会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 5. 发明授权
    • Host receptor for pathogenic bacteria
    • 病原菌宿主受体
    • US07208574B1
    • 2007-04-24
    • US09189415
    • 1998-11-10
    • B. Brett FinlayBrendan KennyRebekah DeVinneyMarkus Stein
    • B. Brett FinlayBrendan KennyRebekah DeVinneyMarkus Stein
    • C07K1/00C07K2/00A61K39/02A61K39/108A61K39/00A61K38/00
    • C07K14/245A61K38/00A61K39/0258C07K16/1232C07K2319/00Y02A50/474Y10S435/975Y10S530/825
    • A polypeptide, called Tir (for translocated intimin receptor, which is secreted by attaching and effacing pathogens, such as the enteropathogenic (EPEC) and enterohemorrhagic (EHEC) E. coli. These bacterial pathogens inserts their own receptors into mammalian cell surfaces, to which the bacterial pathogen then adheres to trigger additional host signaling events and actin nucleation. Diagnosis of disease caused by pathogenic E. coli can be performed by the use of antibodies which bind to Tir to detect the protein or the use of nucleic acid probes for detection of nucleic acids encoding Tir polypeptide. Isolated nucleic acid sequences encoding Tir polypeptide, Tir peptides, a recombinant method for producing recombinant Tir, antibodies which bind to Tir, and a kit for the detection of Tir-producing E. coli are provided. A method of immunizing a host with Tir to induce a protective immune response to Tir or a second polypeptide of interest is also provided. A method for screening for compounds which interfere with the binding of bacterial pathogens to their receptors is further provided.
    • 称为Tir(用于易位的intimin受体)的多肽,其通过附着和消除病原体如肠致病性(EPEC)和肠出血性(EHEC)大肠杆菌而分泌,这些细菌病原体将其自身的受体插入哺乳动物细胞表面,其中 细菌病原体然后粘附以触发另外的宿主信号事件和肌动蛋白成核。由致病性大肠杆菌引起的疾病的诊断可以通过使用结合Tir的抗体来检测蛋白质或使用核酸探针来检测 提供编码Tir多肽的核酸,分离编码Tir多肽,Tir肽,重组Tir重组方法,与Tir结合的抗体的核酸序列,以及用于检测产生Tir的大肠杆菌的试剂盒。 还提供用Tir免疫宿主以诱导针对Tir或第二感兴趣的多肽的保护性免疫应答。用于筛选组合物的方法 进一步提供干扰细菌病原体与其受体的结合的蛋白质。