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1. 发明授权

US08137640B2 Acoustically mediated fluid transfer methods and uses thereof 有权
标题翻译：声介导流体转移方法及其应用
公开(公告)号：US08137640B2
公开(公告)日：2012-03-20
申请号：US11964628
申请日：2007-12-26
申请人： Roger O. Williams , Tarlochan S. Jutty , N. Nicolas Mansour , Lawrence Lee, Jr. , Michael J. Forbush
发明人： Roger O. Williams , Tarlochan S. Jutty , N. Nicolas Mansour , Lawrence Lee, Jr. , Michael J. Forbush
IPC分类号： B01L3/02
CPC分类号： B01L3/0268 , B01J19/0046 , B01J2219/00362 , B01J2219/00378 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00725 , B01L2300/0819 , B01L2400/0433 , B01L2400/0436 , B05B17/0615 , C40B30/04 , C40B40/02 , C40B40/04 , C40B40/08 , C40B40/10 , C40B50/00 , C40B60/14 , F04F7/00 , G01N21/11 , Y10T137/206 , Y10T137/2196 , Y10T436/2575
摘要： Invention methods employ the use of acoustic waves to transfer small amounts of fluid in a non-contact manner. In invention methods, acoustic waves are propagated through a separated pool of a source fluid in such a manner that causes the ejection of a single micro-droplet from the surface of the pool. The droplet is ejected towards a target with sufficient force to provide for contact of the droplet with the target. Because the fluid is not contacted by any fluid transfer device such as a pipette, the opportunities for contamination are minimized. Invention methods may be employed to transfer fluids from an array of source sites to an array of target sites, thereby enabling the precision automation of a wide variety of procedures including screening, and synthesis procedures commonly used in biotechnology.
摘要翻译：本发明的方法采用声波以非接触方式传送少量流体。在本发明的方法中，声波以这样的方式传播通过源流体的分离池，使得从池的表面喷出单个微滴。液滴以足够的力朝向目标喷射以提供液滴与靶的接触。由于流体不被诸如移液管之类的任何流体转移装置接触，污染的机会被最小化。可以采用本发明的方法将流体从源位置阵列转移到目标位点阵列，从而能够精确自动化多种程序，包括生物技术中通常使用的筛选和合成方法。

2. 发明授权

US06916083B2 Control over flow of an acoustic coupling fluid 有权
标题翻译：控制声耦合流体的流动
公开(公告)号：US06916083B2
公开(公告)日：2005-07-12
申请号：US10668534
申请日：2003-09-22
申请人： Michael F. Miller , Glen Krueger , Lawrence Lee, Jr. , David S. Lee
发明人： Michael F. Miller , Glen Krueger , Lawrence Lee, Jr. , David S. Lee
IPC分类号： B41J2/14 , B41J2/135
CPC分类号： B41J2/14008
摘要： An acoustic device is provided comprising a reservoir adapted to contain a fluid and having an exterior surface, an acoustic radiation generator for generating acoustic radiation, and a means for delivering an acoustic coupling fluid to the exterior surface of the reservoir. The acoustic radiation generator is placed in acoustic coupling relationship via the acoustic coupling fluid to the reservoir. Acoustic radiation generated by the acoustic radiation generator is transmitted through the exterior surface and into any fluid contained in the reservoir. Uncontrolled flow of the acoustic coupling fluid at the exterior surface as a result of movement of the acoustic radiation generator is eliminated. Also provided are methods that eliminate such uncontrolled flow.
摘要翻译：提供了一种声学装置，其包括适于容纳流体并具有外表面的储存器，用于产生声辐射的声辐射发生器，以及用于将声耦合流体输送到储存器的外表面的装置。声辐射发生器通过声耦合流体与储存器放置在声耦合关系中。由声辐射发生器产生的声辐射通过外表面传输到包含在储存器中的任何流体。由于声辐射发生器的移动，在外表面处的声耦合流体的不受控制的流动被消除。还提供了消除这种不受控流量的方法。

3. 发明授权

US06596239B2 Acoustically mediated fluid transfer methods and uses thereof 有权
标题翻译：声介导流体转移方法及其应用
公开(公告)号：US06596239B2
公开(公告)日：2003-07-22
申请号：US09735709
申请日：2000-12-12
申请人： Roger O. Williams , Tarlochan Singh , N. Nicolas Mansour , Lawrence Lee, Jr. , Michael J. Forbush
发明人： Roger O. Williams , Tarlochan Singh , N. Nicolas Mansour , Lawrence Lee, Jr. , Michael J. Forbush
IPC分类号： B01L302
CPC分类号： B01L3/0268 , B01J19/0046 , B01J2219/00362 , B01J2219/00378 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00725 , B01L2300/0819 , B01L2400/0433 , B01L2400/0436 , B05B17/0615 , C40B30/04 , C40B40/02 , C40B40/04 , C40B40/08 , C40B40/10 , C40B50/00 , C40B60/14 , F04F7/00 , G01N21/11 , Y10T137/206 , Y10T137/2196 , Y10T436/2575
摘要： Acoustic waves are used to transfer small amounts of fluid in a non-contact manner. Acoustic waves are propagated through a pool of a source fluid in such a manner that causes the ejection of a single micro-droplet from the surface of the pool. The droplet is ejected towards a target with sufficient force to provide contact of the droplet with the target. Because the fluid is not contacted by any fluid transfer device such as a pipette, the opportunities for contamination are minimized. Methods may be employed to transfer fluids from an array of source sites to an array of target sites, thereby enabling the precise automation of a wide variety of procedures including screening and synthesis procedures commonly used in biotechnology.
摘要翻译：声波用于以非接触方式转移少量流体。声波以这样的方式传播通过源流体池，使得从池的表面喷射单个微滴。液滴以足够的力朝向目标喷射以提供液滴与靶的接触。由于流体不被诸如移液管之类的任何流体转移装置接触，污染的机会被最小化。可以采用方法将流体从源位置阵列转移到靶位点阵列，从而能够精确自动化各种程序，包括通常用于生物技术的筛选和合成过程。

4. 外观设计

USD348058S Front panel for a computer 失效
公开(公告)号：USD348058S
公开(公告)日：1994-06-21
申请号：US1259
申请日：1992-11-09
申请人： Michael C. McGrath , Timothy O. Avery , Lawrence Lee, Jr.
设计人： Michael C. McGrath , Timothy O. Avery , Lawrence Lee, Jr.

5. 发明申请

US20120115756A1 ACOUSTICALLY MEDIATED FLUID TRANSFER METHODS AND USES THEREOF 审中-公开
标题翻译：主动介质流体传输方法及其用途
公开(公告)号：US20120115756A1
公开(公告)日：2012-05-10
申请号：US13329122
申请日：2011-12-16
申请人： Roger O. WILLIAMS , Tarlochan Singh , N. Nicolas Mansour , Lawrence Lee, JR. , Michael J. Forbush
发明人： Roger O. WILLIAMS , Tarlochan Singh , N. Nicolas Mansour , Lawrence Lee, JR. , Michael J. Forbush
IPC分类号： C40B50/14
CPC分类号： B01L3/0268 , B01J19/0046 , B01J2219/00362 , B01J2219/00378 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00725 , B01L2300/0819 , B01L2400/0433 , B01L2400/0436 , B05B17/0615 , C40B30/04 , C40B40/02 , C40B40/04 , C40B40/08 , C40B40/10 , C40B50/00 , C40B60/14 , F04F7/00 , G01N21/11 , Y10T137/206 , Y10T137/2196 , Y10T436/2575
摘要： Invention methods employ the use of acoustic waves to transfer small amounts of fluid in a non-contact manner. In invention methods, acoustic waves are propagated through a separated pool of a source fluid in such a manner that causes the ejection of a single micro-droplet from the surface of the pool. The droplet is ejected towards a target with sufficient force to provide for contact of the droplet with the target. Because the fluid is not contacted by any fluid transfer device such as a pipette, the opportunities for contamination are minimized. Invention methods may be employed to transfer fluids from an array of source sites to an array of target sites, thereby enabling the precision automation of a wide variety of procedures including screening, and synthesis procedures commonly used in biotechnology.
摘要翻译：本发明的方法采用声波以非接触方式传送少量流体。在本发明的方法中，声波以这样的方式传播通过源流体的分离池，使得从池的表面喷出单个微滴。液滴以足够的力朝向目标喷射以提供液滴与靶的接触。由于流体不被诸如移液管之类的任何流体转移装置接触，污染的机会被最小化。可以采用本发明的方法将流体从源位置阵列转移到目标位点阵列，从而能够精确自动化多种程序，包括生物技术中通常使用的筛选和合成方法。

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