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1. 发明申请

US20070269462A1 Novel exoenzyme toxin of Aeromonas salmonicida, and uses therefor 有权
标题翻译：气单胞菌属的新型外切酶毒素，并用于此
公开(公告)号：US20070269462A1
公开(公告)日：2007-11-22
申请号：US11638568
申请日：2006-12-14
申请人： Joachim Frey , Peter Kuhnert , Julian Thornton , Tracy Thornton , Michael Kuzyk , Jan Burian , Martin Braun
发明人： Joachim Frey , Peter Kuhnert , Julian Thornton , Tracy Thornton , Michael Kuzyk , Jan Burian , Martin Braun
IPC分类号： A61K39/02 , A61P31/04 , C07K14/195 , G01N33/569
CPC分类号： C12P21/02 , A61K39/00 , A61K2039/521 , A61K2039/523 , A61K2039/53 , C07K14/195 , C12Q1/689 , G01N33/56911 , Y02A50/407
摘要： A novel protein toxin named Aeromonas salmonicida exoenzyme T (AexT), which belongs to the family of ADP-ribosylating toxins, is disclosed as is a novel Calcium (or other cation concentration) dependent promoter of A. salmonicida. Also disclosed are diagnostic, preventative, and therapeutic techniques, including the preparation of traditional, recombinant, and improved bacterin vaccines based on AexT for inducing immunity against A. salmonicida infections.
摘要翻译：属于ADP-核糖基化毒素家族的名为气单胞菌鲑鱼霉素外切酶T（AexT）的新型蛋白质毒素被公开为鲑鱼a a的新型钙（或其他阳离子浓度）依赖性启动子。还公开了诊断，预防和治疗技术，包括制备基于AexT的传统的，重组的和改进的菌苗疫苗，用于诱导对沙门氏菌感染的免疫。

2. 发明授权

US07232569B2 Type III secretion pathway in aeromonas salmonicida, and uses therefor 有权
标题翻译： Ⅲ型分泌途径在鲑鱼气单胞菌中，并用于此
公开(公告)号：US07232569B2
公开(公告)日：2007-06-19
申请号：US10813908
申请日：2004-03-26
申请人： Joachim Frey , Katja Stuber , Julian C. Thornton , Michael A. Kuzyk , Jan Burian
发明人： Joachim Frey , Katja Stuber , Julian C. Thornton , Michael A. Kuzyk , Jan Burian
IPC分类号： A61K39/00 , A61K39/38 , A61K39/02 , A61K38/00 , C07K1/00
CPC分类号： C12P21/02 , A61K39/00 , A61K2039/521 , A61K2039/523 , A61K2039/53 , C07K14/195 , C12Q1/689 , G01N33/56911 , Y02A50/407
摘要： Disclosed is a newly identified and characterized type III secretion system in Aeromonas salmonicida. The invention also encompasses the use of components of the novel secretion system in immunoprotection against A. salmonicida infection, as well as other diagnostic and therapeutic uses thereof.
摘要翻译：公开了一种新鉴定和鉴定的鲑鱼气单胞菌III型分泌系统。本发明还包括在对沙门氏菌感染的免疫保护中使用新型分泌系统的组分以及其它诊断和治疗用途。

3. 发明授权

US06770275B1 Live attenuated RTX-producing bacteria of the family pasteurellaceae 失效
标题翻译：巴斯德氏菌科的活减毒RTX生产细菌
公开(公告)号：US06770275B1
公开(公告)日：2004-08-03
申请号：US08866198
申请日：1997-05-30
申请人： Ruud Philip Antoon Maria Segers , Johannes Franciscus Van Den Bosch , Joachim Frey
发明人： Ruud Philip Antoon Maria Segers , Johannes Franciscus Van Den Bosch , Joachim Frey
IPC分类号： A01N6300
CPC分类号： C12R1/21 , A61K39/00 , C07K14/285 , C12R1/01
摘要： The present invention relates to live attenuated RTX-toxin producing bacteria of the family Pasteurellaceae, of which the attenuation is due to the fact that they produce RTX toxin in a non-activated form. The invention also relates to vaccines for the protection of mammals against infection with RTX-toxin producing bacteria of the family Pasteurellaceae, and to methods for the preparation of said live attenuated bacteria and vaccines.
摘要翻译：本发明涉及巴斯德毕赤氏菌科的活减毒RTX-毒素生产菌，其衰减是由于它们以非活化形式产生RTX毒素的事实。本发明还涉及用于保护哺乳动物免受感染巴斯德毕赤氏菌科的RTX-毒素产生细菌的疫苗以及制备所述活减毒细菌和疫苗的方法。

4. 发明授权

US07538208B2 Type III secretion pathway in Aeromonas salmonicida, and uses therefor 有权
标题翻译： III型分泌途径在鲑鱼气单胞菌中，并用于此
公开(公告)号：US07538208B2
公开(公告)日：2009-05-26
申请号：US11529400
申请日：2006-09-29
申请人： Joachim Frey , Katja Stuber , Julian C. Thornton , Michael A. Kuzyk , Jan Burian
发明人： Joachim Frey , Katja Stuber , Julian C. Thornton , Michael A. Kuzyk , Jan Burian
IPC分类号： C07H21/04 , C07H21/02 , A61K49/00 , A61K39/00 , A61K39/38
CPC分类号： C12P21/02 , A61K39/00 , A61K2039/521 , A61K2039/523 , A61K2039/53 , C07K14/195 , C12Q1/689 , G01N33/56911 , Y02A50/407
摘要： Disclosed is a newly identified and characterized type III secretion system in Aeromonas salmonicida. The invention also encompasses the use of components of the novel secretion system in immunoprotection against A. salmonicida infection, as well as other diagnostic and therapeutic uses thereof.
摘要翻译：公开了一种新鉴定和鉴定的鲑鱼气单胞菌III型分泌系统。本发明还包括在对沙门氏菌感染的免疫保护中使用新型分泌系统的组分以及其它诊断和治疗用途。

5. 发明授权

US07351550B2 Exoenzyme toxin of Aeromonas salmonicida, and uses thereof 有权
标题翻译：气单胞菌麝香菌的毒素毒素及其用途
公开(公告)号：US07351550B2
公开(公告)日：2008-04-01
申请号：US10416981
申请日：2001-11-15
申请人： Joachim Frey , Peter Kuhnert , Tracy A. Thornton, legal representative , Michael A. Kuzyk , Jan Burian , Martin Braun
发明人： Julian C. Thornton
IPC分类号： C12P21/06
CPC分类号： C12P21/02 , A61K39/00 , A61K2039/521 , A61K2039/523 , A61K2039/53 , C07K14/195 , C12Q1/689 , G01N33/56911 , Y02A50/407
摘要： A protein toxin named Aeromonas salmonicida exoenzyme T (AcxT), which belongs to the family of ADP-ribosylating toxins, is disclosed as is a Calcium (or other cation concentration) dependent promoter of A. salmonicida. Also disclosed are diagnostic, preventive, and therapeutic techniques, including the preparation of bacterin vaccines based on AexT for inducing immunity against A. salmonicida infections.
摘要翻译：属于ADP-核糖基化毒素家族的称为气单胞菌鲑鱼霉素外切酶T（AcxT）的蛋白质毒素被公开为鲑鱼a的钙（或其他阳离子浓度）依赖性启动子。还公开了诊断，预防和治疗技术，包括基于AexT制备用于诱导针对沙门氏菌感染的免疫的菌苗疫苗。

6. 发明申请

US20050058662A1 Novel type III secretion pathway in Aeromonas salmonicida, and uses therefor 有权
标题翻译：在鲑鱼气单胞菌中新型III型分泌途径，并用于此
公开(公告)号：US20050058662A1
公开(公告)日：2005-03-17
申请号：US10813908
申请日：2004-03-26
申请人： Joachim Frey , Katja Stuber , Julian Thornton , Michael Kuzyk , Jan Burian
发明人： Joachim Frey , Katja Stuber , Julian Thornton , Michael Kuzyk , Jan Burian
IPC分类号： A61K39/00 , A61K39/02 , C07H21/04 , C07K14/195 , C12N1/21 , C12N15/31 , C12N15/74 , C12P21/02 , C12Q1/68 , G01N33/569 , C12P21/04
CPC分类号： C12P21/02 , A61K39/00 , A61K2039/521 , A61K2039/523 , A61K2039/53 , C07K14/195 , C12Q1/689 , G01N33/56911 , Y02A50/407
摘要： Disclosed is a newly identified and characterized type III secretion system in Aeromonas salmonicida. The invention also encompasses the use of components of the novel secretion system in immunoprotection against A. salmonicida infection, as well as other diagnostic and therapeutic uses thereof.
摘要翻译：公开了一种新鉴定和鉴定的鲑鱼气单胞菌III型分泌系统。本发明还包括在对沙门氏菌感染的免疫保护中使用新型分泌系统的组分以及其它诊断和治疗用途。

7. 发明授权

US06783764B1 Actinobacillus pleuropneumoniae subunit vaccine 有权
标题翻译：放线杆菌胸膜肺炎放线芽孢杆菌亚单位疫苗
公开(公告)号：US06783764B1
公开(公告)日：2004-08-31
申请号：US09387693
申请日：1999-08-31
申请人： Ruud Philip Antoon Maria Segers , Joachim Frey
发明人： Ruud Philip Antoon Maria Segers , Joachim Frey
IPC分类号： A61K4900
CPC分类号： C12R1/01 , A61K39/00 , C07K14/195 , C07K14/285 , C12N15/74
摘要： The present invention relates to live attenuated bacteria of the genus Actinobacillus pleuropneumoniae that have a mutation in an apxIV gene such that no functional ApxIV toxin can be produced. The invention also relates to methods for the production of such bacteria. Also vaccines comprising such bacteria and methods for the production of such vaccines are part of the invention. The invention further relates to subunit vaccines comprising an ApxIV toxin, to methods for the production of such vaccines and to methods for the protection of animals against infection with bacteria of the genus Actinobacillus pleuropneumoniae. In addition, the invention relates to the promotor of the apxIV gene. Finally, the invention relates to diagnostic test for the selective diagnosis of Actinobacillus pleuropneumoniae infections and to diagnostic tests discriminating between Actinobacillus pleuropneumoniae field strains and vaccine strains.
摘要翻译：本发明涉及在apxIV基因中具有突变的胸膜肺炎放线杆菌属的减毒细菌，使得不能产生功能性的ApxIV毒素。本发明还涉及生产这种细菌的方法。还包括这种细菌的疫苗和用于生产这种疫苗的方法是本发明的一部分。本发明还涉及包含ApxIV毒素的亚单位疫苗，用于生产这种疫苗的方法以及用于保护动物免受感染胸膜肺炎放线杆菌属细菌的方法。此外，本发明涉及apxIV基因的启动子。最后，本发明涉及胸膜肺炎放线杆菌感染的选择性诊断的诊断试验和区分放线杆菌胸膜肺炎放线芽孢杆菌野毒株和疫苗株的诊断试验。

8. 发明授权

US6013266A Live attenuated bacteria of the species Actinobacillus pleuropneumoniae 失效
标题翻译：放线杆菌胸膜肺炎放线菌的活减毒细菌
公开(公告)号：US6013266A
公开(公告)日：2000-01-11
申请号：US57570
申请日：1998-04-09
申请人： Ruud Philip Antoon Maria Segers , Joachim Frey
发明人： Ruud Philip Antoon Maria Segers , Joachim Frey
IPC分类号： G01N33/569 , A61K39/00 , A61K39/102 , A61K39/15 , A61K39/23 , A61K39/295 , A61P31/04 , C07K14/195 , C07K14/285 , C12N1/20 , C12N1/21 , C12N15/00 , C12N15/09 , C12N15/74 , C12R1/01 , A61K39/085 , A01N63/00 , A61K39/12
CPC分类号： C12R1/01 , A61K39/102 , C07K14/195 , C07K14/285 , C12N15/74 , A61K2039/522 , A61K39/00
摘要： The present invention relates to live attenuated bacteria of the genus Actinobacillus pleuropneumoniae that have a mutation in an apxIV gene such that no functional ApxIV toxin can be produced. The invention also relates to methods for the production of such bacteria. Also vaccines comprising such bacteria and methods for the production of such vaccines are part of the invention. The invention further relates to subunit vaccines comprising an ApxIV toxin, to methods the production of such vaccines and to methods for the protection of animals against infection with bacteria of the genus Actinobacillus pleuropneumoniae. In addition, the invention relates to the promotor of the apxIV gene. Finally, the invention relates to diagonostic tests for the selective diagnosis of Actinobacillus pleuropneumoniae infections and to diagnostic tests discriminating between Actinobacillus pleuropneumoniae field strain and vaccine strains.
摘要翻译：本发明涉及在apxIV基因中具有突变的胸膜肺炎放线杆菌属的减毒细菌，使得不能产生功能性的ApxIV毒素。本发明还涉及生产这种细菌的方法。还包括这种细菌的疫苗和用于生产这种疫苗的方法是本发明的一部分。本发明还涉及包含ApxIV毒素的亚单位疫苗，用于生产这种疫苗的方法以及用于保护动物免受感染胸膜肺炎放线杆菌属细菌的方法。此外，本发明涉及apxIV基因的启动子。最后，本发明涉及胸膜肺炎放线杆菌感染的选择性诊断的对角线测试，以及区分放线杆菌胸膜肺炎放线芽孢杆菌野毒株和疫苗株的诊断试验。

9. 发明授权

US5996980A Rolling sleeve-type gas spring with dust protection 失效
标题翻译：滚筒式气弹簧带防尘保护
公开(公告)号：US5996980A
公开(公告)日：1999-12-07
申请号：US19080
申请日：1998-02-05
申请人： Joachim Frey , Peter Gonnheimer
发明人： Joachim Frey , Peter Gonnheimer
IPC分类号： F16F9/05 , F16F9/38 , F16F9/04
CPC分类号： F16F9/05 , F16F9/38 , B60G2202/314 , B60G2204/126 , B60G2204/416 , B60G2206/424
摘要： In a rolling sleeve-type gas spring, particularly for a vehicle support structure, wherein the gas spring includes a cylinder, a piston received in the cylinder with an annular space formed therebetween and a rolling sleeve mounted to the piston and the cylinder and having a meniscus portion extending into the annular space from within the cylinder for containing gas under pressure in the cylinder, a second rolling sleeve is connected to the piston and the cylinder and extends into the annular space from without for preventing soiling of the surfaces of the piston and the cylinder defining the annular space.
摘要翻译：在滚动套筒型气弹簧中，特别是用于车辆支撑结构的气弹簧，其中气弹簧包括气缸，活塞被容纳在气缸中，其间形成有环形空间，以及安装在活塞和气缸上的滚动套筒，弯液面部分从气缸内部延伸到环形空间中，用于在气缸内承受压力下的气体，第二滚动套筒连接到活塞和气缸，并且从不会防止活塞表面的污染而延伸到环形空间中，气缸限定环形空间。

10. 发明授权

US07851197B2 Exoenzyme toxin of Aeromonas salmonicida, and uses therefor 有权
标题翻译：鲑鱼气单胞菌的毒素毒素，并用于此
公开(公告)号：US07851197B2
公开(公告)日：2010-12-14
申请号：US12499479
申请日：2009-07-08
申请人： Joachim Frey , Peter Kuhnert , Julian C. Thornton , Tracy A. Thornton, legal representative , Michael A. Kuzyk , Jan Burian , Martin Braun
发明人： Joachim Frey , Peter Kuhnert , Julian C. Thornton , Michael A. Kuzyk , Jan Burian , Martin Braun
IPC分类号： C12N1/12
CPC分类号： C12P21/02 , A61K39/00 , A61K2039/521 , A61K2039/523 , A61K2039/53 , C07K14/195 , C12Q1/689 , G01N33/56911 , Y02A50/407
摘要： A protein toxin named Aeromonas salmonicida exoenzyme T (AexT), which belongs to the family of ADP-ribosylating toxins, is disclosed as is a novel Calcium (or other cation concentration) dependent promoter of A. salmonicida. Also disclosed are diagnostic, preventive, and therapeutic techniques, including the preparation of bacterin vaccines based on AexT for inducing immunity against A. salmonicida infections.
摘要翻译：属于ADP-核糖基化毒素家族的命名为气单胞菌鲑鱼霉素外切酶T（AexT）的蛋白质毒素被公开为鲑鱼a的新型钙（或其它阳离子浓度）依赖性启动子。还公开了诊断，预防和治疗技术，包括基于AexT制备用于诱导针对沙门氏菌感染的免疫的菌苗疫苗。

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