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1. 发明申请

US20120295283A1 FLUORESCENT MOLECULAR PROBES FOR USE IN ASSAYS THAT MEASURE TEST COMPOUND COMPETITIVE BINDING WITH SAM-UTILIZING PROTEINS 有权
标题翻译：用于测试化合物的测定化合物的荧光分子探针与SAM利用蛋白质的竞争性结合
公开(公告)号：US20120295283A1
公开(公告)日：2012-11-22
申请号：US13475618
申请日：2012-05-18
申请人： Stephen Douglas Barrett , Daniel Austin Bochar , Levi Lynn Blazer , Fred Lawrence Ciske , Gregory William Endres , Jeffrey Keith Johnson , Gregory Scott Keyes , Ranjinder Singh Sidhu , Raymond C. Trievel , Margaret Lynn Collins
发明人： Stephen Douglas Barrett , Daniel Austin Bochar , Levi Lynn Blazer , Fred Lawrence Ciske , Gregory William Endres , Jeffrey Keith Johnson , Gregory Scott Keyes , Ranjinder Singh Sidhu , Raymond C. Trievel , Margaret Lynn Collins
IPC分类号： C07D473/34 , G01N21/64
CPC分类号： G01N33/582 , C07D471/04 , C07D473/34 , C07D519/00 , C07H19/16 , G01N21/6428 , G01N2201/061 , G01N2333/91011
摘要： Assay methods may generally comprise forming homogeneous assay mixtures comprising target SAM-utilizing protein, fluorescent detection analyte, and test compound, incubating, and measuring FP or TR-FRET signal emitted in order to determine a measure of test compound-SAM-utilizing protein binding. Assay mixtures comprise a SAM-utilizing protein, and a fluorescent detection analyte that binds with the SAM-utilizing protein in the absence of test compound. Assay mixtures may further comprise a test compound. Assay mixture embodiments may generate FP or TR-FRET signal properties that are a function of the inherent binding interactions of both the test compound and the detection analyte with the SAM-utilizing protein. Fluorescent detection analytes comprise a fluorophore moiety, a covalent linker moiety, and a SAM-utilizing protein ligand moiety and could be utilized in FP or TR-FRET assays to measure test compound binding.
摘要翻译：测定方法通常可以包括形成均匀的测定混合物，其包含目标SAM利用蛋白质，荧光检测分析物和测试化合物，孵育和测量发射的FP或TR-FRET信号，以确定测试化合物-SM利用蛋白质结合的量度。测定混合物包含SAM-利用蛋白质和在不存在测试化合物的情况下与SAM利用蛋白质结合的荧光检测分析物。测定混合物可进一步包含测试化合物。测定混合物实施方案可以产生FP或TR-FRET信号特性，其是测试化合物和检测分析物与SAM-利用蛋白的固有结合相互作用的函数。荧光检测分析物包含荧光团部分，共价连接体部分和SAM-利用蛋白质配体部分，并且可用于FP或TR-FRET测定以测量测试化合物结合。

2. 发明授权

US07913944B1 Cable brake for sea deployments of light cable 有权
标题翻译：用于海上部署光缆的电缆制动器
公开(公告)号：US07913944B1
公开(公告)日：2011-03-29
申请号：US12132091
申请日：2008-06-03
申请人： Tammy Lombardi , Jeff GilChrist , Aaron Bratten , Lynn Collins , Steve Whiteside , Frank Gonzales , Kristin Smith
发明人： Tammy Lombardi , Jeff GilChrist , Aaron Bratten , Lynn Collins , Steve Whiteside , Frank Gonzales , Kristin Smith
IPC分类号： B65H59/14
CPC分类号： B63B35/04 , B65H51/12
摘要： A cable brake system for deployments of cable comprising: a frame configured to be mounted on a ship; a repeater supporting track mounted longitudinally to the frame, the supporting track being configured for slidingly supporting a plurality of repeaters; a spool positioned exterior to the frame, the spool having the cable wrapped therearound and being capable of supplying the cable to an interior of the frame; at least one planar surface on an interior of the frame, the planar surface being positioned approximately parallel to the repeater supporting track; and a plurality of brake sub-assemblies being supported by the planar surface in a manner so as to establish a serpentine path for the cable and to impart variable frictional resistance to the cable.
摘要翻译：一种用于电缆部署的电缆制动系统，包括：构造成安装在船上的框架; 一个纵向安装在框架上的中继器支撑轨道，该支撑轨道被配置用于滑动地支撑多个转发器; 位于所述框架外部的线轴，所述线轴具有绕在其周围的电缆，并且能够将电缆供应到所述框架的内部; 在所述框架的内部上的至少一个平坦表面，所述平面表面大致平行于所述中继器支撑轨道定位; 以及多个制动子组件，其以这样的方式由平面支撑，以便建立用于电缆的蛇形路径并赋予电缆可变的摩擦阻力。

3. 发明授权

US09603768B1 Foot flexion and extension machine 有权
公开(公告)号：US09603768B1
公开(公告)日：2017-03-28
申请号：US14075172
申请日：2013-11-08
申请人： Michael John Widmer , Richard David Lanning , Sammie Lynn Collins
发明人： Michael John Widmer , Richard David Lanning , Sammie Lynn Collins
IPC分类号： A61H1/02
CPC分类号： A61H1/0266 , A61H1/024 , A61H2201/0192 , A61H2201/1215 , A61H2201/1642 , A61H2201/1678 , A61H2201/5005 , A61H2201/5038
摘要： An ankle flexion and extension machine including a lower leg backing beam having upper and lower ends; a support arm cantilevering from the lower leg backing beam; an arm mounting pivot joint interconnecting the lower leg backing beam's lower end and the support arm's proximal end; a foot plate; a plate mounting pivot joint interconnecting the foot plate and the support arm's distal end, the plate mounting pivot joint being adapted for facilitating dorsiflecting and plantarflecting pivoting movements of the foot plate with respect to the lower leg backing beam; a reversible electric motor connected operatively to the foot plate, the reversible electric motor being adapted for driving the pivoting movement of the foot plate; a floor support base; and a triangulating frame supporting the lower leg backing beam, the support arm and the foot plate over the floor support base.

4. 发明申请

US20070199852A1 Product and method for dispensing and packaging items having complementary components 有权
标题翻译：用于分配和包装具有互补部件的物品的产品和方法
公开(公告)号：US20070199852A1
公开(公告)日：2007-08-30
申请号：US11361544
申请日：2006-02-24
申请人： Lynda L. Rutledge , Prateek Lal , Lynn Collins
发明人： Lynda L. Rutledge , Prateek Lal , Lynn Collins
IPC分类号： B65D21/00 , B65D85/62
CPC分类号： B65D85/62 , B65D77/003
摘要： The invention relates to a product and method for dispensing and packaging items comprising at least two nestable complementary components. The complementary components are provided in stacks where each stack comprises a nested portion of each of the complementary components. One stack will have one complementary component located on the top end of the stack and the other complementary component will be present on the bottom end of that stack. As presented for use in a carton, each stack will have a different complementary component on the respective top end of the stack. A user will select a complementary component from each stack to provide a completed item for use. The invention is particularly suited for lidded cups or containers where the cups or containers and lids are packaged together for complementary use.
摘要翻译：本发明涉及一种用于分配和包装物品的产品和方法，包括至少两个可嵌套的互补部件。互补部件在堆叠中提供，其中每个堆叠包括每个互补部件的嵌套部分。一个堆叠将具有位于堆叠顶端的一个补充组件，另一个补充组件将存在于堆叠的底端。如在纸箱中使用的，每个堆叠将在堆叠的相应顶端上具有不同的互补部件。用户将从每个堆栈中选择一个补充组件来提供一个完整的项目供使用。本发明特别适合于杯子或容器和盖子被包装在一起用于补充使用的带盖杯子或容器。

5. 发明授权

US09120820B2 Fluorescent molecular probes for use in assays that measure test compound competitive binding with SAM-utilizing proteins 有权
标题翻译：用于测量与SAM利用蛋白质的测试化合物竞争性结合的测定中的荧光分子探针
公开(公告)号：US09120820B2
公开(公告)日：2015-09-01
申请号：US13475618
申请日：2012-05-18
申请人： Stephen Douglas Barrett , Daniel Austin Bochar , Levi Lynn Blazer , Fred Lawrence Ciske , Gregory William Endres , Jeffrey Keith Johnson , Gregory Scott Keyes , Ranjinder Singh Sidhu , Raymond C. Trievel , Margaret Lynn Collins
发明人： Stephen Douglas Barrett , Daniel Austin Bochar , Levi Lynn Blazer , Fred Lawrence Ciske , Gregory William Endres , Jeffrey Keith Johnson , Gregory Scott Keyes , Ranjinder Singh Sidhu , Raymond C. Trievel , Margaret Lynn Collins
IPC分类号： C07D519/00 , G01N21/64
CPC分类号： G01N33/582 , C07D471/04 , C07D473/34 , C07D519/00 , C07H19/16 , G01N21/6428 , G01N2201/061 , G01N2333/91011
摘要： Assay methods may generally comprise forming homogeneous assay mixtures comprising target SAM-utilizing protein, fluorescent detection analyte, and test compound, incubating, and measuring FP or TR-FRET signal emitted in order to determine a measure of test compound-SAM -utilizing protein binding. Assay mixtures comprise a SAM-utilizing protein, and a fluorescent detection analyte that binds with the SAM-utilizing protein in the absence of test compound. Assay mixtures may further comprise a test compound. Assay mixture embodiments may generate FP or TR-FRET signal properties that are a function of the inherent binding interactions of both the test compound and the detection analyte with the SAM-utilizing protein. Fluorescent detection analytes comprise a fluorophore moiety, a covalent linker moiety, and a SAM-utilizing protein ligand moiety and could be utilized in FP or TR-FRET assays to measure test compound binding.
摘要翻译：测定方法通常可以包括形成均匀的测定混合物，其包含目标SAM-利用蛋白质，荧光检测分析物和测试化合物，孵育和测量发射的FP或TR-FRET信号，以确定测试化合物 - SAM-利用蛋白质结合的量度。测定混合物包含SAM-利用蛋白质和在不存在测试化合物的情况下与SAM利用蛋白质结合的荧光检测分析物。测定混合物可进一步包含测试化合物。测定混合物实施方案可以产生FP或TR-FRET信号特性，其是测试化合物和检测分析物与SAM-利用蛋白的固有结合相互作用的函数。荧光检测分析物包含荧光团部分，共价连接体部分和SAM-利用蛋白质配体部分，并且可用于FP或TR-FRET测定以测量测试化合物结合。

6. 发明授权

US08689977B2 Product and method for dispensing and packaging items having complementary components 有权
标题翻译：用于分配和包装具有互补部件的物品的产品和方法
公开(公告)号：US08689977B2
公开(公告)日：2014-04-08
申请号：US11361544
申请日：2006-02-24
申请人： Lynda L. Rutledge , Prateek Lal , Lynn Collins
发明人： Lynda L. Rutledge , Prateek Lal , Lynn Collins
IPC分类号： B65D21/00
CPC分类号： B65D85/62 , B65D77/003
摘要： The invention relates to a product and method for dispensing and packaging items comprising at least two nestable complementary components. The complementary components are provided in stacks where each stack comprises a nested portion of each of the complementary components. One stack will have one complementary component located on the top end of the stack and the other complementary component will be present on the bottom end of that stack. As presented for use in a carton, each stack will have a different complementary component on the respective top end of the stack. A user will select a complementary component from each stack to provide a completed item for use. The invention is particularly suited for lidded cups or containers where the cups or containers and lids are packaged together for complementary use.
摘要翻译：本发明涉及一种用于分配和包装物品的产品和方法，包括至少两个可嵌套的互补部件。互补部件在堆叠中提供，其中每个堆叠包括每个互补部件的嵌套部分。一个堆叠将具有位于堆叠顶端的一个补充组件，另一个补充组件将存在于堆叠的底端。如在纸箱中使用的，每个堆叠将在堆叠的相应顶端上具有不同的互补部件。用户将从每个堆栈中选择一个补充组件来提供一个完整的项目供使用。本发明特别适合于杯子或容器和盖子被包装在一起用于补充使用的带盖杯子或容器。

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