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1. 发明授权

US08436050B2 Gentle-acting skin-disinfectants and hydroalcoholic gel formulations 有权
标题翻译：温和的皮肤消毒剂和水醇凝胶配方
公开(公告)号：US08436050B2
公开(公告)日：2013-05-07
申请号：US10785207
申请日：2004-02-24
申请人： Shanta Modak , Trupti A. Gaonkar , Lauser Caraos , Lester Sampath
发明人： Shanta Modak , Trupti A. Gaonkar , Lauser Caraos , Lester Sampath
IPC分类号： A01N33/12 , A61K31/08 , A61K31/047
CPC分类号： A61K8/042 , A61K8/347 , A61K8/416 , A61K8/43 , A61K31/79 , A61K2800/75 , A61Q17/005
摘要： Antimicrobial compositions having synergistic combinations of octoxyglycerin and at least one other antimicrobial agent in formulations which are more effective than prior art compositions without causing increased irritation to the skin of the average user. In certain embodiments, skin irritation may be minimized by low concentrations of antimicrobials and/or the presence of soothing compounds such as zinc. Preferred embodiments include combinations of octoxyglycerin, a quaternary compound, and at least one other antimicrobial agent. Without being bound to any particular theory, it is hypothesized that the unexpected antimicrobial effectiveness of combinations of octoxyglycerin may result from an enhancement of the permeability of microbes to antimicrobials caused by octoxyglycerin. Hydroalcoholic gel composition containing alcohol, water, hydrogel, and emollient or emulsifier, wherein the composition has a viscosity of below 2000 centipoises at between 20 and 40° C. This skin-friendly hydroalcoholic gel composition, which can be further combined with silicone polymer, emollient solvent, thickening agent and antimicrobial agent, enhances rapid and long-term antimicrobial efficacy.
摘要翻译：在制剂中具有协同组合的辛氧基甘油和至少一种其它抗微生物剂的抗微生物组合物比现有技术组合物更有效，而不会对一般使用者的皮肤造成更大的刺激。在某些实施方案中，皮肤刺激可以通过低浓度的抗微生物剂和/或舒缓化合物如锌的存在来最小化。优选的实施方案包括辛氧基甘油，季化合物和至少一种其它抗微生物剂的组合。不受任何特定理论的约束，假设辛氧基甘油组合的意想不到的抗菌效果可能是由于由辛氧基甘油引起的微生物对抗微生物剂的渗透性的提高。含有醇，水，水凝胶和软化剂或乳化剂的水醇凝胶组合物，其中组合物在20和40℃之间的粘度低于2000厘泊。该皮肤友好的水醇凝胶组合物可以与硅氧烷聚合物进一步组合，润肤溶剂，增稠剂和抗菌剂，可提高快速和长期的抗菌功效。

2. 发明授权

US07951840B2 Zinc salt compositions for the prevention of dermal and mucosal irritation 有权
标题翻译：锌盐组合物，用于预防皮肤和粘膜刺激
公开(公告)号：US07951840B2
公开(公告)日：2011-05-31
申请号：US10622272
申请日：2003-07-17
申请人： Shanta M. Modak , Milind S. Shintre , Lauser Caraos , Trupti Gaonkar
发明人： Shanta M. Modak , Milind S. Shintre , Lauser Caraos , Trupti Gaonkar
IPC分类号： A61K31/315 , A01N59/16
CPC分类号： A61Q19/00 , A61K8/27 , A61K8/36 , A61K8/365 , A61K2800/75
摘要： The addition of low concentrations of combinations of water-soluble organic salts of zinc to gels, creams, lotions or ointments can increase the ability of these products to reduce or prevent exogenous irritants from causing irritation of the underlying substrate. The addition of low concentrations of combinations of water-soluble organic zinc salts to these gels, creams, lotions or ointments also can reduce the irritation of skin or mucous membranes caused by the addition of potentially-irritating substances such as spermicides, microbicides, fungicides or other therapeutic agents to the gel, cream, lotion or ointment. The advantages of this anti-irritant approach over others, which generally employ high concentrations of single zinc salts, are the reduced potential for zinc toxicity, the reduced potential for toxicity related to zinc itself, and the preservation of the desirable biological properties of potentially-irritating therapeutic substances added to the gel, cream, lotion or ointment.
摘要翻译：将锌的水溶性有机盐的低浓度组合添加到凝胶，乳膏，洗剂或软膏中可以增加这些产物减少或阻止外源刺激物对下面的底物的刺激的能力。向这些凝胶，乳膏，洗剂或软膏中加入低浓度的水溶性有机锌盐的组合也可以减少由于加入潜在刺激性物质（如杀精剂，杀微生物剂，杀真菌剂）引起的对皮肤或粘膜的刺激，凝胶，霜剂，洗剂或软膏的其它治疗剂。这种抗刺激方法优于其他一般使用高浓度单一锌盐的优点是锌毒性的降低的潜力，与锌本身相关的毒性潜在降低，以及保护潜在的锌盐所需的生物学特性，添加到凝胶，霜剂，洗剂或软膏中的刺激性治疗物质。

3. 发明申请

US20100305211A1 Gentle-Acting Skin-Disinfectants and Hydroalcoholic Gel Formulations 有权
标题翻译：温和的皮肤消毒剂和水醇凝胶制剂
公开(公告)号：US20100305211A1
公开(公告)日：2010-12-02
申请号：US12853977
申请日：2010-08-10
申请人： Shanta Modak , Trupti A. Gaonkar , Lauser Caraos , Lester Sampath
发明人： Shanta Modak , Trupti A. Gaonkar , Lauser Caraos , Lester Sampath
IPC分类号： A61K31/155 , A61K31/14 , A61P31/00
CPC分类号： A61K8/042 , A61K8/347 , A61K8/416 , A61K8/43 , A61K31/79 , A61K2800/75 , A61Q17/005
摘要： Antimicrobial compositions having synergistic combinations of octoxyglycerin and at least one other antimicrobial agent in formulations which are more effective than prior art compositions without causing increased irritation to the skin of the average user. In certain embodiments, skin irritation may be minimized by low concentrations of antimicrobials and/or the presence of soothing compounds such as zinc. Preferred embodiments include combinations of octoxyglycerin, a quaternary compound, and at least one other antimicrobial agent. Without being bound to any particular theory, it is hypothesized that the unexpected antimicrobial effectiveness of combinations of octoxyglycerin may result from an enhancement of the permeability of microbes to antimicrobials caused by octoxyglycerin. Hydroalcoholic gel composition containing alcohol, water, hydrogel, and emollient or emulsifier, wherein the composition has a viscosity of below 2000 centipoises at between 20 and 40° C. This skin-friendly hydroalcoholic gel composition, which can be further combined with silicone polymer, emollient solvent, thickening agent and antimicrobial agent, enhances rapid and long-term antimicrobial efficacy.
摘要翻译：在制剂中具有协同组合的辛氧基甘油和至少一种其它抗微生物剂的抗微生物组合物比现有技术组合物更有效，而不会对一般使用者的皮肤造成更大的刺激。在某些实施方案中，皮肤刺激可以通过低浓度的抗微生物剂和/或舒缓化合物如锌的存在来最小化。优选的实施方案包括辛氧基甘油，季化合物和至少一种其它抗微生物剂的组合。不受任何特定理论的约束，假设辛氧基甘油组合的意想不到的抗菌效果可能是由于由辛氧基甘油引起的微生物对抗微生物剂的渗透性的提高。含有醇，水，水凝胶和软化剂或乳化剂的水醇凝胶组合物，其中组合物在20和40℃之间的粘度低于2000厘泊。该皮肤友好的水醇凝胶组合物可以与硅氧烷聚合物进一步组合，润肤溶剂，增稠剂和抗菌剂，可提高快速和长期的抗菌功效。

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