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1. 发明申请

US20110003339A1 Pathogenic Escherichia Coli Associated Protein 失效
标题翻译：致病性大肠杆菌相关蛋白
公开(公告)号：US20110003339A1
公开(公告)日：2011-01-06
申请号：US11693665
申请日：2007-03-29
申请人： B. Brett Finlay , Brendan Kenny , Markus Stein , Michael S. Donnenberg , Li-Ching Lai
发明人： B. Brett Finlay , Brendan Kenny , Markus Stein , Michael S. Donnenberg , Li-Ching Lai
IPC分类号： C12P21/00
CPC分类号： C12Q1/025 , A61K38/00 , A61K39/00 , C07K14/245 , C07K16/1232 , C07K2319/00 , G01N33/56916 , G01N2333/245
摘要： The present invention provides a polypeptide, called EspA, which is secreted by pathogenic E. coli, such as the enteropathogenic (SPEC) and enterohemorrhagic (EHEC) E. coli. The invention also provides isolated nucleic acid sequences encoding EspA polypeptide, EspA peptides, a recombinant method for producing recombinant EspA, antibodies which bind to EspA, and a kit for the detection of EspA-producing E. coli.
摘要翻译：本发明提供称为EspA的多肽，其由病原性大肠杆菌分泌，例如肠致病性（SPEC）和肠出血性（EHEC）大肠杆菌。本发明还提供编码EspA多肽，EspA肽，用于产生重组EspA的重组方法，与EspA结合的抗体的分离的核酸序列和用于检测产生EspA的大肠杆菌的试剂盒。

2. 发明授权

US07300659B2 Enterohemorrhagic Escherichia coli vaccine 有权
标题翻译：肠出血性大肠杆菌疫苗
公开(公告)号：US07300659B2
公开(公告)日：2007-11-27
申请号：US10039760
申请日：2002-01-03
申请人： B. Brett Finlay , Andrew A. Potter
发明人： B. Brett Finlay , Andrew A. Potter
IPC分类号： A61K39/02
CPC分类号： A61K39/0258 , A61K2039/55566 , C07K14/245 , Y02A50/474
摘要： Compositions and methods for stimulating an immune response against a secreted enterohemorragic Escherichia coli (EHEC) antigen are disclosed. The compositions comprise EHEC cell culture supernatants.
摘要翻译：公开了用于刺激针对分泌的肠出血性大肠杆菌（EHEC）抗原的免疫应答的组合物和方法。组合物包含EHEC细胞培养物上清液。

3. 发明申请

US20090068230A1 ENTEROHEMORRHAGIC ESCHERICHIA COLI VACCINE 审中-公开
公开(公告)号：US20090068230A1
公开(公告)日：2009-03-12
申请号：US11876671
申请日：2007-10-22
申请人： B. Brett Finlay , Andrew A. Potter
发明人： B. Brett Finlay , Andrew A. Potter
IPC分类号： A61K39/108 , A61P31/06 , A61P37/04
CPC分类号： A61K39/0258 , A61K2039/55566 , C07K14/245 , Y02A50/474
摘要： Compositions and methods for stimulating an immune response against a secreted enterohemorragic Escherichia coli (EHEC) antigen are disclosed. The compositions comprise EHEC cell culture supernatants.
摘要翻译：公开了用于刺激针对分泌的肠道大肠杆菌（EHEC）抗原的免疫应答的组合物和方法。组合物包含EHEC细胞培养物上清液。

4. 发明授权

US08021861B2 Pathogenic Escherichia coli associated protein 失效
标题翻译：致病性大肠杆菌相关蛋白
公开(公告)号：US08021861B2
公开(公告)日：2011-09-20
申请号：US11693665
申请日：2007-03-29
申请人： B. Brett Finlay , Brendan Kenny , Markus Stein , Michael S. Donnenberg , Li-Ching Lai
发明人： B. Brett Finlay , Brendan Kenny , Markus Stein , Michael S. Donnenberg , Li-Ching Lai
IPC分类号： C12P21/04
CPC分类号： C12Q1/025 , A61K38/00 , A61K39/00 , C07K14/245 , C07K16/1232 , C07K2319/00 , G01N33/56916 , G01N2333/245
摘要： The present invention provides a polypeptide, called EspA, which is secreted by pathogenic E. coli, such as the enteropathogenic (SPEC) and enterohemorrhagic (EHEC) E. coli. The invention also provides isolated nucleic acid sequences encoding EspA polypeptide, EspA peptides, a recombinant method for producing recombinant EspA, antibodies which bind to EspA, and a kit for the detection of EspA-producing E. coli.
摘要翻译：本发明提供称为EspA的多肽，其由病原性大肠杆菌分泌，例如肠致病性（SPEC）和肠出血性（EHEC）大肠杆菌。本发明还提供编码EspA多肽，EspA肽，用于产生重组EspA的重组方法，与EspA结合的抗体的分离的核酸序列和用于检测产生EspA的大肠杆菌的试剂盒。

5. 发明授权

US07208574B1 Host receptor for pathogenic bacteria 失效
标题翻译：病原菌宿主受体
公开(公告)号：US07208574B1
公开(公告)日：2007-04-24
申请号：US09189415
申请日：1998-11-10
申请人： B. Brett Finlay , Brendan Kenny , Rebekah DeVinney , Markus Stein
发明人： B. Brett Finlay , Brendan Kenny , Rebekah DeVinney , Markus Stein
IPC分类号： C07K1/00 , C07K2/00 , A61K39/02 , A61K39/108 , A61K39/00 , A61K38/00
CPC分类号： C07K14/245 , A61K38/00 , A61K39/0258 , C07K16/1232 , C07K2319/00 , Y02A50/474 , Y10S435/975 , Y10S530/825
摘要： A polypeptide, called Tir (for translocated intimin receptor, which is secreted by attaching and effacing pathogens, such as the enteropathogenic (EPEC) and enterohemorrhagic (EHEC) E. coli. These bacterial pathogens inserts their own receptors into mammalian cell surfaces, to which the bacterial pathogen then adheres to trigger additional host signaling events and actin nucleation. Diagnosis of disease caused by pathogenic E. coli can be performed by the use of antibodies which bind to Tir to detect the protein or the use of nucleic acid probes for detection of nucleic acids encoding Tir polypeptide. Isolated nucleic acid sequences encoding Tir polypeptide, Tir peptides, a recombinant method for producing recombinant Tir, antibodies which bind to Tir, and a kit for the detection of Tir-producing E. coli are provided. A method of immunizing a host with Tir to induce a protective immune response to Tir or a second polypeptide of interest is also provided. A method for screening for compounds which interfere with the binding of bacterial pathogens to their receptors is further provided.
摘要翻译：称为Tir（用于易位的intimin受体）的多肽，其通过附着和消除病原体如肠致病性（EPEC）和肠出血性（EHEC）大肠杆菌而分泌，这些细菌病原体将其自身的受体插入哺乳动物细胞表面，其中细菌病原体然后粘附以触发另外的宿主信号事件和肌动蛋白成核。由致病性大肠杆菌引起的疾病的诊断可以通过使用结合Tir的抗体来检测蛋白质或使用核酸探针来检测提供编码Tir多肽的核酸，分离编码Tir多肽，Tir肽，重组Tir重组方法，与Tir结合的抗体的核酸序列，以及用于检测产生Tir的大肠杆菌的试剂盒。还提供用Tir免疫宿主以诱导针对Tir或第二感兴趣的多肽的保护性免疫应答。用于筛选组合物的方法进一步提供干扰细菌病原体与其受体的结合的蛋白质。

6. 发明授权

US07078193B2 Pathogenic Escherichia coli associated protein espA 失效
标题翻译：致病性大肠杆菌相关蛋白质
公开(公告)号：US07078193B2
公开(公告)日：2006-07-18
申请号：US09967347
申请日：2001-09-28
申请人： B. Brett Finlay , Brendan Kenny , Markus Stein , Michael S. Donnenberg , Li-Ching Lai
发明人： B. Brett Finlay , Brendan Kenny , Markus Stein , Michael S. Donnenberg , Li-Ching Lai
IPC分类号： C12P21/04
CPC分类号： C12Q1/025 , A61K38/00 , A61K39/00 , C07K14/245 , C07K16/1232 , C07K2319/00 , G01N33/56916 , G01N2333/245
摘要： The present invention provides a polypeptide, called EspA, which is secreted by pathogenic E. coli, such as the enteropathogenic (EPEC) and enterohemorrhagic (EHEC) E. coli. The invention also provides isolated nucleic acid sequences encoding EspA polypeptide, EspA peptides, a recombinant method for producing recombinant EspA, antibodies which bind to EspA, and a kit for the detection of EspA-producing E. coli.
摘要翻译：本发明提供称为EspA的多肽，其由病原性大肠杆菌分泌，如肠致病性（EPEC）和肠出血性（EHEC）大肠杆菌。本发明还提供编码EspA多肽，EspA肽，用于产生重组EspA的重组方法，与EspA结合的抗体的分离的核酸序列和用于检测产生EspA的大肠杆菌的试剂盒。

7. 发明授权

US08586057B2 Enterohemorrhagic Escherichia coli vaccine 有权
标题翻译：肠出血性大肠杆菌疫苗
公开(公告)号：US08586057B2
公开(公告)日：2013-11-19
申请号：US11876655
申请日：2007-10-22
申请人： B. Brett Finlay , Andrew A. Potter
发明人： B. Brett Finlay , Andrew A. Potter
IPC分类号： A61K39/02
CPC分类号： A61K39/0258 , A61K2039/55566 , C07K14/245 , Y02A50/474
摘要： Compositions and methods for stimulating an immune response against a secreted enterohemorragic Escherichia coli (EHEC) antigen are disclosed. The compositions comprise EHEC cell culture supernatants.
摘要翻译：公开了用于刺激针对分泌的肠道大肠杆菌（EHEC）抗原的免疫应答的组合物和方法。组合物包含EHEC细胞培养物上清液。

8. 发明授权

US07507787B2 Effectors of innate immunity 有权
标题翻译：先天免疫力的作用
公开(公告)号：US07507787B2
公开(公告)日：2009-03-24
申请号：US10308905
申请日：2002-12-02
申请人： Robert E. W. Hancock , B. Brett Finlay , Monisha Gough Scott , Dawn Bowdish , Carrie Melissa Rosenberger , Jon-Paul Steven Powers
发明人： Robert E. W. Hancock , B. Brett Finlay , Monisha Gough Scott , Dawn Bowdish , Carrie Melissa Rosenberger , Jon-Paul Steven Powers
IPC分类号： A61K38/00 , A61K38/28 , A61K38/04 , C07K14/00 , C07K16/00
CPC分类号： A61K38/1709 , A61K38/10 , A61K38/193 , C07K7/08 , C07K14/4723 , C07K14/521 , C07K14/7158 , C12Q1/6883 , C12Q2600/158 , G01N33/505 , A61K2300/00
摘要： A method of identifying a polynucleotide or pattern of polynucleotides regulated by one or more sepsis or inflammatory inducing agents and inhibited by a peptide is described. A method of identifying a pattern of polynucleotide expression for inhibition of an inflammatory or septic response. The method includes contacting cells with LPS, LTA, CpG DNA and/or intact microbe or microbial components in the presence or absence of a cationic peptide; detecting a pattern of polynucleotide expression for the cells in the presence and absence of the peptide, wherein the pattern in the presence of the peptide represents inhibition of an inflammatory or septic response. Also included are compounds and agents identified by the methods of the invention. In another aspect, the invention provides methods and compounds for enhancing innate immunity in a subject.
摘要翻译：描述了鉴定由一种或多种脓毒症或炎性诱导剂调节并被肽抑制的多核苷酸的多核苷酸或图案的方法。鉴定抑制炎性或败血症反应的多核苷酸表达模式的方法。该方法包括在存在或不存在阳离子肽的情况下使细胞与LPS，LTA，CpG DNA和/或完整的微生物或微生物组分接触; 在存在和不存在肽的情况下检测细胞的多核苷酸表达的模式，其中在肽存在下的图案表示炎症或败血病应答的抑制。还包括通过本发明的方法鉴定的化合物和试剂。另一方面，本发明提供用于增强受试者的先天免疫力的方法和化合物。

9. 发明申请

US20080145384A1 ENTEROHEMORRHAGIC ESCHERICHIA COLI VACCINE 有权
公开(公告)号：US20080145384A1
公开(公告)日：2008-06-19
申请号：US11876655
申请日：2007-10-22
申请人： B. Brett Finlay , Andrew A. Potter
发明人： B. Brett Finlay , Andrew A. Potter
IPC分类号： A61K39/108 , A61P31/04
CPC分类号： A61K39/0258 , A61K2039/55566 , C07K14/245 , Y02A50/474
摘要： Compositions and methods for stimulating an immune response against a secreted enterohemorragic Escherichia coli (EHEC) antigen are disclosed. The compositions comprise EHEC cell culture supernatants.
摘要翻译：公开了用于刺激针对分泌的肠道大肠杆菌（EHEC）抗原的免疫应答的组合物和方法。组合物包含EHEC细胞培养物上清液。

10. 发明授权

US06355254B1 Pathogenic Escherichia coli associated protein EspA 有权
标题翻译：致病性大肠杆菌相关蛋白质EspA
公开(公告)号：US06355254B1
公开(公告)日：2002-03-12
申请号：US09171517
申请日：1999-08-10
申请人： B. Brett Finlay , Brendan Kenny , Markus Stein , Michael S. Donnenberg , Li-Ching Lai
发明人： B. Brett Finlay , Brendan Kenny , Markus Stein , Michael S. Donnenberg , Li-Ching Lai
IPC分类号： A61K39108
CPC分类号： C12Q1/025 , A61K38/00 , A61K39/00 , C07K14/245 , C07K16/1232 , C07K2319/00 , G01N33/56916 , G01N2333/245
摘要： The present invention provides the EspA polypeptide, which is secreted by pathogenic E coli, such as the enteropathogenic (EPEC) and enterohemorrhagic (EHEC) E coli. Diagnosis of disease caused by such pathogenic E coli can be performed by standard techniques, such as those based upon the use of antibodies which bind to EspA to detect the protein, as well as those based on the use of nucleic acid probes for detection of nucleic acids encoding EspA protein. The invention also provides isolated nucleic acid sequences encoding EspA, EspA polypeptide, EspA peptides, a method for producing recombinant EspA, antibodies which bind to EspA, and a kit for the detection of EspA-producing E coli. The invention also provides a method of immunizing a host with EspA to induce a protective immune response to EspA.
摘要翻译：本发明提供由致病性大肠杆菌分泌的EspA多肽，例如肠致病性（EPEC）和肠出血性（EHEC）大肠杆菌。由这种致病性大肠杆菌引起的疾病的诊断可以通过标准技术进行，例如基于使用结合EspA的抗体检测蛋白质的那些技术，以及基于使用核酸探针检测核酸的那些编码EspA蛋白的酸。本发明还提供编码EspA，EspA多肽，EspA肽的分离的核酸序列，用于产生重组EspA的方法，与EspA结合的抗体，以及用于检测产生EspA的大肠杆菌的试剂盒。本发明还提供了用EspA免疫宿主以诱导对EspA的保护性免疫应答的方法。

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