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1. 发明授权

US4016276A Treatment of liver dysfunction with 2-amino-6-benzyl-3-ethoxycarbonyl-4,5,6,7-tetrahydro-thieno[2,3-c]pyridi ne hydrochloride 失效
标题翻译：用2-氨基-6-苄基-3-乙氧基羰基-4,5,6,7-四氢噻吩并[8，2,3-c]吡啶盐酸盐处理肝功能障碍
公开(公告)号：US4016276A
公开(公告)日：1977-04-05
申请号：US569118
申请日：1975-04-17
申请人： Toshihiro Kobayakawa , Hiroshi Yasuda , Kazuhiro Goto , Michio Nakanishi
发明人： Toshihiro Kobayakawa , Hiroshi Yasuda , Kazuhiro Goto , Michio Nakanishi
IPC分类号： C07D495/04 , A61K31/435 , A61P1/16
CPC分类号： A61K31/435
摘要： Pharmaceutical compositions containing 2-amino-6-benzyl-3-ethoxycarbonyl-4,5,6,7-tetrahydro-thieno[2,3-c]pyridine hydrochloride and a method of using such compositions in treatment of liver dysfunction in mammals are disclosed.
摘要翻译：含有2-氨基-6-苄基-3-乙氧基羰基-4,5,6,7-四氢 - 噻吩并[2,3-c]吡啶盐酸盐的药物组合物和使用这些组合物治疗哺乳动物肝脏功能障碍的方法被披露。

2. 发明授权

US4053478A 2,5-Di-substituted 4-oxazolealkanoic acids and esters 失效
标题翻译： 2,5-二取代的4-氧杂唑酮酸和酯
公开(公告)号：US4053478A
公开(公告)日：1977-10-11
申请号：US748450
申请日：1976-12-08
申请人： Tsutomu Yamanaka , Toshihiro Kobayakawa , Mitsuhiro Konishi , Kuniki Ikeda
发明人： Tsutomu Yamanaka , Toshihiro Kobayakawa , Mitsuhiro Konishi , Kuniki Ikeda
IPC分类号： C07D263/42 , C07D413/04 , A61K31/42 , A61K31/44 , C07D413/12
CPC分类号： C07D263/42 , Y10S514/822 , Y10S514/824
摘要： 2,5-Di-substituted 4-oxazolealkanoic acids and esters thereof of the formula: ##STR1## WHEREIN M REPRESENTS AN INTEGER OF 1 TO 2; R.sup.1 represents an alkyl group having 1 to 4 carbon atoms; n represents an integer of 1 to 2; R represents a mono- or di-substituted phenyl group (in which the substituents are selected from the group consisting of a halogen atom, a methyl group, a methoxy group, a nitro group, a trifluoromethyl group, a phenyl group, a halogen-substituted phenyl group, a phenoxy group and a halogen-substituted phenoxy group), a pyridyl group, a halogen-substituted pyridyl group, a furyl group, a halogen-substituted furyl group, a thienyl group, a halogen-substituted thienyl group, a naphthyl group or a halogen-substituted naphthyl group; when m represents an integer of 1, Y represents an hydrogen atom, an alkyl group having 1 to 2 carbon atoms, a benzyl group or a pyridylmethyl group; and when m represents an integer of 2, Y represents a trimethylene group. These compounds are useful as drugs for the treatment of arteriosclerosis, thrombosis and hypertension with lipid metabolism disorder.

3. 发明授权

US4012412A 2,5-Di-substituted 4-oxazolealkanoic acid and esters 失效
标题翻译： 2,5-二取代的4-恶唑烷酸和酯
公开(公告)号：US4012412A
公开(公告)日：1977-03-15
申请号：US557692
申请日：1975-03-12
申请人： Tsutomu Yamanaka , Toshihiro Kobayakawa , Mitsuhiro Konishi , Kuniki Ikeda
发明人： Tsutomu Yamanaka , Toshihiro Kobayakawa , Mitsuhiro Konishi , Kuniki Ikeda
IPC分类号： A61K31/421 , C07D263/42
CPC分类号： C07D263/42 , Y10S514/822
摘要： 2,5-Di-substituted 4-oxazolealkanoic acids and esters thereof of the formula: ##STR1## WHEREIN M REPRESENTS AN INTEGER OF 1 TO 2; R.sup.1 represents an alkyl group having 1 to 4 carbon atoms; n represents an integer of 1 to 2; R represents a mono- or di-substituted phenyl group (in which the substituents are selected from the group consisting of a halogen atom, a methyl group, a methoxy group, a nitro group, a trifluoromethyl group, a phenyl group, a halogen-substituted phenyl group, a phenoxy group and a halogen-substituted phenoxy group), a pyridyl group, a halogen-substituted pyridyl group, a furyl group, a halogen-substituted furyl group, a thienyl group, a halogen-substituted thienyl group, a naphthyl group or a halogen-substituted naphthyl group; when m represents an integer of 1, Y represents an hydrogen atom, an alkyl group having 1 to 2 carbon atoms, a benzyl group or a pyridylmethyl group; and when m represents an integer of 2, Y represents a trimethylene group. These compounds are useful as drugs for the treatment of arteriosclerosis, thrombosis and hypertension with lipid metabolism disorder.
摘要翻译： 2,5-二取代的4-恶唑烷酸及其酯，具有下式：其中M代表1至2的整数; R1表示碳原子数1〜4的烷基。 n表示1〜2的整数， R表示单取代或二取代的苯基（其中取代基选自卤素原子，甲基，甲氧基，硝基，三氟甲基，苯基，取代苯基，苯氧基和卤素取代的苯氧基），吡啶基，卤素取代的吡啶基，呋喃基，卤素取代的呋喃基，噻吩基，卤素取代的噻吩基，萘基或卤素取代的萘基; 当m表示1的整数时，Y表示氢原子，碳原子数1〜2的烷基，苄基或吡啶基甲基。当m表示2的整数时，Y表示三亚甲基。这些化合物可用作用于治疗动脉硬化，血栓形成和高血压与脂质代谢紊乱的药物。

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