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1. 发明申请

US20210369666A1 DEVICES AND METHODS FOR THE TREATMENT OF A ZOONOTIC HERPESVIRUS INFECTION 有权
公开(公告)号：US20210369666A1
公开(公告)日：2021-12-02
申请号：US16345300
申请日：2017-10-26
申请人： Thessicar E. ANTOINE , Julia HILLARD , Rainer ADELUNG , Yogendra Kumar MISHRA , Deepak SHUKLA , Mark PRAUSNITZ , GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. , KIEL UNIVERSITY , UNIVERSITY OF ILLINOIS AT CHICAGO , GEORGIA TECH RESEARCH CORPORATION
发明人： Thessicar E. ANTOINE , Julia HILLARD , Rainer ADELUNG , Yogendra Kumar MISHRA , Deepak SHUKLA , Mark PRAUSNITZ
IPC分类号： A61K31/315 , A61K31/522 , A61K9/00
摘要： The present disclosure relates to tetrapodal zinc-oxide nanostructures (T-ZONS), microneedle devices, and methods for treating or preventing a zoonotic herpesvirus infection.

2. 发明申请

US20070260201A1 METHOD FOR DRUG DELIVERY TO OCULAR TISSUE USING MICRONEEDLE 有权
标题翻译：使用MICRONEEDLE将药物递送至眼用组织的方法
公开(公告)号：US20070260201A1
公开(公告)日：2007-11-08
申请号：US11743535
申请日：2007-05-02
申请人： Mark Prausnitz , Ninghao Jiang , Henry Edelhauser
发明人： Mark Prausnitz , Ninghao Jiang , Henry Edelhauser
IPC分类号： A61M5/32
CPC分类号： A61F9/0017 , A61M2037/0061
摘要： Methods and devices are provided for administering a drug to a patient's eye. The methods include (a) inserting a hollow microneedle into the sclera or corneal stroma without penetrating across the sclera or corneal stroma; and (b) infusing a fluid drug formulation through the microneedle and into the sclera or cornea. It further may include partially retracting the microneedle before infusion to enhance delivery. Alternatively, the methods may include (a) inserting a solid microneedle into the sclera or corneal stroma without penetrating across the sclera or corneal stroma, wherein the solid microneedle comprises a first quantity of a drug formulation and inserting causes the solid microneedle to form a pocket in the sclera or corneal stroma; and (b) releasing the drug formulation into the pocket to form a drug depot, whereby a drug is released from the depot. The methods and devices may include an array of multiple microneedles.
摘要翻译：提供了用于向患者的眼睛施用药物的方法和装置。所述方法包括（a）将中空微针插入巩膜或角膜基质中而不穿透巩膜或角膜基质; 和（b）将流体药物制剂通过微针注入巩膜或角膜。它还可以包括在输注之前部分缩回微针以增强递送。或者，所述方法可以包括（a）将固体微针插入巩膜或角膜基质中而不穿透巩膜或角膜基质，其中固体微针包含第一量的药物制剂并且插入导致固体微针形成口袋在巩膜或角膜基质中; 和（b）将药物制剂释放到口袋中以形成药物库，由此从药剂库释放药物。所述方法和装置可以包括多个微针的阵列。

3. 发明申请

US20050137525A1 Drilling microneedle device 审中-公开
标题翻译：钻孔微针装置
公开(公告)号：US20050137525A1
公开(公告)日：2005-06-23
申请号：US10861244
申请日：2004-06-04
申请人： Ping Wang , Mark Prausnitz
发明人： Ping Wang , Mark Prausnitz
IPC分类号： A61B10/00 , A61B10/02 , A61M5/32 , A61M5/42 , A61M37/00 , A61M31/00
CPC分类号： A61M37/0015 , A61B10/0283 , A61M5/3298 , A61M5/425 , A61M5/46 , A61M2005/3289 , A61M2037/0023 , A61M2037/003 , A61M2037/0038 , A61M2037/0053
摘要： Rotating microneedles and microneedle arrays are disclosed that “drill” holes into a biological barrier, such as skin. The holes can of controlled depth and diameter and suitable for microsurgery, administering drugs and withdrawal of body fluids.
摘要翻译：公开了旋转微针和微针阵列，“钻”孔进入生物屏障，如皮肤。孔可以控制深度和直径，适用于显微外科手术，服用药物和排出体液。

4. 发明申请

US20080045879A1 Methods and Devices for Thermal Treatment 有权
标题翻译：热处理方法和装置
公开(公告)号：US20080045879A1
公开(公告)日：2008-02-21
申请号：US11597969
申请日：2005-05-31
申请人： Mark Prausnitz , Mark Allen , Jung-Hwan Park , Yong-Kyu Yoon , Jin-Woo Park
发明人： Mark Prausnitz , Mark Allen , Jung-Hwan Park , Yong-Kyu Yoon , Jin-Woo Park
IPC分类号： A61N1/30
CPC分类号： A61K9/0004 , A61B5/14514 , A61B18/082 , A61B18/10 , A61B2018/00005 , A61B2018/00613 , A61K9/7023 , A61K41/0047 , A61M37/0015 , A61M37/0092 , A61M2037/0007 , A61M2037/0046 , A61N1/0412 , A61N1/0476 , A61N1/0492 , A61N1/327
摘要： The present invention comprises methods and devices for thermal treatment of a barrier to increase the permeability of the barrier. One form of increasing the permeability of the barrier comprises forming micropores which may be used for administration of active agents across the barrier, or may be used for sampling or collecting fluids, or may be used for detecting, measuring or determining analytes, or may be used for monitoring of physiological or other conditions. Devices of the present invention may comprise microheaters that are activated by inductive or ohmic heating power supply components.
摘要翻译：本发明包括用于热处理屏障以增加屏障的渗透性的方法和装置。增加屏障渗透性的一种形式包括形成微孔，该微孔可用于通过阻挡层施用活性剂，或可用于取样或收集流体，或可用于检测，测量或确定分析物，或者可以是用于监测生理或其他条件。本发明的装置可以包括由电感或欧姆加热电源部件激活的微热电。

5. 发明申请

US20080027384A1 Drilling microneedle device 审中-公开
标题翻译：钻孔微针装置
公开(公告)号：US20080027384A1
公开(公告)日：2008-01-31
申请号：US11699206
申请日：2007-01-29
申请人： Ping Wang , Mark Prausnitz
发明人： Ping Wang , Mark Prausnitz
IPC分类号： A61M5/158
CPC分类号： A61M37/0015 , A61B10/0283 , A61M5/3298 , A61M5/425 , A61M5/46 , A61M2005/3289 , A61M2037/0023 , A61M2037/003 , A61M2037/0038 , A61M2037/0053
摘要： Rotating microneedles and microneedle arrays are disclosed that “drill” holes into a biological barrier, such as skin. The holes can of controlled depth and diameter and suitable for microsurgery, administering drugs and withdrawal of body fluids.
摘要翻译：公开了旋转微针和微针阵列，“钻”孔进入生物屏障，如皮肤。孔可以控制深度和直径，适用于显微外科手术，服用药物和排出体液。

6. 发明申请

US20070225676A1 Microneedle drug delivery device 失效
标题翻译：微针药物输送装置
公开(公告)号：US20070225676A1
公开(公告)日：2007-09-27
申请号：US11805096
申请日：2007-05-21
申请人： Mark Prausnitz , Mark Allen , Inder-Jeet Gujral
发明人： Mark Prausnitz , Mark Allen , Inder-Jeet Gujral
IPC分类号： A61M31/00
CPC分类号： A61M37/0015 , A61B5/14514 , A61B5/14532 , A61B5/150022 , A61B5/150969 , A61B5/150984 , A61B17/205 , A61B2090/0814 , A61M5/422 , A61M2037/0023 , A61M2037/003 , B33Y80/00
摘要： Simple microneedle devices for delivery of drugs across or into biological tissue are provided, which permit drug delivery at clinically relevant rates across or into skin or other tissue barriers, with minimal or no damage, pain, or irritation to the tissue. The devices include a substrate to which a plurality of hollow microneedles are attached or integrated, and at least one reservoir, containing the drug, selectably in communication with the microneedles, wherein the volume or amount of drug to be delivered can be selectively altered. The reservoir can be formed of a deformable, preferably elastic, material. The device typically includes a means, such as a plunger, for compressing the reservoir to drive the drug from the reservoir through the microneedles, In one embodiment, the reservoir is a syringe or pump connected to the substrate.
摘要翻译：提供用于在生物组织中或在生物组织中递送药物的简单微针装置，其允许以临床相关的速率穿过或进入皮肤或其它组织屏障的药物递送，对组织进行最小的或没有损伤，疼痛或刺激。所述装置包括多个中空微针连接或整合到其上的基底，以及容纳药物的至少一个储存器，可选择地与微针连通，其中可以选择性地改变要递送的药物的体积或量。储存器可以由可变形的，优选弹性的材料形成。该装置通常包括用于压缩储存器以通过微针从储存器驱动药物的装置，例如柱塞。在一个实施例中，储存器是连接到基板的注射器或泵。

7. 发明申请

US20050137531A1 Devices and methods for enhanced microneedle penetration of biological barriers 审中-公开
标题翻译：增强生物屏障微针穿透的装置和方法
公开(公告)号：US20050137531A1
公开(公告)日：2005-06-23
申请号：US10856691
申请日：2004-05-28
申请人： Mark Prausnitz , Mark Allen , Sebastian Henry , Devin McAllister , Donald Ackley , Thomas Jackson
发明人： Mark Prausnitz , Mark Allen , Sebastian Henry , Devin McAllister , Donald Ackley , Thomas Jackson
IPC分类号： A61B5/00 , A61B5/15 , A61B17/20 , A61M5/42 , A61M37/00 , A61M5/00
CPC分类号： A61M37/0015 , A61B5/14514 , A61B5/14532 , A61B5/150022 , A61B5/150068 , A61B5/150076 , A61B5/150083 , A61B5/150099 , A61B5/150213 , A61B5/150229 , A61B5/150389 , A61B5/150412 , A61B5/150503 , A61B5/150984 , A61B5/151 , A61B17/205 , A61M5/422 , A61M5/425 , A61M2037/0023 , A61M2037/003 , A61M2037/0053 , B33Y80/00
摘要： Microneedle devices and methods of use thereof are provided for the enhanced transport of molecules, including drugs and biological molecules, across tissue by improving the interaction of microneedles and a deformable, elastic biological barrier, such as human skin. The devices and methods act to (1) limit the elasticity, (2) adapt to the elasticity, (3) utilize alternate ways of creating the holes for the microneedles to penetrate the biological barrier, other than the simply direct pressure of the microneedle substrate to the barrier surface, or (4) any combination of these methods. In preferred embodiments for limiting the elasticity of skin, the microneedle device includes features suitable for stretching, pulling, or pinching the skin to present a more rigid, less deformable, surface in the area to which the microneedles are applied (i.e. penetrate). In a preferred embodiments for adapting the device to the elasticity of skin, the device comprising one or more extensions interposed between the substrate and the base end of at least a portion of the microneedles.
摘要翻译：提供微针装置及其使用方法用于通过改善微针和可变形的弹性生物屏障（例如人皮肤）的相互作用来增强跨组织的分子（包括药物和生物分子）的转运。装置和方法用于（1）限制弹性，（2）适应弹性，（3）除了微针衬底的简单直接压力之外，利用替代方式产生微针穿透生物屏障的孔或（4）这些方法的任何组合。在用于限制皮肤弹性的优选实施例中，微针装置包括适于拉伸，拉伸或夹紧皮肤以在微针施加的区域（即，穿透）上呈现更刚性，更不易变形的表面的特征。在用于使装置适应皮肤弹性的优选实施例中，该装置包括一个或多个延伸部，该延伸部插入到基底和至少一部分微针的基端之间。

8. 发明申请

US20070073197A1 Assessment and control of acoustic tissue effects 有权
标题翻译：评估和控制声学组织的影响
公开(公告)号：US20070073197A1
公开(公告)日：2007-03-29
申请号：US11556074
申请日：2006-11-02
申请人： Mark Prausnitz , Jin Liu , Thomas Lewis
发明人： Mark Prausnitz , Jin Liu , Thomas Lewis
IPC分类号： A61H1/00 , A61H1/02
CPC分类号： A61K41/0023 , A61B5/14532 , A61K41/0047 , A61M37/0092
摘要： A method for reversibly, or irreveribly, altering the permeability of cells, tissues or other biological barriers, to molecules to be transported into or through these materials, through the application of acoustic energy, is enhanced by applying the ultrasound in combination with means for monitoring and/or implementing feedback controls. The acoustic energy is applied directly or indirectly to the cells or tissue whose permeability is to be altered, at a frequency and intensity appropriate to alter the permeability to achieve the desired effect, such as the transport of endogenous or exogenous molecules and/or fluid, for drug delivery, measurement of analyte, removal of fluid, alteration of cell or tissue viability or alteration of structure of materials such as kidney or gall bladder stones. In the preferred embodiment, the method includes measuring the strength of the acoustic field applied to the cell or tissue at the applied frequency or other frequencies, and using the acoustic measurement to modify continued or subsequent application of acoustic energy to the cell or tissue. In another preferred embodiment, the method further includes simultaneously, previously, or subsequently exposing the cell or tissue to the chemical or biological agent to be transported into or across the cell or tissue. In another preferred application, the method includes removing biological fluid or molecules from the cell or tissue simultaneously, previously or subsequently to the application of acoustic energy and, optionally, assaying the biological fluid or molecules.
摘要翻译：通过应用声能来结合使用超声波手段来增强通过施加声能可逆地或不可逆地地将细胞，组织或其它生物屏障的透过性改变为要被输送入或穿过这些材料的分子的方法和/或实施反馈控制。将声能直接地或间接地施加到要改变其渗透性的细胞或组织，其频率和强度适于改变渗透性以实现所需的效果，例如内源性或外源性分子和/或流体的转运，用于药物递送，分析物的测量，流体的去除，细胞或组织的活力的改变或材料如肾或胆囊结石的结构的改变。在优选实施例中，该方法包括以施加的频率或其他频率来测量施加到细胞或组织的声场的强度，并且使用声学测量来修改对细胞或组织的声能的持续或随后的应用。在另一个优选的实施方案中，该方法还包括同时，预先或随后将细胞或组织暴露于待转运至细胞或组织中的化学或生物试剂。在另一个优选的应用中，该方法包括在预先或随后施加声能并且任选地测定生物流体或分子的同时，从细胞或组织中移除生物流体或分子。

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