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1. 发明授权

US6162822A Bisimide compounds 失效
标题翻译：双酰亚胺化合物
公开(公告)号：US6162822A
公开(公告)日：2000-12-19
申请号：US221904
申请日：1998-12-28
申请人： Gilbert Lavielle , Patrick Hautefaye , Ghanem Atassi , Alain Pierre , Laurence Kraus-Berthier , Stephane Leonce
发明人： Gilbert Lavielle , Patrick Hautefaye , Ghanem Atassi , Alain Pierre , Laurence Kraus-Berthier , Stephane Leonce
IPC分类号： C07D221/10 , A61K31/435 , A61K31/47 , A61K31/473 , A61K31/55 , A61P35/00 , C07D209/80 , C07D401/12 , C07D403/12 , C07D519/00 , A01N43/38 , C07D487/00 , C07D487/02 , C07D491/00 , A61R31/40
CPC分类号： C07D209/80 , C09B57/08
摘要： A compound of formula (I) ##STR1## in which: m, and n, which may be identical or different, represent 0 or 1,X and Y, which may be identical or different, represent hydrogen or halogen or alky, trihaloalkyl, alkoxy, hydroxyl, cyano, nitro, amino, alkylamino or dialkylamino,Z represent a linear or branched C.sub.4 to C.sub.12 alkylene chain in which one or more --CH.sub.2 -- are optionally replaced by any one of the following atoms or groups: --NR--, --O--, --S--, --SO--, --SO.sub.2 --, or --CONH--, or by a substituted or unsubstituted heterocylcic,A forms, with two adjacent carbon atoms of the phenyl ring, a phenyl, naphthyl or tetrahydronaphthyl ring or a heterocycle, ##STR2## and medicinal products containing the same are useful as anticancer agent.
摘要翻译：式（I）化合物，其中m和n可以相同或不同，表示0或1，X和Y可以相同或不同，表示氢或卤素或烷基，三卤代烷基，烷氧基，羟基，氰基，硝基，氨基，烷基氨基或二烷基氨基，Z表示直链或支链的C 4至C 12亚烷基链，其中一个或多个-CH 2 - 任选被以下任何一个原子或基团取代：-NR-，-O- ，-S-，-SO-，-SO 2 - 或-CONH-，或通过取代或未取代的杂环A形式与苯环的两个相邻碳原子，苯基，萘基或四氢萘基环或杂环，含有该药物的药物可用作抗癌剂。

2. 发明授权

US5854273A Bisimide compounds 失效
标题翻译：双酰亚胺化合物
公开(公告)号：US5854273A
公开(公告)日：1998-12-29
申请号：US899289
申请日：1997-07-23
申请人： Gilbert Lavielle , Patrick Hautefaye , Ghanem Atassi , Alain Pierre , Laurence Kraus-Berthier , Stephane Leonce
发明人： Gilbert Lavielle , Patrick Hautefaye , Ghanem Atassi , Alain Pierre , Laurence Kraus-Berthier , Stephane Leonce
IPC分类号： C07D221/10 , A61K31/435 , A61K31/47 , A61K31/473 , A61K31/55 , A61P35/00 , C07D209/80 , C07D401/12 , C07D403/12 , C07D519/00 , A61K31/40 , C07D403/06
CPC分类号： C07D209/80 , C09B57/08
摘要： A compound of formula (I) ##STR1## in which: X and Y, which may be identical or different, represent hydrogen or halogen or alkyl, trihaloalkyl, alkoxy, hydroxyl, cyano, nitro, amino, alkylamino, or dialkylamino, Z represent a linear or branched C.sub.4 to C.sub.12 alkylene chain in which one or more --CH.sub.2 -- are optionally replaced by any one of the following atoms or groups: --NR--, --O--, --S--, --SO--, --SO.sub.2 --, or --CONH--, A forms, with two adjacent carbon atoms of the phenyl ring, a phenyl, naphthyl or tetrahydronaphthyl ring or a heterocycle, ##STR2## represents any one of the groups as defined in the description, its optical isomers and its addition salts with a pharmaceutically-acceptable acid or base, and medicinal products containing the same which are useful as anticancer agents.
摘要翻译：式（I）化合物其中：X和Y可以相同或不同，表示氢或卤素或烷基，三卤代烷基，烷氧基，羟基，氰基，硝基，氨基，烷基氨基或二烷基氨基 Z表示直链或支链的C 4至C 12亚烷基链，其中一个或多个-CH 2 - 任选被以下原子或基团中的任何一个取代：-NR - ， - O - ， - S - ， - SO-， - SO 2 - 或-CONH-，A形式，其具有苯环的两个相邻碳原子，苯基，萘基或四氢萘基环或杂环，IMAGE表示说明书中定义的任何一个基团，其旋光异构体及其与药学上可接受的酸或碱的加成盐，以及含有该盐的药物，可用作抗癌剂。

3. 发明授权

US06300340B1 Bisimide compounds 失效
标题翻译：双酰亚胺化合物
公开(公告)号：US06300340B1
公开(公告)日：2001-10-09
申请号：US09616857
申请日：2000-07-14
申请人： Gilbert Lavielle , Patrick Hautefaye , Ghanem Atassi , Alain Pierre , Laurence Kraus-Berthier , Stéphane Leonce
发明人： Gilbert Lavielle , Patrick Hautefaye , Ghanem Atassi , Alain Pierre , Laurence Kraus-Berthier , Stéphane Leonce
IPC分类号： C07D48704
CPC分类号： C07D209/80 , C09B57/08
摘要： A compound of formula (I) in which: m, and n, which may be identical or different, represent 0 or 1, X and Y, which may be identical or different, represent hydrogen or halogen or alkyl, trihaloalkyl, alkoxy, hydroxyl, cyano, nitro, amino, alkylamino, or dialkylamino, Z represent a linear or branched C4 to C12 alkylene chain in which one or more —CH2— are optionally replaced by any one of the following atoms or groups: —NR—, —O—, —S—, —SO—, SO2—, or —CONH—, or by a substituted or unsubstituted heterocylcic, A forms, with two adjacent carbon atoms of the phenyl ring, a phenyl, naphthyl or tetrahydronaphthyl ring or a heterocycle, represents any one of the groups as defined in the description, its optical isomers and its addition salts with a pharamaceutically and acceptable acid or base, and medicinal products containing the same which are useful as anticancer agents.
摘要翻译：式（I）化合物，其中m和n可以相同或不同，表示0或1，X和Y可以相同或不同，表示氢或卤素或烷基，三卤代烷基，烷氧基，羟基，氰基，硝基，氨基，烷基氨基或二烷基氨基，Z表示直链或支链的C 4至C 12亚烷基链，其中一个或多个-CH 2 - 任选被以下任何一个原子或基团取代：-NR-，-O - ， - S - ， - SO - ，SO2-或-CONH-，或通过取代或未取代的杂环A形式与苯环的两个相邻碳原子，苯基，萘基或四氢萘基环或杂环，表示在描述中定义的任何一个基团，其光学异构体及其与药物和可接受的酸或碱的加成盐，以及含有该组的药物，其可用作抗癌剂。

4. 发明授权

US06509345B2 Camptothecin analogue compounds 失效
标题翻译：喜树碱类似物
公开(公告)号：US06509345B2
公开(公告)日：2003-01-21
申请号：US10010380
申请日：2001-11-05
申请人： Gilbert Lavielle , Patrick Hautefaye , Alain Pierre , Ghanem Atassi , John Hickman , Bernard Cimetiere
发明人： Gilbert Lavielle , Patrick Hautefaye , Alain Pierre , Ghanem Atassi , John Hickman , Bernard Cimetiere
IPC分类号： C07D47114
CPC分类号： C07D471/14 , A61K31/4745 , Y02P20/55
摘要： Compound of formula (I): wherein: n is 0, 1 or 2, R1, R2, R3, R4 and R5 are selected from hydrogen, halogen, alkyl, alkenyl, alkynyl, perhaloalkyl, cycloalkyl, cycloalkylalkyl, hydroxy, hydroxyalkyl, alkoxy, alkoxyalkyl, alkoxycarbonyl, acyloxy, carboxy, nitro, cyano, aminocarbonyl (optionally substituted), and the groups (CH2)p—NRaRb and —O—C(O)—N—RaRb, with p, Ra and Rb being as defined in the description, or two adjacent groups R2, R3, R4 and R5 together form a group —O—(CH2)t—O, t being an integer from 1 to 3, R60, R70n, R80 and R90 represent a hydrogen atom, a hydroxy group, an alkoxy group, or an O—(CO)—X or O—(CO)—NXW group as defined in the description, R61, R71n, R81 and R91 represent a hydrogen atom, alkyl, alkenyl or alkynyl, or taken in pairs together form a bond or an oxirane group, or two groups together form an oxo group. and medicinal products containing the same are useful for the treatment of cancerous diseases.
摘要翻译：式（I）化合物：其中：n为0,1或2，R1，R2，R3，R4和R5选自氢，卤素，烷基，烯基，炔基，全卤代烷基，环烷基，环烷基烷基，羟基，羟烷基，烷氧基，烷氧基烷基，烷氧基羰基，酰氧基，羧基，硝基，氰基，氨基羰基（任选取代的）和基团（CH 2）p -NR a R b和-OC（O）-NR a R b，其中p，R a和R b如描述或两个相邻基团R 2，R 3，R 4和R 5一起形成基团-O-（CH 2）t O，t为1至3的整数，R 60，R 70n，R 80和R 90表示氢原子，羟基，烷氧基或描述中定义的O-（CO）-X或O-（CO）-NXW基团，R61，R71n，R81和R91表示氢原子，烷基，烯基或炔基，或成对取代一起形成键或环氧乙烷基团，或两个基团一起形成氧代基，并且含有该氧基的药物可用于治疗癌性疾病。

5. 发明授权

US06699876B2 Camptothecin analogue compounds 失效
标题翻译：喜树碱类似物
公开(公告)号：US06699876B2
公开(公告)日：2004-03-02
申请号：US10300330
申请日：2002-11-20
申请人： Gilbert Lavielle , Patrick Hautefaye , Alain Pierre , Ghanem Atassi , John Hickman , Bernard Cimetiere
发明人： Gilbert Lavielle , Patrick Hautefaye , Alain Pierre , Ghanem Atassi , John Hickman , Bernard Cimetiere
IPC分类号： A61K314375
CPC分类号： C07D471/14 , A61K31/4745
摘要： Compound of formula (I): wherein: n is 0, 1 or 2, R1 represents (C3-C11)cycloalkyl or (C3-C11)cycloalkylalkyl, R2, R3, R4 and R5 are selected from hydrogen, halogen, alkyl, alkenyl, alkynyl, perhaloalkyl, cycloalkyl, cycloalkylalkyl, hydroxy, hydroxyalkyl, alkoxy, alkoxyalkyl, alkoxycarbonyl, acyloxy, carboxy, nitro, cyano, aminocarbonyl (optionally substituted), and the groups (CH2)p—NaRb and —O—C(O)—N—RaRb, with p, Ra and Rb being as defined in the description, or two adjacent groups R2, R3, R4 and R5 together form a group —O—(CH2)t—O, t being integer from 1 to 3, R60, R70n, R80 and R90 represent a hydrogen atom, a hydroxy group, an alkoxy group, or an O—(CO)—X or O—(CO)—NXW group as defined in the description, R61, R71n, R81, and R91 represent a hydrogen atom, alkyl, alkenyl or alkynyl, or taken in pairs together form a bond or an oxirane group, or two groups together form an oxo group. and medicinal products containing the same are useful for the treatment of cancerous disesases.
摘要翻译：式（I）化合物：其中：n为0,1或2，R1代表（C3-C11）环烷基或（C3-C11）环烷基烷基，R2，R3，R4和R5选自氢，卤素，烷基，烯基，炔基，全卤代烷基，环烷基，环烷基烷基，羟基，羟基烷基，烷氧基，烷氧基烷基，烷氧基羰基，酰氧基，羧基，硝基，氰基，氨基羰基（任选取代的）和基团（CH 2）p-NaRb和-OC（O） -RaRb，其中p，Ra和Rb如说明书中所定义，或两个相邻基团R 2，R 3，R 4和R 5一起形成基团-O-（CH 2）t O，t为1至3的整数，R 60，R 70n R 80和R 90表示如说明书中定义的氢原子，羟基，烷氧基或O-（CO）-X或O-（CO）-NXW基团，R61，R71n，R81和R91表示氢原子，烷基，烯基或炔基，或成对取成一起形成键或环氧乙烷基，或两个基团一起形成氧代基，并且含有该氧基的药物可用于治疗癌性疾病。

6. 发明申请

US20100168149A1 Camptothecin Analogue Compounds, a Process for Their Preparation and Pharmaceutical Compositions Containing Them 审中-公开
标题翻译：喜树碱类似物，其制备方法和含有他们的药物组合物
公开(公告)号：US20100168149A1
公开(公告)日：2010-07-01
申请号：US11990065
申请日：2006-08-04
申请人： Gilbert Lavielle , Patrick Hautefaye , Alain Pierre , John Hickman , Stephane Leonce
发明人： Gilbert Lavielle , Patrick Hautefaye , Alain Pierre , John Hickman , Stephane Leonce
IPC分类号： A61K31/475 , C07D471/14 , A61P35/00
CPC分类号： C07D471/14
摘要： Compound of formula (I): wherein: R1, R2, R3, R4, R5, R80, R90, R81, R91, Alk and G are as defined in the description. Medicinal products containing the same which are useful in the treatment of cancer diseases.
摘要翻译：式（I）化合物：其中：R1，R2，R3，R4，R5，R80，R90，R81，R91，Alk和G如说明书中所定义。含有该药物的药物可用于治疗癌症疾病。

7. 发明申请

US20100168150A1 Camptothecin Analogue Compounds, a Process for Their Preparation and Pharmaceutical Compositions Containing Them. 审中-公开
标题翻译：喜树碱类似物，其制备方法和含有他们的药物组合物。
公开(公告)号：US20100168150A1
公开(公告)日：2010-07-01
申请号：US11990104
申请日：2006-08-04
申请人： Gilbert Lavielle , Patrick Hautefaye , Alain Pierre , John Hickman , Stephane Leonce
发明人： Gilbert Lavielle , Patrick Hautefaye , Alain Pierre , John Hickman , Stephane Leonce
IPC分类号： A61K31/475 , C07D471/14 , A61P35/00
CPC分类号： C07D471/14
摘要： Compound of formula (I): wherein: R1, R2, R3, R4, R5, R80, R90, R81, R91, Alk, Alk′, X, X′ and G are as defined in the description. Medicinal products containing the same which are useful in the treatment of cancer diseases.
摘要翻译：式（I）化合物：其中：R1，R2，R3，R4，R5，R80，R90，R81，R91，Alk，Alk'，X，X'和G如说明书中所定义。含有该药物的药物可用于治疗癌症疾病。

8. 发明授权

US06627650B2 Indenoindolone compounds 失效
标题翻译：茚并吲哚酮化合物
公开(公告)号：US06627650B2
公开(公告)日：2003-09-30
申请号：US10171191
申请日：2002-06-13
申请人： Michel Wierzbicki , Marie-Françoise Boussard , Anne Rousseau , Ghanem Atassi , John Hickman , Alain Pierre , Stéphane Leonce , Nicolas Guilbaut , Laurence Kraus-Berthier
发明人： Michel Wierzbicki , Marie-Françoise Boussard , Anne Rousseau , Ghanem Atassi , John Hickman , Alain Pierre , Stéphane Leonce , Nicolas Guilbaut , Laurence Kraus-Berthier
IPC分类号： A61K3140
CPC分类号： C07D401/12 , C07D209/94 , C07D405/12 , C07D409/12 , C07D491/04
摘要： A compound of formula (I): wherein: R represents hydrogen, optionally substituted alkyl or alkenyl, R1 to R8, which may be identical or different, each represents hydrogen, optionally substituted alkyl, hydroxy, acyloxy, optionally substituted amino, carboxy, optionally substituted alkoxy, or alkenyloxy, or one of R1 to R8 forms, with another of R1 to R8 that is adjacent, an alkylenedioxy group, X represents oxygen or NR16 wherein R16 represents hydrogen, alkyl, aryl or arylalkyl, R9 represents hydrogen, aryl, heteroaryl, or optionally substituted, saturated or unsaturated alkyl, an isomer thereof, or an addition salt thereof with a pharmaceutically acceptable acid or base. Medicinal products containing the same which are useful as anti-cancer agents.
摘要翻译：式（I）的化合物：其中：R表示氢，任选取代的烷基或烯基，可以相同或不同的R 1至R 8各自表示氢，任选取代的烷基，羟基，酰氧基，任选取代的氨基，羧基，任选地取代的烷氧基或烯氧基，或R 1至R 8中的一个与相邻的R 1至R 8中的另一个相邻，亚烷基二氧基，X表示氧或NR 16，其中R16表示氢，烷基，芳基或芳烷基，R9表示氢，杂芳基或任选取代的饱和或不饱和的烷基，其异构体或其加成盐与药学上可接受的酸或碱的混合物。含有该化合物的药物可用作抗癌剂。

9. 发明申请

US20060135545A1 Benzo[b]pyrano[3,2-h]acridin-7-one cinnamate compounds 失效
标题翻译：苯并[b]吡喃并[3,2-h]吖啶-7-酮肉桂酸酯化合物
公开(公告)号：US20060135545A1
公开(公告)日：2006-06-22
申请号：US11313386
申请日：2005-12-21
申请人： Michel Koch , Francois Tillequin , Sylvie Michel , John Hickman , Alain Pierre , Stephane Leonce , Bruno Pfeiffer , Laurence Kraus-Berthier
发明人： Michel Koch , Francois Tillequin , Sylvie Michel , John Hickman , Alain Pierre , Stephane Leonce , Bruno Pfeiffer , Laurence Kraus-Berthier
IPC分类号： A61K31/4741 , C07D491/02
CPC分类号： C07D491/04
摘要： A compound selected from those of formula (I): wherein: X and Y represent a group selected from hydrogen, halogen, alkoxy, nitro, cyano, alkyl, alkenyl, polyhaloalkyl and —NRaRb wherein Ra and Rb are as defined in the description, Z represents oxygen or NRc wherein Rc is as defined in the description, Ar represents aryl or heteroaryl, R1 represents hydrogen or alkyl, R2 represents a group selected from hydrogen, alkyl, —ORa and —NRaRb wherein Ra and Rb are as defined in the description, R3 and R4 represent hydrogen or alkyl, R5 represents hydrogen, ORc, NRcRd, W1—C(W2)—U—V, W1—C(W2)—W3-T1 or Z-CO—CH═CHAr wherein Rc, Rd, W1, W2, W3, U, V, T, Z and Ar are as defined in the description, its isomers, and addition salts thereof with a pharmaceutically acceptable acid or base, and medicinal products containing the same which are useful in the treatment of cancer.
摘要翻译：选自式（I）的化合物：其中：X和Y表示选自氢，卤素，烷氧基，硝基，氰基，烷基，烯基，多卤代烷基和-NR a R 其中R a a和R b b如说明书中所定义，Z表示氧或NR C c，其中R _{- >如说明书中所定义，Ar表示芳基或杂芳基，R 1表示氢或烷基，R 2表示选自氢，烷基其中R a a和R b都是 - ， - - - - - - - - >如说明书中所定义，R 3和R 4代表氢或烷基，R 5表示氢，或C 1-4烷基， R 1，R 2，R 2，R 2，R 2，R 2，（W 2）-W 3 -T 1或Z-CO-CH-CHAr其中R R 1，R 2，W 3，W 2，W 3，U 3，，V，T，Z和Ar定义如下在其描述中，其异构体及其与药学上可接受的酸或碱的加成盐，以及含有该物质的药物可用于治疗癌症。}

10. 发明授权

US5225411A Disubstituted polymethyleneimines 失效
标题翻译：分离的聚乙烯
公开(公告)号：US5225411A
公开(公告)日：1993-07-06
申请号：US728137
申请日：1991-07-10
申请人： Gilbert Regnier , Alain Dhainaut , Ghanem Atassi , Alain Pierre , Stephane Leonce
发明人： Gilbert Regnier , Alain Dhainaut , Ghanem Atassi , Alain Pierre , Stephane Leonce
IPC分类号： A61K31/505 , A61K31/53 , A61K31/55 , A61P33/00 , A61P35/00 , C07D401/04 , C07D401/12 , C07D403/04
CPC分类号： C07D401/04 , C07D401/12
摘要： The compounds are 2,4-(optionally substituted amino)-6-substituted s.triazines, useful for suppressing the resistance of tumour cells to anti-cancer agents and for suppressing the resistance of parasites to anti-parasitic agents.A compound disclosed is 1-[4,6-bis(allylamino)-2-s-triazinyl]-4-[2,2-bis(p.fluorophenyl)ethylamino]piperidine.
摘要翻译：这些化合物是2,4-（任选取代的氨基）-6-取代的三嗪，可用于抑制肿瘤细胞对抗癌剂的抗性和抑制寄生虫对抗寄生虫药物的抵抗力。公开的化合物是1- [4,6-双（烯丙基氨基）-2-s-三嗪基] -4- [2,2-双（对氟苯基）乙基]哌啶。

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