专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20050158344A1 Exoenzyme toxin of aeromonas salmonicida, and uses thereof 有权
标题翻译：气单胞菌麝香霉素的肠毒素毒素及其用途
公开(公告)号：US20050158344A1
公开(公告)日：2005-07-21
申请号：US10416981
申请日：2001-11-15
申请人： Joachim Frey , Peter Kuhnert , Julian Thornton , Tracy Thornton , Michael Kuzyk , Jan Burian , Martin Braun
发明人： Joachim Frey , Peter Kuhnert , Julian Thornton , Tracy Thornton , Michael Kuzyk , Jan Burian , Martin Braun
IPC分类号： A61K39/00 , A61K39/02 , C07H21/04 , C07K14/195 , C12N1/21 , C12N15/31 , C12N15/74 , C12P21/02 , C12Q1/68 , G01N33/569
CPC分类号： C12P21/02 , A61K39/00 , A61K2039/521 , A61K2039/523 , A61K2039/53 , C07K14/195 , C12Q1/689 , G01N33/56911 , Y02A50/407
摘要： A protein toxin named Aeromonas salmonicida exoenzyme T (AcxT), which belongs to the family of ADP-ribosylating toxins, is disclosed as is a Calcium (or other cation concentration) dependent promoter of A. salmonicida. Also disclosed are diagnostic, preventive, and therapeutic techniques, including the preparation of bacterin vaccines based on AexT for inducing immunity against A. salmonicida infections.
摘要翻译：属于ADP-核糖基化毒素家族的称为气单胞菌鲑鱼霉素外切酶T（AcxT）的蛋白质毒素被公开为鲑鱼a的钙（或其他阳离子浓度）依赖性启动子。还公开了诊断，预防和治疗技术，包括基于AexT制备用于诱导针对沙门氏菌感染的免疫的菌苗疫苗。

2. 发明授权

US08728823B2 Methods for detecting lung cancer and monitoring treatment response 有权
标题翻译：检测肺癌的方法和监测治疗反应
公开(公告)号：US08728823B2
公开(公告)日：2014-05-20
申请号：US12743042
申请日：2008-11-24
申请人： Stephen Lam , John Yee , Michael Kuzyk , Don Sin , Marianne Dorthy Sadar , Carl Martin Tammemagi
发明人： Stephen Lam , John Yee , Michael Kuzyk , Don Sin , Marianne Dorthy Sadar , Carl Martin Tammemagi
IPC分类号： G01N33/00 , G01N33/566
CPC分类号： G01N33/57423 , G01N2800/50 , G01N2800/52
摘要： A method is described for detecting lung cancer comprising detecting an elevated level of a CTAP III-related biomarker in a biological sample from a subject at risk for developing lung cancer. Further, a method is described for predicting risk of developing lung cancer in a subject comprising detecting an elevated level of a CTAP III-related biomarker in a biological sample from a subject. Additionally, a method of monitoring the success of lung cancer treatment is described comprising detecting levels of a CTAP III-related biomarker in a biological sample from a subject undergoing treatment for lung cancer for comparison with a previous level obtained from the subject. Multivariate analysis may be incorporated into these methods, evaluating such clinical, or demographic risk factors as age, sex, smoking history, smoking status, smoking family history, education level, COPD, socio-economic status, body mass index and lung function. Kits for conducting such methods are described.
摘要翻译：描述了一种用于检测肺癌的方法，包括检测来自患有发展为肺癌风险的受试者的生物样品中CTAP III相关生物标志物的升高水平。此外，描述了用于预测受试者中发展肺癌的风险的方法，包括检测来自受试者的生物样品中CTAP III相关生物标志物的升高水平。此外，描述了监测肺癌治疗成功的方法，其包括检测来自接受肺癌治疗的受试者的生物样品中的CTAP III相关生物标志物的水平，以与从受试者获得的先前水平进行比较。多变量分析可纳入这些方法，评估年龄，性别，吸烟史，吸烟状况，吸烟家族史，教育水平，COPD，社会经济状况，体重指数和肺功能等临床或人口学危险因素。描述了用于进行这种方法的套件。

3. 发明申请

US20050058662A1 Novel type III secretion pathway in Aeromonas salmonicida, and uses therefor 有权
标题翻译：在鲑鱼气单胞菌中新型III型分泌途径，并用于此
公开(公告)号：US20050058662A1
公开(公告)日：2005-03-17
申请号：US10813908
申请日：2004-03-26
申请人： Joachim Frey , Katja Stuber , Julian Thornton , Michael Kuzyk , Jan Burian
发明人： Joachim Frey , Katja Stuber , Julian Thornton , Michael Kuzyk , Jan Burian
IPC分类号： A61K39/00 , A61K39/02 , C07H21/04 , C07K14/195 , C12N1/21 , C12N15/31 , C12N15/74 , C12P21/02 , C12Q1/68 , G01N33/569 , C12P21/04
CPC分类号： C12P21/02 , A61K39/00 , A61K2039/521 , A61K2039/523 , A61K2039/53 , C07K14/195 , C12Q1/689 , G01N33/56911 , Y02A50/407
摘要： Disclosed is a newly identified and characterized type III secretion system in Aeromonas salmonicida. The invention also encompasses the use of components of the novel secretion system in immunoprotection against A. salmonicida infection, as well as other diagnostic and therapeutic uses thereof.
摘要翻译：公开了一种新鉴定和鉴定的鲑鱼气单胞菌III型分泌系统。本发明还包括在对沙门氏菌感染的免疫保护中使用新型分泌系统的组分以及其它诊断和治疗用途。

4. 发明申请

US20100248290A1 METHODS FOR DETECTING LUNG CANCER AND MONITORING TREATMENT RESPONSE 有权
标题翻译：检测肺癌和监测治疗反应的方法
公开(公告)号：US20100248290A1
公开(公告)日：2010-09-30
申请号：US12743042
申请日：2008-11-24
申请人： Stephen Lam , John Yee , Michael Kuzyk , Don Sin , Marianne Dorthy Sadar , Carl Martin Tammemagi
发明人： Stephen Lam , John Yee , Michael Kuzyk , Don Sin , Marianne Dorthy Sadar , Carl Martin Tammemagi
IPC分类号： G01N33/68 , C12Q1/02
CPC分类号： G01N33/57423 , G01N2800/50 , G01N2800/52
摘要： A method is described for detecting lung cancer comprising detecting an elevated level of a CTAP III-related biomarker in a biological sample from a subject at risk for developing lung cancer. Further, a method is described for predicting risk of developing lung cancer in a subject comprising detecting an elevated level of a CTAP III-related biomarker in a biological sample from a subject. Additionally, a method of monitoring the success of lung cancer treatment with curative intent is described comprising detecting levels of a CTAP III-related biomarker in a biological sample from a subject undergoing treatment for lung cancer for comparison with the a previous level obtained from the subject. Multivariate analysis may be incorporated into these methods, evaluating such clinical, or demographic risk factors as age, sex, smoking history, smoking status, smoking family history, education level, COPD, socio-economic status, body mass index and lung function. Kits for conducting such methods are described.
摘要翻译：描述了一种用于检测肺癌的方法，包括检测来自患有发展为肺癌风险的受试者的生物样品中CTAP III相关生物标志物的升高水平。此外，描述了用于预测受试者中发展肺癌的风险的方法，包括检测来自受试者的生物样品中CTAP III相关生物标志物的升高水平。另外，描述了以治愈意图监测肺癌治疗成功的方法，其包括检测来自接受肺癌治疗的受试者的生物样品中的CTAP III相关生物标志物的水平，以与从受试者获得的先前水平进行比较。多变量分析可纳入这些方法，评估年龄，性别，吸烟史，吸烟状况，吸烟家族史，教育水平，COPD，社会经济状况，体重指数和肺功能等临床或人口学危险因素。描述了用于进行这种方法的套件。

5. 发明申请

US20070269462A1 Novel exoenzyme toxin of Aeromonas salmonicida, and uses therefor 有权
标题翻译：气单胞菌属的新型外切酶毒素，并用于此
公开(公告)号：US20070269462A1
公开(公告)日：2007-11-22
申请号：US11638568
申请日：2006-12-14
申请人： Joachim Frey , Peter Kuhnert , Julian Thornton , Tracy Thornton , Michael Kuzyk , Jan Burian , Martin Braun
发明人： Joachim Frey , Peter Kuhnert , Julian Thornton , Tracy Thornton , Michael Kuzyk , Jan Burian , Martin Braun
IPC分类号： A61K39/02 , A61P31/04 , C07K14/195 , G01N33/569
CPC分类号： C12P21/02 , A61K39/00 , A61K2039/521 , A61K2039/523 , A61K2039/53 , C07K14/195 , C12Q1/689 , G01N33/56911 , Y02A50/407
摘要： A novel protein toxin named Aeromonas salmonicida exoenzyme T (AexT), which belongs to the family of ADP-ribosylating toxins, is disclosed as is a novel Calcium (or other cation concentration) dependent promoter of A. salmonicida. Also disclosed are diagnostic, preventative, and therapeutic techniques, including the preparation of traditional, recombinant, and improved bacterin vaccines based on AexT for inducing immunity against A. salmonicida infections.
摘要翻译：属于ADP-核糖基化毒素家族的名为气单胞菌鲑鱼霉素外切酶T（AexT）的新型蛋白质毒素被公开为鲑鱼a a的新型钙（或其他阳离子浓度）依赖性启动子。还公开了诊断，预防和治疗技术，包括制备基于AexT的传统的，重组的和改进的菌苗疫苗，用于诱导对沙门氏菌感染的免疫。

6. 发明申请

US20050002946A1 Vaccines and agents for inducing immunity in fish against rickettsial diseases, and associated preventative therapy 审中-公开
标题翻译：用于诱导鱼类抗立克次体疾病免疫的疫苗和药剂，以及相关的预防性治疗
公开(公告)号：US20050002946A1
公开(公告)日：2005-01-06
申请号：US10782234
申请日：2004-02-18
申请人： Michael Kuzyk , Jan Burian , William Kay , Julian Thornton
发明人： Michael Kuzyk , Jan Burian , William Kay , Julian Thornton
IPC分类号： A61K39/00 , C07K14/29 , A61K39/38 , A61K39/02
CPC分类号： C07K14/29 , A61K39/00 , A61K2039/53 , C07K2319/00 , Y02A50/403
摘要： The use of the 17 kDa outer surface lipoprotein (OspA) of Piscirickettsia salmonis, or its homologues, as the basis of, or part thereof, a recombinant vaccine for salmonid rickettsial septicaemia and other rickettsial diseases is disclosed. Surface antigens of the bacterial pathogen P. salmonis are characterized and an immunoreactive antigen, namely the 17 kDa outer surface lipoprotein OspA of P. salmonis, as well as the nucleic acid segment that encodes the OspA immunoreactive antigen, is identified and characterized. Diagnostic techniques including the use of hybridization probes and primers as well as the production of specific antigens and antibodies that may be used in immunization techniques for inducing immunity against P. salmonis and other rickettsial diseases are disclosed, as are the development of recombinant vaccines for SRS and other rickettsial diseases based on the 17 kDa lipoprotein OspA. Augmentation of protective immunity by the inclusion of promiscuous T lymphocyte epitopes (TCE's) in fusion protein constructs in salmonids and to the use of bacterial protein inclusion bodies as a source of the protective immunogen is also disclosed.
摘要翻译：公开了使用沙门氏菌属的17kDa外表面脂蛋白（OspA）或其同系物作为鲑鱼样立克次体败血症和其他立克次体疾病的基础或其一部分的重组疫苗。表征细菌病原体沙门氏菌的表面抗原，并鉴定和表征免疫反应性抗原，即沙门氏菌的17kDa外表面脂蛋白OspA以及编码OspA免疫反应性抗原的核酸片段。公开了包括使用杂交探针和引物的诊断技术以及可用于诱导针对鲑鱼和其他立克次体疾病的免疫的免疫技术中的特异性抗原和抗体的产生，以及用于SRS的重组疫苗的开发和基于17kDa脂蛋白OspA的其他立克次体疾病。还公开了通过在混合型T淋巴细胞表位（TCE）中包含鲑鱼中的融合蛋白构建体和使用细菌蛋白包涵体作为保护性免疫原来源来增强保护性免疫。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式