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1. 发明申请

US20100285470A1 MONOMETHINE DYES 有权
标题翻译：单色眼镜
公开(公告)号：US20100285470A1
公开(公告)日：2010-11-11
申请号：US12680881
申请日：2008-09-30
申请人： Charles K. Brush , Jianqin Liu , Peter Czerney , Matthias Wenzel
发明人： Charles K. Brush , Jianqin Liu , Peter Czerney , Matthias Wenzel
IPC分类号： C12Q1/68 , C07D417/06 , C07D417/14 , C07D413/06 , G01N33/53 , C07H21/00
CPC分类号： C07D417/06 , C07D311/58 , C07D405/06 , C07D413/06 , C07D491/04 , C09B23/04 , C12Q1/6827
摘要： Monomethine dyes that have no or minimal fluorescence in buffer or in the presence of single stranded DNA or RNA, but strongly fluoresce in the presence of double-stranded DNA. In one embodiment, the dye is useful in quantitative RT-PCR.
摘要翻译：在缓冲液或单链DNA或RNA存在下没有或最小荧光的单甲基染料，但在双链DNA存在下强烈发荧光。在一个实施方案中，染料可用于定量RT-PCR。

2. 发明授权

US07563907B2 Compounds based on polymethines 有权
标题翻译：基于聚甲基化合物
公开(公告)号：US07563907B2
公开(公告)日：2009-07-21
申请号：US10846789
申请日：2004-05-14
申请人： Peter Czerney , Matthias Wenzel , Bernd Schweder , Frank Lehmann
发明人： Peter Czerney , Matthias Wenzel , Bernd Schweder , Frank Lehmann
IPC分类号： C07D405/06
CPC分类号： C09B23/107 , C09B57/02
摘要： The invention relates to fluorescent dyes (fluorophores) based on polymethines for use in optical measurement and detection procedures, in particular those employing fluorescence, for example in medicine, in pharmacology and in the biological, materials and environmental sciences. The objective was to create fluorophores based on polymethines that have a large Stokes shift, high photostability, long storage life and a high fluorescent quantum yield, and that can be excited in the simplest possible manner by white-light sources or laser radiation in the UV, visible or NIR spectral region. According to the invention dyes on the basis of polymethines having the general formulas I, II or III are employed.
摘要翻译：本发明涉及基于用于光学测量和检测程序的聚甲基化的荧光染料（荧光团），特别是使用荧光的那些，例如在医学，药理学以及生物，材料和环境科学中。目的是基于具有大的斯托克斯位移，高光稳定性，长存储寿命和高荧光量子产率的聚甲基化产生荧光团，并且可以以最简单的方式通过白光源或UV中的激光辐射来激发荧光团，可见光或近红外光谱区。根据本发明，采用基于具有通式I，II或III的聚甲基的染料。

3. 发明授权

US06924372B2 Benzopyrylo-polymethine-based hydrophilic markers 有权
标题翻译：苯并吡喃聚甲基丙烯酸亲水标记
公开(公告)号：US06924372B2
公开(公告)日：2005-08-02
申请号：US10732928
申请日：2003-12-10
申请人： Peter Czerney , Matthias Wenzel , Bernd Schweder , Wilhelm Frank
发明人： Peter Czerney , Matthias Wenzel , Bernd Schweder , Wilhelm Frank
IPC分类号： C09B23/02 , G01N33/533
CPC分类号： G01N33/533 , C09B23/02
摘要： The present invention relates to the field of optical-fluorescent markers, particularly to benzopyrylo-polymethine-based optical-fluorescent markers.
摘要翻译：本发明涉及光 - 荧光标记物领域，特别涉及基于苯并吡喃 - 聚甲基丙烯酸的光学荧光标记物。

4. 发明授权

US08378115B2 Monomethine dyes 有权
标题翻译：单甲基染料
公开(公告)号：US08378115B2
公开(公告)日：2013-02-19
申请号：US12680881
申请日：2008-09-30
申请人： Charles K. Brush , Jianqin Liu , Peter Czerney , Matthias Wenzel
发明人： Charles K. Brush , Jianqin Liu , Peter Czerney , Matthias Wenzel
IPC分类号： C07D419/00 , C07D417/00 , G01N33/566 , C12Q1/68
CPC分类号： C07D417/06 , C07D311/58 , C07D405/06 , C07D413/06 , C07D491/04 , C09B23/04 , C12Q1/6827
摘要： Monomethine dyes that have no or minimal fluorescence in buffer or in the presence of single stranded DNA or RNA, but strongly fluoresce in the presence of double-stranded DNA. In one embodiment, the dye is useful in quantitative RT-PCR.
摘要翻译：在缓冲液或单链DNA或RNA存在下没有或最小荧光的单甲基染料，但在双链DNA存在下强烈发荧光。在一个实施方案中，染料可用于定量RT-PCR。

5. 发明授权

US4400458A Diazonium salts and a diazo-type material comprising these diazonium salts 失效
标题翻译：重氮盐和包含这些重氮盐的重氮型材料
公开(公告)号：US4400458A
公开(公告)日：1983-08-23
申请号：US302286
申请日：1981-09-14
申请人： Fred Walkow , Peter Czerney , Horst Hartmann , Jorg Marx
发明人： Fred Walkow , Peter Czerney , Horst Hartmann , Jorg Marx
IPC分类号： C07D311/16 , G03C1/54 , C07C113/04
CPC分类号： C07D311/16 , G03C1/54
摘要： It is the purpose and object of the present invention to make better use of the emission range of light sources and to create the diazonium salts necessary for such purpose. The diazonium salts of the present invention of the general formula ##STR1## wherein Y is ##STR2## R.sub.1, R.sub.2 are equal or different and are, alkyl having 1 to 10 carbon atoms, aryl having 6 to 10 carbon atoms in a mono or polycylic ring;R.sub.3 is hydrogen, halogen, alkyl, alkoxy, cyano;R.sub.4 is hydrogen, halogen, alkyl, alkoxy; andX.sup.e is an anion,can be employed with all known couplers and additives in diazotype materials. They have an absorption range of 480 to 550 nm.
摘要翻译：本发明的目的和目的是更好地利用光源的发射范围并产生为此目的所必需的重氮盐。其中Y是R 1，R 2的本发明的重氮盐相同或不同，并且是具有1至10个碳原子的烷基，在单或多环中具有6至10个碳原子的芳基环; R3是氢，卤素，烷基，烷氧基，氰基; R4是氢，卤素，烷基，烷氧基; 并且Xe是阴离子，可以与所有已知的成色剂和添加剂一起用于重氮类材料。它们的吸收范围为480至550nm。

6. 发明授权

US07351829B2 Compounds on the basis of 2- and 4-chromenylidene-merocyanines respectively, and their use 有权
标题翻译：分别以2-和4-亚氯烯基 - 部花青为基础的化合物及其用途
公开(公告)号：US07351829B2
公开(公告)日：2008-04-01
申请号：US10190371
申请日：2002-07-03
申请人： Peter Czerney , Wilhelm Frank , Matthias Wenzel , Frank Lehmann
发明人： Peter Czerney , Wilhelm Frank , Matthias Wenzel , Frank Lehmann
IPC分类号： C07D239/62 , C07D239/66 , C09B57/02
CPC分类号： C07D405/06 , C07D405/14 , C07D491/04 , C07F9/65586 , C09B23/0066 , C09B23/105 , C09B23/107
摘要： The invention relates to compounds based on merocyanines with the general formulas I and/or II, where n=0 or an integer from 1 to 3, X=O or S and the residues R1 to R12 are the same or different and signify in particular hydrogen or various organic residues, without or with functional groups, and R2 incorporates an amine function. The compounds in accordance with the invention are suitable as fluorescent dyes (fluorophores) for used in optical determination and demonstration methods, in particular those employing fluorescence, for example in medicine, pharmacology and the biological, materials and environmental sciences. They are characterized by high photostability and long storage life, and exhibit a high fluorescence quantum yield. Excitation causing them to emit light can be achieved in a simple manner, by white-light sources or by laser irradiation in the UV, visible or NIR spectral region.
摘要翻译：本发明涉及基于具有通式I和/或II的部花青的化合物，其中n = 0或1至3的整数，X = O或S，残基R 1至R“ SUP> 12相同或不同，特别表示没有或具有官能团的氢或各种有机残基，并且R 2包含胺官能团。根据本发明的化合物适用于用于光学测定和显示方法的荧光染料（荧光团），特别是使用荧光的那些，例如在医学，药理学和生物，材料和环境科学中。它们的特征在于高的光稳定性和长的储存寿命，并表现出高的荧光量子产率。可以通过白光源或通过在UV，可见光或NIR光谱区域中的激光照射以简单的方式实现引起它们发光的激发。

7. 发明申请

US20070128659A1 HYDROPHILIC LABELS FOR BIOMOLECULES 有权
标题翻译：生物分子水合物标签
公开(公告)号：US20070128659A1
公开(公告)日：2007-06-07
申请号：US11566699
申请日：2006-12-05
申请人： Peter Czerney , Wilhelm Frank , Frank Lehmann , Bernd Schweder , Matthias Wenzel
发明人： Peter Czerney , Wilhelm Frank , Frank Lehmann , Bernd Schweder , Matthias Wenzel
IPC分类号： G01N33/53 , C07D403/02
CPC分类号： G01N33/582 , G01N33/533
摘要： Compounds, compositions, and methods for optical, including fluorescence optical, determinations useful in labelling biomolecules such as protein and deoxyribonucleic acid for their detection and quantitation. The compounds are diasteromeric cyanines with high hydrophilicity and other desirable properties.
摘要翻译：用于光学的化合物，组合物和方法，包括用于标记生物分子如蛋白质和脱氧核糖核酸的荧光光学测定用于其检测和定量。该化合物是具有高亲水性和其它所需性质的非对映体花青。

8. 发明授权

US06750346B2 Stable near-infrared (NIR) marker dyes based on benzopyrylium-polymethines 有权
标题翻译：基于苯并吡喃 - 聚甲基的稳定近红外（NIR）标记染料
公开(公告)号：US06750346B2
公开(公告)日：2004-06-15
申请号：US10031741
申请日：2002-01-22
申请人： Peter Czerney , Frank Lehmann , Bernd Schweder , Matthias Wenzel
发明人： Peter Czerney , Frank Lehmann , Bernd Schweder , Matthias Wenzel
IPC分类号： C07D51300
CPC分类号： G01N33/582 , C09B23/0066 , C09B23/02 , C12Q2563/107
摘要： The disclosure is directed to so-called laser-compatible NIR marker dyes based on polymethines for use in optical, in particular, fluorescence optical determination and detection methods, for example, in the fields of medicine, pharmaceutics and in the areas of life science, materials science and environmental science. The disclosure further discusses the aim of the invention which was to create NIR marker dyes based on polymethine which have a high degree of photostability and stability in storage as well as a high fluorescent yield and which can be excited to fluorescence in the easiest possible manner by means of laser radiation in the visible or NIR spectral range, particularly with light of an argon, helium/neon, or diode laser. Dyes based on polymethine of general formula (I) are used.
摘要翻译：本公开涉及基于用于光学的聚甲基化的所谓的激光兼容NIR标记染料，特别是荧光光学测定和检测方法，例如在医学，制药领域以及生命科学领域，材料科学与环境科学。本公开进一步讨论了本发明的目的，其是基于聚甲基化产生具有高度光稳定性和储存稳定性以及高荧光产率的基于聚甲炔的NIR标记染料，并且可以以最简单可能的方式将其激发至荧光在可见光或近红外光谱范围内的激光辐射的手段，特别是在氩，氦/氖或二极管激光的光下。使用基于通式（I）的聚甲炔的染料。

9. 发明授权

US4417060A Amino-substituted 2-cumaryl-(3)-chromenylium salts 失效
标题翻译：氨基取代的2-芳基 - （3） - 色烯鎓盐
公开(公告)号：US4417060A
公开(公告)日：1983-11-22
申请号：US247954
申请日：1981-03-26
申请人： Peter Czerney , Horst Hartmann , Jurgen Liebscher
发明人： Peter Czerney , Horst Hartmann , Jurgen Liebscher
IPC分类号： C07D311/08 , C09B57/02 , G03G5/06 , C07D405/14
CPC分类号： C09B57/02 , C07D311/08 , G03G5/0661
摘要： The present invention is directed to novel amino-substituted 2-cumaryl-3'-chromenylium salts of the general formula ##STR1## wherein R.sup.3 and R.sup.7 are a dialkyl or cycloalkyl disubstituted amino group, hydrogen, or hydroxy group, provided that at least one of R.sup.3 and R.sup.7 is an amino group, R.sup.1, R.sup.2, R.sup.4, R.sup.5, R.sup.6, and R.sup.8 are hydrogen, an alkoxy group, or two of these substituents together form an aromatic ring, provided that R.sup.1, R.sup.2 and R.sup.4 may be the same or different, and R.sup.5, R.sup.6 and R.sup.8 may be the same or different, and Y.sup.- is an acidic anion and to the process for their preparation.
摘要翻译：本发明涉及通式为“IMAGE”的新型氨基取代的2-芳基 - 3'-荧光素鎓盐，其中R 3和R 7为二烷基或环烷基二取代的氨基，氢或羟基，条件是至少一个的R 3和R 7是氨基，R 1，R 2，R 4，R 5，R 6和R 8是氢，这些取代基中的烷氧基或两个一起形成芳环，条件是R 1，R 2和R 4可以相同或不同，并且R 5，R 6和R 8可以相同或不同，并且Y-是酸性阴离子，以及它们的制备方法。

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