专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US06353007B1 Substituted 1-(4-aminophenyl)indoles and their use as anti-inflammatory agents 有权
标题翻译：取代的1-（4-氨基苯基）吲哚及其作为抗炎剂的用途
公开(公告)号：US06353007B1
公开(公告)日：2002-03-05
申请号：US09616014
申请日：2000-07-13
申请人： Rajiv Sharma
发明人： Rajiv Sharma
IPC分类号： C07D40110
CPC分类号： C07D405/14 , C07D209/08 , C07D209/42 , C07D401/12 , C07D417/14
摘要： 1-(4-Aminophenyl) indoles optionally substituted on the 2-,4-,5-,6- and 7-positions of the indole ring and on the amino group on the 4-position of the phenyl ring, which indoles inhibit IL-2 production in T-lymphocytes.
摘要翻译：任选在吲哚环的2-，4-，5-，6-和7-位上取代的1-（4-氨基苯基）吲哚，苯基环的4-位上的氨基上，该吲哚抑制IL -2生产在T淋巴细胞。

2. 发明授权

US06362195B1 Branched alkoxy-substituted 2-aminopyridines as NOS inhibitors 失效
标题翻译：支链烷氧基取代的2-氨基吡啶作为NOS抑制剂
公开(公告)号：US06362195B1
公开(公告)日：2002-03-26
申请号：US09381887
申请日：2000-03-28
申请人： John Adams Lowe, III
发明人： John Adams Lowe, III
IPC分类号： C07D40110
CPC分类号： C07D213/73 , C07D401/10
摘要： The present invention relates to 6-phenyl-pyridin-2-ylamine derivatives of the formula wherein R1, R2, R3 and R4 are defined as in the specification, that exhibit activity as nitric oxide synthase (NOS) inhibitors, to pharmaceutical compositions containing them and to their use in the treatment and prevention of central nervous system and other disorders.
摘要翻译：本发明涉及式I的化合物，其中R 1，R 2，R 3和R 4的6-苯基 - 吡啶-2-基胺衍生物如说明书中所定义，其表现出作为一氧化氮合酶（NOS）抑制剂的活性，含有它们的药物组合物，用于治疗和预防中枢神经系统等疾病。

3. 再颁专利

USRE38133E1 Kappa agonist compounds and pharmaceutical formulations thereof 有权
标题翻译：卡帕激动剂化合物及其药物制剂
公开(公告)号：USRE38133E1
公开(公告)日：2003-06-03
申请号：US10066909
申请日：2002-02-04
申请人： Lawrence I. Kruse , An-Chih Chang , Diane L. DeHaven-Hudkins , John J. Farrar , Forrest Gaul , Virendra Kumar , Michael Anthony Marella , Alan L. Maycock , Wei Yuan Zhang
发明人： Lawrence I. Kruse , An-Chih Chang , Diane L. DeHaven-Hudkins , John J. Farrar , Forrest Gaul , Virendra Kumar , Michael Anthony Marella , Alan L. Maycock , Wei Yuan Zhang
IPC分类号： C07D40110
CPC分类号： A61K31/4439 , A61K31/404 , C07D209/42 , C07D213/56 , C07D241/04
摘要： Compounds having kappa opioid agonist activity, compositions containing them and method of using them as analgesics are provided. The compounds of formulae I, II, III and IV have the structure: wherein: X, X4, X5, X7, X9; R1, R2, R3, R4; and Y, Z and n are as described in the specification.
摘要翻译：具有κ阿片激动剂活性的化合物，含有它们的组合物和使用它们作为止痛剂的方法。式I，II，III和IV化合物具有以下结构：其中：X，X4，X5，X7，X9; R1，R2 ，R3，R4; 和Y，Z和n如说明书中所述。

4. 发明授权

US06262263B1 Quinolinium- and pyridinium-based fluorescent dye compounds 有权
公开(公告)号：US06262263B1
公开(公告)日：2001-07-17
申请号：US09412168
申请日：1999-10-05
申请人： Mark William Pennington , David Ian Scopes , Michael Glen Orchard
发明人： Mark William Pennington , David Ian Scopes , Michael Glen Orchard
IPC分类号： C07D40110
摘要： The present invention relates to quinolinium- and pyridinium-based fluorescent dyes. The dyes are useful for staining proteins in solution, in gels and on solid supports. The dyes of the invention exhibit higher fluorescence emission than known compounds when bound to proteins and also exhibit improved contrast of fluorescence intensity between their protein-bound and unbound states.

5. 发明授权

US06559311B1 Process for the synthesis of a photo-stabilizer 失效
标题翻译：合成光稳定剂的方法
公开(公告)号：US06559311B1
公开(公告)日：2003-05-06
申请号：US09984432
申请日：2001-10-30
申请人： Shroj Al Mohitkumar Desai , Raj Pal Singh
发明人： Shroj Al Mohitkumar Desai , Raj Pal Singh
IPC分类号： C07D40110
CPC分类号： C07D401/12
摘要： The present invention relates to a process for the preparation of a photo-stabilizer of the general formula (I): wherein R1 is hydrogen, halogen, C1 to C12 alkyl, alkoxy (linear and branched), R2 is hydrogen, C1-C8 alkyl, cyclopentyl, cyclohexyl or cumyl, R3 is hydrogen, C1-C4 alkyl, R4 is methyl or ethyl, R5 is C1-C8 alkyl, alkyl phenyl, alkoxy, acyl, cycloalkyl and allyl, X is O, NH, C1-C8 alkyloxy and alkylamino (linear or branched), and derivatives and intermediates thereof.
摘要翻译：本发明涉及制备通式（I）的光稳定剂的方法：其中R 1是氢，卤素，C 1 -C 12烷基，烷氧基（直链和支链），R 2是氢，C 1 -C 8烷基，环戊基，环己基或枯基，R3是氢，C1-C4烷基，R4是甲基或乙基，R5是C1-C8烷基，烷基苯基，烷氧基，酰基，环烷基和烯丙基，X是O，NH，C1-C8烷氧基和烷基氨基（直链或支链）及其衍生物和中间体。

6. 发明授权

US06465648B1 REACTION PRODUCT, PROCESS OF PRODUCING SAME, ELECTROPHOTOGRAPHIC PHOTOCONDUCTOR USING SAME, ELECTROPHOTOGRAPHIC APPARATUS HAVING THE PHOTOCONDUCTOR, AND PROCESS CARTRIDGE FOR ELECTROPHOTOGRAPHIC APPARATUS 失效
标题翻译：反应产物，其生产方法，使用其的电子照相光电子器件，具有光电转换器的电子照相设备和电子照相设备的工艺盒
公开(公告)号：US06465648B1
公开(公告)日：2002-10-15
申请号：US09602186
申请日：2000-06-22
申请人： Kaoru Tadokoro , Masayuki Shoshi , Michihiko Namba , Tomoyuki Shimada , Chiaki Tanaka
发明人： Kaoru Tadokoro , Masayuki Shoshi , Michihiko Namba , Tomoyuki Shimada , Chiaki Tanaka
IPC分类号： C07D40110
CPC分类号： C07D487/22 , C09B47/00 , C09B47/045 , G03G5/0696
摘要： A reaction product useful as an organic photoconductive material for electrophotographic photoconductors is provided, obtainable by reacting (i) a nitrile derivative, (ii) a phthalonitrile derivative or a 1,3-diiminoisoindoline derivative and, if necessary, (iii) a metal or a metal-containing compound.
摘要翻译：提供了用作电子照相感光体的有机光电导材料的反应产物，其可通过（i）腈衍生物，（ii）邻苯二甲腈衍生物或1,3-二亚氨基异吲哚啉衍生物和（如果需要）（iii）金属或含金属的化合物。

7. 发明授权

US06639077B2 Tri-aryl-substituted-ethane PDE4 inhibitors 失效
公开(公告)号：US06639077B2
公开(公告)日：2003-10-28
申请号：US10112535
申请日：2002-03-29
申请人： Bernard Cote , Evelyn Martins , Richard Frenette , Rick Friesen , Yves Ducharme
发明人： Bernard Cote , Evelyn Martins , Richard Frenette , Rick Friesen , Yves Ducharme
IPC分类号： C07D40110
CPC分类号： C07D417/06
摘要： Novel ethanes substituted with i) a phenyl, ii) a thiazole, and iii) a pyridyl moiety are PDE4 inhibitors.

8. 发明授权

US06335446B1 Quinolinium- and pyridinium-based fluorescent dye compounds 失效
标题翻译：基于喹啉和吡啶鎓的荧光染料化合物
公开(公告)号：US06335446B1
公开(公告)日：2002-01-01
申请号：US09412168
申请日：1999-10-05
申请人： Mark William Pennington , David Ian Scopes , Michael Glen Orchard
发明人： Mark William Pennington , David Ian Scopes , Michael Glen Orchard
IPC分类号： C07D40110
CPC分类号： C07D213/57 , C07D213/38 , C07D215/12 , C09B23/0058 , C09B23/145
摘要： The present invention relates to quinolinium- and pyridinium-based fluorescent dyes. The dyes are useful for staining proteins in solution, in gels and on solid supports. The dyes of the invention exhibit higher fluorescence emission than known compounds when bound to proteins and also exhibit improved contrast of fluorescence intensity between their protein-bound and unbound states.
摘要翻译：本发明涉及基于喹啉和吡啶鎓的荧光染料。染料可用于在溶液，凝胶和固体支持物上染色蛋白质。当与蛋白质结合时，本发明的染料显示比已知化合物更高的荧光发射，并且还显示其蛋白质结合状态和未结合态之间的荧光强度的对比度改善。

9. 发明授权

US06331630B1 Dimeric arylisoquinoline alkaloids and derivatives thereof 失效
标题翻译：二聚芳基异喹啉生物碱及其衍生物
公开(公告)号：US06331630B1
公开(公告)日：2001-12-18
申请号：US09527002
申请日：2000-03-16
申请人： Gerhard Bringmann , Michael R. Boyd , Matthias Wenzel
发明人： Gerhard Bringmann , Michael R. Boyd , Matthias Wenzel
IPC分类号： C07D40110
CPC分类号： C07D491/04 , A61K31/47 , C07D217/02 , C07D217/04 , C07D217/24
摘要： The present invention provides new naphthylisoquinoline derivatives. In particular, the present invention furthermore provides novel dimeric arylisoquinoline alkaloids comprised of coupled first and second arylisoquinoline monomers. Monomeric and dimeric compounds of the present invention have medically useful properties, such as antimicrobial properties, more specifically such as antimalarial and antiviral properties. Monomeric compounds of the present invention are also useful as building blocks or intermediates for synthesis of novel dimeric arylisoquinoline alkaloids. Monomeric and dimeric compounds of the present invention may be obtained in substantially pure form by total synthesis, partial synthesis, or derivatization from known synthetic or naturally occurring compounds, and by isolation and purification from plants of the Dioncophyllaceae and Ancistrocladaceae families.
摘要翻译：本发明提供新的萘基异喹啉衍生物。特别地，本发明还提供由偶联的第一和第二芳基异喹啉单体组成的新的二聚芳基异喹啉生物碱。本发明的单体和二聚体化合物具有医学上有用的性质，例如抗微生物性质，更具体地，例如抗疟疾和抗病毒性质。本发明的单体化合物也可用作合成新型二聚芳基异喹啉生物碱的结构单元或中间体。本发明的单体和二聚体化合物可以通过从合成或天然存在的化合物的全部合成，部分合成或衍生化，以及通过从Dioncophyllaceae和Ancistrocladaceae家族的植物中分离和纯化而以基本上纯的形式获得。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式