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1. 发明授权

US07951840B2 Zinc salt compositions for the prevention of dermal and mucosal irritation 有权
标题翻译：锌盐组合物，用于预防皮肤和粘膜刺激
公开(公告)号：US07951840B2
公开(公告)日：2011-05-31
申请号：US10622272
申请日：2003-07-17
申请人： Shanta M. Modak , Milind S. Shintre , Lauser Caraos , Trupti Gaonkar
发明人： Shanta M. Modak , Milind S. Shintre , Lauser Caraos , Trupti Gaonkar
IPC分类号： A61K31/315 , A01N59/16
CPC分类号： A61Q19/00 , A61K8/27 , A61K8/36 , A61K8/365 , A61K2800/75
摘要： The addition of low concentrations of combinations of water-soluble organic salts of zinc to gels, creams, lotions or ointments can increase the ability of these products to reduce or prevent exogenous irritants from causing irritation of the underlying substrate. The addition of low concentrations of combinations of water-soluble organic zinc salts to these gels, creams, lotions or ointments also can reduce the irritation of skin or mucous membranes caused by the addition of potentially-irritating substances such as spermicides, microbicides, fungicides or other therapeutic agents to the gel, cream, lotion or ointment. The advantages of this anti-irritant approach over others, which generally employ high concentrations of single zinc salts, are the reduced potential for zinc toxicity, the reduced potential for toxicity related to zinc itself, and the preservation of the desirable biological properties of potentially-irritating therapeutic substances added to the gel, cream, lotion or ointment.
摘要翻译：将锌的水溶性有机盐的低浓度组合添加到凝胶，乳膏，洗剂或软膏中可以增加这些产物减少或阻止外源刺激物对下面的底物的刺激的能力。向这些凝胶，乳膏，洗剂或软膏中加入低浓度的水溶性有机锌盐的组合也可以减少由于加入潜在刺激性物质（如杀精剂，杀微生物剂，杀真菌剂）引起的对皮肤或粘膜的刺激，凝胶，霜剂，洗剂或软膏的其它治疗剂。这种抗刺激方法优于其他一般使用高浓度单一锌盐的优点是锌毒性的降低的潜力，与锌本身相关的毒性潜在降低，以及保护潜在的锌盐所需的生物学特性，添加到凝胶，霜剂，洗剂或软膏中的刺激性治疗物质。

2. 发明授权

US07745425B2 Non-irritating compositions containing zinc salts 有权
标题翻译：含有锌盐的无刺激性组合物
公开(公告)号：US07745425B2
公开(公告)日：2010-06-29
申请号：US11327677
申请日：2006-01-06
申请人： Shanta M. Modak , Milind S. Shintre , Lauserpina Caraos , Trupti Gaonkar , Ingrid Geraldo
发明人： Shanta M. Modak , Milind S. Shintre , Lauserpina Caraos , Trupti Gaonkar , Ingrid Geraldo
IPC分类号： A61K31/60 , A61K31/315 , A61K33/32
CPC分类号： A61K8/27 , A61K8/36 , A61K8/361 , A61K8/365 , A61K8/368 , A61K8/42 , A61K31/195 , A61K33/30 , A61K2800/75 , A61Q17/005 , A61Q19/00 , A61K2300/00
摘要： The present invention relates to methods and compositions which employ low concentrations of combinations of zinc salts to prevent the irritation of skin or mucous membranes that may be caused by therapeutic agents, by personal hygiene products, by articles such as gloves or condoms, or by various physical, chemical, mechanical, or biological irritants.
摘要翻译：本发明涉及使用低浓度的锌盐的组合以防止由治疗剂，个人卫生产品，诸如手套或避孕套等物品或由各种物品引起的皮肤或粘膜的刺激的方法和组合物物理，化学，机械或生物刺激物。

3. 发明授权

US07871649B2 Antimicrobial compositions containing synergistic combinations of quaternary ammonium compounds and essential oils and/or constituents thereof 有权
标题翻译：含有季铵化合物和精油和/或其成分的协同组合的抗微生物组合物
公开(公告)号：US07871649B2
公开(公告)日：2011-01-18
申请号：US10891624
申请日：2004-07-15
申请人： Shanta M. Modak , Milind S. Shintre , Trupti Gaonkar , Lauserpina Caraos
发明人： Shanta M. Modak , Milind S. Shintre , Trupti Gaonkar , Lauserpina Caraos
IPC分类号： A01N65/00
CPC分类号： A61K45/06 , A01N33/12 , A01N65/00 , A61K31/14 , A61K33/30 , A61K36/15 , A61K36/16 , A61K36/185 , A61K36/53 , A61K36/534 , A61K36/537 , A61K36/61 , A61K36/63 , A61K36/738 , A61K36/752 , A61K36/898 , A61K36/899 , A61K36/9068 , A01N2300/00 , A61K2300/00 , A01N49/00 , A01N59/16 , A01N65/08 , A01N65/22 , A01N65/28 , A01N65/36 , A01N65/44
摘要： The present invention relates to compositions comprising quaternary ammonium compounds and essential oils or individual constituents thereof which exhibit enhanced antimicrobial effects. Such combinations may be comprised in lotions, gels, creams, soaps, etc. for application to skin or mucous membranes. The invention is based, at least in part, on the observation that synergistic antimicrobial effects are achieved with combinations of essential oils or individual constituents thereof and low concentrations of quaternary ammonium compounds.
摘要翻译：本发明涉及包含具有增强的抗微生物效果的季铵化合物和精油或其单独成分的组合物。这些组合可以包含在用于皮肤或粘膜的洗剂，凝胶，乳膏，肥皂等中。本发明至少部分地基于通过精油或其各自成分与低浓度季铵化合物的组合实现协同抗菌效果的观察。

4. 发明授权

US09421263B2 Antimicrobial compositions containing synergistic combinations of quaternary ammonium compounds and essential oils and/or constituents thereof 有权
标题翻译：含有季铵化合物和精油和/或其成分的协同组合的抗微生物组合物
公开(公告)号：US09421263B2
公开(公告)日：2016-08-23
申请号：US12955432
申请日：2010-11-29
申请人： Shanta M. Modak , Milind S. Shintre , Trupti Gaonkar , Lauserpina Caraos
发明人： Shanta M. Modak , Milind S. Shintre , Trupti Gaonkar , Lauserpina Caraos
IPC分类号： A61K45/06 , A01N33/12 , A01N65/00 , A61K31/14 , A61K33/30 , A61K36/15 , A61K36/16 , A61K36/185 , A61K36/53 , A61K36/534 , A61K36/537 , A61K36/61 , A61K36/63 , A61K36/738 , A61K36/752 , A61K36/898 , A61K36/899 , A61K36/9068
CPC分类号： A61K45/06 , A01N33/12 , A01N65/00 , A61K31/14 , A61K33/30 , A61K36/15 , A61K36/16 , A61K36/185 , A61K36/53 , A61K36/534 , A61K36/537 , A61K36/61 , A61K36/63 , A61K36/738 , A61K36/752 , A61K36/898 , A61K36/899 , A61K36/9068 , A01N2300/00 , A61K2300/00 , A01N49/00 , A01N59/16 , A01N65/08 , A01N65/22 , A01N65/28 , A01N65/36 , A01N65/44
摘要： The present invention relates to compositions comprising quaternary ammonium compounds and essential oils or individual constituents thereof which exhibit enhanced antimicrobial effects. Such combinations may be comprised in lotions, gels, creams, soaps, etc. for application to skin or mucous membranes. The invention is based, at least in part, on the observation that synergistic antimicrobial effects are achieved with combinations of essential oils or individual constituents thereof and low concentrations of quaternary ammonium compounds.
摘要翻译：本发明涉及包含具有增强的抗微生物效果的季铵化合物和精油或其单独成分的组合物。这些组合可以包含在用于皮肤或粘膜的洗剂，凝胶，乳膏，肥皂等中。本发明至少部分地基于通过精油或其各自成分与低浓度季铵化合物的组合实现协同抗菌效果的观察。

5. 发明申请

US20110070316A1 Antimicrobial Compositions Containing Synergistic Combinations of Quaternary Ammonium Compounds and Essential Oils and/or Constituents Thereof 审中-公开
标题翻译：含有季铵化合物和精油与/或其成分的协同组合的抗微生物组合物
公开(公告)号：US20110070316A1
公开(公告)日：2011-03-24
申请号：US12955432
申请日：2010-11-29
申请人： Shanta M. Modak , Milind S. Shintre , Trupti Gaonkar , Lauserpina Caraos
发明人： Shanta M. Modak , Milind S. Shintre , Trupti Gaonkar , Lauserpina Caraos
IPC分类号： A61K33/30 , A61K31/14 , A61K36/752 , A61K36/61 , A61K36/16 , A61K36/537 , A61K36/18 , A61K36/324 , A61K36/906 , A61K36/534 , A61K31/315 , A61K31/555 , A61K31/60 , A61P31/00
CPC分类号： A61K45/06 , A01N33/12 , A01N65/00 , A61K31/14 , A61K33/30 , A61K36/15 , A61K36/16 , A61K36/185 , A61K36/53 , A61K36/534 , A61K36/537 , A61K36/61 , A61K36/63 , A61K36/738 , A61K36/752 , A61K36/898 , A61K36/899 , A61K36/9068 , A01N2300/00 , A61K2300/00 , A01N49/00 , A01N59/16 , A01N65/08 , A01N65/22 , A01N65/28 , A01N65/36 , A01N65/44
摘要： The present invention relates to compositions comprising quaternary ammonium compounds and essential oils or individual constituents thereof which exhibit enhanced antimicrobial effects. Such combinations may be comprised in lotions, gels, creams, soaps, etc. for application to skin or mucous membranes. The invention is based, at least in part, on the observation that synergistic antimicrobial effects are achieved with combinations of essential oils or individual constituents thereof and low concentrations of quaternary ammonium compounds.
摘要翻译：本发明涉及包含具有增强的抗微生物效果的季铵化合物和精油或其单独成分的组合物。这些组合可以包含在用于皮肤或粘膜的洗剂，凝胶，乳膏，肥皂等中。本发明至少部分地基于通过精油或其各自成分与低浓度季铵化合物的组合实现协同抗菌效果的观察。

6. 发明授权

US07879365B2 Zinc salt compositions for the prevention of dermal and mucosal irritation 有权
标题翻译：锌盐组合物，用于预防皮肤和粘膜刺激
公开(公告)号：US07879365B2
公开(公告)日：2011-02-01
申请号：US10892034
申请日：2004-07-15
申请人： Shanta M. Modak , Trupti Gaonkar , Milind Shintre , Lauserpina Caraos
发明人： Shanta M. Modak , Trupti Gaonkar , Milind Shintre , Lauserpina Caraos
IPC分类号： A01N59/16 , A61K31/60
CPC分类号： A61K8/27 , A61K8/36 , A61K8/365 , A61K2800/75 , A61Q19/00
摘要： The present invention provides for compositions and methods that may offer protection from irritants as well as antimicrobial protection. Preferred embodiments of the invention include topical antimicrobial compositions that lack conventional antibiotics or preservatives, wherein the antimicrobial benefit is created by essential oils (or their active ingredients), emollient solvents and, in some instances, anti-inflammatory agents.
摘要翻译：本发明提供了可以提供对刺激物的保护以及抗微生物保护的组合物和方法。本发明的优选实施方案包括缺乏常规抗生素或防腐剂的局部抗微生物组合物，其中抗微生物益处由精油（或其活性成分），软化剂溶剂以及在一些情况下由抗炎剂产生。

7. 发明授权

US07435429B2 Zinc salt compositions for the prevention of dermal and mucosal irritation 有权
标题翻译：锌盐组合物，用于预防皮肤和粘膜刺激
公开(公告)号：US07435429B2
公开(公告)日：2008-10-14
申请号：US11031258
申请日：2005-01-07
申请人： Shanta M. Modak , Trupti Gaonkar , Milind Shintre , Lauserpina Caraos , Ingrid Geraldo
发明人： Shanta M. Modak , Trupti Gaonkar , Milind Shintre , Lauserpina Caraos , Ingrid Geraldo
IPC分类号： A01N59/16 , A01N55/02 , A01N37/18 , A01N37/52 , A01N33/12
CPC分类号： A61Q19/00 , A61K8/36 , A61K8/361 , A61K8/365 , A61K8/368 , A61K8/42 , A61K31/14 , A61K31/155 , A61K31/315 , A61K2800/75 , A61Q17/005
摘要： The present invention provides for compositions and methods that may offer protection from irritants, as well as antimicrobial protection. Preferred embodiments of the invention include topical antimicrobial compositions comprising two or more water-soluble zinc salts in low concentrations.
摘要翻译：本发明提供可以提供保护免受刺激物以及抗微生物保护的组合物和方法。本发明的优选实施方案包括含有两种或更多种低浓度水溶性锌盐的局部抗微生物组合物。

8. 发明申请

US20120101155A1 Zinc Salt Compositions for the Prevention of Dermal and Mucosal Irritation 审中-公开
标题翻译：锌盐组合物用于预防皮肤和粘膜刺激
公开(公告)号：US20120101155A1
公开(公告)日：2012-04-26
申请号：US13343452
申请日：2012-01-04
申请人： Shanta M. Modak , Trupti Gaonkar , Milind Shintre
发明人： Shanta M. Modak , Trupti Gaonkar , Milind Shintre
IPC分类号： A61K31/315 , A61P17/16 , A61P43/00 , A61K31/155
CPC分类号： A61K8/27 , A61K8/36 , A61K8/365 , A61K2800/75 , A61Q19/00
摘要： The present invention provides for compositions and methods that may offer protection from irritants as well as antimicrobial protection. Preferred embodiments of the invention include topical antimicrobial compositions that lack conventional antibiotics or preservatives, wherein the antimicrobial benefit is created by essential oils (or their active ingredients), emollient solvents and, in some instances, anti-inflammatory agents.
摘要翻译：本发明提供了可以提供对刺激物的保护以及抗微生物保护的组合物和方法。本发明的优选实施方案包括缺乏常规抗生素或防腐剂的局部抗微生物组合物，其中抗微生物益处由精油（或其活性成分），软化剂溶剂以及在一些情况下由抗炎剂产生。

9. 发明授权

US07563461B2 Zinc salt compositions for the prevention of dermal and mucosal irritation 有权
标题翻译：锌盐组合物，用于预防皮肤和粘膜刺激
公开(公告)号：US07563461B2
公开(公告)日：2009-07-21
申请号：US11143012
申请日：2005-06-02
申请人： Shanta M. Modak , Trupti Gaonkar , Milind Shintre , Lauserpina Caraos , Ingrid Geraldo
发明人： Shanta M. Modak , Trupti Gaonkar , Milind Shintre , Lauserpina Caraos , Ingrid Geraldo
IPC分类号： A61K33/32 , A61K9/50 , A61K33/34
CPC分类号： A61K31/14 , A61K8/27 , A61K8/36 , A61K8/361 , A61K8/365 , A61K8/368 , A61K8/42 , A61K31/155 , A61K31/195 , A61K31/315 , A61K33/30 , A61K45/06 , A61K2800/75 , A61L15/18 , A61L31/088 , A61Q17/005 , A61Q19/00 , Y02A50/473 , A61K2300/00
摘要： The present invention relates to methods and compositions which employ low concentrations of combinations of zinc salts to prevent the irritation of skin or mucous membranes that may be caused by therapeutic agents, by personal hygiene products, or by various physical, chemical, mechanical, or biological irritants, including infectious agents.
摘要翻译：本发明涉及使用低浓度的锌盐的组合以防止可能由治疗剂，个人卫生产品或各种物理，化学，机械或生物体引起的对皮肤或粘膜的刺激的方法和组合物刺激物，包括感染因子。

10. 发明申请

US20110117140A1 Zinc Salt Compositions for the Prevention of Dermal and Mucosal Irritation 审中-公开
标题翻译：锌盐组合物用于预防皮肤和粘膜刺激
公开(公告)号：US20110117140A1
公开(公告)日：2011-05-19
申请号：US12972036
申请日：2010-12-17
申请人： Shanta M. Modak , Trupti Gaonkar , Milind Shintre , Lauserpina Caraos
发明人： Shanta M. Modak , Trupti Gaonkar , Milind Shintre , Lauserpina Caraos
IPC分类号： A61K31/315 , A61K31/555 , A61K31/60 , A61K9/00 , A61P17/16 , A61P31/00
CPC分类号： A61K8/27 , A61K8/36 , A61K8/365 , A61K2800/75 , A61Q19/00
摘要： The present invention provides for compositions and methods that may offer protection from irritants as well as antimicrobial protection. Preferred embodiments of the invention include topical antimicrobial compositions that lack conventional antibiotics or preservatives, wherein the antimicrobial benefit is created by essential oils (or their active ingredients), emollient solvents and, in some instances, anti-inflammatory agents.
摘要翻译：本发明提供了可以提供对刺激物的保护以及抗微生物保护的组合物和方法。本发明的优选实施方案包括缺乏常规抗生素或防腐剂的局部抗微生物组合物，其中抗微生物益处由精油（或其活性成分），软化剂溶剂以及在一些情况下由抗炎剂产生。

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