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1. 发明申请

US20100294732A1 SEPARATION CHIP AND SEPARATION METHOD 有权
标题翻译：分离芯片和分离方法
公开(公告)号：US20100294732A1
公开(公告)日：2010-11-25
申请号：US12864283
申请日：2009-01-27
申请人： Kentaro Ishii , Masashi Higasa , Shingo Hiramatsu
发明人： Kentaro Ishii , Masashi Higasa , Shingo Hiramatsu
IPC分类号： B01D21/26
CPC分类号： G01N1/4077 , B01L3/50273 , B01L2200/04 , B01L2300/0816 , B01L2400/0409 , G01N33/49 , G01N2035/00495
摘要： A separation chip for separating an insoluble component from a suspension using centrifugal force by rotation, includes a suspension holding tank, a separation liquid holding tank, and an insoluble component holding tank arranged in order from an inner circumferential side during rotation, wherein the suspension holding tank and the insoluble component holding tank are connected to each other, the insoluble component holding tank and the separation liquid holding tank are connected to each other by a narrow portion, and in the insoluble component holding tank, a connecting portion with the suspension holding tank is positioned further toward an outer circumferential side than the narrow portion.
摘要翻译：一种用于通过旋转离心力将不溶性成分与悬浮液分离的分离芯片，包括悬挂保持槽，分离液容纳槽，以及在旋转期间从内周侧依次配置的不溶性成分保持槽，罐和不溶性成分保持槽彼此连接，不溶性成分保持槽和分离液容纳槽相互连接，在不溶性成分保持槽中，与悬浮液保持槽被定位成比狭窄部分更靠外周侧。

2. 发明授权

US08409447B2 Separation chip and separation method 有权
标题翻译：分离芯片和分离方法
公开(公告)号：US08409447B2
公开(公告)日：2013-04-02
申请号：US12864283
申请日：2009-01-27
申请人： Kentaro Ishii , Masashi Higasa , Shingo Hiramatsu
发明人： Kentaro Ishii , Masashi Higasa , Shingo Hiramatsu
IPC分类号： B01D21/26 , B04B5/04 , G01N33/49
CPC分类号： G01N1/4077 , B01L3/50273 , B01L2200/04 , B01L2300/0816 , B01L2400/0409 , G01N33/49 , G01N2035/00495
摘要： A separation chip for separating an insoluble component from a suspension using centrifugal force by rotation, includes a suspension holding tank, a separation liquid holding tank, and an insoluble component holding tank arranged in order from an inner circumferential side during rotation, wherein the suspension holding tank and the insoluble component holding tank are connected to each other, the insoluble component holding tank and the separation liquid holding tank are connected to each other by a narrow portion, and in the insoluble component holding tank, a connecting portion with the suspension holding tank is positioned further toward an outer circumferential side than the narrow portion.
摘要翻译：一种用于通过旋转离心力将不溶性成分与悬浮液分离的分离芯片，包括悬挂保持槽，分离液容纳槽，以及在旋转期间从内周侧依次配置的不溶性成分保持槽，罐和不溶性成分保持槽彼此连接，不溶性成分保持槽和分离液容纳槽相互连接，在不溶性成分保持槽中，与悬浮液保持槽被定位成比狭窄部分更靠外周侧。

3. 发明申请

US20070178240A1 Substrate for labo-on-a-chip 审中-公开
标题翻译：基板实验室芯片
公开(公告)号：US20070178240A1
公开(公告)日：2007-08-02
申请号：US11587024
申请日：2005-04-21
申请人： Yoshiaki Yamazaki , Naoki Kawazoe , Masashi Higasa , Giman Jung , Hitoshi Nobumasa , Yuji Murakami
发明人： Yoshiaki Yamazaki , Naoki Kawazoe , Masashi Higasa , Giman Jung , Hitoshi Nobumasa , Yuji Murakami
IPC分类号： B05D3/02
CPC分类号： G01N27/44747
摘要： The present invention relates to a lab-on-chip substrate, comprising a resin having a silicon content of 10% or less by weight as its base material and a hydrophilic polymer covalently bound onto the surface thereof by high-energy ray irradiation, and in particular, to a protein-processing chip. The present invention provides a lab-on-chip substrate resistant to washing and usable for an extended period of time without adsorption of proteins on the base material surface, i.e., a protein electrophoretic polymeric chip having a microchannel allowing high-accuracy analysis of trace amounts of proteins because of reduction in the amount of detection noise.
摘要翻译：本发明涉及一种芯片上芯片基板，其包括硅含量为10重量％以下的树脂作为其基材，以及通过高能射线照射共价结合到其表面上的亲水性聚合物，特别是蛋白质加工芯片。本发明提供一种耐洗涤实验室的片上基片，并且可延长使用时间，而不会在基材表面上吸附蛋白质，即具有微通道的蛋白质电泳聚合物芯片，允许微量的高精度分析的蛋白质，因为检测噪声量的减少。

4. 发明申请

US20130075665A1 WATER-SOLUBLE POLYMER AND WATER-SOLUBLE NANOPARTICLE COMPOSITE 有权
标题翻译：水溶性聚合物和水溶性纳米复合材料
公开(公告)号：US20130075665A1
公开(公告)日：2013-03-28
申请号：US13703237
申请日：2011-06-24
申请人： Joonsik Park , Masashi Higasa , Asako Sogame
发明人： Joonsik Park , Masashi Higasa , Asako Sogame
IPC分类号： C08G73/02
CPC分类号： C08G73/0233 , B82Y5/00 , B82Y40/00 , C08K3/10 , Y10S977/773 , Y10T428/2982 , C08L79/02 , C08K3/0075
摘要： A water-soluble nanoparticle complex has a plurality of accumulated nanoparticles and has excellent uniformity and stability by forming a complex of nanoparticles using a water-soluble polymer and which allows for use of nanoparticles in biochemical applications.
摘要翻译：水溶性纳米颗粒复合物具有多个累积的纳米颗粒，并且通过使用水溶性聚合物形成纳米颗粒的复合物并且允许在生化应用中使用纳米颗粒而具有优异的均匀性和稳定性。

5. 发明申请

US20100255483A1 LIQUID-FEEDING CHIP AND ANALYSIS METHOD 有权
标题翻译：液体进料和分析方法
公开(公告)号：US20100255483A1
公开(公告)日：2010-10-07
申请号：US12743248
申请日：2008-11-20
申请人： Kentaro Ishii , Masashi Higasa , Shingo Hiramatsu
发明人： Kentaro Ishii , Masashi Higasa , Shingo Hiramatsu
IPC分类号： C12Q1/68 , C12Q1/02 , C12M1/34 , G01N33/48 , G01N33/50 , C12Q1/00 , G01N33/53
CPC分类号： B01L3/50273 , B01L2200/04 , B01L2200/0621 , B01L2200/16 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2400/0409 , B01L2400/0457 , G01N2035/00158 , G01N2035/00495 , Y10T436/143333 , Y10T436/206664
摘要： A liquid-feeding chip for feeding a liquid utilizing the action of centrifugal force and gravity by rotating the chip around an axis of rotation, includes a first storage tank (1-1) into which the liquid can be introduced when rotation of the chip is stopped, and two or more liquid-feeding units arranged in a plurality of levels adjacent to each other, each liquid-feeding unit (U-1, U-2, U-3) being composed of a first holding tank (10-1, 20-1, 30-1), a second holding tank (10-2, 20-2, 30-2) positioned in the direction of gravity with respect to the first holding tank, and a channel B (B-1, B-2, B-3) which extends from the first holding tank in the direction of gravity and which connects the first holding tank and the second holding tank, the first holding tank at a first level being connected with a channel A (A-1) which extends from the first storage tank toward an outer circumferential side. In the liquid-feeding chip, the adjacent liquid-feeding units are connected by a channel C (C-1, C-2) which extends from the second holding tank of the liquid-feeding unit at an upper level to an outer circumferential side during rotation, and which is in communication with the first holding tank of the liquid-feeding unit at a lower level.
摘要翻译：一种利用离心力和重力作用使液体沿着旋转轴旋转的液体供给芯片，包括：第一储存罐（1-1），当芯片旋转时可以引入液体每个供液单元（U-1，U-2，U-3）由第一容纳槽（10-1）组成，每个液体供给单元，20-1,30-1），相对于第一容纳槽位于重力方向上的第二保持箱（10-2,20-2,30-2），以及通道B（B-1， B-2，B-3），其从重力方向从第一容纳箱延伸并且连接第一保持箱和第二保持箱，第一水平的第一保持箱与通道A（A- 1），其从第一储罐延伸到外周侧。在供液芯片中，相邻的送液单元通过从上述液体供给单元的第二容纳槽延伸到外周侧的通道C（C-1，C-2）在旋转期间，其与较低水平的液体供给单元的第一容纳槽连通。

6. 发明申请

US20090297733A1 SUBSTRATE FOR LAB-ON-A-CHIP 审中-公开
标题翻译：基于实验室的芯片
公开(公告)号：US20090297733A1
公开(公告)日：2009-12-03
申请号：US12540832
申请日：2009-08-13
申请人： Yoshiaki Yamazaki , Naoki Kawazoe , Masashi Higasa , Giman Jung , Hitoshi Nobumasa , Yuji Murakami
发明人： Yoshiaki Yamazaki , Naoki Kawazoe , Masashi Higasa , Giman Jung , Hitoshi Nobumasa , Yuji Murakami
IPC分类号： C23C14/28
CPC分类号： G01N27/44747
摘要： A lab-on-chip substrate includes a resin having a silicon content of 10% or less by weight as its base material and a hydrophilic polymer covalently bound onto the surface thereof by high-energy ray irradiation suitable for a protein-processing chip. The lab-on-chip substrate is resistant to washing and usable for an extended period of time without adsorption of proteins on the base material surface, i.e., a protein electrophoretic polymeric chip having a microchannel allowing high-accuracy analysis of trace amounts of proteins because of reduction in the amount of detection noise.
摘要翻译：片上芯片基板包括硅含量为10重量％以下的树脂作为其基材，以及通过适用于蛋白质加工芯片的高能射线照射共价结合到其表面上的亲水性聚合物。芯片上的实验室衬底耐洗涤并且可在不在基材表面上吸附蛋白质的情况下使用，即具有微通道的蛋白质电泳聚合物芯片，允许对微量蛋白进行高精度分析，因为检测噪声量减少。

7. 发明授权

US5499227A Information recording and reproducing apparatus 失效
标题翻译：信息记录和再现装置
公开(公告)号：US5499227A
公开(公告)日：1996-03-12
申请号：US275791
申请日：1994-07-15
申请人： Masashi Higasa
发明人： Masashi Higasa
IPC分类号： G11B7/00 , G11B7/0045 , G11B7/005 , G11B7/007 , G11B7/125 , G11B11/105 , G11B20/10
CPC分类号： G11B7/126 , G11B11/1053 , G11B20/10194 , G11B7/0045 , G11B7/005
摘要： A recording pulse circuit first divides a recording pulse into multiple pulses in accordance with a recording reference clock signal to generate a short-pulse group. The recording pulse circuit then connects a preset number of pulses of the short-pulse group beginning with a top one of the pulses of the short-pulse group to form a top long pulse. Finally, the recording pulse circuit shifts the positions of the front edge and the rear edge of the top long pulse by a designated time, and outputs the shifted top long pulse and the following pulses of the short-pulse group as recording pulses to a semiconductor laser drive circuit.
摘要翻译：记录脉冲电路首先根据记录参考时钟信号将记录脉冲分成多个脉冲以产生短脉冲组。记录脉冲电路然后连接短脉冲组的预设数量的脉冲，从短脉冲组的脉冲的顶部开始，形成顶部的长脉冲。最后，记录脉冲电路将顶部长脉冲的前沿和后沿的位置移动指定时间，并将短脉冲组的移位的顶部长脉冲和随后的脉冲作为记录脉冲输出到半导体激光驱动电路。

8. 发明授权

US08907047B2 Water-soluble polymer and water-soluble nanoparticle composite 有权
标题翻译：水溶性聚合物和水溶性纳米颗粒复合材料
公开(公告)号：US08907047B2
公开(公告)日：2014-12-09
申请号：US13703237
申请日：2011-06-24
申请人： Joonsik Park , Masashi Higasa , Asako Sogame
发明人： Joonsik Park , Masashi Higasa , Asako Sogame
IPC分类号： H01B1/20 , C09D5/23 , C08G73/06 , C08G73/02 , B82Y5/00 , B82Y40/00 , C08L79/02 , B82Y30/00
CPC分类号： C08G73/0233 , B82Y5/00 , B82Y40/00 , C08K3/10 , Y10S977/773 , Y10T428/2982 , C08L79/02 , C08K3/0075
摘要： A water-soluble nanoparticle complex has a plurality of accumulated nanoparticles and has excellent uniformity and stability by forming a complex of nanoparticles using a water-soluble polymer and which allows for use of nanoparticles in biochemical applications.
摘要翻译：水溶性纳米颗粒复合物具有多个累积的纳米颗粒，并且通过使用水溶性聚合物形成纳米颗粒的复合物并且允许在生化应用中使用纳米颗粒而具有优异的均匀性和稳定性。

9. 发明授权

US08821813B2 Liquid-feeding chip and analysis method 有权
标题翻译：送液芯片及分析方法
公开(公告)号：US08821813B2
公开(公告)日：2014-09-02
申请号：US12743248
申请日：2008-11-20
申请人： Kentaro Ishii , Masashi Higasa , Shingo Hiramatsu
发明人： Kentaro Ishii , Masashi Higasa , Shingo Hiramatsu
IPC分类号： B01L3/00 , B01D45/00 , C12M1/00 , G01N35/00
CPC分类号： B01L3/50273 , B01L2200/04 , B01L2200/0621 , B01L2200/16 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2400/0409 , B01L2400/0457 , G01N2035/00158 , G01N2035/00495 , Y10T436/143333 , Y10T436/206664
摘要： A liquid-feeding chip for feeding a liquid utilizing the action of centrifugal force and gravity by rotating the chip around an axis of rotation, includes a first storage tank (1-1) into which the liquid can be introduced when rotation of the chip is stopped, and two or more liquid-feeding units arranged in a plurality of levels adjacent to each other, each liquid-feeding unit (U-1, U-2, U-3) being composed of a first holding tank (10-1, 20-1, 30-1), a second holding tank (10-2, 20-2, 30-2) positioned in the direction of gravity with respect to the first holding tank, and a channel B (B-1, B-2, B-3) which extends from the first holding tank in the direction of gravity and which connects the first holding tank and the second holding tank, the first holding tank at a first level being connected with a channel A (A-1) which extends from the first storage tank toward an outer circumferential side. In the liquid-feeding chip, the adjacent liquid-feeding units are connected by a channel C (C-1, C-2) which extends from the second holding tank of the liquid-feeding unit at an upper level to an outer circumferential side during rotation, and which is in communication with the first holding tank of the liquid-feeding unit at a lower level.
摘要翻译：一种利用离心力和重力作用使液体沿着旋转轴旋转的液体供给芯片，包括：第一储存罐（1-1），当芯片旋转时可以引入液体每个供液单元（U-1，U-2，U-3）由第一容纳槽（10-1）组成，每个液体供给单元，20-1,30-1），相对于第一容纳槽位于重力方向上的第二保持箱（10-2,20-2,30-2），以及通道B（B-1， B-2，B-3），其从重力方向从第一容纳箱延伸并且连接第一保持箱和第二保持箱，第一水平的第一保持箱与通道A（A- 1），其从第一储罐延伸到外周侧。在供液芯片中，相邻的送液单元通过从上述液体供给单元的第二容纳槽延伸到外周侧的通道C（C-1，C-2）在旋转期间，其与较低水平的液体供给单元的第一容纳槽连通。

10. 发明申请

US20110177551A1 METHOD FOR PRODUCING A CHEMICAL PRODUCT AND CONTINUOUS FERMENTATION APPARATUS 审中-公开
标题翻译：生产化学产品和连续发酵装置的方法
公开(公告)号：US20110177551A1
公开(公告)日：2011-07-21
申请号：US13121727
申请日：2009-09-16
申请人： Takashi Mimitsuka , Kentaro Ishii , Ken Morita , Masashi Higasa , Kenji Sawai , Hideki Sawai , Katsushige Yamada , Shinichi Minegishi
发明人： Takashi Mimitsuka , Kentaro Ishii , Ken Morita , Masashi Higasa , Kenji Sawai , Hideki Sawai , Katsushige Yamada , Shinichi Minegishi
IPC分类号： C12P1/00 , C12M1/12
CPC分类号： C12P7/56 , C12M29/18 , C12M47/10 , C12N9/00 , C12P1/00 , C12P7/02 , C12P7/40 , C12P13/001 , C12P13/04 , C12P13/08 , C12P19/34 , C12P21/02
摘要： To control flow velocity of a culture liquid inside a membrane separation tank without giving influences to culture conditions in the fermentation tank, and also suppress precipitation of microorganisms or culture cells so that the production efficiency of the chemical product can be improved, in a method for producing a chemical product including the steps of: cultivating microorganisms or culture cells in a fermentation tank; transferring a culture liquid from the fermentation tank to a membrane separation tank so as to filter the culture liquid through a separation membrane; and collecting a fermentation product from a filtration liquid as the chemical product while refluxing an unfiltered culture liquid that has not been filtered so as to be joined to the culture liquid on an upstream side of the membrane separation tank, one portion of the culture liquid to be transferred from the fermentation tank is allowed to bypass the membrane separation tank depending on a pressure at the culture liquid flow-in side of the membrane separation tank.
摘要翻译：为了控制膜分离槽内的培养液的流速，不影响发酵罐中的培养条件，并且还抑制微生物或培养细胞的沉淀，从而可以提高化学品的生产效率生产化学产品，包括以下步骤：在发酵罐中培养微生物或培养细胞; 将培养液从发酵罐转移到膜分离罐中，以通过分离膜过滤培养液; 并将来自过滤液的发酵产物作为化学产品收集，同时回流未过滤的未过滤的培养液，以便在膜分离罐的上游侧与培养液接合，将一部分培养液转移至根据膜分离罐的培养液流入侧的压力，从发酵罐转移允许绕过膜分离罐。

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