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1. 发明授权

US09314546B2 Adhesive composition for soft tissues, adhesive composition for wound dressing or wound dressing composition 有权
标题翻译：用于软组织的粘合剂组合物，用于伤口敷料或伤口敷料组合物的粘合剂组合物
公开(公告)号：US09314546B2
公开(公告)日：2016-04-19
申请号：US13508009
申请日：2010-11-18
申请人： Noriaki Asada , Shinya Aoki , Hiroshi Naruse , Shoichi Miyakoshi , Masami Arata
发明人： Noriaki Asada , Shinya Aoki , Hiroshi Naruse , Shoichi Miyakoshi , Masami Arata
IPC分类号： A61L24/00 , A61L15/58 , A61L15/00 , A61L15/44 , A61L26/00 , C08L33/06 , A61L24/04
CPC分类号： A61L24/043 , A61L15/00 , A61L15/44 , A61L15/58 , A61L26/0014 , C08L33/06
摘要： The adhesive composition for soft tissues, the adhesive composition for wound dressing or the wound dressing agent composition of the present invention is an adhesive composition for soft tissues, an adhesive composition for wound dressing or a wound dressing agent composition, comprising a monomer (A), a polymer (B) and a polymerization initiator composition (C) containing an organoboron compound, and is characterized by having a viscosity of 0.4 to 75,000 cp within 30 seconds after mixing of the components (A), (B) and (C). The composition of the present invention not only has low toxicity, low harmfulness and high adhesive strength but also is excellent in workability during application and is capable of forming films of excellent properties.
摘要翻译：本发明的软组织用粘合剂组合物，伤口敷料用粘合剂组合物或伤口敷料剂组合物是软组织用粘合剂组合物，伤口敷料用粘合剂组合物或伤口敷料剂组合物，其含有单体（A），聚合物（B）和含有有机硼化合物的聚合引发剂组合物（C），其特征在于组分（A），（B）和（C）混合后30秒内的粘度为0.4至75,000cp，。本发明的组合物不仅毒性低，危害性低，粘合强度高，而且涂布时的加工性也优异，能够形成优异的膜。

2. 发明授权

US08389598B2 Dental polymerizable composition and kit therefor 有权
标题翻译：牙科可聚合组合物及其试剂盒
公开(公告)号：US08389598B2
公开(公告)日：2013-03-05
申请号：US12678068
申请日：2008-09-12
申请人： Yasukazu Saimi , Yasuhiro Nukii , Masami Arata
发明人： Yasukazu Saimi , Yasuhiro Nukii , Masami Arata
IPC分类号： A61L24/06 , A61K6/083 , A61C5/09 , C08L33/12 , C08L33/10 , C08F265/04 , C08F265/06 , C08F120/18
CPC分类号： A61K6/083 , C08L33/04 , C08L43/02
摘要： The present invention provides a dental polymerizable composition which has excellent handling property by the brush-dip technique and the bulk-mix technique, particularly excellent handling property by the brush-dip technique, contains few air bubbles, is excellent in color tone, polishability, mechanical properties and the discoloration resistance of a cured product at the time of curing and is used for many purposes such as the repair of a denture base or artificial tooth, a tooth crown prosthetic restoration and a temporary prosthetic restoration which is used until a bridge is completed when it is a two-composition type self-curing resin. The dental polymerizable composition comprises three different types of (meth)acrylate polymer particles, each having specific particle size characteristics and specific molecular weight characteristics.
摘要翻译：本发明提供一种通过刷涂技术和本体混合技术具有优异的处理性能，通过刷涂技术特别优异的处理性能的牙科可聚合组合物含有少量气泡，色调，抛光性，机械性能和固化产物在固化时的耐变色性，并且用于许多目的，例如修补义齿基座或人造牙齿，牙冠假肢修复物和临时假体修复，其直到桥梁被使用当它是双组分型自固化树脂时完成。牙科可聚合组合物包含三种不同类型的（甲基）丙烯酸酯聚合物颗粒，其具有特定的粒度特性和特定的分子量特性。

3. 发明申请

US20120225012A1 COMPOSITION FOR HARD TISSUE REPAIR 有权
标题翻译：硬组织修复组合物
公开(公告)号：US20120225012A1
公开(公告)日：2012-09-06
申请号：US13508451
申请日：2010-11-18
申请人： Noriaki Asada , Shinya Aoki , Hiroshi Naruse , Shoichi Miyakoshi , Masami Arata
发明人： Noriaki Asada , Shinya Aoki , Hiroshi Naruse , Shoichi Miyakoshi , Masami Arata
IPC分类号： A61L24/06 , A61K39/395 , A61K38/11 , A61K39/00 , A61K31/137 , A61P31/00 , A61P31/04 , A61P31/12 , A61P29/00 , A61P3/04 , A61P19/02 , A61P25/06 , A61P1/08 , A61P35/00 , A61P11/06 , A61P25/08 , A61P25/24 , A61P7/12 , A61P1/12 , A61P25/16 , A61P17/04 , A61P25/18 , A61P1/06 , A61P9/00 , A61P9/06 , A61P9/12 , A61P7/10 , A61P9/08 , A61P37/06 , A61P21/02 , A61P37/04 , A61K51/00 , A61P25/20 , A61P7/04 , A61P1/16 , A61P25/00 , A61K38/02 , A61K38/17 , A61K31/7088 , A61K31/715 , A61K47/32
CPC分类号： A61L27/54 , A61L24/0015 , A61L24/06 , A61L27/16 , A61L2300/404 , A61L2430/02 , C08F265/06 , C08L33/06 , C08L33/12
摘要： The composition for hard tissue repair of the present invention is characterized by comprising 5 to 98.95 parts by weight of a monomer (A), 1 to 75 parts by weight of a (meth)acrylate polymer (B) and 0.05 to 20 parts by weight of a polymerization initiator composition (C) containing an organoboron compound (c1), with the proviso that the total amount of the components (A), (B) and (C) is 100 parts by weight. The composition undergoes small-scale heat generation during curing and can ensure a sufficient working time.
摘要翻译：本发明的硬组织修复用组合物的特征在于，含有5〜98.95重量份单体（A），1〜75重量份（甲基）丙烯酸酯聚合物（B）和0.05〜20重量份含有有机硼化合物（c1）的聚合引发剂组合物（C），前提条件是组分（A），（B）和（C）的总量为100重量份。组合物在固化期间经历小规模的发热并且可以确保足够的工作时间。

4. 发明授权

US5879663A Dental composition for dentin hypersensitivity 失效
标题翻译：牙质组合物牙质过敏
公开(公告)号：US5879663A
公开(公告)日：1999-03-09
申请号：US687521
申请日：1996-08-07
申请人： Nobuo Nakabayashi , Takashi Yamamoto , Yasukazu Saimi , Masami Arata , Harumi Tanaka
发明人： Nobuo Nakabayashi , Takashi Yamamoto , Yasukazu Saimi , Masami Arata , Harumi Tanaka
IPC分类号： A61K6/00 , A61K6/083 , A61K33/14 , A61K7/22 , A61K9/10
CPC分类号： A61K6/083 , A61K33/14 , A61K6/0008 , A61K6/0017
摘要： There is provided a dental composition for relieving dentin hypersensitivity, which occludes dentinal tubules having an opening on the surface of dentin to relieve dentin hypersensitivity thereby to give an immediate relieving effect and to maintain the relieving effect for a long time.The dental composition for relieving dentin hypersensitivity, which comprises (A) a low molecular weight compound which can produce a precipitate which is hardly soluble in water when it reacts with a calcium compound, or which comprises the above component (A), (B) a calcium compound and/or (C) an aqueous polymer emulsion having a particle size smaller than that of a dentinal tubule and forming an agglomerate or a hardly soluble gel larger than the diameter of a dentinal tubule when it reacts with a calcium compound.
摘要翻译： PCT No.PCT / JP95 / 02511 Sec。 371日期：1996年8月7日 102（e）日期1996年8月7日PCT 1995年12月7日PCT PCT。公开号WO96 / 17581 日期1996年6月13日提供了用于缓解牙本质过敏症的牙科用组合物，其堵塞在牙质表面上具有开口的牙质小管以减轻牙质过敏，从而立即释放效果并长时间保持缓解作用。用于缓解牙本质过敏症的牙科用组合物，其包含（A）低分子量化合物，其可以产生当与钙化合物反应时难溶于水的沉淀物，或包含上述组分（A），（B）钙化合物和/或（C）具有小于牙质小管的颗粒尺寸的颗粒尺寸的水性聚合物乳液，并且当其与钙化合物反应时，形成大于牙质小管的直径的凝聚体或难溶性凝胶。

5. 发明授权

US5834532A Primer composition and curable composition 失效
公开(公告)号：US5834532A
公开(公告)日：1998-11-10
申请号：US871686
申请日：1997-06-09
申请人： Takashi Yamamoto , Weiping Zeng , Masami Arata , Tsuyoshi Banba , Harumi Tanaka
发明人： Takashi Yamamoto , Weiping Zeng , Masami Arata , Tsuyoshi Banba , Harumi Tanaka
IPC分类号： A61K6/00 , A61K6/083 , C09J4/00 , C08L47/00 , C08K5/20
CPC分类号： A61K6/083 , A61K6/0008 , A61K6/0088 , A61K6/024 , C09J4/00
摘要： A curable composition comprising a polymerizable monomer having an acidic group in its molecule and an initiator. The composition has a viscosity in the range of from 100 to 30,000 cP at 37.5.degree. C. and may have additionally contain other polymerizable monomer and/or a filler. The composition is applied to a tooth surface directly or after applying a primer composition. There is also provided the primer composition which comprises a polymerizable monomer having an acidic group and a solvent.

6. 发明授权

US5766328A Dental composition for relieving dentin hypersensitivity 失效
标题翻译：用于缓解牙本质过敏的牙科成分
公开(公告)号：US5766328A
公开(公告)日：1998-06-16
申请号：US788566
申请日：1997-01-24
申请人： Nobuo Nakabayashi , Takashi Yamamoto , Yasukazu Saimi , Masami Arata , Harumi Tanaka
发明人： Nobuo Nakabayashi , Takashi Yamamoto , Yasukazu Saimi , Masami Arata , Harumi Tanaka
IPC分类号： A61K8/362 , A61K8/81 , A61Q11/00 , C08F2/26 , A61K6/00 , C09J133/06 , C09J133/12
CPC分类号： A61K8/362 , A61K6/0008 , A61K6/0017 , A61K8/8152 , A61Q11/00 , A61K2800/88
摘要： There is provided a dental composition for relieving dentin hypersensitivity comprising (A) an aqueous emulsion component which contains, as emulsion particles, polymer particles having a diameter smaller than that of a dentinal tubule and forming an agglomerate larger than the diameter of a dentinal tubule when they react with a calcium compound, and (B) a water-soluble organic acid component or a water-soluble salt component thereof, a calcium salt of the organic acid being insoluble or hardly soluble in water. Using this composition, dentinal tubules open to the surface of dentin are occluded to relieve dentin hypersensitivity immediately and lastingly.
摘要翻译：提供了一种用于缓解牙本质过敏的牙科用组合物，其包含（A）含水乳液组分，其含有直径小于牙质小管的直径的聚合物颗粒作为乳液颗粒，并形成大于牙质小管直径的团聚体，它们与钙化合物反应，和（B）水溶性有机酸组分或其水溶性盐组分，有机酸的钙盐不溶或几乎不溶于水。使用这种组合物，开放到牙本质表面的牙质小管被闭塞，以立即和持续地缓解牙质过敏。

7. 发明授权

US5670559A Primer solution composition for dental bonding 失效
标题翻译：用于牙科粘合的底漆溶液组合物
公开(公告)号：US5670559A
公开(公告)日：1997-09-23
申请号：US447943
申请日：1995-05-23
申请人： Weiping Zeng , Masami Arata , Tsuyoshi Banba
发明人： Weiping Zeng , Masami Arata , Tsuyoshi Banba
IPC分类号： A61K6/00 , C08L33/02 , A61K6/083 , C08K3/10
CPC分类号： A61K6/0073
摘要： A primer composition for the treatment of a tooth surface, which comprises a) at least one metal compound selected from the group consisting of an iron compound, a copper compound and a cobalt compound, b) a polymerizable monomer having an acidic group, and c) water or water and an organic solvent miscible with water; and a method of forming an adhesive layer on a tooth surface, which comprises applying this primer composition to the tooth surface and then applying a curable composition containing trialkylborane or partial oxide thereof and a polymerizable monomer. According to the present invention, both the enamel and the dentin of a tooth can be simultaneously surface-treated without acid treatment or washing with water, and adhesion dental treatment can be reliably carried out by a simple operation without causing pains on a patient.
摘要翻译：一种用于牙齿表面处理的底漆组合物，其包含：a）至少一种选自铁化合物，铜化合物和钴化合物的金属化合物，b）具有酸性基团的可聚合单体，c ）水或水和与水混溶的有机溶剂; 以及在牙齿表面上形成粘合剂层的方法，其包括将该底漆组合物涂布在牙齿表面上，然后涂布含有三烷基硼烷或其部分氧化物的可固化组合物和可聚合单体。根据本发明，牙齿的牙釉质和牙本质可以在不进行酸处理或用水洗涤的情况下同时进行表面处理，并且可以通过简单的操作可靠地进行粘合牙科治疗，而不会对患者造成疼痛。

8. 发明授权

US08946317B2 Composition for hard tissue repair 有权
标题翻译：组织硬组织修复
公开(公告)号：US08946317B2
公开(公告)日：2015-02-03
申请号：US13508451
申请日：2010-11-18
申请人： Noriaki Asada , Shinya Aoki , Hiroshi Naruse , Shoichi Miyakoshi , Masami Arata
发明人： Noriaki Asada , Shinya Aoki , Hiroshi Naruse , Shoichi Miyakoshi , Masami Arata
IPC分类号： A61F2/00 , A61L27/54 , A61L27/16 , C08F265/06 , A61L24/00 , A61L24/06
CPC分类号： A61L27/54 , A61L24/0015 , A61L24/06 , A61L27/16 , A61L2300/404 , A61L2430/02 , C08F265/06 , C08L33/06 , C08L33/12
摘要： The composition for hard tissue repair of the present invention is characterized by comprising 5 to 98.95 parts by weight of a monomer (A), 1 to 75 parts by weight of a (meth)acrylate polymer (B) and 0.05 to 20 parts by weight of a polymerization initiator composition (C) containing an organoboron compound (c1), with the proviso that the total amount of the components (A), (B) and (C) is 100 parts by weight. The composition undergoes small-scale heat generation during curing and can ensure a sufficient working time.
摘要翻译：本发明的硬组织修复用组合物的特征在于，含有5〜98.95重量份单体（A），1〜75重量份（甲基）丙烯酸酯聚合物（B）和0.05〜20重量份含有有机硼化合物（c1）的聚合引发剂组合物（C），前提条件是组分（A），（B）和（C）的总量为100重量份。组合物在固化期间经历小规模的发热并且可以确保足够的工作时间。

9. 发明授权

US08242188B2 Dental self-etching primer composition 有权
标题翻译：牙科自蚀底漆组合物
公开(公告)号：US08242188B2
公开(公告)日：2012-08-14
申请号：US12447874
申请日：2007-10-26
申请人： Masami Arata , Akari Yamamoto , Yoshiaki Katsura
发明人： Masami Arata , Akari Yamamoto , Yoshiaki Katsura
IPC分类号： C08L47/00
CPC分类号： A61K6/0079 , A61K6/0029 , C08L33/00 , C08L43/02
摘要： A dental self-etching primer composition and a dental self-etching primer kit comprising a mixture of (A) a polymerizable monomer, (B) a reducing inorganic compound containing sulfur, (C) a ketone-based solvent and (D) water and having a storage stability of 2 hours or longer at 65° C.
摘要翻译：牙科自蚀刻底漆组合物和牙科自蚀刻底漆试剂盒，其包含（A）可聚合单体，（B）含硫还原性无机化合物，（C）酮类溶剂和（D）水的混合物和在65℃下具有2小时或更长时间的储存稳定性

10. 发明申请

US20100292359A1 Reaction-Curable Adhesive Composition and Dental Adhesive Kit 有权
标题翻译：反应可固化粘合剂组合物和牙科粘合剂套件
公开(公告)号：US20100292359A1
公开(公告)日：2010-11-18
申请号：US12599821
申请日：2008-05-14
申请人： Takashi Yamamoto , Toshiki Ono , Masami Arata , Tatsuya Ori
发明人： Takashi Yamamoto , Toshiki Ono , Masami Arata , Tatsuya Ori
IPC分类号： C08F2/46 , A61K6/08
CPC分类号： A61K6/09 , A61K6/0017 , A61K6/0023 , A61K6/0038 , A61K6/083 , C08K5/175 , C08K5/18 , C09J11/06 , C08L33/00 , C08L75/16 , C08L31/04 , C08L25/04
摘要： A reaction-curable adhesive composition exhibiting acidity is formed form a weakly acidic to alkaline composition (I) comprising (a) a polymerizable monomer and (b) a compound represented by the following formula (1) and a strongly acidic composition (II) comprising (a) a polymerizable monomer. R1—C6H4—NR2CH2COOR3 (1) wherein R1 and R2 are each independently a hydrogen atom or an alkyl group which may have a functional group, and R3 is a hydrogen atom or a metal atom. The composition containing the polymerizable monomer can be stably stored for a long period of time.
摘要翻译：表现出酸性的反应性固化型粘合剂组合物由弱酸性至碱性组合物（I）形成，其包含（a）可聚合单体和（b）由下式（1）表示的化合物和强酸性组合物（II），包含（a）可聚合单体。 R1-C6H4-NR2CH2COOR3（1）其中R1和R2各自独立地为氢原子或可具有官能团的烷基，R3为氢原子或金属原子。含有可聚合单体的组合物可以长期稳定地储存。

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