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    • 3. 发明授权
    • Dimeric arylisoquinoline alkaloids and derivatives thereof
    • 二聚芳基异喹啉生物碱及其衍生物
    • US06331630B1
    • 2001-12-18
    • US09527002
    • 2000-03-16
    • Gerhard BringmannMichael R. BoydMatthias Wenzel
    • Gerhard BringmannMichael R. BoydMatthias Wenzel
    • C07D40110
    • C07D491/04A61K31/47C07D217/02C07D217/04C07D217/24
    • The present invention provides new naphthylisoquinoline derivatives. In particular, the present invention furthermore provides novel dimeric arylisoquinoline alkaloids comprised of coupled first and second arylisoquinoline monomers. Monomeric and dimeric compounds of the present invention have medically useful properties, such as antimicrobial properties, more specifically such as antimalarial and antiviral properties. Monomeric compounds of the present invention are also useful as building blocks or intermediates for synthesis of novel dimeric arylisoquinoline alkaloids. Monomeric and dimeric compounds of the present invention may be obtained in substantially pure form by total synthesis, partial synthesis, or derivatization from known synthetic or naturally occurring compounds, and by isolation and purification from plants of the Dioncophyllaceae and Ancistrocladaceae families.
    • 本发明提供新的萘基异喹啉衍生物。 特别地,本发明还提供由偶联的第一和第二芳基异喹啉单体组成的新的二聚芳基异喹啉生物碱。 本发明的单体和二聚体化合物具有医学上有用的性质,例如抗微生物性质,更具体地,例如抗疟疾和抗病毒性质。 本发明的单体化合物也可用作合成新型二聚芳基异喹啉生物碱的结构单元或中间体。 本发明的单体和二聚体化合物可以通过从合成或天然存在的化合物的全部合成,部分合成或衍生化,以及通过从Dioncophyllaceae和Ancistrocladaceae家族的植物中分离和纯化而以基本上纯的形式获得。
    • 4. 发明申请
    • Coupling for a Medical Delivery Device
    • 医疗输送装置的联轴器
    • US20110270268A1
    • 2011-11-03
    • US13015097
    • 2011-01-27
    • Christian S. EversullStephen A. LeeflangMatthias Wenzel
    • Christian S. EversullStephen A. LeeflangMatthias Wenzel
    • A61B19/00
    • A61M39/10A61M25/0097A61M25/0668A61M2039/1027A61M2039/1033
    • The present disclosure relates to a coupling, in particular a hub (2 a-i), with a base body (23 a-i) having a proximal end (24 a-i), embodied as a connecting region (25 a-i) for an applicator (26 a-i), and a distal end (27 a-i), embodied as connecting region (28 a-i) for a delivery device (29 a-i) with a tubular member (30 a-i) for delivering a medical device (31 a-1) into a part of an animal or human body, and having a recess (9 a-i) extending between the proximal end (24 a-i) and the distal end (27 a-i). It is provided that the recess (9 a-i) is positioned eccentrically from an outer diameter (20 a-i) of the base body (23 a-i) and a central axis (18 a-i) of the recess (9 a-i) is nonparallel in respect to a central axis (32 a-i) of the outer diameter (20 a-i) of the base body (23 a-i).
    • 本公开涉及一种联接器,特别是具有基体(23a)的联轴器(2a),所述基体具有近端(24a),其被实施为用于施用器(26a)的连接区域(25i) ,以及远端(27a),其被实施为用于输送装置(29a)的连接区域(28a),其具有用于将医疗装置(31a-1)输送到 动物或人体,并且具有在近端(24a)和远端(27a)之间延伸的凹陷(9i)。 设置凹部(9ai)从基体(23a)的外径(20a)偏心定位,凹部(9a)的中心轴线(18a)相对于 所述基体(23a)的外径(20a)的中心轴线(32a)。
    • 9. 发明授权
    • Stable near-infrared (NIR) marker dyes based on benzopyrylium-polymethines
    • 基于苯并吡喃 - 聚甲基的稳定近红外(NIR)标记染料
    • US06750346B2
    • 2004-06-15
    • US10031741
    • 2002-01-22
    • Peter CzerneyFrank LehmannBernd SchwederMatthias Wenzel
    • Peter CzerneyFrank LehmannBernd SchwederMatthias Wenzel
    • C07D51300
    • G01N33/582C09B23/0066C09B23/02C12Q2563/107
    • The disclosure is directed to so-called laser-compatible NIR marker dyes based on polymethines for use in optical, in particular, fluorescence optical determination and detection methods, for example, in the fields of medicine, pharmaceutics and in the areas of life science, materials science and environmental science. The disclosure further discusses the aim of the invention which was to create NIR marker dyes based on polymethine which have a high degree of photostability and stability in storage as well as a high fluorescent yield and which can be excited to fluorescence in the easiest possible manner by means of laser radiation in the visible or NIR spectral range, particularly with light of an argon, helium/neon, or diode laser. Dyes based on polymethine of general formula (I) are used.
    • 本公开涉及基于用于光学的聚甲基化的所谓的激光兼容NIR标记染料,特别是荧光光学测定和检测方法,例如在医学,制药领域以及生命科学领域, 材料科学与环境科学。 本公开进一步讨论了本发明的目的,其是基于聚甲基化产生具有高度光稳定性和储存稳定性以及高荧光产率的基于聚甲炔的NIR标记染料,并且可以以最简单可能的方式将其激发至荧光 在可见光或近红外光谱范围内的激光辐射的手段,特别是在氩,氦/氖或二极管激光的光下。 使用基于通式(I)的聚甲炔的染料。