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1. 发明授权

US08628754B2 Highly efficient delivery of a large therapeutic mass aerosol 有权
标题翻译：高效率地传送大量治疗性气溶胶
公开(公告)号：US08628754B2
公开(公告)日：2014-01-14
申请号：US13334236
申请日：2011-12-22
申请人： David A. Edwards , Richard P. Batycky , Lloyd Johnston
发明人： David A. Edwards , Richard P. Batycky , Lloyd Johnston
IPC分类号： A61K9/14
CPC分类号： A61K9/14 , A61K9/0075 , A61K9/1617 , A61K31/198
摘要： A method for delivering an agent to the pulmonary system, in a single, breath-activated step or a single breath, comprises administering from a receptacle enclosing a mass of particles, to a subject's respiratory tract, particles which have a tap density of less than 0.4 g/cm3 and deliver at least about 50% of the mass of particles. The particles are capable of carrying agents. The agent is (1) part of the spray-drying pre-mixture and thereby incorporated into the particles, (2) added to separately-prepared particles so that the agent is in chemical association with the particles or (3) blended so that the agent is mixed with, and co-delivered with the particles.Respirable compositions comprising carrier particles having a tap density of less than 0.4 g/cm3 and a composition comprising an agent are also disclosed. Methods of delivering these respirable compositions are also included.
摘要翻译：用于在单个呼吸激活步骤或单次呼吸中将药物递送至肺部系统的方法包括从包围大量颗粒的容器向受试者的呼吸道施用具有小于 0.4克/厘米3，并输送至少约50％的颗粒。颗粒能够携带。试剂是（1）部分喷雾干燥预混合物，由此加入到颗粒中，（2）加入到单独制备的颗粒中，使得试剂与颗粒化学缔合，或（3）混合试剂与颗粒混合并与颗粒共同传送。还公开了包含振实密度小于0.4g / cm 3的载体颗粒和包含试剂的组合物的可吸入组合物。还包括递送这些可呼吸组合物的方法。

2. 发明申请

US20110293701A1 MULTIVALENT SYNTHETIC NANOCARRIER VACCINES 审中-公开
标题翻译：多功能合成纳米抗体疫苗
公开(公告)号：US20110293701A1
公开(公告)日：2011-12-01
申请号：US13116488
申请日：2011-05-26
申请人： Robert L. Bratzler , Lloyd Johnston , Grayson B. Lipford , Charles Zepp
发明人： Robert L. Bratzler , Lloyd Johnston , Grayson B. Lipford , Charles Zepp
IPC分类号： A61K9/127 , A61K39/116 , A61K39/00 , A61K38/21 , A61P31/00 , A61P35/00 , A61P25/30 , A61K39/295 , A61K9/14
CPC分类号： A61K45/06 , A61K9/5153 , A61K31/4745 , A61K31/7115 , A61K33/06 , A61K39/0005 , A61K39/0013 , A61K39/35 , A61K39/385 , A61K39/39 , A61K47/02 , A61K47/22 , A61K47/24 , A61K47/58 , A61K47/593 , A61K47/60 , A61K47/646 , A61K47/68 , A61K47/6921 , A61K47/6929 , A61K47/6931 , A61K2039/54 , A61K2039/541 , A61K2039/542 , A61K2039/543 , A61K2039/555 , A61K2039/55511 , A61K2039/55522 , A61K2039/55555 , A61K2039/55561 , A61K2039/6093 , A61K2039/70 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/396 , Y02A50/401 , Y02A50/403 , Y02A50/466 , Y02A50/469 , Y02A50/478 , Y02A50/48 , Y02A50/484 , A61K2300/00
摘要： The invention relates, at least in part, to compositions comprising populations of synthetic nanocarriers that comprise different sets of antigens as well as related methods.
摘要翻译：本发明至少部分涉及包含包含不同组抗原的合成纳米载体群以及相关方法的组合物。

3. 发明申请

US20110293700A1 NANOCARRIER COMPOSITIONS WITH UNCOUPLED ADJUVANT 审中-公开
标题翻译：纳诺卡尔组合物与未经佐证的ADJUVANT
公开(公告)号：US20110293700A1
公开(公告)日：2011-12-01
申请号：US13116453
申请日：2011-05-26
申请人： Robert L. Bratzler , Lloyd Johnston , Grayson B. Lipford , Charles Zepp
发明人： Robert L. Bratzler , Lloyd Johnston , Grayson B. Lipford , Charles Zepp
IPC分类号： A61K9/127 , A61K47/30 , A61K47/42 , A61K39/385 , A61P29/00 , A61K9/14 , A61P35/00 , A61P31/00 , A61P17/00 , A61P11/06 , A61P11/00 , A61K39/00 , A61P37/00
CPC分类号： A61K45/06 , A61K9/5153 , A61K31/4745 , A61K31/7115 , A61K33/06 , A61K39/0005 , A61K39/0013 , A61K39/35 , A61K39/385 , A61K39/39 , A61K47/02 , A61K47/22 , A61K47/24 , A61K47/58 , A61K47/593 , A61K47/60 , A61K47/646 , A61K47/68 , A61K47/6921 , A61K47/6929 , A61K47/6931 , A61K2039/54 , A61K2039/541 , A61K2039/542 , A61K2039/543 , A61K2039/555 , A61K2039/55511 , A61K2039/55522 , A61K2039/55555 , A61K2039/55561 , A61K2039/6093 , A61K2039/70 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/396 , Y02A50/401 , Y02A50/403 , Y02A50/466 , Y02A50/469 , Y02A50/478 , Y02A50/48 , Y02A50/484 , A61K2300/00
摘要： Disclosed are synthetic nanocarrier compositions with separate adjuvant compositions as well as related methods.
摘要翻译：公开了具有单独的佐剂组合物的合成纳米载体组合物以及相关方法。

4. 发明申请

US20090068274A1 HIGHLY EFFICIENT DELIVERY OF A LARGE THERAPEUTIC MASS AEROSOL 审中-公开
标题翻译：高效治疗大剂量气溶胶的高效运输
公开(公告)号：US20090068274A1
公开(公告)日：2009-03-12
申请号：US12253449
申请日：2008-10-17
申请人： David A. Edwards , Richard P. Batycky , Lloyd Johnston
发明人： David A. Edwards , Richard P. Batycky , Lloyd Johnston
IPC分类号： A61K9/14 , A61P11/00
CPC分类号： A61K9/14 , A61K9/0075 , A61K9/1617 , A61K31/198
摘要： A method for delivering an agent to the pulmonary system, in a single, breath-activated step or a single breath, comprises administering from a receptacle enclosing a mass of particles, to a subject's respiratory tract, particles which have a tap density of less than 0.4 g/cm3 and deliver at least about 50% of the mass of particles. The particles are capable of carrying agents. The agent is (1) part of the spray-drying pre-mixture and thereby incorporated into the particles, (2) added to separately-prepared particles so that the agent is in chemical association with the particles or (3) blended so that the agent is mixed with, and co-delivered with the particles.Respirable compositions comprising carrier particles having a tap density of less than 0.4 g/cm3 and a composition comprising an agent are also disclosed. Methods of delivering these respirable compositions are also included.
摘要翻译：用于在单个呼吸激活步骤或单次呼吸中将药物递送至肺部系统的方法包括从包围大量颗粒的容器向受试者的呼吸道施用具有小于 0.4克/厘米3，并输送至少约50％的颗粒。颗粒能够携带。试剂是（1）部分喷雾干燥预混合物，由此加入到颗粒中，（2）加入到单独制备的颗粒中，使得试剂与颗粒化学缔合，或（3）混合试剂与颗粒混合并与颗粒共同传送。还公开了包含振实密度小于0.4g / cm 3的载体颗粒和包含试剂的组合物的可吸入组合物。还包括递送这些可呼吸组合物的方法。

5. 发明授权

US06921528B2 Highly efficient delivery of a large therapeutic mass aerosol 有权
标题翻译：高效率地传送大量治疗性气溶胶
公开(公告)号：US06921528B2
公开(公告)日：2005-07-26
申请号：US10681416
申请日：2003-10-08
申请人： David A. Edwards , Richard P. Batvcky , Lloyd Johnston
发明人： David A. Edwards , Richard P. Batvcky , Lloyd Johnston
IPC分类号： A61K9/12 , A61K9/00 , A61K9/14 , A61K9/16 , A61K9/72 , A61K31/137 , A61K31/198 , A61K31/46 , A61K31/56 , A61K38/27 , A61K38/28 , A61K39/395 , A61L9/04 , B05D7/14
CPC分类号： A61K9/14 , A61K9/0075 , A61K9/1617 , A61K31/198
摘要： A method for delivering a therapeutic dose of a bioactive agent to the pulmonary system, in a single, breath-activated step, comprises administering from a receptacle enclosing a mass of particles, to a subject's respiratory tract, particles which have a tap density of less than 0.4 g/cm3 and deliver at least about 50% of the mass of particles. Another method of delivering a therapeutic dose of a bioactive agent to the pulmonary system, in a single breath, includes administering from a receptacle enclosing a mass of particles, to a subject's respiratory tract, particles which have a tap density of at least 0.4 g/cm3 and deliver at least about 10 milligrams of the bioactive agent. The receptacle can have a volume of at least 0.37 cm3.
摘要翻译：在单一呼吸激活步骤中将治疗剂量的生物活性剂递送到肺系统的方法包括从包围大量颗粒的容器向受试者的呼吸道施用具有较小振幅密度的颗粒超过0.4g / cm 3，并输送至少约50％的质量的颗粒。在单次呼吸中将治疗剂量的生物活性剂递送到肺系统的另一种方法包括从包围大量颗粒的容器向受试者的呼吸道施用具有至少0.4g / 并输送至少约10毫克的生物活性剂。容器可具有至少0.37厘米3的体积。

6. 发明授权

US06858199B1 High efficient delivery of a large therapeutic mass aerosol 有权
标题翻译：高效率输送大量治疗性气溶胶
公开(公告)号：US06858199B1
公开(公告)日：2005-02-22
申请号：US09591307
申请日：2000-06-09
申请人： David A. Edwards , Richard P. Batycky , Lloyd Johnston
发明人： David A. Edwards , Richard P. Batycky , Lloyd Johnston
IPC分类号： A61K9/12 , A61K9/00 , A61K9/14 , A61K9/16 , A61K9/72 , A61K31/137 , A61K31/198 , A61K31/46 , A61K31/56 , A61K38/27 , A61K38/28 , A61K39/395 , A61L9/04 , B05D7/14
CPC分类号： A61K9/14 , A61K9/0075 , A61K9/1617 , A61K31/198
摘要： A method for delivering a therapeutic dose of a bioactive agent to the pulmonary system, in a single, breath-activated step, comprises administering from a receptacle enclosing a mass of particles, to a subject's respiratory tract, particles which have a tap density of less than 0.4 g/cm3 and deliver at least about 50% of the mass of particles. Another method of delivering a therapeutic dose of a bioactive agent to the pulmonary system, in a single breath, includes administering from a receptacle enclosing a mass of particles, to a subject's respiratory tract, particles which have a tap density of at least 0.4 g/cm3 and deliver at least about 10 milligrams of the bioactive agent. The receptacle can have a volume of at least 0.37 cm3.
摘要翻译：在单一呼吸激活步骤中将治疗剂量的生物活性剂递送到肺系统的方法包括从包围大量颗粒的容器向受试者的呼吸道施用具有较小振幅密度的颗粒超过0.4g / cm 3并且输送至少约50％的质量的颗粒。在单次呼吸中将治疗剂量的生物活性剂递送到肺系统的另一种方法包括从包围大量颗粒的容器向受试者的呼吸道施用具有至少0.4g / 并输送至少约10毫克的生物活性剂。容器可具有至少0.37厘米3的体积。

7. 发明授权

US06848197B2 Control of process humidity to produce large, porous particles 有权
标题翻译：控制工艺湿度以产生大的多孔颗粒
公开(公告)号：US06848197B2
公开(公告)日：2005-02-01
申请号：US09837620
申请日：2001-04-18
申请人： Donghao Chen , Richard P. Batycky , Lloyd Johnston , Jeffrey Mintzes
发明人： Donghao Chen , Richard P. Batycky , Lloyd Johnston , Jeffrey Mintzes
IPC分类号： A61K9/72 , A61K9/00 , A61K9/14 , A61K9/16 , A61K47/24 , A61L9/04 , B05D7/00 , E02F5/10 , A01N25/02
CPC分类号： A61K9/0075 , A61K9/1694 , Y10S514/951
摘要： Spray dried particles having specified aerodynamic characteristics are produced by atomizing a liquid feed and contacting the liquid feed with a drying gas, such as, for example, air or nitrogen. The humidity of the drying gas is controlled to a value, expressed, for instance, as dew point, which is known to produce particles having a specified tap density or aerodynamic diameter. Particles having a volume median geometric diameter greater than about 5 microns and a tap density less than about 0.4 g/cm3 are preferred.
摘要翻译：通过雾化液体进料并使液体进料与例如空气或氮气的干燥气体接触来产生具有特定空气动力特性的喷雾干燥颗粒。干燥气体的湿度被控制为例如表示为露点，其已知产生具有特定振实密度或空气动力学直径的颗粒。体积中值几何直径大于约5微米且振实密度小于约0.4g / cm 3的颗粒是优选的。

8. 发明授权

US11426451B2 Methods and compositions related to combined treatment with antiinflammatories and synthetic nanocarriers comprising an immunosuppressant 有权
公开(公告)号：US11426451B2
公开(公告)日：2022-08-30
申请号：US15917742
申请日：2018-03-11
申请人： Selecta Biosciences, Inc. , Lloyd Johnston
发明人： Lloyd Johnston
IPC分类号： A61K38/44 , A61K31/436 , A61K9/51 , A61K45/00 , A61K38/43 , A61P29/00 , A61K31/165 , A61K31/192 , A61K31/445 , A61K31/573 , A61K45/06
摘要： Provided herein are methods and compositions, such as kits, related to compositions comprising synthetic nanocarriers comprising an immunosuppressant and compositions comprising an uricase and a composition comprising an anti-inflammatory therapeutic. Also provided herein are methods and compositions for the treatment of subjects in need of administration or treatment with the uricase.

9. 发明授权

US07556798B2 Highly efficient delivery of a large therapeutic mass aerosol 有权
公开(公告)号：US07556798B2
公开(公告)日：2009-07-07
申请号：US09878146
申请日：2001-06-08
申请人： David A. Edwards , Richard P. Batycky , Lloyd Johnston
发明人： David A. Edwards , Richard P. Batycky , Lloyd Johnston
IPC分类号： A61K9/12 , A61K9/14
CPC分类号： A61K9/14 , A61K9/0075 , A61K9/1617 , A61K31/198
摘要： A method for delivering an agent to the pulmonary system, in a single, breath-activated step or a single breath, comprises administering from a receptacle enclosing a mass of particles, to a subject's respiratory tract, particles which have a tap density of less than 0.4 g/cm3 and deliver at least about 50% of the mass of particles. The particles are capable of carrying agents. The agent is (1) part of the spray-drying pre-mixture and thereby incorporated into the particles, (2) added to separately-prepared particles so that the agent is in chemical association with the particles or (3) blended so that the agent is mixed with, and co-delivered with the particles.Respirable compositions comprising carrier particles having a tap density of less than 0.4 g/cm3 and a composition comprising an agent are also disclosed. Methods of delivering these respirable compositions are also included.

10. 发明申请

US20060039987A1 Method and apparatus for producing dry particles 审中-公开
公开(公告)号：US20060039987A1
公开(公告)日：2006-02-23
申请号：US11255879
申请日：2005-10-24
申请人： Richard Batycky , Blair Jackson , Lloyd Johnston , Jeffrey Mintzes , Ernest Penachio
发明人： Richard Batycky , Blair Jackson , Lloyd Johnston , Jeffrey Mintzes , Ernest Penachio
IPC分类号： A61K39/395 , A61K38/28 , A61K31/56 , A61K9/14
CPC分类号： A61K9/0075 , A61K9/1611 , A61K9/1617 , A61K9/1688 , A61K9/1694 , A61K31/137 , A61K38/27 , A61K38/28 , B01D1/18 , B01F3/0803 , B01F5/0619 , B01J2/04 , B01J2/10
摘要： Method and apparatus for producing dry particles. Two liquid components are combined in a static mixer, atomized into droplets, and the droplets dried to form dry particles. Use of the static mixer enables incompatible liquid components to be rapidly and homogeneously combined. The present invention optimizes process conditions for increasing and controlling particle porosity. The present invention also allows for optimization of particle size in real-time during particle production.

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