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1. 发明授权

US08021861B2 Pathogenic Escherichia coli associated protein 失效
标题翻译：致病性大肠杆菌相关蛋白
公开(公告)号：US08021861B2
公开(公告)日：2011-09-20
申请号：US11693665
申请日：2007-03-29
申请人： B. Brett Finlay , Brendan Kenny , Markus Stein , Michael S. Donnenberg , Li-Ching Lai
发明人： B. Brett Finlay , Brendan Kenny , Markus Stein , Michael S. Donnenberg , Li-Ching Lai
IPC分类号： C12P21/04
CPC分类号： C12Q1/025 , A61K38/00 , A61K39/00 , C07K14/245 , C07K16/1232 , C07K2319/00 , G01N33/56916 , G01N2333/245
摘要： The present invention provides a polypeptide, called EspA, which is secreted by pathogenic E. coli, such as the enteropathogenic (SPEC) and enterohemorrhagic (EHEC) E. coli. The invention also provides isolated nucleic acid sequences encoding EspA polypeptide, EspA peptides, a recombinant method for producing recombinant EspA, antibodies which bind to EspA, and a kit for the detection of EspA-producing E. coli.
摘要翻译：本发明提供称为EspA的多肽，其由病原性大肠杆菌分泌，例如肠致病性（SPEC）和肠出血性（EHEC）大肠杆菌。本发明还提供编码EspA多肽，EspA肽，用于产生重组EspA的重组方法，与EspA结合的抗体的分离的核酸序列和用于检测产生EspA的大肠杆菌的试剂盒。

2. 发明申请

US20100256951A1 Method for Contactless Capacitive Thickness Measurements 有权
标题翻译：非接触电容厚度测量方法
公开(公告)号：US20100256951A1
公开(公告)日：2010-10-07
申请号：US12664975
申请日：2008-08-19
申请人： Stefan Konermann , Markus Stein
发明人： Stefan Konermann , Markus Stein
IPC分类号： G01B7/06 , G01R27/26 , G06F15/00
CPC分类号： G01B7/087
摘要： A method for contactless capacitive thickness measurement of a flat material (10) that is placed in the fringe field (32) of a capacitor (C1, C2), with simultaneous measurement of the width L of an air gap (16) between the flat material and the capacitor plates, in which the capacities gL, kL of two capacitors (C1, C2) are measured whose fringe fields (32) decay at different rates towards the flat material (10), and in that both, the thickness D of the flat material (10) and the width L of the air gap (16) are determined on the basis of the condition that, for each capacitor (C1, C2), the measured capacity gL, kL is equal to the integral of the capacity gradient g′, k′ over the thickness of the flat material (10).
摘要翻译：一种放置在电容器（C1，C2）的边缘区域（32）中的扁平材料（10）的非接触电容厚度测量方法，同时测量平坦的空气间隙（16）的宽度L 材料和电容器板，其中测量两个电容器（C1，C2）的电容gL，kL，其边缘场（32）以不同的速率朝向扁平材料（10）衰减，并且在两者中，厚度D 基于对于每个电容器（C1，C2），测量容量gL，kL等于容量的积分的条件来确定气隙（16）的扁平材料（10）和气隙（16）的宽度L 梯度g'，k'超过扁平材料（10）的厚度。

3. 发明申请

US20070218518A1 Host Receptor for Pathogenic Bacteria 审中-公开
公开(公告)号：US20070218518A1
公开(公告)日：2007-09-20
申请号：US11558275
申请日：2006-11-09
申请人： Brett Finlay , Brendan Kenny , Rebekah DeVinney , Markus Stein
发明人： Brett Finlay , Brendan Kenny , Rebekah DeVinney , Markus Stein
IPC分类号： G01N33/569
CPC分类号： C07K14/245 , A61K38/00 , A61K39/0258 , C07K16/1232 , C07K2319/00 , Y02A50/474 , Y10S435/975 , Y10S530/825
摘要： A polypeptide, called Tir (for translocated intimin receptor, which is secreted by attaching and effacing pathogens, such as the enteropathogenic (EPEC) and enterohemorrhagic (EHEC) E. coli. These bacterial pathogens inserts their own receptors into mammalian cell surfaces, to which the bacterial pathogen then adheres to trigger additional host signaling events and actin nucleation. Diagnosis of disease caused by pathogenic E. coli can be performed by the use of antibodies which bind to Tir to detect the protein or the use of nucleic acid probes for detection of nucleic acids encoding Tir polypeptide. Isolated nucleic acid sequences encoding Tir polypeptide, Tir peptides, a recombinant method for producing recombinant Tir, antibodies which bind to Tir, and a kit for the detection of Tir-producing E. coli are provided. A method of immunizing a host with Tir to induce a protective immune response to Tir or a second polypeptide of interest is also provided. A method for screening for compounds which interfere with the binding of bacterial pathogens to their receptors is further provided.

4. 发明授权

US07208574B1 Host receptor for pathogenic bacteria 失效
标题翻译：病原菌宿主受体
公开(公告)号：US07208574B1
公开(公告)日：2007-04-24
申请号：US09189415
申请日：1998-11-10
申请人： B. Brett Finlay , Brendan Kenny , Rebekah DeVinney , Markus Stein
发明人： B. Brett Finlay , Brendan Kenny , Rebekah DeVinney , Markus Stein
IPC分类号： C07K1/00 , C07K2/00 , A61K39/02 , A61K39/108 , A61K39/00 , A61K38/00
CPC分类号： C07K14/245 , A61K38/00 , A61K39/0258 , C07K16/1232 , C07K2319/00 , Y02A50/474 , Y10S435/975 , Y10S530/825
摘要： A polypeptide, called Tir (for translocated intimin receptor, which is secreted by attaching and effacing pathogens, such as the enteropathogenic (EPEC) and enterohemorrhagic (EHEC) E. coli. These bacterial pathogens inserts their own receptors into mammalian cell surfaces, to which the bacterial pathogen then adheres to trigger additional host signaling events and actin nucleation. Diagnosis of disease caused by pathogenic E. coli can be performed by the use of antibodies which bind to Tir to detect the protein or the use of nucleic acid probes for detection of nucleic acids encoding Tir polypeptide. Isolated nucleic acid sequences encoding Tir polypeptide, Tir peptides, a recombinant method for producing recombinant Tir, antibodies which bind to Tir, and a kit for the detection of Tir-producing E. coli are provided. A method of immunizing a host with Tir to induce a protective immune response to Tir or a second polypeptide of interest is also provided. A method for screening for compounds which interfere with the binding of bacterial pathogens to their receptors is further provided.
摘要翻译：称为Tir（用于易位的intimin受体）的多肽，其通过附着和消除病原体如肠致病性（EPEC）和肠出血性（EHEC）大肠杆菌而分泌，这些细菌病原体将其自身的受体插入哺乳动物细胞表面，其中细菌病原体然后粘附以触发另外的宿主信号事件和肌动蛋白成核。由致病性大肠杆菌引起的疾病的诊断可以通过使用结合Tir的抗体来检测蛋白质或使用核酸探针来检测提供编码Tir多肽的核酸，分离编码Tir多肽，Tir肽，重组Tir重组方法，与Tir结合的抗体的核酸序列，以及用于检测产生Tir的大肠杆菌的试剂盒。还提供用Tir免疫宿主以诱导针对Tir或第二感兴趣的多肽的保护性免疫应答。用于筛选组合物的方法进一步提供干扰细菌病原体与其受体的结合的蛋白质。

5. 发明申请

US20070010184A1 TOOL WITH A CARRIER PART AND A DISC-SHAPED WORKING PART 审中-公开
标题翻译：具有运输部件和盘形工作部件的工具
公开(公告)号：US20070010184A1
公开(公告)日：2007-01-11
申请号：US11428753
申请日：2006-07-05
申请人： Markus Stein , Nicolas Huth
发明人： Markus Stein , Nicolas Huth
IPC分类号： B23F21/03
CPC分类号： B24D13/20 , B24B45/003 , B24D9/085
摘要： A tool exhibits a carrier part and a disc-shaped working part for chip-forming machining. The two parts are detachably connected with each other by means of a coupling part and a counter-coupling part that inter-lock. They exhibit convex and concave wall sections adapted to each other. Moreover, there is created a latch-in connection by an inside hexagon aperture and an outside hexagon.
摘要翻译：刀具具有用于芯片成形加工的托架部件和盘形加工部件。这两个部件通过联锁部分和相互锁定的反耦合部分可拆卸地彼此连接。它们表现出适合于彼此的凸和凹壁部分。此外，通过内六角孔和外六边形形成闩锁连接。

6. 发明申请

US20060292180A1 Pathogenic Escherichia coli associated protein 失效
标题翻译：致病性大肠杆菌相关蛋白
公开(公告)号：US20060292180A1
公开(公告)日：2006-12-28
申请号：US11411382
申请日：2006-04-25
申请人： B. Finlay , Brendan Kenny , Markus Stein , Michael Donnenberg , Li-Ching Lai
发明人： B. Finlay , Brendan Kenny , Markus Stein , Michael Donnenberg , Li-Ching Lai
IPC分类号： A61K39/108 , C07K14/245
CPC分类号： C12Q1/025 , A61K38/00 , A61K39/00 , C07K14/245 , C07K16/1232 , C07K2319/00 , G01N33/56916 , G01N2333/245
摘要： The present invention provides a polypeptide, called EspA, which is secreted by pathogenic E. coli, such as the enteropathogenic (SPEC) and enterohemorrhagic (EHEC) E. coli. The invention also provides isolated nucleic acid sequences encoding EspA polypeptide, EspA peptides, a recombinant method for producing recombinant EspA, antibodies which bind to EspA, and a kit for the detection of EspA-producing E. coli.
摘要翻译：本发明提供称为EspA的多肽，其由病原性大肠杆菌分泌，例如肠致病性（SPEC）和肠出血性（EHEC）大肠杆菌。本发明还提供编码EspA多肽，EspA肽，用于产生重组EspA的重组方法，与EspA结合的抗体的分离的核酸序列和用于检测产生EspA的大肠杆菌的试剂盒。

7. 发明授权

US07078193B2 Pathogenic Escherichia coli associated protein espA 失效
标题翻译：致病性大肠杆菌相关蛋白质
公开(公告)号：US07078193B2
公开(公告)日：2006-07-18
申请号：US09967347
申请日：2001-09-28
申请人： B. Brett Finlay , Brendan Kenny , Markus Stein , Michael S. Donnenberg , Li-Ching Lai
发明人： B. Brett Finlay , Brendan Kenny , Markus Stein , Michael S. Donnenberg , Li-Ching Lai
IPC分类号： C12P21/04
CPC分类号： C12Q1/025 , A61K38/00 , A61K39/00 , C07K14/245 , C07K16/1232 , C07K2319/00 , G01N33/56916 , G01N2333/245
摘要： The present invention provides a polypeptide, called EspA, which is secreted by pathogenic E. coli, such as the enteropathogenic (EPEC) and enterohemorrhagic (EHEC) E. coli. The invention also provides isolated nucleic acid sequences encoding EspA polypeptide, EspA peptides, a recombinant method for producing recombinant EspA, antibodies which bind to EspA, and a kit for the detection of EspA-producing E. coli.
摘要翻译：本发明提供称为EspA的多肽，其由病原性大肠杆菌分泌，如肠致病性（EPEC）和肠出血性（EHEC）大肠杆菌。本发明还提供编码EspA多肽，EspA肽，用于产生重组EspA的重组方法，与EspA结合的抗体的分离的核酸序列和用于检测产生EspA的大肠杆菌的试剂盒。

8. 发明授权

US06541986B2 Sensor for the capacitive measurement of film with thicknesses 失效
标题翻译：用于具有厚度的膜的电容测量的传感器
公开(公告)号：US06541986B2
公开(公告)日：2003-04-01
申请号：US09931445
申请日：2001-08-16
申请人： Markus Stein , Stefan Konermann
发明人： Markus Stein , Stefan Konermann
IPC分类号： G01R2726
CPC分类号： G01B7/087 , G01D5/2405
摘要： A sensor for the capacitive measurement of film thicknesses, with a drum (10), which rolls along the film (12) and has at least one measuring capacitor (C1-C4), the plates of which are disposed in the peripheral surface of the drum (10), so that its capacitance is effected by the thickness of the firm, and with a transformer (26), for transmitting the measurement signal from the rotating drum (10) to the stationary part (28), where an oscillator (OSZ1-OSZ4), which is integrated in the drum (10), generates a frequency signal (24), which depends on the capacitance of the measuring capacitor (C1-C4).
摘要翻译：一种用于电容测量膜厚度的传感器，具有滚筒（10），其沿着膜（12）滚动并且具有至少一个测量电容器（C1-C4），其板被设置在所述膜的外周表面中鼓（10），使得其电容由公司的厚度和用于将测量信号从旋转鼓（10）传输到静止部分（28）的变压器（26）实现，其中振荡器集成在滚筒（10）中的OSZ1-OSZ4）产生取决于测量电容器（C1-C4）的电容的频率信号（24）。

9. 发明授权

US08315833B2 Method for contactless capacitive thickness measurements 有权
标题翻译：非接触电容厚度测量方法
公开(公告)号：US08315833B2
公开(公告)日：2012-11-20
申请号：US12664975
申请日：2008-08-19
申请人： Stefan Konermann , Markus Stein
发明人： Stefan Konermann , Markus Stein
IPC分类号： G01B7/02 , G01B11/02 , G01B13/02
CPC分类号： G01B7/087
摘要： A method for contactless capacitive thickness measurement of a flat material (10) that is placed in the fringe field (32) of a capacitor (C1,C2), with simultaneous measurement of the width L of an air gap (16) between the flat material and the capacitor plates, in which the capacities gL, kL of two capacitors (C1, C2) are measured whose fringe fields (32) decay at different rates towards the flat material (10), and in that both, the thickness D of the flat material (10) and the width L of the air gap (16) are determined on the basis of the condition that, for each capacitor (C1, C2), the measured capacity gL, kL is equal to the integral of the capacity gradient g′, k′ over the thickness of the flat material (10).
摘要翻译：一种放置在电容器（C1，C2）的边缘区域（32）中的扁平材料（10）的非接触电容厚度测量方法，同时测量平坦的空气间隙（16）的宽度L 材料和电容器板，其中测量两个电容器（C1，C2）的电容gL，kL，其边缘场（32）以不同的速率朝向扁平材料（10）衰减，并且在两者中，厚度D 基于对于每个电容器（C1，C2），测量容量gL，kL等于容量的积分的条件来确定气隙（16）的扁平材料（10）和气隙（16）的宽度L 梯度g'，k'超过扁平材料（10）的厚度。

10. 发明授权

US07531315B2 Method for detecting a host receptor for pathogenic bacteria 失效
标题翻译：检测病原菌宿主受体的方法
公开(公告)号：US07531315B2
公开(公告)日：2009-05-12
申请号：US11558277
申请日：2006-11-09
申请人： Brett B. Finlay , Brendan Kenny , Rebekah DeVinney , Markus Stein
发明人： Brett B. Finlay , Brendan Kenny , Rebekah DeVinney , Markus Stein
IPC分类号： G01N33/53 , G01N33/569 , G01N33/00
CPC分类号： C07K14/245 , A61K38/00 , A61K39/0258 , C07K16/1232 , C07K2319/00 , Y02A50/474 , Y10S435/975 , Y10S530/825
摘要： A polypeptide, called Tir (for translocated intimin receptor, which is secreted by attaching and effacing pathogens, such as the enteropathogenic (EPEC) and enterohemorrhagic (EHEC) E. coli. These bacterial pathogens inserts their own receptors into mammalian cell surfaces, to which the bacterial pathogen then adheres to trigger additional host signaling events and actin nucleation. Diagnosis of disease caused by pathogenic E. coli can be performed by the use of antibodies which bind to Tir to detect the protein or the use of nucleic acid probes for detection of nucleic acids encoding Tir polypeptide. Isolated nucleic acid sequences encoding Tir polypeptide, Tir peptides, a recombinant method for producing recombinant Tir, antibodies which bind to Tir, and a kit for the detection of Tir-producing E. coli are provided. A method of immunizing a host with Tir to induce a protective immune response to Tir or a second polypeptide of interest is also provided. A method for screening for compounds which interfere with the binding of bacterial pathogens to their receptors is further provided.
摘要翻译：称为Tir的多肽（用于易位的intimin受体，其通过附着和消除病原体如肠致病性（EPEC）和肠出血性（EHEC）大肠杆菌）分泌，这些细菌病原体将它们自己的受体插入哺乳动物细胞表面，其中细菌病原体然后粘附以触发另外的宿主信号事件和肌动蛋白成核。由病原性大肠杆菌引起的疾病的诊断可以通过使用结合Tir的抗体来检测蛋白质或使用核酸探针来检测提供编码Tir多肽的核酸，分离编码Tir多肽，Tir肽，重组Tir重组方法，与Tir结合的抗体的核酸序列，以及用于检测产生Tir的大肠杆菌的试剂盒。还提供用Tir免疫宿主以诱导针对Tir或第二感兴趣的多肽的保护性免疫应答。用于筛选组合物的方法进一步提供干扰细菌病原体与其受体的结合的蛋白质。

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