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1. 发明授权

US08664593B2 Control of gas flow in high field asymmetric waveform ion mobility spectrometry 有权
标题翻译：高场不对称波形离子迁移谱中气流的控制
公开(公告)号：US08664593B2
公开(公告)日：2014-03-04
申请号：US13787574
申请日：2013-03-06
申请人： Satendra Prasad , Michael W. Belford , Jean Jacques Dunyach
发明人： Satendra Prasad , Michael W. Belford , Jean Jacques Dunyach
IPC分类号： H01J49/00 , H01J49/40 , B01D59/44
CPC分类号： H01J49/0422 , G01N27/624
摘要： A High Field Asymmetric Waveform Ion Mobility Spectrometry (FAIMS) apparatus comprises (a) a first and a second gas inlet; (b) an expansion chamber receiving ions from an ion source and the first and second gas flows from the first and second gas inlets, respectively; (c) an outer electrode having a generally concave inner surface and comprising: (i) an ion inlet operable to receive, from the expansion chamber, the ions and a combined gas flow comprising portions of the first and second gas flows; and (ii) an ion outlet; and (d) an inner electrode having a generally convex outer surface that is disposed in a spaced-apart and facing arrangement relative to the inner surface of the outer electrode for defining an ion separation region therebetween, wherein the combined gas flow and a portion of the ions travel through the ion separation region from the ion inlet to the ion outlet.
摘要翻译：高场不对称波形离子迁移光谱法（FAIMS）装置包括：（a）第一和第二气体入口; （b）从离子源接收离子的膨胀室，并且第一和第二气体分别从第一和第二气体入口流出; （c）具有大致凹入的内表面的外电极，包括：（i）可操作以从膨胀室接收离子的离子入口和包含第一和第二气流的部分的组合气流; 和（ii）离子出口; 和（d）具有大致凸形的外表面的内电极，其相对于外电极的内表面以间隔开和面对的方式布置，用于在其间限定离子分离区域，其中组合的气流和一部分离子通过离子入口离开离子入口到离子出口。

2. 发明授权

US07550717B1 Quadrupole FAIMS apparatus 有权
标题翻译：四极FAIMS仪器
公开(公告)号：US07550717B1
公开(公告)日：2009-06-23
申请号：US11607789
申请日：2006-11-30
申请人： Michael W. Belford , Jean Jacques Dunyach , Randy W. Purves
发明人： Michael W. Belford , Jean Jacques Dunyach , Randy W. Purves
IPC分类号： B01D59/44 , H01J49/00 , H01J49/28
CPC分类号： H01J49/063 , G01N27/624
摘要： A combined rf-only/FAIMS analyzer is disclosed for use in mass spectrometry and other applications. The disclosed apparatus includes a plurality of flat-plate electrodes arranged around a longitudinal axis of the apparatus so as to define generally a parallelogram in a cross section taken in a plane that is normal to the longitudinal axis. FAIMS is removed electronically when not desired by application of radio frequency (rf) waveforms to the flat-plate electrodes.
摘要翻译：公开了一种用于质谱法和其他应用的组合的仅纯/ FAIMS分析仪。所公开的装置包括围绕装置的纵向轴线布置的多个平板电极，以便在垂直于纵向轴线的平面中截取的横截面中大体上限定平行四边形。当不需要通过向平板电极施加射频（rf）波形时，FAIMS被电子地去除。

3. 发明授权

US07858934B2 Quadrupole FAIMS apparatus 有权
标题翻译：四极FAIMS仪器
公开(公告)号：US07858934B2
公开(公告)日：2010-12-28
申请号：US11962036
申请日：2007-12-20
申请人： Michael W. Belford , Jean Jacques Dunyach
发明人： Michael W. Belford , Jean Jacques Dunyach
IPC分类号： H01J49/36
CPC分类号： H01J49/063 , G01N27/624
摘要： A combined rf-only/FAIMS apparatus is disclosed for use in mass spectrometry and other applications. The disclosed apparatus includes a plurality of curved electrodes arranged around a central ion transmission channel. FAIMS functionality is removed electronically when not desired by application of radio frequency (rf) waveforms to the curved electrodes.
摘要翻译：公开了用于质谱法和其它应用的组合的仅纯/ FAIMS装置。所公开的装置包括围绕中心离子传输通道布置的多个弯曲电极。当不需要通过将射频（RF）波形施加到弯曲电极时，FAIMS功能被电子地去除。

4. 发明授权

US07638765B1 FAIMS cell with separate desolvation and carrier gas inlets 有权
标题翻译：具有单独去溶剂化和载气入口的FAIMS电池
公开(公告)号：US07638765B1
公开(公告)日：2009-12-29
申请号：US11829489
申请日：2007-07-27
申请人： Michael W. Belford , Jean Jacques Dunyach
发明人： Michael W. Belford , Jean Jacques Dunyach
IPC分类号： H01J49/40
CPC分类号： G01N27/624
摘要： A method for analyzing ions includes providing a desolvation chamber in communication with an analytical gap of a FAIMS analyzer, via an ion inlet orifice. A flow of ions is introduced into the desolvation chamber along a flow path that is toward the ion inlet orifice and into the analytical gap of the FAIMS analyzer. A flow of a desolvation gas is provided into the desolvation chamber via a first gas inlet, such that a portion of the flow of the desolvation gas is counter-current to the flow of ions. A flow of a carrier gas is provided separately via a second gas inlet, which is defined downstream relative to the desolvation chamber. In particular, the composition of the carrier gas is different than the composition of the desolvation gas. Accordingly, the flow of the carrier gas is provided substantially into the analytical gap for transporting ions along a path between the ion inlet orifice and an ion outlet orifice of the analytical gap.
摘要翻译：用于分析离子的方法包括通过离子入口孔提供与FAIMS分析器的分析间隙连通的去溶剂化室。离子流将沿着朝向离子入口孔并进入FAIMS分析仪的分析间隙的流动路径引入去溶剂化室。通过第一气体入口将去溶剂化气体的流动提供到去溶剂化室中，使得去溶剂化气体的一部分流与离子流逆流。通过第二气体入口单独提供载气流，第二气体入口相对于去溶剂化室限定在下游。特别地，载气的组成与去溶剂化气体的组成不同。因此，载气的流动基本上设置在用于沿离子入口孔和分析间隙的离子出口孔之间的路径输送离子的分析间隙中。

5. 发明授权

US07683315B2 FAIMS cell having an offset ion inlet orifice 有权
标题翻译： FAIMS单元具有偏移离子入口孔
公开(公告)号：US07683315B2
公开(公告)日：2010-03-23
申请号：US11767280
申请日：2007-06-22
申请人： Michael W. Belford , Jean Jacques Dunyach
发明人： Michael W. Belford , Jean Jacques Dunyach
IPC分类号： B01D59/44 , H01J49/00 , H01J49/40
CPC分类号： H01J49/42
摘要： A FAIMS cell has an elongated inner electrode with a longitudinal axis extending along a first direction. The inner electrode has a curved outer surface that defines a circle when viewed in a cross section that is taken in a plane normal to the longitudinal axis, which itself passes through the center of the circle so defined. An outer electrode having an inner surface is disposed in a spaced-apart facing relationship relative to the outer surface of the inner electrode so as to define an analytical gap therebetween. A first ion inlet orifice is defined through a first portion of the outer electrode, and an ion outlet orifice is defined through a second portion of the outer electrode. In particular, the first ion inlet orifice has a first ion injection axis that does not pass through the center of the circle. Furthermore, the second electrode does not have defined through any portion thereof an ion inlet orifice having an ion injection axis that passes through the center of the circle.
摘要翻译： FAIMS单元具有细长的内部电极，纵向轴线沿着第一方向延伸。内部电极具有弯曲的外表面，其在垂直于纵向轴线的平面中截取的横截面中观察时限定圆形，该横向本身穿过如此限定的圆的中心。具有内表面的外电极相对于内电极的外表面以间隔开的面对关系设置，以便在它们之间限定分析间隙。第一离子入口孔限定在外电极的第一部分上，离子出口孔限定在外电极的第二部分上。特别地，第一离子入口孔具有不通过圆心的第一离子注入轴线。此外，第二电极的任何部分都不具有通过圆心的离子注入轴的离子入口孔。

6. 发明申请

US20090159796A1 Quadrupole FAIMS Apparatus 有权
标题翻译：四极FAIMS仪器
公开(公告)号：US20090159796A1
公开(公告)日：2009-06-25
申请号：US11962036
申请日：2007-12-20
申请人： Michael W. Belford , Jean Jacques Dunyach
发明人： Michael W. Belford , Jean Jacques Dunyach
IPC分类号： H01J49/28
CPC分类号： H01J49/063 , G01N27/624
摘要： A combined rf-only/FAIMS apparatus is disclosed for use in mass spectrometry and other applications. The disclosed apparatus includes a plurality of curved electrodes arranged around a central ion transmission channel. FAIMS functionality is removed electronically when not desired by application of radio frequency (rf) waveforms to the curved electrodes.
摘要翻译：公开了用于质谱法和其它应用的组合的仅纯/ FAIMS装置。所公开的装置包括围绕中心离子传输通道布置的多个弯曲电极。当不需要通过将射频（RF）波形施加到弯曲电极时，FAIMS功能被电子地去除。

7. 发明申请

US20080315085A1 FAIMS Cell Having an Offset Ion Inlet Orifice 有权
标题翻译：具有偏移离子入口孔的FAIMS单元
公开(公告)号：US20080315085A1
公开(公告)日：2008-12-25
申请号：US11767280
申请日：2007-06-22
申请人： Michael W. Belford , Jean Jacques Dunyach
发明人： Michael W. Belford , Jean Jacques Dunyach
IPC分类号： B01D59/44
CPC分类号： H01J49/42
摘要： A FAIMS cell has an elongated inner electrode with a longitudinal axis extending along a first direction. The inner electrode has a curved outer surface that defines a circle when viewed in a cross section that is taken in a plane normal to the longitudinal axis, which itself passes through the center of the circle so defined. An outer electrode having an inner surface is disposed in a spaced-apart facing relationship relative to the outer surface of the inner electrode so as to define an analytical gap therebetween. A first ion inlet orifice is defined through a first portion of the outer electrode, and an ion outlet orifice is defined through a second portion of the outer electrode. In particular, the first ion inlet orifice has a first ion injection axis that does not pass through the center of the circle. Furthermore, the second electrode does not have defined through any portion thereof an ion inlet orifice having an ion injection axis that passes through the center of the circle.
摘要翻译： FAIMS单元具有细长的内部电极，纵向轴线沿着第一方向延伸。内部电极具有弯曲的外表面，其在垂直于纵向轴线的平面中截取的横截面中观察时限定圆形，该横向本身穿过如此限定的圆的中心。具有内表面的外电极相对于内电极的外表面以间隔开的面对关系设置，以便在它们之间限定分析间隙。第一离子入口孔限定在外电极的第一部分上，离子出口孔限定在外电极的第二部分上。特别地，第一离子入口孔具有不通过圆心的第一离子注入轴线。此外，第二电极的任何部分都不具有通过圆心的离子注入轴的离子入口孔。

8. 发明申请

US20110139972A1 Methods and Apparatus for Providing FAIMS Waveforms Using Solid-State Switching Devices 审中-公开
标题翻译：使用固态开关器件提供FAIMS波形的方法和装置
公开(公告)号：US20110139972A1
公开(公告)日：2011-06-16
申请号：US12636403
申请日：2009-12-11
申请人： Mark HARDMAN , Michael W. Belford , Jean Jacques Dunyach
发明人： Mark HARDMAN , Michael W. Belford , Jean Jacques Dunyach
IPC分类号： B01D59/44 , H01J49/00
CPC分类号： G01N27/624
摘要： A high field asymmetric waveform ion mobility spectrometry (FAIMS) comprises an electrical power supply electrically connected to at least one of the FAIMS electrodes and operable to as to apply a periodic asymmetric square-wave waveform voltage to at least one of the electrodes so as to selectively transmit a type of ion in and through a FAIMS analyzer region to an ion outlet, wherein the electrical power supply is operable so as to vary a time duration of pulses of the asymmetric square-wave waveform so as to control the type of ion selectively transmitted, an efficiency of said selective transmission or the ability to prevent transmission of a different type of ions in and through said analyzer region to the ion outlet.
摘要翻译：高场非对称波形离子迁移谱（FAIMS）包括电连接到FAIMS电极中的至少一个的电源，并可操作以将周期性非对称方波波形电压施加到至少一个电极，以便选择性地将一种类型的离子通过FAIMS分析仪区域传输到离子出口，其中电源可操作以改变非对称方波波形的脉冲持续时间，以便有选择地控制离子的类型透射，所述选择性透射的效率或防止不同类型的离子通过所述分析器区域传输到离子出口的能力。

9. 发明授权

US08847154B2 Ion transfer tube for a mass spectrometer system 有权
标题翻译：用于质谱仪系统的离子转移管
公开(公告)号：US08847154B2
公开(公告)日：2014-09-30
申请号：US13333948
申请日：2011-12-21
申请人： Eloy R. Wouters , Alexander A. Makarov , R. Paul Atherton , Jean Jacques Dunyach
发明人： Eloy R. Wouters , Alexander A. Makarov , R. Paul Atherton , Jean Jacques Dunyach
IPC分类号： H01J49/26 , H01J49/42 , H01J49/04
CPC分类号： H01J49/0404 , B23H7/02 , B23H9/14
摘要： An ion transfer tube for a mass spectrometer comprises a core member and a first jacket tube member at least partially enclosing the core member and providing one or more channels therethrough. A method of forming an ion transfer tube, comprises: providing a first jacket tube member having a length and an internal bore, the internal bore passing along the length and defining an interior surface of circular cross section; removing at least one portion of the first jacket tube member adjacent to the interior surface so as to form at least one groove, channel, slot, recess or embayment of or in the interior surface; and providing a core member within the bore of the jacket tube member such that remnant portions of the interior surface of circular cross section mate against portions of an exterior surface of the core member.
摘要翻译：用于质谱仪的离子传递管包括芯构件和至少部分地包围芯构件并且提供穿过其中的一个或多个通道的第一护套管构件。一种形成离子转移管的方法，包括：提供具有长度和内孔的第一套管构件，所述内孔沿着所述长度通过并限定圆形横截面的内表面; 移除与所述内表面相邻的所述第一套管构件的至少一部分，以便形成所述内表面中或所述内表面中的至少一个凹槽，通道，槽，凹槽或沉积物; 并且在所述护套管构件的所述孔内提供芯构件，使得所述圆形横截面的内表面的残留部分与所述芯构件的外表面的部分配合。

10. 发明申请

US20120248304A1 Ion Guide with Improved Gas Dynamics and Combined Noise Reduction Device 有权
标题翻译：具有改进气体动力学和组合降噪装置的离子导向器
公开(公告)号：US20120248304A1
公开(公告)日：2012-10-04
申请号：US13073880
申请日：2011-03-28
申请人： Jean Jacques Dunyach , August A. Specht , R. Paul Atherton
发明人： Jean Jacques Dunyach , August A. Specht , R. Paul Atherton
IPC分类号： H01J49/26
CPC分类号： H01J49/063 , H01J49/044 , H01J49/24
摘要： A mass spectrometry system arrangement includes a curved ion guide, where the curve of the ion guide is positioned such that a portion of the ion optics are visible from at the ion guide entrance, e.g. line of sight or z-axis. There are four electrodes parallel with each other and the central curved axis. Each electrode is equally radially spaced from the curved central axis. For each cross section of the ion guide, the central curved axis being positioned at the origin, the curved electrodes being radially positioned at 45°, 135°, 225°, and 315°. Depending upon the system, a blocking device is positioned external to the ion guide but within the “line of sight” or positioned tangential to the rising section of the bent ion guide.
摘要翻译：质谱系统装置包括弯曲离子导向器，其中离子导向器的曲线被定位成使得离子光学器件的一部分可以在离子导向入口处可见，例如离子导向器。视线或z轴。有四个电极彼此平行和中心弯曲的轴线。每个电极与弯曲的中心轴线径向间隔开。对于离子导向件的每个横截面，中心弯曲轴线位于原点，弯曲电极径向定位在45°，135°，225°和315°处。根据系统，阻挡装置位于离子导向器的外部，但位于视线内，或者定位成与弯曲离子导向件的上升部分相切。

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