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1. 发明申请

US20110184112A1 SILICONE RUBBER COMPOSITIONS 审中-公开
标题翻译：硅橡胶组合物
公开(公告)号：US20110184112A1
公开(公告)日：2011-07-28
申请号：US12992408
申请日：2009-05-14
申请人： Catherine Dickins , Phillip Joseph Griffith , Michael Protor , Rosemary Margaret Taylor
发明人： Catherine Dickins , Phillip Joseph Griffith , Michael Protor , Rosemary Margaret Taylor
IPC分类号： C08K3/22
CPC分类号： C09C1/407 , C08G77/12 , C08G77/16 , C08G77/18 , C08G77/20 , C08G77/24 , C08G77/70 , C08K5/14 , C08K9/06 , C08L83/04 , C09C1/0081 , C09C1/402 , C09C3/08 , C09C3/12 , C08L2666/54 , C08L83/00
摘要： There is provided a silicone rubber composition comprising an organopolysiloxane having a viscosity of at least 250,000 mPa·s at 250C, treated filler, and an organic peroxide curing agent. The composition is substantially free of reinforcing silica fillers and is characterised in that the filler comprises a mixture of aluminium trihydroxide and kaolin in a ratio of from 1:3 to 4:1.
摘要翻译：提供一种硅橡胶组合物，其包含在250℃下粘度为至少25万mPa·s的有机聚硅氧烷，处理过的填料和有机过氧化物固化剂。所述组合物基本上不含增强二氧化硅填料，其特征在于填料包含比例为1:3至4:1的三氢氧化铝和高岭土的混合物。

2. 发明授权

US5919298A Method for preparing hydrophobic fumed silica 失效
标题翻译：制备疏水性热解法二氧化硅的方法
公开(公告)号：US5919298A
公开(公告)日：1999-07-06
申请号：US5852
申请日：1998-01-12
申请人： Phillip Joseph Griffith , William Herron , Brian Robert Harkness , Rosemary Margaret Taylor , David James Wilson
发明人： Phillip Joseph Griffith , William Herron , Brian Robert Harkness , Rosemary Margaret Taylor , David James Wilson
IPC分类号： C01B33/18 , C08K3/36 , C08K9/06 , C09C1/30 , C04B14/04
CPC分类号： C09C1/3081 , C08K3/36 , C08K9/06 , C01P2006/12 , C01P2006/90
摘要： A method for the preparation of hydrophobic fumed silicas which are useful, for example, as reinforcing fillers in rubber compositions. The method comprises two steps, where in the first step an aqueous suspension of fumed silica is contacted with an organosilicon compound in the presence of a catalytic amount of an acid to effect hydrophobing of the fumed silica. In the preferred method the first step is conducted in the presence of a water miscible organic solvent which facilitates hydrophobing of the fumed silica with the organosilicon compound and the fumed silica has a BET surface area greater than 50 m.sup.2 /g. In the second step the aqueous suspension of the fumed silica is contacted with a water-immiscible organic solvent at a solvent to silica weight ratio greater than 0.1:1 to effect separation of the hydrophobic fumed silica from the aqueous phase. In a preferred process the hydrophobic fumed silica has a surface area within a range of about 100 m.sup.2 /g to 750 m.sup.2 /g.
摘要翻译：用于制备疏水性热解法二氧化硅的方法，其可用于例如橡胶组合物中的增强填料。该方法包括两个步骤，其中在第一步骤中，在催化量的酸存在下，将热解法二氧化硅的水悬浮液与有机硅化合物接触以进行热解法二氧化硅的疏水。在优选的方法中，第一步是在水混溶性有机溶剂的存在下进行，该有机溶剂有利于有机硅化合物的热解法二氧化硅的疏水化，并且煅制二氧化硅的BET表面积大于50m 2 / g。在第二步中，将热解法二氧化硅的水悬浮液与水不混溶的有机溶剂以溶剂与二氧化硅重量比大于0.1:1的比例接触，以使疏水性热解二氧化硅与水相分离。在优选的方法中，疏水性热解法二氧化硅具有在约100m 2 / g至750m 2 / g范围内的表面积。

3. 发明授权

US09849247B2 Low dose prefilled drug delivery device and method 有权
公开(公告)号：US09849247B2
公开(公告)日：2017-12-26
申请号：US13261383
申请日：2011-01-31
申请人： Margaret Taylor , James Bates , Roman Tunkel , Jay Butterbrodt , Gary Searle , Joshua Horvath , Keith Knapp, II , Edward Gillen
发明人： Margaret Taylor , James Bates , Roman Tunkel , Jay Butterbrodt , Gary Searle , Joshua Horvath , Keith Knapp, II , Edward Gillen
IPC分类号： A61M5/24 , A61M5/32 , A61M5/42 , A61M5/00 , A61M5/20
CPC分类号： A61M5/2425 , A61M5/2459 , A61M5/3287 , A61M5/425 , A61M2005/005 , A61M2005/206
摘要： A drug delivery device (100) for administering a low dose of a medicament includes a housing (111) and a drug reservoir (101) disposed in the housing (111). A needle (135) is connected to the drug reservoir (101). A pressure applying member (113) is movably connected to the housing (111) and is movable between first and second positions. The pressure applying member (113) does not apply pressure to the drug reservoir (101) in the first position and applies pressure to the drug reservoir (101) in the second position to dispense medicament stored in the drug reservoir (101). A method of administering a low dose of insulin to simulate a first-phase insulin response of a pancreas is also disclosed.

4. 发明授权

US09107988B2 Circuitous band needle changing apparatus 有权
标题翻译：电路带更换装置
公开(公告)号：US09107988B2
公开(公告)日：2015-08-18
申请号：US13206405
申请日：2011-08-09
申请人： Michel Bruehwiler , Cole Constantineau , Ryan Schoonmaker , James Bates , Margaret Taylor , Robert Banik
发明人： Michel Bruehwiler , Cole Constantineau , Ryan Schoonmaker , James Bates , Margaret Taylor , Robert Banik
IPC分类号： A61M5/00
CPC分类号： A61M5/008 , A61M2005/004
摘要： An apparatus is disclosed for storing and changing needles for a medicament delivery device having a medicament container, including a fixed mount for connecting the apparatus with the medicament delivery device, a needle holder displaceable along a circuitous path and connecting a plurality of needles displaceably disposed thereon, and a guide member for guiding displacement of the needle holder, the guide member being disposed about the fixed mount. The apparatus also includes a user interface rotatably disposed about the fixed mount and having at least one internal engaging structure for displacing the needle holder along the circuitous path.
摘要翻译：公开了一种用于存储和更换用于具有药物容器的药物输送装置的针的装置，其包括用于将装置与药物输送装置连接的固定支架，可沿着迂回路径移动并连接可移动地设置在其上的多个针的针保持器以及用于引导针保持器的位移的引导构件，所述引导构件围绕固定座设置。该装置还包括一个可旋转地设置在固定安装件周围的用户界面，并具有至少一个用于沿着迂回路径移动针座的内部接合结构。

5. 发明申请

US20120041385A1 Attachable Needle Changing Device For Medicament Delivery Device 有权
标题翻译：用于药物输送装置的可附接针更换装置
公开(公告)号：US20120041385A1
公开(公告)日：2012-02-16
申请号：US13206469
申请日：2011-08-09
申请人： Michel Bruehwiler , Cole Constantineau , Ryan Schoonmaker , Margaret Taylor , James Bates
发明人： Michel Bruehwiler , Cole Constantineau , Ryan Schoonmaker , Margaret Taylor , James Bates
IPC分类号： A61M5/32
CPC分类号： A61M5/002 , A61M5/34 , A61M5/343 , A61M2005/004
摘要： An attachable needle storage device is provided with a main body and a rotatable sleeve and a plurality of new needles stored within the sleeve, a leaf spring to direct each needle into a circumferential position of the pen body when rotated, and a ramp to move the needle into an axial position of the pen body when retracted or pulled rearward by the user. The attachable needle storage device is configured to attach to a pen device in a manner substantially the same as a conventional needle hub. In doing so, the rotation of the sleeve can be used to rotate a new needle onto a shuttle, and the retraction of the device can be used to cause a ramp to engage the needle and needle hub, moving the needle toward the axial position of the pen body and the septum. Once under the septum, the user continues pulling the device rearward, such that the needle is then moved rearward, pierces the septum of the medicament cartridge and exposes the distal end of the needle for injection. After use, a needle shield is used to unlock a compressed spring, which is configured to pull the needle from the septum, and return the device to the transport state, after which the previous steps can be repeated.
摘要翻译：可附接的针存储装置设置有主体和可旋转的套筒以及存储在套筒内的多个新针，一个板簧，用于将每个针定位成旋转时的笔体周向位置，并且使斜坡移动当用户收回或向后拉时，针头进入笔体的轴向位置。可连接针存储装置被配置为以与常规针毂基本相同的方式附接到笔式装置。在这样做时，套筒的旋转可以用于将新的针旋转到梭子上，并且装置的缩回可以用于引起斜面接合针和针座，使针朝着轴向位置移动笔体和隔膜。一旦在隔膜下方，用户继续向后拉动装置，使得针随后向后移动，刺穿药剂盒的隔膜并暴露注射针的远端。使用后，使用针护罩来解锁压缩弹簧，压缩弹簧被配置为从隔膜拉动针头，并将装置返回到运输状态，之后可以重复前述步骤。

6. 发明申请

US20090131848A1 METHOD FOR IMPLANTING A TRANSCORNEAL IMPLANT THROUGH A PARACENTESIS T-INCISION, AND TRANSCORNEAL IMPLANT SO IMPLANTED 审中-公开
标题翻译：通过引导T淋巴结植入手术植入物的方法，以及植入的透视植入物
公开(公告)号：US20090131848A1
公开(公告)日：2009-05-21
申请号：US11941150
申请日：2007-11-16
申请人： Margaret Taylor
发明人： Margaret Taylor
IPC分类号： A61M1/00 , A61F9/01
CPC分类号： A61F9/00781
摘要： A method for implanting a transcorneal implant having a cap, a foot, and a body connecting the cap and the foot, the body having a lesser circumference than either the cap or the foot, the method including the operations: creating a first corneal incision to create a tunnel, such that the a far end of the first incision enters the anterior chamber; creating a second corneal incision opening a roof of the tunnel to an end point past the far end of the first incision and creating flaps; guiding the implant to the end point, so that the foot of the implant is under the flaps; rotating the implant until the foot is entirely within the anterior chamber; and rotating the implant back to a neutral position, such that a portion of the foot is beneath a floor of the tunnel.
摘要翻译：一种用于植入具有帽，脚和连接帽和脚的身体的经睾丸植入物的方法，所述身体具有比帽或脚更小的圆周，所述方法包括以下操作：产生第一角膜切口至创建隧道，使得第一切口的远端进入前房; 创建第二角膜切口，将隧道的屋顶打开到通过第一切口的远端的终点并产生瓣; 将植入物引导到终点，使得植入物的脚在襟翼下方; 旋转植入物直到足部完全在前房内; 以及将所述植入物旋转回到中立位置，使得所述脚的一部分在所述隧道的地板下方。

7. 发明授权

US06678366B1 System and method for locating subscribers using a best guess location algorithm 有权
标题翻译：使用最佳猜测位置算法定位用户的系统和方法
公开(公告)号：US06678366B1
公开(公告)日：2004-01-13
申请号：US09501105
申请日：2000-02-09
申请人： Eric William Burger , John Kimball , Walter Joseph O'Connor , Nancy Margaret Taylor , Sanjiv Parikh , Christina Pax
发明人： Eric William Burger , John Kimball , Walter Joseph O'Connor , Nancy Margaret Taylor , Sanjiv Parikh , Christina Pax
IPC分类号： H04M342
CPC分类号： H04M3/42229 , H04M3/46 , H04M3/53308
摘要： A system and method for locating the subscriber of a telephony product in which a best guess location is assigned to each subscriber of the telephony product. Under certain predetermined conditions, the telephony product directs incoming phone calls to a subscriber by first attempting to locate the subscriber at the best guess location. If the best guess location does not successfully answer or is not attempted first, an alternate search method is used.
摘要翻译：一种用于定位电话产品的订户的系统和方法，其中将最佳猜测位置分配给电话产品的每个订户。在某些预定条件下，电话产品通过首先尝试将用户定位在最佳猜测位置来引导来电者的来电。如果最佳猜测位置没有成功应答，或者没有首先尝试，则使用替代搜索方法。

8. 发明申请

US20120255500A1 FORCE MEASUREMENT 有权
标题翻译：强制测量
公开(公告)号：US20120255500A1
公开(公告)日：2012-10-11
申请号：US13440310
申请日：2012-04-05
申请人： Michael John Dixon , Polly Margaret Taylor , Benjamin Dixon
发明人： Michael John Dixon , Polly Margaret Taylor , Benjamin Dixon
IPC分类号： A01K1/03 , G06T11/20 , G01L1/14
CPC分类号： A01K1/031 , A61B5/4827 , A61B2503/40 , A61B2503/42 , G01L1/142 , G01L3/1442
摘要： A rodent enclosure dimensioned in length, width and height so as to allow a rodent to run freely along the length of the enclosure, but not turn around without standing on its hind legs. The enclosure has a floor with bars extending transversely to allow access for a force sensor's probe from below. A force measurement device for use with the rodent enclosure to measure the tactile response of a rodent comprising a measurement probe connected to a device body. The probe has a tip which can be engaged with a rodent's paw through the floor of the enclosure. The device body has a fixed body part and a rotatable body part arranged to allow relative rotation between them. A rotation sensor detects the relative rotation and outputs a measurement parameter having values that are calibrated against force values associated with forces applied to the probe's tip.
摘要翻译：一种啮齿动物外壳的长度，宽度和高度的尺寸，以便啮齿动物能够沿着外壳的长度自由行进，但不会在其后腿上站立时转动。外壳具有底板，横杆横向延伸，以便从下方进入力传感器的探头。用于与啮齿动物外壳一起使用以测量啮齿动物的触觉反应的力测量装置，包括连接到装置主体的测量探头。探头具有可以通过外壳的地板与啮齿动物的爪接合的尖端。装置主体具有固定主体部分和被布置成允许它们之间的相对旋转的可旋转主体部分。旋转传感器检测相对旋转并输出测量参数，其具有根据与施加到探针尖端的力相关联的力值校准的值。

9. 发明申请

US20120041383A1 Circuitous Band Needle Changing Apparatus 有权
标题翻译：电路带针更换装置
公开(公告)号：US20120041383A1
公开(公告)日：2012-02-16
申请号：US13206405
申请日：2011-08-09
申请人： Michel Bruehwiler , Cole Constantineau , Ryan Schoonmaker , James Bates , Margaret Taylor , Robert Banik
发明人： Michel Bruehwiler , Cole Constantineau , Ryan Schoonmaker , James Bates , Margaret Taylor , Robert Banik
IPC分类号： A61M5/34 , A61M5/31 , A61M5/32
CPC分类号： A61M5/008 , A61M2005/004
摘要： An apparatus is disclosed for storing and changing needles for a medicament delivery device having a medicament container, including a fixed mount for connecting the apparatus with the medicament delivery device, a needle holder displaceable along a circuitous path and connecting a plurality of needles displaceably disposed thereon, and a guide member for guiding displacement of the needle holder, the guide member being disposed about the fixed mount. The apparatus also includes a user interface rotatably disposed about the fixed mount and having at least one internal engaging structure for displacing the needle holder along the circuitous path.
摘要翻译：公开了一种用于存储和更换用于具有药物容器的药物输送装置的针的装置，其包括用于将装置与药物输送装置连接的固定支架，可沿着迂回路径移位并连接可移动地设置在其上的多个针的针保持器以及用于引导针保持器的位移的引导构件，所述引导构件围绕固定座设置。该装置还包括可旋转地设置在固定安装件周围的用户界面，并且具有至少一个内部接合结构，用于沿着迂回路径移动针保持器。

10. 发明申请

US20080064628A1 Fibrinogen Targetting Microparticles For Promoting Haemostasis 审中-公开
标题翻译：纤维蛋白原靶向微粒促进止血
公开(公告)号：US20080064628A1
公开(公告)日：2008-03-13
申请号：US10574872
申请日：2004-10-07
申请人： Alison Helena Goodall , Sarah Margaret Taylor
发明人： Alison Helena Goodall , Sarah Margaret Taylor
IPC分类号： A61K38/16 , A61P7/02
CPC分类号： A61K38/08 , A61K47/62 , A61K47/6927
摘要： The present invention provides an injectable pharmaceutical product comprising an agent, the agent comprising an insoluble carrier to which is bound a peptide, the peptide being capable of binding fibrinogen such that the agent binds via the bound fibrinogen to activated platelets in preference to inactive platelets, and wherein the peptide is not fibrinogen.
摘要翻译：本发明提供包含试剂的可注射药物产品，该药剂包含与肽结合的不溶性载体，所述肽能够结合纤维蛋白原，使得所述药剂优先于结合的纤维蛋白原与活性血小板结合，优先于无活性血小板，并且其中所述肽不是纤维蛋白原。

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