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1. 发明授权

US08436050B2 Gentle-acting skin-disinfectants and hydroalcoholic gel formulations 有权
标题翻译：温和的皮肤消毒剂和水醇凝胶配方
公开(公告)号：US08436050B2
公开(公告)日：2013-05-07
申请号：US10785207
申请日：2004-02-24
申请人： Shanta Modak , Trupti A. Gaonkar , Lauser Caraos , Lester Sampath
发明人： Shanta Modak , Trupti A. Gaonkar , Lauser Caraos , Lester Sampath
IPC分类号： A01N33/12 , A61K31/08 , A61K31/047
CPC分类号： A61K8/042 , A61K8/347 , A61K8/416 , A61K8/43 , A61K31/79 , A61K2800/75 , A61Q17/005
摘要： Antimicrobial compositions having synergistic combinations of octoxyglycerin and at least one other antimicrobial agent in formulations which are more effective than prior art compositions without causing increased irritation to the skin of the average user. In certain embodiments, skin irritation may be minimized by low concentrations of antimicrobials and/or the presence of soothing compounds such as zinc. Preferred embodiments include combinations of octoxyglycerin, a quaternary compound, and at least one other antimicrobial agent. Without being bound to any particular theory, it is hypothesized that the unexpected antimicrobial effectiveness of combinations of octoxyglycerin may result from an enhancement of the permeability of microbes to antimicrobials caused by octoxyglycerin. Hydroalcoholic gel composition containing alcohol, water, hydrogel, and emollient or emulsifier, wherein the composition has a viscosity of below 2000 centipoises at between 20 and 40° C. This skin-friendly hydroalcoholic gel composition, which can be further combined with silicone polymer, emollient solvent, thickening agent and antimicrobial agent, enhances rapid and long-term antimicrobial efficacy.
摘要翻译：在制剂中具有协同组合的辛氧基甘油和至少一种其它抗微生物剂的抗微生物组合物比现有技术组合物更有效，而不会对一般使用者的皮肤造成更大的刺激。在某些实施方案中，皮肤刺激可以通过低浓度的抗微生物剂和/或舒缓化合物如锌的存在来最小化。优选的实施方案包括辛氧基甘油，季化合物和至少一种其它抗微生物剂的组合。不受任何特定理论的约束，假设辛氧基甘油组合的意想不到的抗菌效果可能是由于由辛氧基甘油引起的微生物对抗微生物剂的渗透性的提高。含有醇，水，水凝胶和软化剂或乳化剂的水醇凝胶组合物，其中组合物在20和40℃之间的粘度低于2000厘泊。该皮肤友好的水醇凝胶组合物可以与硅氧烷聚合物进一步组合，润肤溶剂，增稠剂和抗菌剂，可提高快速和长期的抗菌功效。

2. 发明授权

US08293802B2 Gentle-acting skin-disinfectants and hydroalcoholic gel formulations 有权
标题翻译：温和的皮肤消毒剂和水醇凝胶配方
公开(公告)号：US08293802B2
公开(公告)日：2012-10-23
申请号：US12853977
申请日：2010-08-10
申请人： Shanta Modak , Trupti A. Gaonkar , Lauserpina Algenio Caraos , Lester Sampath
发明人： Shanta Modak , Trupti A. Gaonkar , Lauserpina Algenio Caraos , Lester Sampath
IPC分类号： A61K31/08
CPC分类号： A61K8/042 , A61K8/347 , A61K8/416 , A61K8/43 , A61K31/79 , A61K2800/75 , A61Q17/005
摘要： Antimicrobial compositions having synergistic combinations of octoxyglycerin and at least one other antimicrobial agent in formulations which are more effective than prior art compositions without causing increased irritation to the skin of the average user. In certain embodiments, skin irritation may be minimized by low concentrations of antimicrobials and/or the presence of soothing compounds such as zinc. Preferred embodiments include combinations of octoxyglycerin, a quaternary compound, and at least one other antimicrobial agent. Without being bound to any particular theory, it is hypothesized that the unexpected antimicrobial effectiveness of combinations of octoxyglycerin may result from an enhancement of the permeability of microbes to antimicrobials caused by octoxyglycerin. Hydroalcoholic gel composition containing alcohol, water, hydrogel, and emollient or emulsifier, wherein the composition has a viscosity of below 2000 centipoises at between 20 and 40° C. This skin-friendly hydroalcoholic gel composition, which can be further combined with silicone polymer, emollient solvent, thickening agent and antimicrobial agent, enhances rapid and long-term antimicrobial efficacy.
摘要翻译：在制剂中具有协同组合的辛氧基甘油和至少一种其它抗微生物剂的抗微生物组合物比现有技术组合物更有效，而不会对一般使用者的皮肤造成更大的刺激。在某些实施方案中，皮肤刺激可以通过低浓度的抗微生物剂和/或舒缓化合物如锌的存在来最小化。优选的实施方案包括辛氧基甘油，季化合物和至少一种其它抗微生物剂的组合。不受任何特定理论的约束，假设辛氧基甘油组合的意想不到的抗菌效果可能是由于由辛氧基甘油引起的微生物对抗微生物剂的渗透性的提高。含有醇，水，水凝胶和软化剂或乳化剂的水醇凝胶组合物，其中组合物在20和40℃之间的粘度低于2000厘泊。该皮肤友好的水醇凝胶组合物可以与硅氧烷聚合物进一步组合，润肤溶剂，增稠剂和抗菌剂，可提高快速和长期的抗菌功效。

3. 发明授权

US5133090A Antiviral glove 失效
标题翻译：抗病毒手套
公开(公告)号：US5133090A
公开(公告)日：1992-07-28
申请号：US555093
申请日：1990-07-18
申请人： Shanta M. Modak , Lester Sampath
发明人： Shanta M. Modak , Lester Sampath
IPC分类号： A01N25/24 , A01N47/44 , A01N59/16 , A41D19/00 , A61B19/04 , A61K31/155 , A61L2/16 , A61L15/46 , A61L17/00 , A61L27/34 , A61L27/54 , A61L29/08 , A61L29/16 , A61L31/10 , A61L31/16 , A61M25/00 , A61P31/12
CPC分类号： A01N25/24 , A01N47/44 , A01N59/16 , A41D19/0055 , A61B42/00 , A61L2/16 , A61L31/10 , A61L31/16 , A41D2400/34 , A61L2300/206 , A61L2300/408 , A61L2300/606
摘要： An antiviral surgical or examination glove is obtained by blocking adsorption sites for the antiinfective agent which may exist in the lubricating agent, e.g., cross-linked corn starch, or in the material of the glove itself. The glove of the invention comprises an elastomeric hand-shaped body having interior and exterior surfaces and an inner coating disposed on the interior surface of the elastomeric body. The inner coating comprises (a) an antiinfective agent selected from the group consisting of chlorhexidine and pharmaceutically acceptable salts of chlorhexidine and (b) a lubricating agent which does not significantly adsorb the antiinfective agent. The inner coating is effective to deliver an antivirally effective amount of the antiinfective agent within ten minutes of exposure to a liquid.
摘要翻译：通过阻止可能存在于润滑剂例如交联玉米淀粉中或在手套本身的材料中的抗感染剂的吸附部位来获得抗病毒手术或检查手套。本发明的手套包括具有内表面和外表面的弹性手形体，以及设置在弹性体本体的内表面上的内涂层。内涂层包含（a）选自氯己定和氯己定的药学上可接受的盐的抗感染剂和（b）不显着吸附抗感染剂的润滑剂。内涂层有效地在暴露于液体的十分钟内递送抗病毒有效量的抗感染剂。

4. 发明申请

US20050124725A1 Triclosan and silver compound containing medical devices 审中-公开
公开(公告)号：US20050124725A1
公开(公告)日：2005-06-09
申请号：US11031607
申请日：2005-01-06
申请人： Shanta Modak , Lester Sampath
发明人： Shanta Modak , Lester Sampath
IPC分类号： A01N59/16 , A61L2/18 , A61L15/44 , A61L17/00 , A61L27/54 , A61L29/00 , A61L29/16 , A61L31/16 , C08K3/00
CPC分类号： A61L31/16 , A01N59/16 , A61L2/18 , A61L15/44 , A61L17/005 , A61L27/54 , A61L29/16 , A61L2300/104 , A61L2300/202 , A61L2300/21 , A61L2300/404 , A61L2300/406 , A61L2300/41 , A61L2300/45 , D06M11/83 , D06M13/432 , D06M16/00 , Y10T428/1352 , A01N31/16 , A01N31/12 , A01N31/08 , A01N25/34 , A01N2300/00
摘要： The present invention relates to polymeric medical articles comprising combinations of triclosan and silver-containing compounds. It is based, at least in part, on the discovery that these agents act synergistically, thereby permitting the use of relatively low levels of both agents. While it had been previously found that triclosan can be particularly useful when used in conjunction with chlorhexidine, it has been further discovered that medical articles having suitable antimicrobial properties may be prepared, according to the present invention, which contain triclosan without chlorhexidine. Such medical articles offer the advantage of preventing or inhibiting infection while avoiding undesirable adverse reactions to chlorhexidine by individuals that may have sensitivity to chlorhexidine.

5. 发明授权

US06846846B2 Gentle-acting skin disinfectants 有权
标题翻译：温和的皮肤消毒剂
公开(公告)号：US06846846B2
公开(公告)日：2005-01-25
申请号：US10047631
申请日：2001-10-23
申请人： Shanta Modak , Trupti A. Gaonkar , Lester Sampath
发明人： Shanta Modak , Trupti A. Gaonkar , Lester Sampath
IPC分类号： A61K8/04 , A61K8/34 , A61K8/41 , A61K8/43 , A61K31/79 , A61Q17/00 , A61Q19/00 , A61K31/08 , A61K7/32 , A61K31/14 , A61K31/27
CPC分类号： A61K8/042 , A61K8/347 , A61K8/416 , A61K8/43 , A61K31/79 , A61K2800/75 , A61Q17/005
摘要： Antimicrobial compositions having synergistic combinations of octoxyglycerin and at least one other antimicrobial agent in formulations which are more effective than prior art compositions without causing increased irritation to the skin of the average user. In certain embodiments, skin irritation may be minimized by low concentrations of antimicrobials and/or the presence of soothing compounds such as zinc. Preferred embodiments include combinations of octoxyglycerin, a quaternary compound, and at least one other antimicrobial agent. Without being bound to any particular theory, it is hypothesized that the unexpected antimicrobial effectiveness of combinations of octoxyglycerin may result from an enhancement of the permeability of microbes to antimicrobials caused by octoxyglycerin.
摘要翻译：在制剂中具有协同组合的辛氧基甘油和至少一种其它抗微生物剂的抗微生物组合物比现有技术组合物更有效，而不会对一般使用者的皮肤造成更大的刺激。在某些实施方案中，皮肤刺激可以通过低浓度的抗微生物剂和/或舒缓化合物如锌的存在来最小化。优选的实施方案包括辛氧基甘油，季化合物和至少一种其它抗微生物剂的组合。不受任何特定理论的约束，假设辛氧基甘油组合的意想不到的抗菌效果可能是由于由辛氧基甘油引起的微生物对抗微生物剂的渗透性的提高。

6. 发明授权

US06626873B1 Tricolosan-containing medical devices 有权
标题翻译：含三环素的医疗器械
公开(公告)号：US06626873B1
公开(公告)日：2003-09-30
申请号：US09618432
申请日：2000-07-18
申请人： Shanta Modak , Lester Sampath
发明人： Shanta Modak , Lester Sampath
IPC分类号： A61M532
CPC分类号： A61L31/16 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L2300/104 , A61L2300/202 , A61L2300/206 , A61L2300/404 , A61L2300/45 , Y10T428/1331 , Y10T428/1352 , A61L29/06 , C08L83/04 , C08L75/04 , A61L27/507
摘要： The present invention relates to polymeric medical articles comprising the anti-infective agents chlorhexidine and triclosan. It is based, at least in part, on the discovery that the synergistic relationship between these compounds permits the use of relatively low levels of both agents, and on the discovery that effective antimicrobial activity may be achieved when these compounds are comprised in either hydrophilic or hydrophobic polymers. It is also based on the discovery that chlorhexidine free base and triclosan, used together, are incorporated into polymeric medical articles more efficiently. Medical articles prepared according to the invention offer the advantage of preventing or inhibiting infection while avoiding undesirably high release of anti-infective agent, for example into the bloodstream of a subject.
摘要翻译：本发明涉及包含抗感染剂氯己定和三氯生的聚合物医疗制品。至少部分地基于以下发现：这些化合物之间的协同关系允许使用相对低水平的两种试剂，并且发现当这些化合物包括在亲水性或亲水性中时，可以实现有效的抗微生物活性疏水聚合物。也是基于以下发现：一起使用氯己定游离碱和三氯生，更有效地掺入到聚合物医疗用品中。根据本发明制备的医疗制品提供了预防或抑制感染的优点，同时避免了抗感染剂的不期望的高释放，例如进入受试者的血液中。

7. 发明授权

US6106505A Triclosan-containing medical devices 失效
标题翻译：含三氯生的医疗器械
公开(公告)号：US6106505A
公开(公告)日：2000-08-22
申请号：US101129
申请日：1998-06-30
申请人： Shanta Modak , Lester Sampath
发明人： Shanta Modak , Lester Sampath
IPC分类号： A61L15/44 , A61L27/00 , A61L27/34 , A61L27/54 , A61L29/00 , A61L29/08 , A61L29/16 , A61L31/10 , A61L31/16 , A61M5/32
CPC分类号： A61L31/16 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L2300/104 , A61L2300/202 , A61L2300/206 , A61L2300/404 , A61L2300/45 , Y10T428/1331 , Y10T428/1352
摘要： The present invention relates to polymeric medical articles comprising the antiinfective agents chlorhexidine and triclosan. It is based, at least in part, on the discovery that the synergistic relationship between these compounds permits the use of relatively low levels of both agents, and on the discovery that effective antimicrobial activity may be achieved when these compounds are comprised in either hydrophilic or hydrophobic polymers. It is also based on the discovery that chlorhexidine free base and triclosan, used together, are incorporated into polymeric medical articles more efficiently. Medical articles prepared according to the invention offer the advantage of preventing or inhibiting infection while avoiding undesirably high release of antiinfective agent, for example into the bloodstream of a subject.
摘要翻译： PCT No.PCT / US96 / 20932 Sec。 371日期1998年6月30日第 102（e）日期1998年6月30日PCT 1996年12月23日PCT PCT。公开号WO97 / 25085 日期1997年7月17日本发明涉及包含抗感染剂氯己定和三氯生的聚合物医疗制品。至少部分地基于以下发现：这些化合物之间的协同关系允许使用相对低水平的两种试剂，并且发现当这些化合物包括在亲水性或亲水性中时，可以实现有效的抗微生物活性疏水聚合物。也是基于以下发现：一起使用氯己定游离碱和三氯生，更有效地掺入到聚合物医疗用品中。根据本发明制备的医疗制品提供了预防或抑制感染的优点，同时避免了抗感染剂的不期望的高释放，例如进入受试者的血液中。

8. 发明申请

US20100305211A1 Gentle-Acting Skin-Disinfectants and Hydroalcoholic Gel Formulations 有权
标题翻译：温和的皮肤消毒剂和水醇凝胶制剂
公开(公告)号：US20100305211A1
公开(公告)日：2010-12-02
申请号：US12853977
申请日：2010-08-10
申请人： Shanta Modak , Trupti A. Gaonkar , Lauser Caraos , Lester Sampath
发明人： Shanta Modak , Trupti A. Gaonkar , Lauser Caraos , Lester Sampath
IPC分类号： A61K31/155 , A61K31/14 , A61P31/00
CPC分类号： A61K8/042 , A61K8/347 , A61K8/416 , A61K8/43 , A61K31/79 , A61K2800/75 , A61Q17/005
摘要： Antimicrobial compositions having synergistic combinations of octoxyglycerin and at least one other antimicrobial agent in formulations which are more effective than prior art compositions without causing increased irritation to the skin of the average user. In certain embodiments, skin irritation may be minimized by low concentrations of antimicrobials and/or the presence of soothing compounds such as zinc. Preferred embodiments include combinations of octoxyglycerin, a quaternary compound, and at least one other antimicrobial agent. Without being bound to any particular theory, it is hypothesized that the unexpected antimicrobial effectiveness of combinations of octoxyglycerin may result from an enhancement of the permeability of microbes to antimicrobials caused by octoxyglycerin. Hydroalcoholic gel composition containing alcohol, water, hydrogel, and emollient or emulsifier, wherein the composition has a viscosity of below 2000 centipoises at between 20 and 40° C. This skin-friendly hydroalcoholic gel composition, which can be further combined with silicone polymer, emollient solvent, thickening agent and antimicrobial agent, enhances rapid and long-term antimicrobial efficacy.
摘要翻译：在制剂中具有协同组合的辛氧基甘油和至少一种其它抗微生物剂的抗微生物组合物比现有技术组合物更有效，而不会对一般使用者的皮肤造成更大的刺激。在某些实施方案中，皮肤刺激可以通过低浓度的抗微生物剂和/或舒缓化合物如锌的存在来最小化。优选的实施方案包括辛氧基甘油，季化合物和至少一种其它抗微生物剂的组合。不受任何特定理论的约束，假设辛氧基甘油组合的意想不到的抗菌效果可能是由于由辛氧基甘油引起的微生物对抗微生物剂的渗透性的提高。含有醇，水，水凝胶和软化剂或乳化剂的水醇凝胶组合物，其中组合物在20和40℃之间的粘度低于2000厘泊。该皮肤友好的水醇凝胶组合物可以与硅氧烷聚合物进一步组合，润肤溶剂，增稠剂和抗菌剂，可提高快速和长期的抗菌功效。

9. 发明授权

US06872195B2 Chlorhexidine-containing medical devices 失效
标题翻译：含洗必泰的医疗器械
公开(公告)号：US06872195B2
公开(公告)日：2005-03-29
申请号：US10647740
申请日：2003-08-25
申请人： Shanta Modak , Lester Sampath
发明人： Shanta Modak , Lester Sampath
IPC分类号： A61L15/44 , A61L27/00 , A61L27/34 , A61L27/54 , A61L29/00 , A61L29/08 , A61L29/16 , A61L31/10 , A61L31/16 , A61M5/32
CPC分类号： A61L31/16 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L2300/104 , A61L2300/202 , A61L2300/206 , A61L2300/404 , A61L2300/45 , Y10T428/1331 , Y10T428/1352 , A61L29/06 , C08L83/04 , C08L75/04 , A61L27/507
摘要： The present invention relates to polymeric medical articles comprising the anti-infective agents chlorhexidine and triclosan. It is based, at least in part, on the discovery that the synergistic relationship between these compounds permits the use of relatively low levels of both agents, and on the discovery that effective antimicrobial activity may be achieved when these compounds are comprised in either hydrophilic or hydrophobic polymers. It is also based on the discovery that chlorhexidine free base and triclosan, used together, are incorporated into polymeric medical articles more efficiently. Medical articles prepared according to the invention offer the advantage of preventing or inhibiting infection while avoiding undesirably high release of anti-infective agent, for example into the bloodstream of a subject.
摘要翻译：本发明涉及包含抗感染剂氯己定和三氯生的聚合物医疗制品。至少部分地基于以下发现：这些化合物之间的协同关系允许使用相对低水平的两种试剂，并且发现当这些化合物包括在亲水性或亲水性中时，可以实现有效的抗微生物活性疏水聚合物。也是基于以下发现：一起使用氯己定游离碱和三氯生，更有效地掺入到聚合物医疗用品中。根据本发明制备的医疗制品提供了预防或抑制感染的优点，同时避免了抗感染剂的不期望的高释放，例如进入受试者的血液中。

10. 发明授权

US5985931A Triple antimicrobial composition 失效
标题翻译：三重抗菌组成
公开(公告)号：US5985931A
公开(公告)日：1999-11-16
申请号：US11841
申请日：1998-06-02
申请人： Shanta Modak , Lester Sampath
发明人： Shanta Modak , Lester Sampath
IPC分类号： A01N47/44 , A61K31/155
CPC分类号： A01N47/44
摘要： The present invention relates to antimicrobial compositons comprising (i) less than or equal to two percent by weight chlorhexidine or chlorhexidine salt; (ii) less than or equal to 1 percent by weight of a quaternary ammonium compound, such as benzalkonium chloride; and (iii) less than or equal to two percent by weight of parachlorometaxylenol. The antimicrobial compositions of the invention may be utilized in antimicrobial deterents, soaps, creams rinses, and emulsions for use in the medical community as well as general public use.
摘要翻译： PCT No.PCT / US96 / 18104 Sec。 371日期1998年6月2日 102（e）1998年6月2日PCT PCT 1996年11月12日PCT公布。出版物WO97 / 17849 日期1997年5月22日本发明涉及抗微生物组合物，其包含（i）小于或等于2重量％的氯己定或氯己定盐; （ii）小于或等于1重量％的季铵化合物，例如苯扎氯铵; 和（iii）小于或等于2％（重量）的对氯甲ax en酚。本发明的抗微生物组合物可用于抗菌消毒剂，肥皂，乳膏漂洗剂和用于医学界的乳剂以及一般公众使用。

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