom and a sulphur atom; and the pharmaceutically acceptable acid addition salts thereof are disclosed. These compounds are useful as minor tranquillizers (anti-anxiety drugs), sleep inducers, and anti-epileptics.
摘要翻译：三唑并噻吩并二氮杂化合物; 其中X是选自氢原子，甲基，甲氧基和三氟甲基的成员; R 1和R 2各自为选自氢原子和具有1至4个碳原子的烷基的成员，或者R 1和R 2一起可以形成四亚甲基，即 - （CH 2）4 - ; R是选自氢原子，具有1至4个碳原子的烷基，-CONHR 3（R 3是具有1至4个碳原子的烷基）和-alk-N（R 4）（R 5））（R4和R5各自为氢原子和碳原子数1〜4的烷基，R4，R5和N可以形成杂环，烷基为2以上的亚烷基至4个碳原子）; Z为选自氧原子和硫原子的成员; 及其药学上可接受的酸加成盐。这些化合物可用作轻度镇定剂（抗焦虑药），睡眠诱导剂和抗癫痫药。

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