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1. 发明授权

US5359122A Preparation of 3-arylacrylic acids and their derivatives 失效
标题翻译： 3-芳基丙烯酸及其衍生物的制备
公开(公告)号：US5359122A
公开(公告)日：1994-10-25
申请号：US193872
申请日：1994-02-08
申请人： Michael Huellmann , Josef Gnad , Rainer Becker
发明人： Michael Huellmann , Josef Gnad , Rainer Becker
IPC分类号： C07C57/44 , C07C59/64 , C07C67/46 , C07C69/734
CPC分类号： C07C59/64 , C07C57/44 , C07C67/46
摘要： The preparation of 3-arylacrylic acids and their derivatives I ##STR1## where Ar is aryl which can additionally have substituents which do not react with ketene and are stable under the conditions of the reaction described below, andR.sup.1 is hydrogen, an alkali metal, an alkaline earth metal, ammonium or C.sub.1 -C.sub.20 -alkyl,comprises a first stage in which a dialkyl acetal of an aromatic aldehyde of the formula II ##STR2## where R.sup.2 is C.sub.1 -C.sub.4 -alkyl, is reacted with ketene of the formula CH.sub.2 .dbd.C.dbd.O in the presence of catalytic amounts of a protic or Lewis acid to give a 3-arylpropionic acid derivative of the formula III ##STR3## and a second stage in which this intermediate III is reacted in the presence of acid or base and, in the case where R.sup.1 is C.sub.1 -C.sub.20 -alkyl, additionally with a C.sub.1 -C.sub.20 -alkanol to give the final product I.
摘要翻译： 3-芳基丙烯酸及其衍生物的制备I（I）其中Ar是可以另外具有不与乙烯酮反应并且在下述反应条件下稳定的取代基的芳基，R 1是氢，碱金属，碱土金属，铵或C 1 -C 20烷基，包括其中R 2为C 1 -C 4 - 烷基的式II的芳族醛的二烷基缩醛反应的第一阶段在催化量的质子或路易斯酸存在下，式CH 2 = C = O的烯酮，得到式III的3-芳基丙酸衍生物（III），其中该中间体III为在酸或碱的存在下反应，在R1为C1-C20烷基的情况下，另外加入C1-C20链烷醇，得到最终产物I.

2. 发明授权

US5120880A Preparation of muscone, intermediates for this preparation and preparation of said intermediates 失效
标题翻译：麦芽糖的制备，本制剂的中间体和制备中间体
公开(公告)号：US5120880A
公开(公告)日：1992-06-09
申请号：US757305
申请日：1991-09-10
申请人： Michael Huellmann , Thomas Kuekenhoehner , Karl Brenner , Rainer Becker , Matthias Irgang , Charles Schommer
发明人： Michael Huellmann , Thomas Kuekenhoehner , Karl Brenner , Rainer Becker , Matthias Irgang , Charles Schommer
IPC分类号： B01J21/06 , B01J23/04 , B01J23/10 , B01J23/12 , C07B61/00 , C07C45/30 , C07C45/61 , C07C45/62 , C07C45/66 , C07C45/68 , C07C45/72 , C07C49/203 , C07C49/385
CPC分类号： C07C45/68 , C07C45/30 , C07C45/62 , C07C45/66 , C07C45/72
摘要： Muscone of the formula I ##STR1## is prepared by a process in which an open-chain 2,15-diketone of the general formula IICH.sub.3 --CO--X--CO--CH.sub.3 (II)whereX is one of the radicals--(--CH.sub.2 --).sub.12 -- (a)--CH.dbd.CH--(--CH.sub.2 --).sub.8 --CH.dbd.CH-- (b)--CH.sub.2 --CH.dbd.CH--(--CH.sub.2 --).sub.6 --CH.dbd.CH--CH.sub.2 --(c)--CH.sub.2 --CH.sub.2 --CH.dbd.CH--(--CH.sub.2 --).sub.4 --CH.dbd.CH--CH.sub.2 --CH.sub.2 -- (d)or--CH.sub.2 --CH.sub.2 --CH.sub.2 --CH.dbd.CH--(--CH.sub.2 --).sub.2 --CH.dbd.CH--CH.sub.2 --CH.sub.2 --CH.sub.2 -- (e)is brought into contact, at from 300.degree. to 400.degree. C. in the presence of from 5 to 15% by weight, based on the amount of catalyst, of water, in the gas phase, with a fixed-bed catalyst containing TiO.sub.2, CeO.sub.2 or ThO.sub.2 as the catalytically active compound and the unsaturated cyclic ketone formed by intramolecular aldol condensation is subjected to catalytic hydrogenation. Furthermore, the open-chain unsaturated ketones of the formulae IIb, IIc and IId and advantageous processes for their preparation and their use as intermediates for a simple industrial synthesis of muscone are claimed.

3. 发明授权

US5081311A Preparation of muscone, intermediates for this preparation and preparation of said intermediates 失效
标题翻译：麦芽糖的制备，本制剂的中间体和制备中间体
公开(公告)号：US5081311A
公开(公告)日：1992-01-14
申请号：US524929
申请日：1990-05-18
申请人： Michael Huellmann , Thomas Kuekenhoehner , Karl Brenner , Rainer Becker , Matthias Irgang , Charles Schommer
发明人： Michael Huellmann , Thomas Kuekenhoehner , Karl Brenner , Rainer Becker , Matthias Irgang , Charles Schommer
IPC分类号： B01J21/06 , B01J23/04 , B01J23/10 , B01J23/12 , C07B61/00 , C07C45/30 , C07C45/61 , C07C45/62 , C07C45/66 , C07C45/68 , C07C45/72 , C07C49/203 , C07C49/385
CPC分类号： C07C45/68 , C07C45/30 , C07C45/62 , C07C45/66 , C07C45/72
摘要： Muscone of the formula I ##STR1## is prepared by a process in which an open-chain 2,15-diketone of the general formula IICH.sub.3 --CO--X--CO--CH.sub.3 (II)where X is one of the radicals--(--CH.sub.2 --).sub.12 -- (a)--CH.dbd.CH--(--CH.sub.2 --).sub.8 --CH.dbd.CH-- (b)--CH.sub.2 --CH.dbd.CH--(--CH.sub.2 --).sub.6 --CH.dbd.CH--CH.sub.2 --(c)--CH.sub.2 --CH.sub.2 --CH.dbd.CH--(--CH.sub.2 --).sub.4 --CH.dbd.CH--CH.sub.2 --CH.sub.2 -- (d) or--CH.sub.2 --CH.sub.2 CH.sub.2 --CH.dbd.CH--(--CH.sub.2 --).sub.2 --CH.dbd.CH--CH.sub.2 --CH.sub.2 --CH.sub.2 -- (e)is brought into contact, at from 300.degree. to 400.degree. C. in the presence of from 5 to 15% by weight, based on the amount of catalyst, of water, in the gas phase, with a fixed-bed catalyst containing TiO.sub.2, CeO.sub.2 or the ThO.sub.2 as the catalytically active compound and the unsaturated cyclic ketone formed by intramolecular aldol condensation is subjected to catalytic hydrogenation. Furthermore, the open-chain unsaturated ketones of the formulae IIb, IIc and IId and advantageous processes for their preparation and their use as intermediates for a simple industrial synthesis of muscone are claimed.
摘要翻译：通式Ⅰ（I）的肌醇通过以下方法制备，其中通式II CH3-CO-X-CO-CH3（Ⅱ）的开链2,15-二酮其中X是基团 - （ - CH2-）12-（a）-CH = CH - （ - CH2-）8-CH = CH-（b）-CH2-CH = CH-（ - CH2-）6-CH = CH-CH2 - （c）-CH 2 -CH 2 -CH = CH - （ - CH 2 - ）4 -CH = CH-CH 2 -CH 2 - （d）或-CH 2 -CH 2 CH 2 -CH = CH - （ - CH 2 - ）2 -CH = CH-CH 2 -CH 2 -CH 2 - （e）在300-400℃下，以5-15重量％的量存在下，基于催化剂的量，在气体中使用含有TiO 2，CeO 2或ThO 2作为催化活性化合物的固定床催化剂和通过分子内醛醇缩合形成的不饱和环酮进行催化氢化。此外，要求具有式IIb，IIc和IId的开链不饱和酮及其制备的有利方法及其作为简单的工业合成肌肉的中间体的用途。

4. 发明授权

US5463020A Preparation of polytetrahydrofuran or tetrahydrofuran/alkylene oxide copolymers 失效
标题翻译：聚四氢呋喃或四氢呋喃/烯化氧共聚物的制备
公开(公告)号：US5463020A
公开(公告)日：1995-10-31
申请号：US268954
申请日：1994-06-30
申请人： Rainer Becker , Michael Huellmann , Christof Palm , Wolfgang Franzischka
发明人： Rainer Becker , Michael Huellmann , Christof Palm , Wolfgang Franzischka
IPC分类号： C08G65/06 , C08G65/02 , C08G65/20 , C08G65/26 , C08G65/10
CPC分类号： C08G65/2654 , C08G65/20 , C08G65/269
摘要： Polytetrahydrofuran or C.sub.2 -C.sub.10 -alkylene oxide/tetrahydrofuran copolymers having a molecular weight of from 250 to 20,000 Dalton are prepared by the cationic polymerization of tetrahydrofuran or tetrahydrofuran and C.sub.2 -C.sub.10 -alkylene oxides in the prsence of a promoter by a process in which the catalyst used is a mixture of one or more C.sub.2 -C.sub.6 -di- or tricarboxylic acids with boric acid.
摘要翻译：分子量为250至20,000道尔顿的聚四氢呋喃或C2-C10-环氧烷/四氢呋喃共聚物是通过四氢呋喃或四氢呋喃和C 2 -C 10 - 环氧烷在促进剂中的阳离子聚合制备的，其中，所使用的催化剂是一种或多种C 2 -C 6 - 二 - 或三羧酸与硼酸的混合物。

5. 发明授权

US4965376A 3,9-dihydroxynonyne and its derivatives protected at the 9-OH function 失效
标题翻译： 3,9-二羟基壬炔及其衍生物以9-OH官能团保护
公开(公告)号：US4965376A
公开(公告)日：1990-10-23
申请号：US340035
申请日：1989-04-18
申请人： Michael Huellmann , Rainer Becker , Gerald Lauterbach , Ernst Buschmann , Heinz Eckhardt , Walter Himmele , Christiane Brueckner
发明人： Michael Huellmann , Rainer Becker , Gerald Lauterbach , Ernst Buschmann , Heinz Eckhardt , Walter Himmele , Christiane Brueckner
IPC分类号： C07C27/00 , C07C29/42 , C07C33/042 , C07C33/044 , C07C41/00 , C07C41/06 , C07C43/178 , C07C67/00 , C07C69/28 , C07C69/78 , C07D309/12 , C07F7/18
CPC分类号： C07C43/178 , C07C29/42 , C07C33/042 , C07C67/293 , C07C69/16 , C07D309/12 , C07F7/1852 , Y02P20/55
摘要： 3,9-Dihydroxynonyne and its derivatives protected at the 9-OH function, of the general formula I ##STR1## where R is hydrogen or a conventional alcohol protective group, and processes for the preparation of the compounds I.
摘要翻译： 3,9-二羟基壬炔及其衍生物以9-OH官能团保护，其通式为I，其中R为氢或常规的醇保护基，以及制备化合物I的方法。

6. 发明授权

US5455352A Preparation of N-(2-hydroxyethyl)-piperazine 失效
标题翻译：制备N-（2-羟乙基） - 哌嗪
公开(公告)号：US5455352A
公开(公告)日：1995-10-03
申请号：US282073
申请日：1994-07-28
申请人： Michael Huellmann , Rainer Becker , Emil Scharf
发明人： Michael Huellmann , Rainer Becker , Emil Scharf
IPC分类号： B01J23/74 , B01J23/88 , C07B61/00 , C07D295/08 , C07D295/088
CPC分类号： C07D295/088 , Y02P20/582
摘要： Preparation of N-(2-hydroxyethyl)-piperazine by reacting triethanolamine with ammonia in the presence of hydrogen at from 100.degree. to 500.degree. C. and from 10 to 500 bar over a heterogeneous catalyst in which the catalytically active material contains from 20 to 85% by weight of ZrO.sub.2 or Al.sub.2 O.sub.3 or mixtures thereof, from 1 to 30% by weight of at least one copper oxide, calculated as CuO, and from 1 to 60% by weight of at least one oxide of cobalt, nickel or molybdenum, calculated as CoO, NiO and MoO.sub.3, respectively.
摘要翻译：通过使三乙醇胺与氨在100〜500℃的氢气和10〜500巴的存在下，在非均相催化剂上制备N-（2-羟乙基） - 哌嗪，其中催化活性物质含有20〜 85重量％的ZrO 2或Al 2 O 3或其混合物，1至30重量％的以CuO计算的至少一种氧化铜和1至60重量％的至少一种钴，镍或钼的氧化物，分别计算为CoO，NiO和MoO3。

7. 发明授权

US5410070A Preparation of N-alkenylpyrrolidones 失效
标题翻译： N-烯基吡咯烷酮的制备
公开(公告)号：US5410070A
公开(公告)日：1995-04-25
申请号：US188206
申请日：1994-01-27
申请人： Lothar Franz , Michael Huellmann
发明人： Lothar Franz , Michael Huellmann
IPC分类号： C07B61/00 , C07D207/26 , C07D207/267
CPC分类号： C07D207/267
摘要： Process for the preparation of N-alkenylpyrrolidones of the general formula ##STR1## in which R denotes hydrogen or C.sub.1 -C.sub.20 alkyl, by the reaction of an N-alkylpyrrolidone of the general formula ##STR2## in which R has the aforementioned meanings, and x and Y stand for OH, C.sub.1 -C.sub.20 alkoxy or C.sub.2 -C.sub.20 alkoxycarbonyl, provided that one of the two radicals x and denotes hydrogen, at temperatures ranging from 200.degree. to 600.degree. C. and pressures ranging from 0.1 to 5 bar, wherein the process is carried out in the presence of an acid heterogenous catalyst except for an oxide of a Group IIb, Group IIIb, Group IVb, and Group VIb metal.
摘要翻译：制备通式为（Ⅰ）的N-烯基吡咯烷酮的方法，其中R表示氢或C 1 -C 20烷基，通过其中R具有通式为（II）的N-烷基吡咯烷酮上述含义，x和Y表示OH，C 1 -C 20烷氧基或C 2 -C 20烷氧基羰基，条件是两个基团中的一个x表示氢，温度范围为200-600℃，压力范围为0.1至5 其中所述方法在除了IIb族，IIIb族，IVb族和VIb族金属的氧化物之外的酸异种催化剂的存在下进行。

8. 发明授权

US5336815A Preparation of vinyl glycols 失效
标题翻译：乙烯基二醇的制备
公开(公告)号：US5336815A
公开(公告)日：1994-08-09
申请号：US54819
申请日：1993-04-29
申请人： Rainer Becker , Walter Gramlich , Michael Huellmann , Hans-Ulrich Scholz
发明人： Rainer Becker , Walter Gramlich , Michael Huellmann , Hans-Ulrich Scholz
IPC分类号： B01J23/36 , C07B61/00 , C07C29/56 , C07C33/035
CPC分类号： C07C29/56
摘要： Preparation of vinyl glycols (I) ##STR1## (R.sup.1 to R.sup.6 =H, a carbo-organic radical, optionally substituted) in which an unsaturated diol of formula II ##STR2## is isomerized in the presence of a rhenium catalyst under neutral conditions. The compounds (I) serve as intermediates for the preparation of active substances and for the preparation of polymers.
摘要翻译：乙烯基二醇的制备（I）（Ⅰ）（R1至R6 = H，可以被取代的碳 - 有机基团），其中式II的不饱和二醇在（II）存在下异构化铼催化剂在中性条件下。化合物（I）用作制备活性物质和制备聚合物的中间体。

9. 发明授权

US5068479A Preparation of 1,1,3,4,4,6-hexamethyl-1,2,3,4-tetra-hydronaphthalene 失效
标题翻译：制备1,1,3,4,4,6-六甲基-1,2,3,4-四氢化萘
公开(公告)号：US5068479A
公开(公告)日：1991-11-26
申请号：US668484
申请日：1991-03-13
申请人： Michael Huellmann , Herbert Mayr , Rainer Becker
发明人： Michael Huellmann , Herbert Mayr , Rainer Becker
IPC分类号： B01J31/26 , C07B61/00 , C07C2/72 , C07C13/48
CPC分类号： C07C2/72 , C07C2102/10
摘要： A process for preparing 1,1,3,4,4,6-hexamethyl-1,2,3,4-tetrahydronaphthalene of the formula I ##STR1## comprises reacting p-cymene of the formula II ##STR2## with a hexene of the formula IIIa, IIIb and/or IIIc ##STR3## in the presence of a catalytic amount of aluminum halide and a catalytic amount of a triphenylmethyl compound of the formula IV ##STR4## wherein R.sup.1, R.sup.2 and R.sup.3 are each, independently of one another, hydrogen, C.sub.1 -C.sub.4 -alkyl, nitro or halogen and X is hydrogen or halogen.
摘要翻译：制备式I（I）的1,1,3,4,4,6-六甲基-1,2,3,4-四氢化萘的方法包括使式II的对甲基异丙苯（IMAGE）（ II）与式IIIa，IIIb和/或IIIc（IIIa）（IIIb）（IIIc）的己烯在催化量的卤化铝和催化量的三苯基甲基式IV的化合物其中R 1，R 2和R 3各自独立地为氢，C 1 -C 4 - 烷基，硝基或卤素，X为氢或卤素。

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