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1. 发明申请

US20120045507A1 STABLE SOFT CAPSULE DOSAGE FORM FOR ACETYLSALICYLIC ACID 失效
标题翻译：稳定的软胶囊用于乙酰胆酸的剂型
公开(公告)号：US20120045507A1
公开(公告)日：2012-02-23
申请号：US12859389
申请日：2010-08-19
申请人： Lionel Borkan
发明人： Lionel Borkan
IPC分类号： A61K9/66 , A61P29/00 , B05D7/00 , A61P9/08 , B65D83/04 , A61K31/616 , A61P7/02
CPC分类号： A61K31/616 , A61K9/4858
摘要： A stable soft gel dosage form for acetylsalicylic acid (ASA), aspirin, is provided wherein soft gel capsules containing the ASA can be stored for prolonged periods under typical home storage conditions with better than 98% or 99% ASA integrity and with negligible physical or chemical deterioration of the soft gelatin capsule over the period of six months. A suspension of ASA in a monoglyceride component comprising more than about 50% glyceryl monooleate is packaged in a soft gelatin capsule, which can be substantially free of other components. The ASA in this composition is resistant to hydrolysis from water contained within the soft gelatin matrix or diffusing through the matrix. Methods of preparation and methods of use are also provided.
摘要翻译：提供了一种用于乙酰水杨酸（ASA），阿司匹林的稳定的软凝胶剂型，其中含有ASA的软凝胶胶囊可以在典型的家庭储存条件下长期储存，具有优于98％或99％的ASA完整性，并且具有可忽略的物理或软胶囊在六个月内的化学变质。包含大于约50％甘油单油酸酯的单酸甘油酯组分中的ASA的悬浮液包装在软明胶胶囊中，其可以基本上不含其它组分。该组合物中的ASA对软明胶基质中含有的水的水解具有抗性，或通过基质扩散。还提供了制备方法和使用方法。

2. 发明授权

US4935243A Chewable, edible soft gelatin capsule 失效
标题翻译：咀嚼食用软胶囊
公开(公告)号：US4935243A
公开(公告)日：1990-06-19
申请号：US286324
申请日：1988-12-19
申请人： Lionel Borkan , Ira R. Berry , Dilip Shah
发明人： Lionel Borkan , Ira R. Berry , Dilip Shah
IPC分类号： A61K9/00 , A61K9/48
CPC分类号： A61K9/0056 , A61K9/4825 , A61K9/4858
摘要： In accordance with the present invention, there is provided a chewable, edible soft gelatin capsule which comprises a shell comprising water, gelatin, plasticizer, and an amount of hydrogenated starch hydrolysate effective to render said shell dispersible and soluble in the mouth of the user; and a soft gelatin capsule fill material in which an active ingredient, preferably a biologically-active agent, is dispersed or dissolved.

3. 发明授权

US4597885A Encapsulated foaming bath composition 失效
标题翻译：包封泡沫浴组成
公开(公告)号：US4597885A
公开(公告)日：1986-07-01
申请号：US688748
申请日：1985-01-02
申请人： Ira R. Berry , Dilip Shah , Lionel Borkan
发明人： Ira R. Berry , Dilip Shah , Lionel Borkan
IPC分类号： A61J3/07 , A61K8/11 , A61Q19/10 , C11D17/08
CPC分类号： A61Q19/10 , A61K8/11
摘要： Cosmetic unit dosage forms comprising encapsulated liquid blends of acidic and basic surfactants are provided. The blends are both high-foaming bath compositions and compatible with soft gelatin capsules.
摘要翻译：提供包含酸性和碱性表面活性剂的包封液体共混物的化妆品单位剂量形式。共混物都是高泡沫浴组合物，并且与软明胶胶囊相容。

4. 发明授权

US4795642A Gelatin-encapsulated controlled-release composition 失效
标题翻译：明胶包封的控释组合物
公开(公告)号：US4795642A
公开(公告)日：1989-01-03
申请号：US85795
申请日：1987-08-17
申请人： Jonathan M. Cohen , Ira R. Berry , Lionel Borkan
发明人： Jonathan M. Cohen , Ira R. Berry , Lionel Borkan
IPC分类号： A61K9/48 , A61K9/52 , A61K9/66 , B01J13/02
CPC分类号： A61K9/4866 , A61K9/4858 , Y10S424/15 , Y10S514/944 , Y10S514/963 , Y10S514/965 , Y10T428/2984 , Y10T428/2989
摘要： A controlled-release pharmaceutical unit dosage form is provided comprising a gelatin capsule enclosing a solid matrix formed by the cation-assisted gellation of a liquid fill incorporating vegatable gum and a pharmaceutically-active compound, as well as methods for the preparation thereof.
摘要翻译：提供了一种控释药物单位剂型，其包含包封由包含可植入口香糖和药物活性化合物的液体填充物的阳离子辅助凝胶形成的固体基质的明胶胶囊以及其制备方法。

5. 发明授权

US08287904B2 Stable soft capsule dosage form for acetylsalicylic acid 失效
标题翻译：乙酰水杨酸稳定软胶囊剂型
公开(公告)号：US08287904B2
公开(公告)日：2012-10-16
申请号：US12859389
申请日：2010-08-19
申请人： Lionel Borkan
发明人： Lionel Borkan
IPC分类号： A61K9/66 , A61K31/60 , A61K47/14
CPC分类号： A61K31/616 , A61K9/4858
摘要： A stable soft gel dosage form for acetylsalicylic acid (ASA), aspirin, is provided wherein soft gel capsules containing the ASA can be stored for prolonged periods under typical home storage conditions with better than 98% or 99% ASA integrity and with negligible physical or chemical deterioration of the soft gelatin capsule over the period of six months. A suspension of ASA in a monoglyceride component comprising more than about 50% glyceryl monooleate is packaged in a soft gelatin capsule, which can be substantially free of other components. The ASA in this composition is resistant to hydrolysis from water contained within the soft gelatin matrix or diffusing through the matrix. Methods of preparation and methods of use are also provided.
摘要翻译：提供了一种用于乙酰水杨酸（ASA），阿司匹林的稳定的软凝胶剂型，其中含有ASA的软凝胶胶囊可以在典型的家庭储存条件下长期储存，具有优于98％或99％的ASA完整性，并且具有可忽略的物理或软胶囊在六个月内的化学变质。包含大于约50％甘油单油酸酯的单酸甘油酯组分中的ASA的悬浮液包装在软明胶胶囊中，其可以基本上不含其它组分。该组合物中的ASA对软明胶基质中含有的水的水解具有抗性，或通过基质扩散。还提供了制备方法和使用方法。

6. 发明授权

US4708834A Preparation of gelatin-encapsulated controlled release composition 失效
标题翻译：明胶胶囊控释组合物的制备
公开(公告)号：US4708834A
公开(公告)日：1987-11-24
申请号：US858969
申请日：1986-05-01
申请人： Jonathan M. Cohen , Ira R. Berry , Lionel Borkan
发明人： Jonathan M. Cohen , Ira R. Berry , Lionel Borkan
IPC分类号： A61K9/48 , A61K9/52 , A61K47/00 , A61K47/36 , B01J13/02
CPC分类号： A61K9/4866 , A61K9/4858 , Y10S514/944 , Y10S514/966 , Y10S514/967 , Y10T428/2984 , Y10T428/2989
摘要： A controlled-release pharmaceutical unit dosage form is provided comprising a gelatin capsule enclosing a solid matrix formed by the cation-assisted gellation of a liquid fill incorporating a vegetable gum and a pharmaceutically-active compound, as well as methods for the preparation thereof.

7. 发明授权

US4486412A Encapsulated antacid dispersions 失效
标题翻译：包封的抗酸分散体
公开(公告)号：US4486412A
公开(公告)日：1984-12-04
申请号：US475491
申请日：1983-03-15
申请人： Dilip Shah , Lionel Borkan , Ira R. Berry
发明人： Dilip Shah , Lionel Borkan , Ira R. Berry
IPC分类号： A61K9/48 , A61K33/06 , A61K33/10 , A61K33/08 , A61K33/42
CPC分类号： A61K9/4866 , A61K33/06 , A61K9/4858 , Y10S514/82 , Y10S514/962
摘要： Pharmaceutical unit dosage forms comprising dispersions of basic salts in a carrier mixture comprising polyalkylene glycols and a C.sub.2 -C.sub.5 polyol encapsulated in soft gelatin capsules are prepared without deleteriously affecting the stability of the capsules.
摘要翻译：制备包含碱性盐在包含聚亚烷基二醇和包封在软明胶胶囊中的C2-C5多元醇的载体混合物中的分散体的药物单位剂型，而不会有害地影响胶囊的稳定性。

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