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1. 发明授权

US08701471B2 Method and system for background suppression in magneto-motive photoacoustic imaging of magnetic contrast agents 有权
标题翻译：磁性造影剂磁光成像中背景抑制的方法和系统
公开(公告)号：US08701471B2
公开(公告)日：2014-04-22
申请号：US13273095
申请日：2011-10-13
申请人： Matthew O'Donnell , Xiaohu Gao
发明人： Matthew O'Donnell , Xiaohu Gao
IPC分类号： G01N29/02 , A61B5/05
CPC分类号： G01N29/2418 , G01N29/222 , G01N2291/02466
摘要： Method and system for background suppression in magneto-motive photoacoustic imaging of labeled target objects.
摘要翻译：标记目标物体磁光成像中背景抑制的方法和系统。

2. 发明授权

US08427906B2 Acoustic sensor utilizing acoustoelectric effect 有权
标题翻译：声传感器利用声电效应
公开(公告)号：US08427906B2
公开(公告)日：2013-04-23
申请号：US12250289
申请日：2008-10-13
申请人： Russell S. Witte , Ragnar Olafsson , Sheng-Wen Huang , Timothy L Hall , Matthew O'Donnell
发明人： Russell S. Witte , Ragnar Olafsson , Sheng-Wen Huang , Timothy L Hall , Matthew O'Donnell
IPC分类号： G01H17/00
CPC分类号： G01H11/06
摘要： An ultrasound system that detects a characteristic of an ultrasound wave. The system includes a circuit member defining a sensing portion operable to be exposed to the ultrasound wave. The system also includes a current generating device that generates a current in the sensing portion of the circuit member. Furthermore, the system includes a voltage sensor that detects a voltage across the sensing portion due to the exposure to the ultrasound wave to thereby detect the characteristic of the ultrasound wave.
摘要翻译：检测超声波特性的超声波系统。该系统包括限定可操作以暴露于超声波的感测部分的电路部件。该系统还包括在电路构件的感测部分中产生电流的电流产生装置。此外，该系统包括电压传感器，其通过暴露于超声波来检测感测部分两端的电压，从而检测超声波的特性。

3. 发明申请

US20090034711A1 Multiple Queuing and Servicing of a Contact 有权
标题翻译：多个排队和服务的联系人
公开(公告)号：US20090034711A1
公开(公告)日：2009-02-05
申请号：US11831549
申请日：2007-07-31
申请人： Joaquin Omar Alvarado , David Bauer , Matthew O'Donnell
发明人： Joaquin Omar Alvarado , David Bauer , Matthew O'Donnell
IPC分类号： H04M3/428
CPC分类号： H04M3/523
摘要： A contact originator is given a choice to enqueue the contact in multiple contact queues, to serve multiple needs or interests of the originator. If the contact reaches the head of the queue for the primary need while the contact is being serviced from a queue for a secondary need, the contact either remains at the head of the primary-need queue until the servicing at the secondary-need queue is completed, or a resource of the primary-need queue is conferenced in with the contact and the resource of the secondary-need queue so that the resources can serve both needs simultaneously.
摘要翻译：联系人发起者可以选择将联系人排队在多个联系人队列中，以满足发起者的多种需求或兴趣。如果联系人在从辅助需求的队列中服务联系人的情况下到达主要需要的队列的头部，则该联系人将保留在主要需要队列的头部，直到辅助需要队列的服务为或者主要需求队列的资源与辅助需求队列的联系人和资源进行会议，以便资源同时满足两个需求。

4. 发明申请

US20080183076A1 HIGH-RESOLUTION MAPPING OF BIO-ELECTRIC FIELDS 失效
标题翻译：生物电场高分辨率映射
公开(公告)号：US20080183076A1
公开(公告)日：2008-07-31
申请号：US12019225
申请日：2008-01-24
申请人： Russell S. Witte , Ragnar Olafsson , Matthew O'Donnell
发明人： Russell S. Witte , Ragnar Olafsson , Matthew O'Donnell
IPC分类号： A61B8/00
CPC分类号： A61B5/0093 , A61B5/04 , A61B5/05 , A61B5/4064 , A61B5/4094
摘要： A current source density mapping system includes an ultrasound transducer emitting an ultrasound wave traveling along an ultrasound beam directed at a mapping field in a region of living tissue and an ultrasound pulser delivering a transmit pulse to said ultrasound transducer. The system includes a timing device producing controlled excitation of the transmit pulse; a plurality of recording electrodes positioned in contact with the living tissue detecting an acoustoelectric voltage signal generated at a bioelectric current source and within a focal zone of said ultrasound beam. An amplifier operatively connected to the recording electrodes amplifying the acoustoelectric voltage signal at a predetermined gain; and an analyzing component comprising a digitizer, a sampling device, a signal processor and a display unit operatively connected to the amplifier determining the location of the bioelectric current source by analyzing the acoustoelectric voltage signal detected by the recording electrodes in response to an interaction between the ultrasound wave and the presence of a current source in the mapping field.
摘要翻译：电流源密度映射系统包括：超声波换能器，其发射沿着指向生物体组织区域中的映射场的超声波行进的超声波;以及超声脉冲发生器，其向所述超声换能器传送发射脉冲。该系统包括产生发射脉冲的受控激励的定时装置; 多个记录电极，其与生物体组织接触，检测在生物电流源处产生的声电压信号，并且在所述超声波束的聚焦区域内。可操作地连接到记录电极的放大器，以预定增益放大声电压信号; 以及包括数字转换器，采样装置，信号处理器和显示单元的分析部件，所述数字转换器，采样装置，信号处理器和显示单元，其可操作地连接到所述放大器，以通过分析响应于所述记录电极之间的相互作用而由所述记录电极检测的声电压信号超声波和映射场中电流源的存在。

5. 发明申请

US20080081994A1 MEASUREMENT OF TISSUE ELASTIC MODULUS 有权
标题翻译：组织弹性模量的测量
公开(公告)号：US20080081994A1
公开(公告)日：2008-04-03
申请号：US11866000
申请日：2007-10-02
申请人： KANG KIM , William Weitzel , Jonathan Rubin , Congxian Jia , Matthew O'Donnell , Theodore Kolias
发明人： KANG KIM , William Weitzel , Jonathan Rubin , Congxian Jia , Matthew O'Donnell , Theodore Kolias
IPC分类号： A61B8/00
CPC分类号： A61B5/0285 , A61B8/06 , A61B8/08 , A61B8/485 , G01S7/52036 , G01S7/52042
摘要： An optimized elastic modulus reconstruction procedure can estimate the nonlinear elastic properties of vascular wall from intramural strain and pulse wave velocity (PWV) measurements. A noninvasive free-hand ultrasound scanning procedure is used to apply external force, comparable to the force in measuring a subject's blood pressure, to achieve higher strains by equalizing the internal arterial baseline pressure. PWV is estimated at the same location where intramural strain is measured. The reconstructed elastic modulus is optimized and the arterial elastic modulus can be determined and monitored using a simple dual elastic modulus reconstruction procedure.
摘要翻译：优化的弹性模量重建程序可以从壁内应变和脉搏波速度（PWV）测量中估计血管壁的非线性弹性特性。使用非侵入性自由手超声扫描程序来施加外力，与测量受试者血压的力相当，以通过平衡内部动脉基线压力来实现更高的应变。 PWV估计在测量壁内应变的相同位置。重建的弹性模量被优化，并且可以使用简单的双弹性模量重建程序来确定和监测动脉弹性模量。

6. 发明申请

US20050219096A1 Beamformed ultrasonic imager with delta-sigma feedback control 有权
标题翻译：具有Δ-Σ反馈控制的成像超声波成像仪
公开(公告)号：US20050219096A1
公开(公告)日：2005-10-06
申请号：US10973235
申请日：2004-10-26
申请人： Steven Freeman , Matthew O'Donnell , Thomas Linnenbrink , Marc Morin , Marshall Quick , Charles Desilets
发明人： Steven Freeman , Matthew O'Donnell , Thomas Linnenbrink , Marc Morin , Marshall Quick , Charles Desilets
IPC分类号： G01S7/52 , G01S7/521 , H03M1/78 , H03M3/00 , H03M3/02
CPC分类号： G01S7/52034 , G01S7/52028 , G01S7/52044 , G01S7/5208 , G01S7/52095 , G01S15/8927 , H03M3/324 , H03M3/43 , H03M3/454
摘要： A method and apparatus are provided for reducing distortion in a dynamically delayed digital sample stream of an imaging system. The method includes the steps of delta-sigma modulating an input analog signal of the imaging system at a frequency above the Nyquist frequency of the input analog signal to generate a digital sample stream and changing a length of the sample stream to delay a portion of the sample stream while maintaining synchronism between a delta-sigma modulator and a demodulator of the system.
摘要翻译：提供了一种用于减少成像系统的动态延迟的数字样本流中的失真的方法和装置。该方法包括以高于输入模拟信号的奈奎斯特频率的频率调制成像系统的输入模拟信号的Δ-sigma步骤，以产生数字样本流并改变样本流的长度以延迟部分同时保持Δ-Σ调制器和系统的解调器之间的同步。

7. 发明申请

US20050124892A1 Methods and systems for measuring mechanical property of a vascular wall and method and system for determining health of a vascular structure 有权
标题翻译：用于测量血管壁的机械性能的方法和系统，以及用于确定血管结构健康的方法和系统
公开(公告)号：US20050124892A1
公开(公告)日：2005-06-09
申请号：US10731302
申请日：2003-12-09
申请人： William Weitzel , Kang Kim , Matthew O'Donnell , Jonathan Rubin , Hua Xie , Xunchang Chen
发明人： William Weitzel , Kang Kim , Matthew O'Donnell , Jonathan Rubin , Hua Xie , Xunchang Chen
IPC分类号： A61B8/08 , A61B8/06
CPC分类号： A61B8/485 , A61B8/08
摘要： Methods and systems for measuring mechanical property of a vascular wall and a method and system for determining health of a vascular structure are provided wherein local deformation of a vessel wall resulting from physiologic pressures with altered transmural forces is measured. A non-invasive free-hand ultrasound scanning-procedure was performed to apply external force, comparable to the force generated in measuring a subject's blood pressure, to achieve higher strains by equalizing the internal arterial baseline pressure. When the applied pressure matched the internal baseline diastolic pressure, strain and strain rate increased by a factor of 10 over a cardiac cycle. Radial arterial strain was assessed in the vessel wall over the entire deformation procedure using a phase-sensitive, two-dimensional speckle-tracking algorithm. An elastic modulus reconstruction procedure was developed to estimate the non-linear elastic properties of the vascular wall.
摘要翻译：提供了用于测量血管壁的机械性能的方法和系统以及用于确定血管结构健康的方法和系统，其中测量由具有改变的透壁力的生理压力引起的血管壁的局部变形。进行非侵入性自由手超声扫描程序以施加外力，与测量受试者血压时产生的力相当，以通过平衡内部动脉基线压力来实现更高的应变。当施加的压力与内部基线舒张压相匹配时，应变和应变率在心脏周期上增加10倍。使用相敏二维斑点跟踪算法，在整个变形过程的血管壁中评估径向动脉应变。开发弹性模量重建程序来估计血管壁的非线性弹性性质。

8. 发明授权

US06867720B1 Beamformed ultrasonic imager with delta-sigma feedback control 有权
公开(公告)号：US06867720B1
公开(公告)日：2005-03-15
申请号：US10649209
申请日：2003-08-27
申请人： Steven R. Freeman , Matthew O'Donnell , Thomas E. Linnenbrink , Marc A. Morin , Marshall K. Quick , Charles S. Desilets
发明人： Steven R. Freeman , Matthew O'Donnell , Thomas E. Linnenbrink , Marc A. Morin , Marshall K. Quick , Charles S. Desilets
IPC分类号： G01S7/52 , G01S7/521 , H03M1/78 , H03M3/00 , H03M3/02
CPC分类号： G01S7/52034 , G01S7/52028 , G01S7/52044 , G01S7/5208 , G01S7/52095 , G01S15/8927 , H03M3/324 , H03M3/43 , H03M3/454
摘要： A method and apparatus are provided for reducing distortion in a dynamically delayed digital sample stream of an imaging system. The method includes the steps of delta-sigma modulating an input analog signal of the imaging system at a frequency above the Nyquist frequency of the input analog signal to generate a digital sample stream and changing a length of the sample stream to delay a portion of the sample stream while maintaining synchronism between a delta-sigma modulator and a demodulator of the system.

9. 发明授权

US06110115A Medical diagnostic ultrasonic imaging system and method 有权
标题翻译：医学诊断超声成像系统及方法
公开(公告)号：US06110115A
公开(公告)日：2000-08-29
申请号：US213996
申请日：1998-12-17
申请人： Kutay F. Ustuner , Matthew O'Donnell
发明人： Kutay F. Ustuner , Matthew O'Donnell
IPC分类号： G01S7/52 , A61B8/00
CPC分类号： G01S7/52046 , H04L25/03993
摘要： An ultrasonic imaging system and method provide whitening using a two dimensional pre-detection filter followed by low pass filtering using a two dimensional post-detection filter to reduce speckle variance and enhance spatial resolution of the resulting image.
摘要翻译：超声成像系统和方法使用二维预检测滤波器提供白化，然后使用二维后检测滤波器进行低通滤波，以减少斑点变化并增强所得图像的空间分辨率。

10. 发明授权

US5891037A Ultrasonic Doppler imaging system with frequency dependent focus 失效
标题翻译：超声多普勒成像系统具有频率依赖关系
公开(公告)号：US5891037A
公开(公告)日：1999-04-06
申请号：US993393
申请日：1997-12-18
申请人： John A. Hossack , John W. Allison , Albert Gee , Matthew O'Donnell
发明人： John A. Hossack , John W. Allison , Albert Gee , Matthew O'Donnell
IPC分类号： A61B8/06 , A61B8/00
CPC分类号： A61B8/06 , A61B8/13
摘要： A method for measuring Doppler ultrasound information transmits a transmit beam having a frequency dependent focus in which low-frequency components of the transmit beam are focused at long ranges and progressively higher frequency components of the transmit beam are focused at progressively shorter ranges. Beamformed receive signals are generated in response to receive signals from the transducers, and these beamformed receive signals are applied to Doppler processors. The frequency dependent focus of the transmit beam provides a transmit beam that is more uniform in width and intensity, and the Doppler processors thereby provide an improved Doppler image signal.
摘要翻译：用于测量多普勒超声信息的方法发送具有频率相关焦点的发射波束，其中发射波束的低频分量聚焦在远距离处，并且逐渐更高频率的发射波束分量聚焦在逐渐更短的范围。响应于来自换能器的接收信号而产生波束形成的接收信号，并且将这些波束形成的接收信号施加到多普勒处理器。发射波束的频率依赖的焦点提供在宽度和强度上更均匀的发射波束，并且多普勒处理器因此提供改进的多普勒图像信号。

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