专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US08664593B2 Control of gas flow in high field asymmetric waveform ion mobility spectrometry 有权
标题翻译：高场不对称波形离子迁移谱中气流的控制
公开(公告)号：US08664593B2
公开(公告)日：2014-03-04
申请号：US13787574
申请日：2013-03-06
申请人： Satendra Prasad , Michael W. Belford , Jean Jacques Dunyach
发明人： Satendra Prasad , Michael W. Belford , Jean Jacques Dunyach
IPC分类号： H01J49/00 , H01J49/40 , B01D59/44
CPC分类号： H01J49/0422 , G01N27/624
摘要： A High Field Asymmetric Waveform Ion Mobility Spectrometry (FAIMS) apparatus comprises (a) a first and a second gas inlet; (b) an expansion chamber receiving ions from an ion source and the first and second gas flows from the first and second gas inlets, respectively; (c) an outer electrode having a generally concave inner surface and comprising: (i) an ion inlet operable to receive, from the expansion chamber, the ions and a combined gas flow comprising portions of the first and second gas flows; and (ii) an ion outlet; and (d) an inner electrode having a generally convex outer surface that is disposed in a spaced-apart and facing arrangement relative to the inner surface of the outer electrode for defining an ion separation region therebetween, wherein the combined gas flow and a portion of the ions travel through the ion separation region from the ion inlet to the ion outlet.
摘要翻译：高场不对称波形离子迁移光谱法（FAIMS）装置包括：（a）第一和第二气体入口; （b）从离子源接收离子的膨胀室，并且第一和第二气体分别从第一和第二气体入口流出; （c）具有大致凹入的内表面的外电极，包括：（i）可操作以从膨胀室接收离子的离子入口和包含第一和第二气流的部分的组合气流; 和（ii）离子出口; 和（d）具有大致凸形的外表面的内电极，其相对于外电极的内表面以间隔开和面对的方式布置，用于在其间限定离子分离区域，其中组合的气流和一部分离子通过离子入口离开离子入口到离子出口。

2. 发明授权

US08158932B2 FAIMS having a displaceable electrode for on/off operation 有权
标题翻译： FAIMS具有用于开/关操作的可移位电极
公开(公告)号：US08158932B2
公开(公告)日：2012-04-17
申请号：US12762176
申请日：2010-04-16
申请人： Michael W. Belford , Jean-Jacques Dunyach , Mark E. Hardman
发明人： Michael W. Belford , Jean-Jacques Dunyach , Mark E. Hardman
IPC分类号： H01J49/40 , H01J49/04
CPC分类号： G01N27/624
摘要： A system for analyzing ions comprises: an ion source; a FAIMS cell comprising: (a) a gas inlet; (b) an outer electrode having a generally concave inner surface and comprising: (i) an ion inlet operable to receive the ions from the ion source and a carrier gas from the gas inlet; and (ii) an ion outlet; and (c) an inner electrode having a conduit therethrough and having a generally convex outer surface that is disposed in a spaced-apart and facing arrangement relative to the inner surface of the outer electrode for defining an ion separation region therebetween; and a mass analyzer for mass analyzing ions transmitted by the FAIMS cell through the ion outlet, wherein the inner electrode is moveable between a first position and a second position, the first position facilitating movement of the ions through the ion separation region, the second position facilitating movement of the ions through the conduit.
摘要翻译：用于分析离子的系统包括：离子源; FAIMS单元包括：（a）气体入口; （b）具有大致凹入的内表面的外电极，包括：（i）可操作以从离子源接收离子的离子入口和来自气体入口的载气; 和（ii）离子出口; 和（c）内部电极，其具有穿过其中的导管，并且具有大致凸形的外表面，该外表面相对于外部电极的内表面以间隔开和相对的方式布置，用于在其间形成离子分离区域; 以及质量分析器，用于质量分析由FAIMS单元通过离子出口传输的离子，其中内部电极可在第一位置和第二位置之间移动，第一位置便于离子通过离子分离区域的移动，第二位置促进离子通过导管的运动。

3. 发明授权

US07858934B2 Quadrupole FAIMS apparatus 有权
标题翻译：四极FAIMS仪器
公开(公告)号：US07858934B2
公开(公告)日：2010-12-28
申请号：US11962036
申请日：2007-12-20
申请人： Michael W. Belford , Jean Jacques Dunyach
发明人： Michael W. Belford , Jean Jacques Dunyach
IPC分类号： H01J49/36
CPC分类号： H01J49/063 , G01N27/624
摘要： A combined rf-only/FAIMS apparatus is disclosed for use in mass spectrometry and other applications. The disclosed apparatus includes a plurality of curved electrodes arranged around a central ion transmission channel. FAIMS functionality is removed electronically when not desired by application of radio frequency (rf) waveforms to the curved electrodes.
摘要翻译：公开了用于质谱法和其它应用的组合的仅纯/ FAIMS装置。所公开的装置包括围绕中心离子传输通道布置的多个弯曲电极。当不需要通过将射频（RF）波形施加到弯曲电极时，FAIMS功能被电子地去除。

4. 发明授权

US07638765B1 FAIMS cell with separate desolvation and carrier gas inlets 有权
标题翻译：具有单独去溶剂化和载气入口的FAIMS电池
公开(公告)号：US07638765B1
公开(公告)日：2009-12-29
申请号：US11829489
申请日：2007-07-27
申请人： Michael W. Belford , Jean Jacques Dunyach
发明人： Michael W. Belford , Jean Jacques Dunyach
IPC分类号： H01J49/40
CPC分类号： G01N27/624
摘要： A method for analyzing ions includes providing a desolvation chamber in communication with an analytical gap of a FAIMS analyzer, via an ion inlet orifice. A flow of ions is introduced into the desolvation chamber along a flow path that is toward the ion inlet orifice and into the analytical gap of the FAIMS analyzer. A flow of a desolvation gas is provided into the desolvation chamber via a first gas inlet, such that a portion of the flow of the desolvation gas is counter-current to the flow of ions. A flow of a carrier gas is provided separately via a second gas inlet, which is defined downstream relative to the desolvation chamber. In particular, the composition of the carrier gas is different than the composition of the desolvation gas. Accordingly, the flow of the carrier gas is provided substantially into the analytical gap for transporting ions along a path between the ion inlet orifice and an ion outlet orifice of the analytical gap.
摘要翻译：用于分析离子的方法包括通过离子入口孔提供与FAIMS分析器的分析间隙连通的去溶剂化室。离子流将沿着朝向离子入口孔并进入FAIMS分析仪的分析间隙的流动路径引入去溶剂化室。通过第一气体入口将去溶剂化气体的流动提供到去溶剂化室中，使得去溶剂化气体的一部分流与离子流逆流。通过第二气体入口单独提供载气流，第二气体入口相对于去溶剂化室限定在下游。特别地，载气的组成与去溶剂化气体的组成不同。因此，载气的流动基本上设置在用于沿离子入口孔和分析间隙的离子出口孔之间的路径输送离子的分析间隙中。

5. 发明授权

US08759757B2 Interchangeable ion source for electrospray and atmospheric pressure chemical ionization 有权
标题翻译：用于电喷雾和大气压化学电离的可互换离子源
公开(公告)号：US08759757B2
公开(公告)日：2014-06-24
申请号：US13280069
申请日：2011-10-24
申请人： Mark Hardman , Jean-Jacques Dunyach , R. Paul Atherton , Michael W. Belford
发明人： Mark Hardman , Jean-Jacques Dunyach , R. Paul Atherton , Michael W. Belford
IPC分类号： H01J49/04 , H01J49/10 , H01J49/16 , H01J49/14
CPC分类号： H01J49/167 , H01J49/107 , H01J49/145 , H01J49/165
摘要： A ion source for a mass spectrometer comprises: a capillary having a nozzle for emitting a nebulized fluid sample; an electrode of the capillary; a high voltage power supply; a second electrode disposed within or configurable to be disposed within a path of the nebulized fluid sample; and at least one switch for selecting application of an electrical potential provided by the high voltage power supply to either or both of the capillary electrode or the second electrode, wherein the capillary and capillary electrode are configurable so as to ionize the nebulized fluid sample by electrospray ionization and the second electrode is configurable so as to ionize the nebulized sample by atmospheric pressure chemical ionization.
摘要翻译：用于质谱仪的离子源包括：具有用于发射雾化流体样品的喷嘴的毛细管; 毛细管的电极; 高压电源; 设置在所述喷雾流体样本的路径内或可配置为设置在所述雾化流体样本的路径内的第二电极; 以及至少一个开关，用于选择将所述高电压电源提供给所述毛细管电极或所述第二电极中的任一个或两者的电位施加，其中所述毛细管和毛细管电极可配置为通过电喷雾使雾化的流体样品电离电离和第二电极是可配置的，以便通过大气压化学电离使雾化的样品离子化。

6. 发明申请

US20110253890A1 FAIMS Having a Displaceable Electrode for On/Off Operation 有权
标题翻译： FAIMS具有用于开/关操作的可移动电极
公开(公告)号：US20110253890A1
公开(公告)日：2011-10-20
申请号：US12762176
申请日：2010-04-16
申请人： Michael W. BELFORD , Jean-Jacques Dunyach , Mark E. Hardman
发明人： Michael W. BELFORD , Jean-Jacques Dunyach , Mark E. Hardman
IPC分类号： H01J49/04 , H01J49/24 , H01J49/26
CPC分类号： G01N27/624
摘要： A system for analyzing ions comprises: an ion source; a FAIMS cell comprising: (a) a gas inlet; (b) an outer electrode having a generally concave inner surface and comprising: (i) an ion inlet operable to receive the ions from the ion source and a carrier gas from the gas inlet; and (ii) an ion outlet; and (c) an inner electrode having a conduit therethrough and having a generally convex outer surface that is disposed in a spaced-apart and facing arrangement relative to the inner surface of the outer electrode for defining an ion separation region therebetween; and a mass analyzer for mass analyzing ions transmitted by the FAIMS cell through the ion outlet, wherein the inner electrode is moveable between a first position and a second position, the first position facilitating movement of the ions through the ion separation region, the second position facilitating movement of the ions through the conduit.
摘要翻译：用于分析离子的系统包括：离子源; FAIMS单元包括：（a）气体入口; （b）具有大致凹入的内表面的外电极，包括：（i）可操作以从离子源接收离子的离子入口和来自气体入口的载气; 和（ii）离子出口; 和（c）内部电极，其具有穿过其中的导管，并且具有大致凸形的外表面，该外表面相对于外部电极的内表面以间隔开和相对的方式布置，用于在其间形成离子分离区域; 以及质量分析器，用于质量分析由FAIMS单元通过离子出口传输的离子，其中内部电极可在第一位置和第二位置之间移动，第一位置便于离子通过离子分离区域的移动，第二位置促进离子通过导管的运动。

7. 发明申请

US20110139972A1 Methods and Apparatus for Providing FAIMS Waveforms Using Solid-State Switching Devices 审中-公开
标题翻译：使用固态开关器件提供FAIMS波形的方法和装置
公开(公告)号：US20110139972A1
公开(公告)日：2011-06-16
申请号：US12636403
申请日：2009-12-11
申请人： Mark HARDMAN , Michael W. Belford , Jean Jacques Dunyach
发明人： Mark HARDMAN , Michael W. Belford , Jean Jacques Dunyach
IPC分类号： B01D59/44 , H01J49/00
CPC分类号： G01N27/624
摘要： A high field asymmetric waveform ion mobility spectrometry (FAIMS) comprises an electrical power supply electrically connected to at least one of the FAIMS electrodes and operable to as to apply a periodic asymmetric square-wave waveform voltage to at least one of the electrodes so as to selectively transmit a type of ion in and through a FAIMS analyzer region to an ion outlet, wherein the electrical power supply is operable so as to vary a time duration of pulses of the asymmetric square-wave waveform so as to control the type of ion selectively transmitted, an efficiency of said selective transmission or the ability to prevent transmission of a different type of ions in and through said analyzer region to the ion outlet.
摘要翻译：高场非对称波形离子迁移谱（FAIMS）包括电连接到FAIMS电极中的至少一个的电源，并可操作以将周期性非对称方波波形电压施加到至少一个电极，以便选择性地将一种类型的离子通过FAIMS分析仪区域传输到离子出口，其中电源可操作以改变非对称方波波形的脉冲持续时间，以便有选择地控制离子的类型透射，所述选择性透射的效率或防止不同类型的离子通过所述分析器区域传输到离子出口的能力。

8. 发明授权

US07351960B2 Enhanced ion desolvation for an ion mobility spectrometry device 有权
标题翻译：用于离子迁移光谱装置的增强的离子去溶剂化
公开(公告)号：US07351960B2
公开(公告)日：2008-04-01
申请号：US11131072
申请日：2005-05-16
申请人： Michael W. Belford
发明人： Michael W. Belford
IPC分类号： H01J49/04
CPC分类号： G01N27/624 , H01J49/0404 , H01J49/049
摘要： An ion spectrometer apparatus is disclosed having an ion source, an ion mobility spectrometer device such as a FAIMS cell, and a capillary for transporting ions from the ion source to the entrance of the FAIMS cell. The capillary is heated to promote evaporation of solvent from incompletely desolvated droplets entering the capillary inlet, thereby preventing or minimizing operational problems associated with the presence of wet material in the FAIMS cell. The FAIMS cell may be used to selectively transmit ions to a mass analyzer.
摘要翻译：公开了一种具有离子源，诸如FAIMS单元的离子迁移谱仪装置和用于将离子从离子源输送到FAIMS单元的入口的毛细管的离子光谱仪装置。毛细管被加热以促进溶剂从进入毛细管入口的不完全溶解的液滴中蒸发，从而防止或最小化与FAIMS细胞中湿物质的存在相关的操作问题。 FAIMS单元可用于选择性地将离子传输到质量分析器。

9. 发明申请

US20080067366A1 FAIMS electrodes with lateral ion focusing 有权
标题翻译： FAIMS电极与横向离子聚焦
公开(公告)号：US20080067366A1
公开(公告)日：2008-03-20
申请号：US11451636
申请日：2006-06-13
申请人： Michael W. Belford
发明人： Michael W. Belford
IPC分类号： H01J49/28
CPC分类号： H01J49/42
摘要： A FAIMS cell including one of side-to-side cylindrical geometry electrodes and stacked-plate electrodes is adapted with a medial surface feature for focusing ions along a lateral direction within an ion separation region of the FAIMS cell. The medial surface feature is provided as one of a recessed channel within an electrode surface and a protruding ridge extending from an electrode surface. The medial surface feature is aligned with a defined aggregate direction of ion travel within the ion separation region for focusing ions along the lateral direction in opposition to the tendency of ions to spread out as a result of space charge repulsion, ion-ion repulsive forces, diffusion and gas flows. The electrical field and fluid dynamic effects produced by the medial surface feature beneficially affect ion transmission efficiency through the FAIMS cell.
摘要翻译：包括侧面到侧面的圆柱形几何电极和层叠电极之一的FAIMS单元适于具有用于在FAIMS单元的离子分离区域内沿着横向聚焦离子的中间表面特征。内侧表面特征被提供为电极表面内的凹陷通道之一和从电极表面延伸的突出脊。内侧表面特征与离子分离区域内限定的离子行程聚集方向对齐，用于沿着横向聚焦离子，以抵抗由于空间电荷排斥，离子离子排斥力引起的离子扩展的倾向，扩散和气体流动。由内侧表面特征产生的电场和流体动力学效应通过FAIMS单元有利地影响离子传播效率。

10. 发明授权

US08692190B2 FAIMS having a displaceable electrode for on/off operation 有权
标题翻译： FAIMS具有用于开/关操作的可移位电极
公开(公告)号：US08692190B2
公开(公告)日：2014-04-08
申请号：US13429311
申请日：2012-03-23
申请人： Michael W. Belford , Jean-Jacques Dunyach , Mark E. Hardman
发明人： Michael W. Belford , Jean-Jacques Dunyach , Mark E. Hardman
IPC分类号： B01D59/44 , H01J49/42
CPC分类号： G01N27/624
摘要： A system for analyzing ions comprises: an ion source; a FAIMS cell comprising: (a) a gas inlet; (b) an outer electrode having a generally concave inner surface and comprising: (i) an ion inlet operable to receive the ions from the ion source and a carrier gas from the gas inlet; and (ii) an ion outlet; and (c) an inner electrode having a conduit therethrough and having a generally convex outer surface disposed in a spaced-apart and facing arrangement relative to the inner surface of the outer electrode defining at least one annular on separation region therebetween; and a mass analyzer for mass analyzing ions transmitted by the FAIMS cell through the ion outlet, wherein the inner electrode is moveable between a first position and a second position, the first and second positions facilitating movement of the ions through the at least one annular ion separation region and the conduit, respectively.
摘要翻译：用于分析离子的系统包括：离子源; FAIMS单元包括：（a）气体入口; （b）具有大致凹入的内表面的外电极，包括：（i）可操作以从离子源接收离子的离子入口和来自气体入口的载气; 和（ii）离子出口; 和（c）内部电极，其具有穿过其中的导管并且具有大致凸形的外表面，该外部表面相对于所述外部电极的内表面间隔开并面向布置，所述内部表面限定了其间的至少一个环形分离区域; 以及用于质量分析由FAIMS单元通过离子出口传输的离子的质量分析器，其中所述内部电极可在第一位置和第二位置之间移动，所述第一和第二位置有助于所述离子通过所述至少一个环形离子分离区和导管。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式