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1. 发明申请

US20180052106A1 DUAL DETECTION SCHEME FOR DNA SEQUENCING 审中-公开
公开(公告)号：US20180052106A1
公开(公告)日：2018-02-22
申请号：US15239032
申请日：2016-08-17
申请人： Kerry Gunning , Donald Ackley , Chan-Long Shieh
发明人： Kerry Gunning , Donald Ackley , Chan-Long Shieh
IPC分类号： G01N21/64 , C12Q1/68 , G01N27/414
CPC分类号： G01N21/6428 , C12Q1/6869 , G01N27/4145 , G01N2021/6439 , G01N2201/062 , C12Q2563/107 , C12Q2565/607
摘要： Apparatus for fluorescent and ion sensing of DNA nucleotide incorporation events including DNA nucleotide incorporation structure designed to have sequencing primers bonded to a surface for the incorporation of DNA nucleotides thereon. At least some of the DNA nucleotides having a fluorescent label. A photodiode positioned adjacent the incorporation structure and an illumination device positioned adjacent the DNA nucleotide incorporation structure to illuminate DNA nucleotides incorporated onto the sequencing primers. The illumination device exciting the fluorescent labels when incorporation occurs and the photodiode positioned to sense the excited fluorescent labels. Ion sensing apparatus positioned adjacent the DNA nucleotide incorporation structure including a metal oxide thin film transistor with a gate electrically coupled to receive an electrical signal indicative of ion emissions produced by the DNA nucleotide incorporated onto DNA target fragments or sequencing primers.

2. 发明授权

US06203981B1 Transistor-based molecular detection apparatus and method 失效
标题翻译：基于晶体管的分子检测装置及方法
公开(公告)号：US06203981B1
公开(公告)日：2001-03-20
申请号：US09068172
申请日：1999-02-08
申请人： Donald Ackley , Chan-Long Shieh , Thomas B. Harvey, III
发明人： Donald Ackley , Chan-Long Shieh , Thomas B. Harvey, III
IPC分类号： C12Q168
CPC分类号： G01N33/5438 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00653 , B01J2219/00659 , G01N27/4145
摘要： Adjacent first and second transistors are integrated with a substrate. Each of the first and second transistors has a gate electrode, a source electrode, a drain electrode and a semiconductive channel formed of an organic material, the semiconductive channel electrically coupling the source electrode with the drain electrode. The source electrode of the first transistor is electrically coupled to the source electrode of the second transistor. A molecular receptor is bound directly to a surface of the semiconductive channel of the first transistor. A non-zero offset voltage, which produces equal channel currents in the semiconductive channels of the first and second transistors after a molecule has bound with the molecular receptor without a like binding event proximate to the second transistor, is sensed between the gate electrodes of the first and second transistors.
摘要翻译：相邻的第一和第二晶体管与衬底集成。第一和第二晶体管中的每一个具有栅电极，源电极，漏电极和由有机材料形成的半导体沟道，半导体沟道将源电极与漏电极电耦合。第一晶体管的源电极电耦合到第二晶体管的源电极。分子受体直接结合到第一晶体管的半导体通道的表面。在零分子与分子受体结合而没有靠近第二晶体管的相似结合事件之后，在第一和第二晶体管的半导体通道中产生相等的沟道电流的非零偏移电压被感测在第一和第二晶体管。

3. 发明申请

US20050137531A1 Devices and methods for enhanced microneedle penetration of biological barriers 审中-公开
标题翻译：增强生物屏障微针穿透的装置和方法
公开(公告)号：US20050137531A1
公开(公告)日：2005-06-23
申请号：US10856691
申请日：2004-05-28
申请人： Mark Prausnitz , Mark Allen , Sebastian Henry , Devin McAllister , Donald Ackley , Thomas Jackson
发明人： Mark Prausnitz , Mark Allen , Sebastian Henry , Devin McAllister , Donald Ackley , Thomas Jackson
IPC分类号： A61B5/00 , A61B5/15 , A61B17/20 , A61M5/42 , A61M37/00 , A61M5/00
CPC分类号： A61M37/0015 , A61B5/14514 , A61B5/14532 , A61B5/150022 , A61B5/150068 , A61B5/150076 , A61B5/150083 , A61B5/150099 , A61B5/150213 , A61B5/150229 , A61B5/150389 , A61B5/150412 , A61B5/150503 , A61B5/150984 , A61B5/151 , A61B17/205 , A61M5/422 , A61M5/425 , A61M2037/0023 , A61M2037/003 , A61M2037/0053 , B33Y80/00
摘要： Microneedle devices and methods of use thereof are provided for the enhanced transport of molecules, including drugs and biological molecules, across tissue by improving the interaction of microneedles and a deformable, elastic biological barrier, such as human skin. The devices and methods act to (1) limit the elasticity, (2) adapt to the elasticity, (3) utilize alternate ways of creating the holes for the microneedles to penetrate the biological barrier, other than the simply direct pressure of the microneedle substrate to the barrier surface, or (4) any combination of these methods. In preferred embodiments for limiting the elasticity of skin, the microneedle device includes features suitable for stretching, pulling, or pinching the skin to present a more rigid, less deformable, surface in the area to which the microneedles are applied (i.e. penetrate). In a preferred embodiments for adapting the device to the elasticity of skin, the device comprising one or more extensions interposed between the substrate and the base end of at least a portion of the microneedles.
摘要翻译：提供微针装置及其使用方法用于通过改善微针和可变形的弹性生物屏障（例如人皮肤）的相互作用来增强跨组织的分子（包括药物和生物分子）的转运。装置和方法用于（1）限制弹性，（2）适应弹性，（3）除了微针衬底的简单直接压力之外，利用替代方式产生微针穿透生物屏障的孔或（4）这些方法的任何组合。在用于限制皮肤弹性的优选实施例中，微针装置包括适于拉伸，拉伸或夹紧皮肤以在微针施加的区域（即，穿透）上呈现更刚性，更不易变形的表面的特征。在用于使装置适应皮肤弹性的优选实施例中，该装置包括一个或多个延伸部，该延伸部插入到基底和至少一部分微针的基端之间。

4. 发明申请

US20080121733A1 Droplet generating device and method 审中-公开
标题翻译：液滴生成装置及方法
公开(公告)号：US20080121733A1
公开(公告)日：2008-05-29
申请号：US11605683
申请日：2006-11-29
申请人： Donald Ackley , Anita Forster
发明人： Donald Ackley , Anita Forster
IPC分类号： B05B17/00
CPC分类号： B05B7/0012 , B05B17/04
摘要： A method of generating mono-dispersed nano- and micro-liposomes using droplet generators includes a step of providing a droplet generator with a carrier fluid inlet, a focusing fluid inlet, and an outlet for focusing fluid and liposomes. A carrier fluid including an aqueous solution and a focusing fluid including a solvent and lipid mixture are selected to form a partially miscible fluid system. The selected carrier fluid is injected into the carrier fluid inlet and the selected focusing fluid is injected into the focusing fluid inlet and the focusing fluid and liposomes are collected from the outlet. The focusing fluid is removed from the liposomes by diluting the focusing fluid in water.
摘要翻译：使用液滴发生器产生单分散纳米和微脂质体的方法包括向液滴发生器提供载体流体入口，聚焦流体入口和用于聚焦流体和脂质体的出口的步骤。选择包括水溶液和包含溶剂和脂质混合物的聚焦流体的载体流体以形成部分可混溶的流体系统。将所选择的载体流体注入到载体流体入口中，并将所选择的聚焦流体注入聚焦流体入口，并从出口收集聚焦流体和脂质体。通过将聚焦流体稀释在水中，将聚焦流体从脂质体中除去。

5. 发明申请

US20060250236A1 Pod-based wireless sensor system 审中-公开
标题翻译：基于荚的无线传感器系统
公开(公告)号：US20060250236A1
公开(公告)日：2006-11-09
申请号：US11121675
申请日：2005-05-04
申请人： Donald Ackley , Inder-Jeet Gujiral
发明人： Donald Ackley , Inder-Jeet Gujiral
IPC分类号： G08B21/00
CPC分类号： G08B13/1966 , G08B13/19697 , G08B25/009 , G08B25/08 , G08B25/10 , H04L67/04 , H04L67/12
摘要： A pod-based wireless security system has a plurality of sensor pods with each sensor pod including a plurality of different sensors, a battery pack, a low bandwidth wireless interface, a high bandwidth wireless interface, and a sensor controller. The invention further contemplates a method of using the pod-based wireless security system, which includes providing the plurality of sensor pods, distributing the plurality of sensor pods about an area to be protected, coupling adjacent sensor pods with a low bandwidth wireless protocol and with a high bandwidth wireless protocol through the low bandwidth wireless interface and high bandwidth wireless interface, and using the low bandwidth wireless protocol for routine data transfer and system maintenance and coordination.
摘要翻译：基于pod的无线安全系统具有多个传感器盒，每个传感器盒包括多个不同的传感器，电池组，低带宽无线接口，高带宽无线接口和传感器控制器。本发明进一步考虑了一种使用基于荚的无线安全系统的方法，该系统包括提供多个传感器盒，围绕要保护的区域分布多个传感器盒，将相邻的传感器盒与低带宽无线协议相结合，并且通过低带宽无线接口和高带宽无线接口实现高带宽无线协议，并采用低带宽无线协议进行日常数据传输和系统维护与协调。

6. 发明申请

US20080019872A1 Circuits for the Control of Output Current in an Electronic Device for Performing Active Biological Operations 失效
标题翻译：用于控制电子设备中用于执行主动生物操作的输出电流的电路
公开(公告)号：US20080019872A1
公开(公告)日：2008-01-24
申请号：US11775724
申请日：2007-07-10
申请人： Donald Ackley , Scott Graham
发明人： Donald Ackley , Scott Graham
IPC分类号： G01N33/48
CPC分类号： C12Q1/6816 , B01J19/0046 , B01J19/0093 , B01J2219/00315 , B01J2219/00317 , B01J2219/00527 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00617 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00653 , B01J2219/00659 , B01J2219/00686 , B01J2219/00689 , B01J2219/00695 , B01J2219/00702 , B01J2219/00713 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , B01L3/5027 , B01L3/502707 , B01L3/50273 , B01L3/502761 , B01L3/5085 , B01L9/527 , B01L2200/025 , B01L2200/027 , B01L2200/0647 , B01L2200/0689 , B01L2200/12 , B01L2300/0636 , B01L2300/0645 , B01L2300/0654 , B01L2300/0816 , B01L2300/0877 , B01L2300/0887 , B01L2400/0415 , B01L2400/0421 , B82Y5/00 , B82Y10/00 , C07B2200/11 , C07H21/00 , C07K1/04 , C07K1/045 , C07K1/047 , C12Q1/6813 , C12Q1/6825 , C12Q1/6837 , C40B40/06 , C40B40/10 , C40B40/12 , C40B60/14 , F04B19/006 , G01N27/44743 , G11C13/0014 , G11C13/0019 , G11C13/04 , G11C19/00 , H01L25/50 , H01L2924/0002 , C12Q2565/515 , C12Q2565/607 , H01L2924/00
摘要： A circuit for control of an output current in a multiple unit cell array includes an array of unit cells arranged in rows and columns. Each unit cell includes a column select transistor being adapted for control by a column selector and a row select transistor being adapted for control by a row selector. The column select transistor and the row select transistor are connected together in series to each other and between an output node and a first supply. A return electrode is provided to complete the circuit.
摘要翻译：用于控制多单元电池阵列中的输出电流的电路包括以行和列布置的单元电池阵列。每个单位单元包括适于由列选择器控制的列选择晶体管和适于由行选择器控制的行选择晶体管。列选择晶体管和行选择晶体管彼此串联连接在输出节点和第一电源之间。提供返回电极来完成电路。

7. 发明申请

US20060251275A1 Output circuit for use with musical instruments 审中-公开
标题翻译：输出电路用于乐器
公开(公告)号：US20060251275A1
公开(公告)日：2006-11-09
申请号：US11121676
申请日：2005-05-04
申请人： Donald Ackley
发明人： Donald Ackley
IPC分类号： G10H1/00
CPC分类号： G10H3/186
摘要： An attenuation circuit is disclosed that is adapted to be electrically connected between an output stage of a guitar amplifier and a speaker. The attenuation circuit includes a plurality of passive components including a series resistor, a parallel resistor, and an inductance. The series resistor, the parallel resistor, and the inductance are coupled to connect the series resistor in series between the output stage of the guitar amplifier and the speaker, to connect the parallel resistor in series with the inductance, and to connect the series connected parallel resistor and the inductance in parallel with the speaker to present a constant resistive impedance to said output stage and to attenuate power delivered from the output stage to the speaker.
摘要翻译：公开了一种适于电连接在吉他放大器的输出级与扬声器之间的衰减电路。衰减电路包括多个无源元件，包括串联电阻，并联电阻和电感。串联电阻，并联电阻和电感耦合，将串联电阻串联连接在吉他放大器的输出级与扬声器之间，将并联电阻串联连接到电感上，并将串联连接的并联电阻器和与扬声器并联的电感，以向所述输出级呈现恒定的阻抗阻抗并且衰减从输出级传递到扬声器的功率。

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