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1. 发明申请

US20120115756A1 ACOUSTICALLY MEDIATED FLUID TRANSFER METHODS AND USES THEREOF 审中-公开
标题翻译：主动介质流体传输方法及其用途
公开(公告)号：US20120115756A1
公开(公告)日：2012-05-10
申请号：US13329122
申请日：2011-12-16
申请人： Roger O. WILLIAMS , Tarlochan Singh , N. Nicolas Mansour , Lawrence Lee, JR. , Michael J. Forbush
发明人： Roger O. WILLIAMS , Tarlochan Singh , N. Nicolas Mansour , Lawrence Lee, JR. , Michael J. Forbush
IPC分类号： C40B50/14
CPC分类号： B01L3/0268 , B01J19/0046 , B01J2219/00362 , B01J2219/00378 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00725 , B01L2300/0819 , B01L2400/0433 , B01L2400/0436 , B05B17/0615 , C40B30/04 , C40B40/02 , C40B40/04 , C40B40/08 , C40B40/10 , C40B50/00 , C40B60/14 , F04F7/00 , G01N21/11 , Y10T137/206 , Y10T137/2196 , Y10T436/2575
摘要： Invention methods employ the use of acoustic waves to transfer small amounts of fluid in a non-contact manner. In invention methods, acoustic waves are propagated through a separated pool of a source fluid in such a manner that causes the ejection of a single micro-droplet from the surface of the pool. The droplet is ejected towards a target with sufficient force to provide for contact of the droplet with the target. Because the fluid is not contacted by any fluid transfer device such as a pipette, the opportunities for contamination are minimized. Invention methods may be employed to transfer fluids from an array of source sites to an array of target sites, thereby enabling the precision automation of a wide variety of procedures including screening, and synthesis procedures commonly used in biotechnology.
摘要翻译：本发明的方法采用声波以非接触方式传送少量流体。在本发明的方法中，声波以这样的方式传播通过源流体的分离池，使得从池的表面喷出单个微滴。液滴以足够的力朝向目标喷射以提供液滴与靶的接触。由于流体不被诸如移液管之类的任何流体转移装置接触，污染的机会被最小化。可以采用本发明的方法将流体从源位置阵列转移到目标位点阵列，从而能够精确自动化多种程序，包括生物技术中通常使用的筛选和合成方法。

2. 发明申请

US20100249995A1 Method and Apparatus for Online Procurement of Chemical Screening Assays 审中-公开
标题翻译：化学筛选试验在线采购方法与装置
公开(公告)号：US20100249995A1
公开(公告)日：2010-09-30
申请号：US12416079
申请日：2009-03-31
申请人： Roger O. Williams , Ronald D. Jones , Charles A. Reichel , Gregory B. Stephens , Michael J. Forbush
发明人： Roger O. Williams , Ronald D. Jones , Charles A. Reichel , Gregory B. Stephens , Michael J. Forbush
IPC分类号： G06F17/00 , G06Q30/00 , G06Q50/00
CPC分类号： G06Q30/0603 , G06Q30/0601
摘要： A method and apparatus for ordering a preloaded chemical assay plate. The method comprises the steps accessing an Internet based order entry site; viewing a list of target chemical compounds; creating an order on the order entry site that lists the desired target compounds for the assay; specifying one or more well plate parameters, such as the number of wells in a well plate that will be used to hold the target compounds; specifying one or more assay parameters in the order, such as specifying the final test volume and concentration of the target compounds in the wells; and placing the order from the order entry site. The apparatus comprises a server for accepting the customer order transmitted over the Internet; a storage means for electronically storing the list of target compounds; process control means for generating a work order that contains instructions for retrieving one or more working plates that contain the chemical compounds specified in the customer order; and assay printing means for acoustically dispensing the chemical compounds onto the assay substrate.
摘要翻译：一种用于订购预加载的化学测定板的方法和装置。该方法包括访问基于因特网的订单输入站点的步骤; 查看目标化合物列表; 在订单输入站点上创建列出所需测试化合物的订单; 指定一个或多个孔板参数，例如将用于保持目标化合物的孔板中的孔的数量; 指定一个或多个测定参数，例如指定孔中的目标化合物的最终测试体积和浓度; 并从订单输入站点下订单。该装置包括用于接受通过因特网传送的客户订单的服务器; 用于电子存储目标化合物列表的存储装置; 用于生成包含用于检索包含客户订单中指定的化学化合物的一个或多个工作板的指令的工作订单的过程控制装置; 以及用于将化学化合物声学分配到测定基底上的测定印刷装置。

3. 发明授权

US06976639B2 Apparatus and method for droplet steering 有权
标题翻译：液滴转向装置及方法
公开(公告)号：US06976639B2
公开(公告)日：2005-12-20
申请号：US10006489
申请日：2001-12-06
申请人： Roger O. Williams , Michael Van Tuyl , Michael Forbush
发明人： Roger O. Williams , Michael Van Tuyl , Michael Forbush
IPC分类号： B41J2/14 , B05B1/28
CPC分类号： B41J2/14008
摘要： An apparatus and method for droplet steering is disclosed herein. A throated structure having a nozzle defines a converging throat with an inlet and an outlet and a vectored fluid stream directed therethrough. The fluid stream is driven through the system via a vacuum pump. As the fluid approaches the outlet, its velocity increases and is drawn away from the nozzle through a connecting channel. As a droplet is ejected from a liquid therebelow, it will have a first trajectory until it is introduced to the high velocity fluid stream at the perimeter of the interior walls of the nozzle. The fluid accordingly steers the momentum of the droplet such that it obtains a second or corrected trajectory. Alternative variations include an electrically chargeable member, e.g., a pin, positionable to be in apposition to the outlet and capillary tubes for controlling the ejection surface of the pool of source fluid.
摘要翻译：本文公开了一种用于液滴转向的装置和方法。具有喷嘴的带喉的结构限定了具有入口和出口的会聚喉部以及从其中引导的向量流体流。流体流经真空泵驱动通过系统。当流体接近出口时，其速度增加，并通过连接通道从喷嘴中拉出。当液滴从其下方的液体喷射时，它将具有第一轨迹，直到其被引入喷嘴内壁周边处的高速流体流。流体相应地引导液滴的动量，使得其获得第二或校正的轨迹。替代的变型包括可定位成与出口相配合的可引起电荷的构件，用于控制源流体池的喷射表面的毛细管。

4. 发明授权

US5515212A Very high-density diskette format method and computer implemented process 失效
标题翻译：非常高密度的磁盘格式方法和计算机实现的过程
公开(公告)号：US5515212A
公开(公告)日：1996-05-07
申请号：US111778
申请日：1993-08-25
申请人： James Chiao , Jimmy D. Godwin , Alton B. Otis, Jr. , Andrew M. Rose , Roger O. Williams , Stephen P. Williams , Mark E. Strysko
发明人： James Chiao , Jimmy D. Godwin , Alton B. Otis, Jr. , Andrew M. Rose , Roger O. Williams , Stephen P. Williams , Mark E. Strysko
IPC分类号： G11B5/596 , G11B20/12 , G11B20/18 , G11B21/10 , G11B27/30 , G11B27/32
CPC分类号： G11B20/1866 , G11B20/1252 , G11B27/3027 , G11B27/329 , G11B5/59677 , G11B2020/1087 , G11B2220/2512
摘要： A diskette comprising a jacket, a liner material disposed within said jacket, a flat circular media having a magnetic coating on both sides disposed within said liner material, a hub attached at the center of said media, a plurality of servo grooves on at least one of said sides of said media that have stitched patterns that will alternate on-and-off at twenty kilohertz in the presence of a constant, unmodulated light source. The diskette is magnetically formatted with reference and data tracks recorded in such a way that extremely accurate position determinations can be made by looking at the analog amplitude of the detected tracks and comparing them at different head positions. The innermost tracks contain redundant copies of a disk mapping table that comprises data for a media type code, a sector size code, a sector interleave code, a total track count, a reassignment area starting address, a data area starting address, a total sector count, an update count, and a reassignment table having at least room for 250 entries of three bytes each.
摘要翻译：一种软盘，包括夹套，设置在所述护套中的衬垫材料，平坦的圆形介质，其两侧上设置有磁性涂层，设置在所述衬垫材料内;安装在所述介质中心的毂;至少一个所述介质的所述侧面，在存在恒定的未调制的光源的情况下，其缝合图案将在二十千赫兹交替地开启和关闭。磁盘被磁格式化，其参考和数据轨迹以这样的方式记录，即通过观察检测到的轨迹的模拟幅度并在不同的头部位置进行比较，可以进行非常精确的位置确定。最内侧的轨道包含盘映射表的冗余副本，该盘映射表包括用于媒体类型码，扇区大小码，扇区交织码，总轨迹数，数据区起始地址，数据区起始地址，总扇区计数，更新计数和重新分配表，其具有至少有250个条目的空间，每个条目为三个字节。

5. 发明授权

US5065387A Method and apparatus for generating tracking error signals by means of an optical servo system 失效
标题翻译：用于通过光学伺服系统产生跟踪误差信号的方法和装置
公开(公告)号：US5065387A
公开(公告)日：1991-11-12
申请号：US537053
申请日：1990-06-12
申请人： Maxim Roth , Jimmy D. Godwin , Roger O. Williams
发明人： Maxim Roth , Jimmy D. Godwin , Roger O. Williams
IPC分类号： G11B5/584 , G11B5/596
CPC分类号： G11B5/59677 , G11B5/584
摘要： An optical servo head and method for reading position information on a medium, such as a magnetic disk, having a plurality of optical servo tracks in the form of relatively nonreflective regions on a reflective surface of the medium. With a magnetic disk, the nonreflective regions comprise concentric grooves etched in the disk surface and the reflective regions comprise the land areas between the grooves. The optical servo head is mounted on a carriage/head assembly of a disk drive and comprises an infrared light emitting diode, a collection lens, a routing mirror and a multicell photodetector. The method of reading position information from the magnetic disk comprises the steps of illuminating the disk with the infrared diode, focusing the image of the optical tracks on the cells of the photodetector such that a linear signal will be generated as the optical tracks pass the photodetector cells, and generating a continuous output signal from the photodetector cell output which is used to control the positioning of the carriage/head assembly. The output signal can be directed through a synchronous detection circuit to improve the S/N contrast between the reflective and nonreflective areas. Additionally, the output signal can be routed to an alignment circuit comprising a pair of digital-to-analog converters, a pair of digital signal generators, an adder and an electronic filter and which electronically compensates for imprecision in the servo head - data head separation distance. Track sweeping without leaving the position loop is also accomplished through use of the alignment circuit.
摘要翻译：一种在诸如磁盘的介质上读取位于介质的反射表面上的相对非反射区域形式的多个光学伺服磁道的位置信息的光学伺服磁头和方法。利用磁盘，非反射区域包括蚀刻在盘表面中的同心凹槽，并且反射区域包括凹槽之间的焊盘区域。光学伺服头安装在磁盘驱动器的滑架/磁头组件上，并包括红外发光二极管，集合透镜，路由反射镜和多单元光电检测器。从磁盘读取位置信息的方法包括用红外二极管照亮盘的步骤，将光学轨迹的图像聚焦在光电检测器的单元上，使得当光轨通过光电检测器时将产生线性信号并且从用于控制滑架/头组件的定位的光电检测器单元输出产生连续的输出信号。输出信号可以被引导通过同步检测电路来改善反射区域和非反射区域之间的S / N对比度。另外，输出信号可以路由到包括一对数模转换器，一对数字信号发生器，加法器和电子滤波器的对准电路，并且电子地补偿伺服头中的不精确性 - 数据头分离距离。通过使用对准电路也可以实现不离开位置环的轨道扫描。

6. 发明授权

US4961123A Magnetic information media storage with optical servo tracks 失效
标题翻译：带光学伺服磁道的磁性信息介质存储
公开(公告)号：US4961123A
公开(公告)日：1990-10-02
申请号：US202719
申请日：1988-06-03
申请人： Roger O. Williams , Milton C. Kurtz , Jimmy D. Godwin , Stephen P. Williams , Gregory K. Roberts
发明人： Roger O. Williams , Milton C. Kurtz , Jimmy D. Godwin , Stephen P. Williams , Gregory K. Roberts
IPC分类号： G11B5/58 , G11B5/584 , G11B5/596 , G11B5/82 , G11B21/10
CPC分类号： G11B5/82 , G11B5/58 , G11B5/584 , G11B5/59677
摘要： A magnetic information storage medium, such as a floppy or rigid magnetic disk having a plurality of indelible grooves inscribed on a surface of the medium to function as optical servo tracks. The grooves can be in the form of a plurality of continuous or noncontinuous concentric circles. The grooves can also be a continuous spiral or a plurality of continuous concentric circles having non-constant widths and/or depths.

7. 发明授权

US07281413B2 Acoustic method for determining the viscosity and/or surface tension of a liquid 有权
标题翻译：用于确定液体的粘度和/或表面张力的声学方法
公开(公告)号：US07281413B2
公开(公告)日：2007-10-16
申请号：US11088436
申请日：2005-03-24
申请人： Roger O. Williams , James Chiao , Humphrey W. Chow , Michael J. Forbush , Andrew M. Rose
发明人： Roger O. Williams , James Chiao , Humphrey W. Chow , Michael J. Forbush , Andrew M. Rose
IPC分类号： G01N11/00
CPC分类号： G01N13/02 , B41J2/14008 , G01N11/16
摘要： The present invention comprises a noncontact method for measuring viscosity and/or surface tension information of a liquid in a liquid containment structure. The steps of the method include exciting a surface of the liquid with an excitation burst of acoustic energy that causes the surface to oscillate; generating a positional data set comprised of a plurality of positional measurements related to the detected position of the surface at a plurality of times after the surface is excited; generating a frequency domain data set from the positional data set, the amplitude spectrum of the frequency domain data set comprising information about the oscillation frequency of at least one vibrational mode of the of the surface as it oscillates; and processing the frequency domain data set and/or the positional data set to yield information about the surface tension and/or viscosity of the liquid. A Fast Fourier Transform technique may be used in generating the frequency domain data set.
摘要翻译：本发明包括用于测量液体容纳结构中的液体的粘度和/或表面张力信息的非接触方法。该方法的步骤包括以引起表面振荡的声能的激发脉冲激发液体的表面; 在所述表面被激发之后，多次生成与所述表面的检测位置有关的多个位置测量值的位置数据集; 从所述位置数据集合生成频域数据集，所述频域数据集的振幅谱包括当所述表面振荡时至少一个振动模式的振荡频率的信息; 并且处理频域数据集和/或位置数据集以产生关于液体的表面张力和/或粘度的信息。快速傅立叶变换技术可用于产生频域数据集。

8. 发明授权

US07232549B2 Apparatus for controlling the free surface of a liquid in a well plate 有权
标题翻译：用于控制井板中的液体的自由表面的装置
公开(公告)号：US07232549B2
公开(公告)日：2007-06-19
申请号：US11186150
申请日：2005-07-20
申请人： Roger O. Williams , Humphrey W. Chow , Charles A. Reichel
发明人： Roger O. Williams , Humphrey W. Chow , Charles A. Reichel
IPC分类号： B01L3/02
CPC分类号： B01L3/50853 , B01L3/5085 , B01L2200/0642 , B01L2200/14 , B01L2300/047 , B01L2300/0838 , B01L2400/0406 , B41J2/14008 , G01N2035/1041
摘要： Devices useful in liquid transfer applications and in particular, devices for controlling the free surface of a source liquid in acoustic liquid ejection systems are disclosed. The devices advantageously maintain a source liquid to be transferred at a constant height and reduce disturbances formed in the liquid due to droplet ejection. In one variation, a well plate includes a plurality of wells each having a capillary. Source liquid in a well moves up the capillary due to capillary action and arrives at a certain height. The height arrived at remains constant despite the source liquid depleting from the well during the ejection process. The capillary can be separately joined or integral with the well plate. An acoustic wave emitter positioned adjacent to the well plate emits a focused acoustic beam that causes at least some of the liquid in the capillary to be ejected.
摘要翻译：公开了可用于液体转移应用的装置，特别是用于控制声学液体喷射系统中源液体的自由表面的装置。这些装置有利地将待传输的源液体保持在恒定的高度并且减少由于液滴喷射而在液体中形成的干扰。在一个变型中，孔板包括多个具有毛细管的孔。井中的源液体由于毛细作用而向上移动毛细管并达到一定的高度。尽管在喷射过程中源的液体从井中耗尽，达到的高度保持恒定。毛细管可以单独接合或与孔板一体。邻近孔板定位的声波发射器发射聚焦的声束，其使得毛细管中的至少一些液体被喷出。

9. 发明授权

US06925856B1 Non-contact techniques for measuring viscosity and surface tension information of a liquid 有权
标题翻译：用于测量液体的粘度和表面张力信息的非接触技术
公开(公告)号：US06925856B1
公开(公告)日：2005-08-09
申请号：US10290626
申请日：2002-11-07
申请人： Roger O. Williams
发明人： Roger O. Williams
IPC分类号： G01N11/00 , G01N11/16 , G01N13/00 , G01N13/02 , G01N29/02 , G01N29/22 , G01N29/10
CPC分类号： G01N13/02 , G01N11/16 , G01N29/02 , G01N29/222 , G01N2011/0073 , G01N2291/02818 , G01N2291/044
摘要： A non-contact method for measuring viscosity and surface tension information of a liquid in a first liquid containment structure. The steps of the method include oscillating a free surface of the liquid in the liquid containment structure; detecting wave characteristics of the oscillating free surface; and analyzing the wave characteristics. The oscillating step may be performed by propagating an acoustic wave from an acoustic wave emitter, through said liquid containment structure, towards the free surface. The detecting step may be performed by delivering a series of acoustic pulses at the free surface and detecting acoustic reflections from the free surface as the oscillating free surface relaxes. The analyzing step can be performed by comparing the wave characteristics with a candidate liquid wave characteristics. Prior knowledge and behavior of the selected candidate liquid can thus be imputed to the source or sample liquid. The sample liquid can be one of photoresist, solder or a biological compound. In a variation a method for acoustically ejecting a droplet of a first liquid from a first liquid containment structure comprises measuring viscosity and surface tension information of the first liquid in the first liquid containment structure and directing a variable amount of acoustic energy through the first liquid to cause the droplet ejection wherein the variable amount of acoustic energy is based on the measuring viscosity and surface tension information of the first liquid in the first liquid containment structure. Apparatuses and systems for carrying out the same are included.
摘要翻译：用于测量第一液体容纳结构中的液体的粘度和表面张力信息的非接触方法。该方法的步骤包括振荡液体容纳结构中液体的自由表面; 检测摆动自由表面的波特性; 并分析波特性。可以通过将来自声波发射器的声波通过所述液体容纳结构传播到自由表面来执行振荡步骤。检测步骤可以通过在自由表面处递送一系列声脉冲并且随着振荡自由表面松弛而从自由表面检测声反射来执行。可以通过将波特性与候选液波特性进行比较来执行分析步骤。因此，所选择的候选液体的先验知识和行为可以归因于源或样品液体。样品液体可以是光致抗蚀剂，焊料或生物化合物之一。在一种变型中，用于从第一液体容纳结构声学喷射第一液体的液滴的方法包括测量第一液体容纳结构中的第一液体的粘度和表面张力信息，并将可变量的声能通过第一液体引导至导致液滴喷射，其中可变量的声能基于第一液体容纳结构中的第一液体的测量粘度和表面张力信息。包括用于执行它们的装置和系统。

10. 发明授权

US06594542B1 Method and system for controlling chemical mechanical polishing thickness removal 失效
标题翻译：化学机械抛光厚度去除控制方法和系统
公开(公告)号：US06594542B1
公开(公告)日：2003-07-15
申请号：US09297223
申请日：1999-10-18
申请人： Roger O. Williams
发明人： Roger O. Williams
IPC分类号： G06F1900
CPC分类号： B24B37/013 , B24B37/042 , B24B49/03 , Y10S438/959
摘要： An improved method and apparatus for controlling the depth of removal by chemical mechanical polishing of a selected material on a supporting semiconductor underlayer where it is desired to terminate removal of the selected material, such as silicon oxide, at a specified depth. In accordance with at least some embodiments of this novel method and system, the selected material, such as a surface oxidization layer, is polished to initiate removal thereof in the direction of the material-underlayer interface. This system includes three primary components: a chemical mechanical wafer polishing machine, a semiconductor thin film thickness measurement device, and statistical signal process algorithm and its associated computer system provides a chemical mechanical polishing system control by analysis and prediction of the current and future removal rates based on performance of past ratios for the before and after semiconductor thin film thickness measurements.
摘要翻译：一种改进的方法和装置，用于通过在支撑半导体底层上通过化学机械抛光选择的材料来控制去除深度，其中期望在指定深度终止所选材料（例如氧化硅）的移除。根据这种新颖的方法和系统的至少一些实施例，抛光所选择的材料，例如表面氧化层，以在材料 - 底层界面的方向上开始去除它。该系统包括三个主要组分：化学机械晶片抛光机，半导体薄膜厚度测量装置和统计信号处理算法及其相关的计算机系统通过分析和预测目前和未来的去除率来提供化学机械抛光系统，基于以前的比例的性能并经过半导体薄膜厚度测量。

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