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1. 发明授权

US09814553B1 Bioabsorbable semi-crystalline polymer for controlling release of drug from a coating 有权
公开(公告)号：US09814553B1
公开(公告)日：2017-11-14
申请号：US11870394
申请日：2007-10-10
申请人： Lothar Walter Kleiner , Yiwen Tang , Syed Faiyaz Ahmed Hossainy , Florencia Lim , Michael Ngo , Mikael Trollsas , Qing Lin
发明人： Lothar Walter Kleiner , Yiwen Tang , Syed Faiyaz Ahmed Hossainy , Florencia Lim , Michael Ngo , Mikael Trollsas , Qing Lin
IPC分类号： A61F2/00
CPC分类号： A61F2/00 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/416 , C08L67/04
摘要： The present invention provides a semi-crystalline polymer for a coating on an implantable device for controlling release of drug and methods of making and using the same.

2. 发明授权

US08637111B2 Methods for modulating the release rate of a drug-coated stent 失效
标题翻译：调节药物涂层支架释放速率的方法
公开(公告)号：US08637111B2
公开(公告)日：2014-01-28
申请号：US13605795
申请日：2012-09-06
申请人： Shaw Ling Hsu , Ni Ding , Yiwen Tang , Fuh-Wei Tang , Lothar Walter Kleiner , Syed Faiyaz Ahmed Hossainy
发明人： Shaw Ling Hsu , Ni Ding , Yiwen Tang , Fuh-Wei Tang , Lothar Walter Kleiner , Syed Faiyaz Ahmed Hossainy
IPC分类号： B05D3/02 , A61L33/00 , A61F2/06
CPC分类号： A61L31/10 , A61F2240/001 , A61F2250/0056 , A61F2250/0068 , A61L31/16 , A61L2300/416 , A61L2300/60 , C08L33/10 , C08L27/16 , C08L27/20 , C08L29/04
摘要： Methods for modulating the release rate of a drug coated stent are disclosed.
摘要翻译：公开了调节药物涂层支架释放速率的方法。

3. 发明申请

US20130108681A1 Injectable Depot Compositions and Uses Thereof 审中-公开
标题翻译：可注射仓库组合物及其用途
公开(公告)号：US20130108681A1
公开(公告)日：2013-05-02
申请号：US13593371
申请日：2012-08-23
申请人： Guohua Chen , Paul R. Houston , Lothar Walter Kleiner , John J. Spaltro
发明人： Guohua Chen , Paul R. Houston , Lothar Walter Kleiner , John J. Spaltro
IPC分类号： A61K9/00
CPC分类号： A61K38/1858 , A61K9/0002 , A61K9/0024 , A61K9/1617 , A61K31/445 , A61K38/27 , A61K45/06 , A61K47/10 , A61K47/14 , A61K47/34
摘要： Injectable depot compositions are provided that include a bioerodible, biocompatible polymer, a solvent having a miscibility in water of less than or equal to 7 wt. % at 25° C., in an amount effective to plasticize the polymer and form a gel therewith, a thixotropic agent, and a beneficial agent. The solvent comprises an aromatic alcohol, an ester of an aromatic acid, an aromatic ketone, or mixtures thereof. The compositions have substantially improved the shear thinning behavior and reduced injection force, rendering the compositions readily implanted beneath a patients body surface by injection.
摘要翻译：提供了可注射的储库组合物，其包括生物可腐蚀的生物相容性聚合物，在水中的混溶性小于或等于7wt。％，以有效塑化聚合物并与其形成凝胶的量，触变剂和有益剂。溶剂包括芳族醇，芳族酸的酯，芳族酮或其混合物。组合物已经显着改善了剪切稀化行为和降低的注射力，使组合物通过注射容易地植入患者体表下方。

4. 发明申请

US20120328770A1 Methods For Modulating The Release Rate Of A Drug-Coated Stent 失效
标题翻译：用于调节药物包被支架释放速率的方法
公开(公告)号：US20120328770A1
公开(公告)日：2012-12-27
申请号：US13605795
申请日：2012-09-06
申请人： Shaw Ling Hsu , Ni Ding , Yiwen Tang , Fuh-Wei Tang , Lothar Walter Kleiner , Syed Faiyaz Ahmed Hossainy
发明人： Shaw Ling Hsu , Ni Ding , Yiwen Tang , Fuh-Wei Tang , Lothar Walter Kleiner , Syed Faiyaz Ahmed Hossainy
IPC分类号： B05D7/00
CPC分类号： A61L31/10 , A61F2240/001 , A61F2250/0056 , A61F2250/0068 , A61L31/16 , A61L2300/416 , A61L2300/60 , C08L33/10 , C08L27/16 , C08L27/20 , C08L29/04
摘要： Methods for modulating the release rate of a drug coated stent are disclosed.
摘要翻译：公开了调节药物涂层支架释放速率的方法。

5. 发明授权

US08293318B1 Methods for modulating the release rate of a drug-coated stent 有权
标题翻译：调节药物涂层支架释放速率的方法
公开(公告)号：US08293318B1
公开(公告)日：2012-10-23
申请号：US11847222
申请日：2007-08-29
申请人： Shaw Ling Hsu , Ni Ding , Yiwen Tang , Fuh-Wei Tang , Lothar Walter Kleiner , Syed Faiyaz Ahmed Hossainy
发明人： Shaw Ling Hsu , Ni Ding , Yiwen Tang , Fuh-Wei Tang , Lothar Walter Kleiner , Syed Faiyaz Ahmed Hossainy
IPC分类号： B05D3/02 , A61L33/00 , A61F2/06
CPC分类号： A61L31/10 , A61F2240/001 , A61F2250/0056 , A61F2250/0068 , A61L31/16 , A61L2300/416 , A61L2300/60 , C08L33/10 , C08L27/16 , C08L27/20 , C08L29/04
摘要： Methods for modulating the release rate of a drug coated stent are disclosed.
摘要翻译：公开了调节药物涂层支架释放速率的方法。

6. 发明申请

US20090041845A1 Implantable medical devices having thin absorbable coatings 审中-公开
标题翻译：具有薄吸收性涂层的可植入医疗器械
公开(公告)号：US20090041845A1
公开(公告)日：2009-02-12
申请号：US11891131
申请日：2007-08-08
申请人： Lothar Walter Kleiner , Jessica Renee DesNoyer , Bozena Zofia Maslanka , Mikael Trollsas , Syed F.A. Hossainy , Yiwen Tang , Thierry Glauser , Michael Ngo
发明人： Lothar Walter Kleiner , Jessica Renee DesNoyer , Bozena Zofia Maslanka , Mikael Trollsas , Syed F.A. Hossainy , Yiwen Tang , Thierry Glauser , Michael Ngo
IPC分类号： A61K9/00 , A61K31/436
CPC分类号： A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/602 , A61L2420/06
摘要： Disclosed herein is a coating having a layer that includes a matrix phase and a dispersed phase substantially immiscible in the matrix phase and methods of using the same.
摘要翻译：本文公开了一种涂层，其具有包括基质相和在基质相中基本上不混溶的分散相的层及其使用方法。

7. 发明授权

US06168313A Bearing unit including linear bearing 有权
标题翻译：轴承单元包括直线轴承
公开(公告)号：US06168313A
公开(公告)日：2001-01-02
申请号：US09247518
申请日：1999-02-10
申请人： Ludwig Edelmann , Andreas Geyer , Hermann Glöckner , Georg Hierl , Holger Kristandt , Uwe Mayer , Henryk Velde , Lothar Walter
发明人： Ludwig Edelmann , Andreas Geyer , Hermann Glöckner , Georg Hierl , Holger Kristandt , Uwe Mayer , Henryk Velde , Lothar Walter
IPC分类号： F16C2906
CPC分类号： F16C29/069
摘要： A bearing unit includes a housing provided with a cylindrical bore and a linear bearing positioned within the cylindrical bore. The linear bearing includes a cage in which are arranged a plurality of endless ball rows each defined by a longitudinally extending ball track for load-bearing balls, a longitudinally extending return track for non-load-bearing balls, and deflection tracks connecting ends of the longitudinally extending ball track and the longitudinally extending return track. Each longitudinally extending ball track opens radially outwardly with a track plate being arranged to cover the longitudinally extending ball track for the load-bearing balls. The cylindrical bore of the housing is provided with a plurality of recesses each located in an area of the cylindrical bore facing one axial end of one of the track plates to permit radial deflection of the one axial end of the track plate.
摘要翻译：轴承单元包括设置有圆柱形孔的壳体和位于圆柱形孔内的直线轴承。线性轴承包括保持架，其中布置有多个环形滚珠排，每个环形滚珠排由用于承载滚珠的纵向延伸的滚珠轨道，用于非承载滚珠的纵向延伸的返回轨道和连接端部的偏转轨道纵向延伸的球道和纵向延伸的返回轨道。每个纵向延伸的球轨径向向外打开，轨道板布置成覆盖用于承载球的纵向延伸的球轨。壳体的圆柱形孔设置有多个凹槽，每个凹槽各自位于圆柱形孔的面向一个轨道板的一个轴向端部的区域中，以允许轨道板的一个轴向端部的径向偏转。

8. 发明授权

US6155719A Linear guide assembly with positively guided cage 有权
标题翻译：带导向保持架的直线导轨组件
公开(公告)号：US6155719A
公开(公告)日：2000-12-05
申请号：US287687
申请日：1999-04-07
申请人： Ludwig Edelmann , Andreas Geyer , Hermann Glockner , Georg Hierl , Holger Kristandt , Uwe Mayer , Henryk Velde , Lothar Walter
发明人： Ludwig Edelmann , Andreas Geyer , Hermann Glockner , Georg Hierl , Holger Kristandt , Uwe Mayer , Henryk Velde , Lothar Walter
IPC分类号： F16C29/04 , F16C33/46
CPC分类号： F16C33/46 , F16C29/041 , F16C29/043 , F16C33/306 , Y10T74/18992 , Y10T74/19981
摘要： Linear guide assembly comprising at least two guide rails, which are movable in the longitudinal direction with respect to each other having similarly shaped raceways, a plurality rolling elements, guided in a cage, at least one gear wheel connected to the cage for the positive guidance of the cage, which wheel engages in toothed racks or the like, each of which is connected to a guide rail, said gear wheel consisting of a disk, having an external circumference which is provided with uniformly distributed axial rolling elements, which project slightly beyond the disk, and wherein said recesses, correspond to the external shape of the rolling elements and into which the rolling elements can engage, are provided equal distances apart directly in the guide rails.
摘要翻译：线性引导组件，其包括至少两个导轨，它们可相对于彼此在纵向方向上可移动，具有类似形状的滚道，多个滚动元件，在保持架中被引导，至少一个连接到所述保持架的齿轮用于正引导的齿轮啮合在齿条等中，每个齿条连接到导轨，所述齿轮由盘组成，外圆周设有均匀分布的轴向滚动元件，其略微突出盘，并且其中所述凹槽对应于滚动元件的外部形状，并且滚动元件可以接合到其中，在导轨中直接间隔开等距离。

9. 发明授权

US6123338A Radial seal for ball bearing 失效
标题翻译：滚珠轴承径向密封
公开(公告)号：US6123338A
公开(公告)日：2000-09-26
申请号：US19779
申请日：1998-02-06
申请人： Ludwig Edelmann , Andreas Geyer , Hermann Glockner , Holger Kristandt , Uwe Mayer , Henryk Velde , Lothar Walter
发明人： Ludwig Edelmann , Andreas Geyer , Hermann Glockner , Holger Kristandt , Uwe Mayer , Henryk Velde , Lothar Walter
IPC分类号： F16C33/78 , F16C29/08 , F16C33/72 , F16J15/32 , F16C29/06
CPC分类号： F16C29/084
摘要： A radial seal useful in linear ball bearings and designed to be secured during transportation as well as during operation of the bearing includes an arcuate disk portion having opposite sides. An arcuate projection is provided on each side of the disk portion, at least one of which is axially oriented. The projections are designed to have different diameters. This produces a stepped seating surface along the outside diameter of the radial seal that effects a reliable seating of the radial seal in the linear ball bearing. The radial seal can also be designed with two axially oriented projections disposed at different diameters on one side of the disk portion for projecting into an annular groove on the frontal face of the outer ring of the linear ball bearing. By constructing the projections with circumferential outer faces that slightly diverge in a cone-shaped manner, the projections further inhibit the seal from falling out of the groove.
摘要翻译：用于线性球轴承并被设计成在运输期间以及在轴承运行期间固定的径向密封件包括具有相对侧面的弓形盘部分。在圆盘部分的每一侧上设有弧形突起，其中至少一个轴向定向。突起被设计成具有不同的直径。这沿着径向密封件的外径产生阶梯式的座面，其实现了径向密封件在直线球轴承中的可靠安置。径向密封件还可以设计成具有两个轴向定向的突起，该突出部设置在盘部分的一侧上的不同直径处，用于突出到线性球轴承的外圈的前表面上的环形槽中。通过以圆锥形的方式构造具有稍微发散的圆周外表面的突起，突起进一步禁止密封件从凹槽中脱落。

10. 发明授权

US6068404A Ball bearing for longitudinal movements 有权
标题翻译：滚珠轴承用于纵向运动
公开(公告)号：US6068404A
公开(公告)日：2000-05-30
申请号：US156644
申请日：1998-09-18
申请人： Ludwig Edelmann , Andreas Geyer , Hermann Glockner , Holger Kristandt , Zoltan Laszlofalvi , Uwe Mayer , Henryk Velde , Lothar Walter
发明人： Ludwig Edelmann , Andreas Geyer , Hermann Glockner , Holger Kristandt , Zoltan Laszlofalvi , Uwe Mayer , Henryk Velde , Lothar Walter
IPC分类号： F16C33/66 , F16C29/06
CPC分类号： F16C29/069 , F16C29/084
摘要： A ball bearing for permitting longitudinal movements with respect to a shaft includes a cage provided with at least two longitudinally extending guide tracks having opposite ends that are connected by semicircular turn around tracks. A plurality of balls are positioned in the guide tracks, with balls positioned in one of the guide tracks forming load-bearing balls and balls positioned in another one of the guide tracks forming non-load-bearing balls. The longitudinally extending guide track for the load-bearing balls is provided with a slit that is open radially inwardly for passage of the balls in a direction radially inwardly towards the shaft. The longitudinally extending guide track for the non-load-bearing balls has an interior wall which, in cross-section, possesses at least two substantially diametrically opposed first sections having a circular contour and at least two substantially diametrically opposed second sections laterally offset from the first sections and having a base that is set back from the circular contour.
摘要翻译：用于允许相对于轴的纵向移动的滚珠轴承包括设置有至少两个纵向延伸的引导轨道的保持架，该引导轨道具有通过围绕轨道的半圆形转弯连接的相对端部。多个球定位在导轨中，其中一个导轨中的滚珠形成承载球和定位在另一个导轨中的球，形成非承载球。用于承载球的纵向延伸的导轨设置有向径向向内开放的狭缝，用于使球沿径向向内朝向轴的方向通过。用于非承载滚珠的纵向延伸的导轨具有内壁，其横截面具有至少两个具有圆形轮廓的基本上直径相对的第一部分，以及至少两个基本上直径相对的第二部分，其横向偏离第一部分并且具有从圆形轮廓回退的基部。

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