专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US07319107B2 1,2,4-thiadiazolium derivatives as melanocortin receptor modulators 失效
标题翻译：作为黑皮质素受体调节剂的1,2,4-噻二唑衍生物
公开(公告)号：US07319107B2
公开(公告)日：2008-01-15
申请号：US10287096
申请日：2002-11-04
申请人： Magdalena Eisinger , Louis J. Fitzpatrick , Daniel H. Lee , Kevin Pan , Carlos Plata-Salaman , Allen B. Reitz , Virginia L. Smith-Swintosky , Boyu Zhao
发明人： Magdalena Eisinger , Louis J. Fitzpatrick , Daniel H. Lee , Kevin Pan , Carlos Plata-Salaman , Allen B. Reitz , Virginia L. Smith-Swintosky , Boyu Zhao
IPC分类号： A61K31/433 , C07D285/08
CPC分类号： C07D285/08 , A61K8/49 , A61Q5/006 , A61Q19/00 , A61Q19/007 , C07D333/16 , C07D417/12 , C07F9/4018
摘要： The present invention is directed to novel 1,2,4-thiadiazol-2-ium derivatives useful as agonists or antagonists of the melanocortin receptor. More particularly, the compounds of the present invention are useful for the treatment of metabolic, CNS and dermatological disorders such as obesity, impaired oral glucose tolerance, elevated blood glucose levels, type II diabetes, Syndrome X, diabetic retinopathy, spinal cord injury, nerve injury, acute neurodegenerative disorders, chronic neurodegenerative disorders, plexopathies, male erectile dysfunction, dry eyes, acne, dry skin, aged skin, seborrheic dermatitis, rosacea, excessive ear wax, meibomian gland disorder, pseudofolliculitis, yeast infections, dandruff, hidradenitis suppurativa, ocular rosacea and eccrine gland disorder.
摘要翻译：本发明涉及可用作黑皮质素受体的激动剂或拮抗剂的新颖的1,2,4-噻二唑-2-基衍生物。更具体地，本发明的化合物可用于治疗代谢，CNS和皮肤病学障碍，例如肥胖症，口服葡萄糖耐量降低，血糖水平升高，II型糖尿病，X综合征，糖尿病性视网膜病变，脊髓损伤，神经伤口，急性神经退行性疾病，慢性神经退行性疾病，性欲症，男性勃起功能障碍，干眼症，痤疮，干性皮肤，老年皮肤，脂溢性皮炎，酒渣鼻，过度耳垢，睑板腺疾病，假性结石炎，酵母菌感染，头皮屑，眼红斑痤疮和外分泌腺疾病。

2. 发明授权

US07049331B2 1,2,4-thiadiazole derivatives as melanocortin receptor modulators 有权
标题翻译：作为黑皮质素受体调节剂的1,2,4-噻二唑衍生物
公开(公告)号：US07049331B2
公开(公告)日：2006-05-23
申请号：US10287095
申请日：2002-11-04
申请人： Magdalena Eisinger , Louis J. Fitzpatrick , Daniel H. Lee , Kevin Pan , Carlos Plata-Salaman , Allen B. Reitz , Virginia L. Smith-Swintosky , Boyu Zhao
发明人： Magdalena Eisinger , Louis J. Fitzpatrick , Daniel H. Lee , Kevin Pan , Carlos Plata-Salaman , Allen B. Reitz , Virginia L. Smith-Swintosky , Boyu Zhao
IPC分类号： A61K31/433 , C07D285/08
CPC分类号： C07D285/08 , A61K8/49 , A61Q5/006 , A61Q19/00 , A61Q19/007 , C07D417/12
摘要： The present invention is directed to novel 1,2,4-thiadiazole derivatives useful as agonists or antagonists of the melanocortin receptor. More particularly, the compounds of the present invention are useful for the treatment of metabolic, CNS and dermatological disorders such as obesity, impaired oral glucose tolerance, elevated blood glucose levels, type II diabetes, Syndrome X, diabetic retinopathy, spinal cord injury, nerve injury, acute neurodegenerative disorders, chronic neurodegenerative disorders, plexopathies, male erectile dysfunction, dry eyes, acne, dry skin, aged skin, seborrheic dermatitis, rosacea, excessive ear wax, meibomian gland disorder, pseudofolliculitis, yeast infections, dandruff, hidradenitis suppurativa, ocular rosacea and eccrine gland disorder.
摘要翻译：本发明涉及可用作黑皮质素受体的激动剂或拮抗剂的新颖的1,2,4-噻二唑衍生物。更具体地，本发明的化合物可用于治疗代谢，CNS和皮肤病学障碍，例如肥胖症，口服葡萄糖耐量降低，血糖水平升高，II型糖尿病，X综合征，糖尿病性视网膜病变，脊髓损伤，神经伤口，急性神经退行性疾病，慢性神经退行性疾病，性欲症，男性勃起功能障碍，干眼症，痤疮，干性皮肤，老年皮肤，脂溢性皮炎，酒渣鼻，过度耳垢，睑板腺疾病，假性结石炎，酵母菌感染，头皮屑，眼红斑痤疮和外分泌腺疾病。

3. 发明申请

US20060128772A1 Novel 1,2,4-thiadiazole derivatives as melanocortin receptor modulators 失效
公开(公告)号：US20060128772A1
公开(公告)日：2006-06-15
申请号：US11344772
申请日：2006-02-01
申请人： Magdalena Eisinger , Louis Fitzpatrick , Daniel Lee , Kevin Pan , Carlos Plata-Salaman , Allen Reitz , Virginia Smith-Swintosky , Boyu Zhao
发明人： Magdalena Eisinger , Louis Fitzpatrick , Daniel Lee , Kevin Pan , Carlos Plata-Salaman , Allen Reitz , Virginia Smith-Swintosky , Boyu Zhao
IPC分类号： A61K31/433 , C07D285/08
CPC分类号： C07D285/08 , A61K8/49 , A61Q5/006 , A61Q19/00 , A61Q19/007 , C07D417/12
摘要： The present invention is directed to novel 1,2,4-thiadiazole derivatives useful as agonists or antagonists of the melanocortin receptor. More particularly, the compounds of the present invention are useful for the treatment of metabolic, CNS and dermatological disorders such as obesity, impaired oral glucose tolerance, elevated blood glucose levels, type II diabetes, Syndrome X, diabetic retinopathy, spinal cord injury, nerve injury, acute neurodegenerative disorders, chronic neurodegenerative disorders, plexopathies, male erectile dysfunction, dry eyes, acne, dry skin, aged skin, seborrheic dermatitis, rosacea, excessive ear wax, meibomian gland disorder, pseudofolliculitis, yeast infections, dandruff, hidradenitis suppurativa, ocular rosacea and eccrine gland disorder.

4. 发明授权

US5720981A Epidermal cell extracts and method to enhance wound healing and regenerate epidermis 失效
标题翻译：表皮细胞提取物和增强伤口愈合和再生表皮的方法
公开(公告)号：US5720981A
公开(公告)日：1998-02-24
申请号：US339573
申请日：1994-11-14
申请人： Magdalena Eisinger
发明人： Magdalena Eisinger
IPC分类号： A61K35/36 , A61L27/60
CPC分类号： A61K35/36 , A61L27/60 , Y10S424/13
摘要： This invention provides a composition capable of stimulating growth and regeneration of epidermal cells. The composition comprises an aqueous, cell-free extract derived from epidermal cells.
摘要翻译：本发明提供能够刺激表皮细胞生长和再生的组合物。该组合物包含衍生自表皮细胞的水性无细胞提取物。

5. 发明授权

US5491220A Surface loop structural analogues of fibroblast growth factors 失效
标题翻译：成纤维细胞生长因子的表面环结构类似物
公开(公告)号：US5491220A
公开(公告)日：1996-02-13
申请号：US290373
申请日：1994-08-15
申请人： Andrew P. Seddon , Luyuan Li , Peter Bohlen , Magdalena Eisinger , Avner Yayon
发明人： Andrew P. Seddon , Luyuan Li , Peter Bohlen , Magdalena Eisinger , Avner Yayon
IPC分类号： A61K38/00 , C07K14/50 , C07K14/545 , C12N15/18
CPC分类号： C07K14/501 , C07K14/50 , C07K14/503 , C07K14/545 , A61K38/00
摘要： Structural analogues of fibroblast growth factors have an amino acid sequence replacement in the ninth or tenth .beta.-strand of the factor, or the sequence that corresponds to the surface loop that connects the ninth and tenth .beta.-strands, such that the folding of the molecule is not significantly perturbed. Preferred analogues have the amino acid sequence replacement in the surface loop that extends from the ninth .beta.-strand to the tenth .beta.-strand and have the overall secondary and tertiary structure of the original factor, and bind to heparin and a member or members of the fibroblast growth factor receptor family with high affinity. In some embodiments, the analogues are prepared by replacing the surface loop sequence that connects the ninth and tenth .beta.-strand with another amino acid sequence such as a loop sequence from another structurally related fibroblast growth factor or an interleukin. Preferred analogues exhibit different biological properties and/or receptor binding specificity profiles from native factors.
摘要翻译：成纤维细胞生长因子的结构类似物在该因子的第9或第10个β链中具有氨基酸序列替换，或者对应于连接第9和第10个β链的表面环的序列，使得分子的折叠没有明显的扰动。优选的类似物在表面循环中具有从第九个β链延伸到第十个β链的氨基酸序列替代物，并具有原始因子的总体二级结构和三级结构，并且结合肝素和成员成纤维细胞生长因子受体家族具有高亲和力。在一些实施方案中，通过将来自另一结构相关的成纤维细胞生长因子或白介素的另一个氨基酸序列例如环序列替换连接第九和第十个β链的表面环序列来制备类似物。优选的类似物表现出与天然因素不同的生物学特性和/或受体结合特异性谱。

6. 发明授权

US08501791B2 1,2,4-thiadiazolium derivatives as melanocortin receptor modulators 失效
标题翻译：作为黑皮质素受体调节剂的1,2,4-噻二唑衍生物
公开(公告)号：US08501791B2
公开(公告)日：2013-08-06
申请号：US12835220
申请日：2010-07-13
申请人： Magdalena Eisinger , Louis J. Fitzpatrick , Daniel H. Lee , Kevin Pan , Carlos Plata-Salaman , Allen B. Reitz , Virginia L. Smith-Swintosky , Boyu Zhao
发明人： Magdalena Eisinger , Louis J. Fitzpatrick , Daniel H. Lee , Kevin Pan , Carlos Plata-Salaman , Allen B. Reitz , Virginia L. Smith-Swintosky , Boyu Zhao
IPC分类号： A61K31/433 , C07D285/08
CPC分类号： C07D285/08 , A61K8/49 , A61Q5/006 , A61Q19/00 , A61Q19/007 , C07D333/16 , C07D417/12 , C07F9/4018
摘要： The present invention is directed to novel 1,2,4-thiadiazol-2-ium derivatives useful as agonists or antagonists of the melanocortin receptor. More particularly, the compounds of the present invention are useful for the treatment of metabolic, CNS and dermatological disorders such as obesity, impaired oral glucose tolerance, elevated blood glucose levels, type II diabetes, Syndrome X, diabetic retinopathy, spinal cord injury, nerve injury, acute neurodegenerative disorders, chronic neurodegenerative disorders, plexopathies, male erectile dysfunction, dry eyes, acne, dry skin, aged skin, seborrheic dermatitis, rosacea, excessive ear wax, meibomian gland disorder, pseudofolliculitis, yeast infections, dandruff, hidradenitis suppurativa, ocular rosacea and eccrine gland disorder.
摘要翻译：本发明涉及可用作黑皮质素受体的激动剂或拮抗剂的新颖的1,2,4-噻二唑-2-基衍生物。更具体地，本发明的化合物可用于治疗代谢，CNS和皮肤病学障碍，例如肥胖症，口服葡萄糖耐量降低，血糖水平升高，II型糖尿病，X综合征，糖尿病性视网膜病变，脊髓损伤，神经伤口，急性神经退行性疾病，慢性神经退行性疾病，性欲症，男性勃起功能障碍，干眼症，痤疮，干性皮肤，老年皮肤，脂溢性皮炎，酒渣鼻，过度耳垢，睑板腺疾病，假性结石炎，酵母菌感染，头皮屑，眼红斑痤疮和外分泌腺疾病。

7. 发明申请

US20120283330A1 METHODS FOR THE TREATMENT OF DERMATOLOGICAL DISORDERS 失效
标题翻译：治疗病理性疾病的方法
公开(公告)号：US20120283330A1
公开(公告)日：2012-11-08
申请号：US13546646
申请日：2012-07-11
申请人： Magdalena Eisinger , Fa Zhang
发明人： Magdalena Eisinger , Fa Zhang
IPC分类号： A61K31/17 , A61P17/10 , A61P31/10 , A61P17/00
CPC分类号： A61K31/155
摘要： The present invention is directed to the use of a compound of formula (I) or pharmaceutically acceptable salt thereof, for the treatment of disorders mediated by the melanocortin-5 receptor, particularly dermatological disorders; and further directed to pharmaceutical compositions containing the compound of formula (I) or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明涉及式（I）化合物或其药学上可接受的盐在治疗黑皮质素-5受体介导的疾病，特别是皮肤病学障碍中的用途; 并且还涉及含有式（I）化合物或其药学上可接受的盐的药物组合物。

8. 发明申请

US20100280079A1 0NOVEL, 1,2,4-THIADIAZOLIUM DERIVATIVES AS MELANOCORTIN RECEPTOR MODULATORS 失效
标题翻译： 0号，1,2,4-噻二唑衍生物作为米考康宁受体调节剂
公开(公告)号：US20100280079A1
公开(公告)日：2010-11-04
申请号：US12835220
申请日：2010-07-13
申请人： Magdalena Eisinger , Louis J. Fitzpatrick , Daniel H. Lee , Kevin Pan , Carlos Plata-Salaman , Allen B. Reitz , Virginia L. Smith-Swintosky , Boyu Zhao
发明人： Magdalena Eisinger , Louis J. Fitzpatrick , Daniel H. Lee , Kevin Pan , Carlos Plata-Salaman , Allen B. Reitz , Virginia L. Smith-Swintosky , Boyu Zhao
IPC分类号： A61K31/433 , A61K31/4439 , A61P25/00 , A61P17/00 , A61P3/00 , A61P15/00
CPC分类号： C07D285/08 , A61K8/49 , A61Q5/006 , A61Q19/00 , A61Q19/007 , C07D333/16 , C07D417/12 , C07F9/4018
摘要： The present invention is directed to novel 1,2,4-thiadiazol-2-ium derivatives useful as agonists or antagonists of the melanocortin receptor. More particularly, the compounds of the present invention are useful for the treatment of metabolic, CNS and dermatological disorders such as obesity, impaired oral glucose tolerance, elevated blood glucose levels, type II diabetes, Syndrome X, diabetic retinopathy, spinal cord injury, nerve injury, acute neurodegenerative disorders, chronic neurodegenerative disorders, plexopathies, male erectile dysfunction, dry eyes, acne, dry skin, aged skin, seborrheic dermatitis, rosacea, excessive ear wax, meibomian gland disorder, pseudofolliculitis, yeast infections, dandruff, hidradenitis suppurativa, ocular rosacea and eccrine gland disorder.
摘要翻译：本发明涉及可用作黑皮质素受体的激动剂或拮抗剂的新颖的1,2,4-噻二唑-2-基衍生物。更具体地，本发明的化合物可用于治疗代谢，CNS和皮肤病学障碍，例如肥胖症，口服葡萄糖耐量降低，血糖水平升高，II型糖尿病，X综合征，糖尿病性视网膜病变，脊髓损伤，神经伤口，急性神经退行性疾病，慢性神经退行性疾病，性欲症，男性勃起功能障碍，干眼症，痤疮，干性皮肤，老年皮肤，脂溢性皮炎，酒渣鼻，过度耳垢，睑板腺疾病，假性结石炎，酵母菌感染，头皮屑，眼红斑痤疮和外分泌腺疾病。

9. 发明申请

US20090215902A1 METHODS FOR THE TREATMENT OF DERMATOLOGICAL DISORDERS 失效
标题翻译：治疗病理性疾病的方法
公开(公告)号：US20090215902A1
公开(公告)日：2009-08-27
申请号：US12389687
申请日：2009-02-20
申请人： Magdalena Eisinger , Fa Zhang
发明人： Magdalena Eisinger , Fa Zhang
IPC分类号： A61K31/17 , C07C275/24 , A61P17/00 , A61P17/10
CPC分类号： A61K31/155
摘要： The present invention is directed to the use of a compound of formula (I) or pharmaceutically acceptable salt thereof, for the treatment of disorders mediated by the melanocortin-5 receptor, particularly dermatological disorders; and further directed to pharmaceutical compositions containing the compound of formula (I) or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明涉及式（I）化合物或其药学上可接受的盐在治疗黑皮质素-5受体介导的疾病，特别是皮肤病学障碍中的用途; 并且还涉及含有式（I）化合物或其药学上可接受的盐的药物组合物。

10. 发明授权

US4806628A Monoclonal antibodies against melanocytes 失效
标题翻译：针对黑素细胞的单克隆抗体
公开(公告)号：US4806628A
公开(公告)日：1989-02-21
申请号：US840632
申请日：1986-03-17
申请人： Anthony Albino , J. Gregory Cairncross , Magdalena Eisinger , Alan N. Houghton , Lloyd Old
发明人： Anthony Albino , J. Gregory Cairncross , Magdalena Eisinger , Alan N. Houghton , Lloyd Old
IPC分类号： A61K38/00 , A61K51/10 , C07K16/28 , C07K16/30 , G01N33/569 , G01N33/574 , G01N33/577 , C07K15/00 , C12N5/00
CPC分类号： G01N33/574 , A61K51/1066 , C07K16/28 , C07K16/3053 , G01N33/56966 , G01N33/577 , A61K2123/00 , A61K38/00 , Y10S530/808 , Y10S530/809
摘要： Monoclonal antibodies were discovered which recognize differentiation antigens on melanocytes and melanoma cells at various stages of differentiation. A system of classification based on these antigens is proposed and their use in the diagnosis and treatment of melanoma is given.
摘要翻译：发现单克隆抗体在不同的分化阶段识别黑素细胞和黑素瘤细胞上的分化抗原。提出了基于这些抗原的分类系统，并给出了它们在黑色素瘤诊断和治疗中的应用。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式