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1. 发明授权

US5346621A Hollow fiber blood oxygenator 失效
标题翻译：中空纤维血液充氧器
公开(公告)号：US5346621A
公开(公告)日：1994-09-13
申请号：US63996
申请日：1993-05-19
申请人： William S. Haworth , Robert W. Olsen , Mark S. Goodin , Larry E. Fuller
发明人： William S. Haworth , Robert W. Olsen , Mark S. Goodin , Larry E. Fuller
IPC分类号： A61M1/18 , B01D63/02 , B01D11/00 , A61M1/14 , A61M1/34 , B01D61/00
CPC分类号： B01D63/021 , B01D63/02 , B01D63/025 , B01D2313/10
摘要： A radial flow hollow fiber blood oxygenator is provided. The oxygenator includes a hollow fiber bundle within an oxygenator chamber defined by a hollow core around which the hollow fibers are wound and an outer housing. A gas entry port is coupled to the interior of the fibers adjacent one end of the bundle and a gas outlet is coupled to the interior of the fibers at the opposite end of the bundle. A blood inlet to the core is provided adjacent one end of the bundle, and a blood outlet from the chamber is provided adjacent the same end of the bundle. The direction of blood flow through the chamber is generally radial and the oxygenator includes an inlet manifold and an outlet manifold.
摘要翻译：提供径向流中空纤维血液充氧器。氧合器包括中空纤维束，所述中空纤维束在由中空纤维围绕的中空纤维所限定的充氧器室内，以及外部壳体。气体进入口连接到邻近纤维束的一端的纤维内部，气体出口在束的相对端与纤维的内部连接。在芯的一端附近提供到芯的血液入口，并且邻近于束的同一端设置来自腔室的血液出口。通过腔室的血液流动的方向通常是径向的，并且氧合器包括入口歧管和出口歧管。

2. 发明授权

US4776843A Blood access systems 失效
标题翻译：血液通道系统
公开(公告)号：US4776843A
公开(公告)日：1988-10-11
申请号：US209058
申请日：1980-11-21
申请人： Felix J. Martinez , Louis C. Cosentino , Bruce P. Amiot , Raymond F. Cracauer , Larry E. Fuller
发明人： Felix J. Martinez , Louis C. Cosentino , Bruce P. Amiot , Raymond F. Cracauer , Larry E. Fuller
IPC分类号： A61M1/00 , A61M37/00
CPC分类号： A61M39/0247 , A61M2039/0258 , A61M2039/0264 , A61M2039/027
摘要： Improvements and accessories for a septum closed T-shaped blood access device adapted for implantation into a patient. The implantable device has a stem portion extending above the skin of the patient and defining a septum closed opening into the device. The improvements include an improved septum having a groove in the side thereof encircling the septum and an elastomeric ring carried within the side groove, an improved needle assembly which provides access to the circulatory system through the septum, and a flexible cap for sealing the stem of the implantable device from the outside atmosphere which may be fitted in place or removed without the necessity of specialized tools.
摘要翻译：适于植入患者的隔膜闭合的T形血液进入装置的改进和附件。可植入装置具有延伸在患者皮肤上方的杆部分，并且将隔膜限定在装置中。这些改进包括改进的隔膜，其在其一侧包围隔膜，以及在侧槽内承载的弹性体环，改进的针头组件，其提供通过隔膜进入循环系统;以及柔性帽，来自外部气氛的可植入装置，其可以安装在适当位置或移除而不需要专门的工具。

3. 发明授权

US4517081A Dialyzer reuse machine 失效
标题翻译：透析机回用机
公开(公告)号：US4517081A
公开(公告)日：1985-05-14
申请号：US472075
申请日：1983-03-04
申请人： Bruce P. Amiot , Larry E. Fuller , Felix J. Martinez , Louis C. Cosentino , William H. Harm , Wayne I. Nelson
发明人： Bruce P. Amiot , Larry E. Fuller , Felix J. Martinez , Louis C. Cosentino , William H. Harm , Wayne I. Nelson
IPC分类号： A61M1/16 , A61M1/36 , B01D65/02 , B01D65/10 , B01D31/00
CPC分类号： B01D65/102 , A61M1/168 , A61M1/3643 , B01D65/02 , B01D65/022 , A61M2205/705 , A61M2209/082 , B01D2321/168
摘要： A dialyzer reuse machine comprising means for passing a series of liquid and gaseous fluids through the dialysate and blood compartments of the dialyzer at different flow rates according to a predetermined sequence for cleaning and disinfecting the dialyzer and means for accurately measuring the volume of the blood compartment upon completion of the dialyzer cleaning steps. Capacitive probe and load cell embodiments of the volume measuring means are disclosed. A specially designed jet pump permits a pressure leak test and dilution of stock chemicals to be performed using only tap water pressure as a source of motive force.
摘要翻译：一种透析器再利用机器，其包括用于根据用于清洁和消毒透析器的预定顺序使一系列液体和气体流体通过透析器的透析液和血液隔室的不同流量的装置和用于精确测量血液室的体积的装置完成透析器清洁步骤后。公开了体积测量装置的电容式探头和称重传感器实施例。专门设计的喷射泵允许使用自来水压力作为动力来源进行压力泄漏测试和稀释化学药品。

4. 发明授权

US4488877A Percutaneous implant for peritoneal dialysis 失效
标题翻译：经皮植入物进行腹膜透析
公开(公告)号：US4488877A
公开(公告)日：1984-12-18
申请号：US410365
申请日：1982-08-23
申请人： Elias Klein , Ronald L. Wathen , Richard A. Ward , Louis C. Cosentino , Larry E. Fuller , Felix J. Martinez
发明人： Elias Klein , Ronald L. Wathen , Richard A. Ward , Louis C. Cosentino , Larry E. Fuller , Felix J. Martinez
IPC分类号： A61M1/00 , A61M1/28 , A61F1/00 , A61M25/02
CPC分类号： A61M39/0247 , A61M1/285 , A61M2039/0282 , A61M2039/0288
摘要： An implant device for peritoneal dialysis which permits a flexible catheter to be removed and replaced without invasive surgery. The catheter is passed through a substantially rigid tubular percutaneous device and a flexible sleeve member which together form a continuous conduit from the body exterior through the peritoneal wall. The catheter is associated with a percutaneous tubular device so as to be removable and replaceable through the sleeve member after implantation. The catheter preferably has a relatively weak memory which gives it a tendency to maintain a compact coiled configuration near the peritoneal wall. The catheter may extend through the percutaneous device or, more preferably, terminates within the interior cavity of the percutaneous device and is sealed from the environment by means of a septum closure within the device cavity.
摘要翻译：用于腹膜透析的植入装置，其允许在没有侵入性手术的情况下移除和更换柔性导管。导管通过基本上刚性的管状经皮装置和柔性套筒构件，它们一起从身体外部通过腹膜壁形成连续导管。导管与经皮管状装置相关联，以便在植入后通过套筒构件可移除和可更换。导管优选具有相对较弱的记忆，这使其具有在腹膜壁附近保持紧凑的盘绕构型的趋势。导管可以延伸穿过经皮装置，或者更优选地终止于经皮装置的内腔内，并且借助于装置腔内的隔膜封闭件与环境密封。

5. 发明授权

US4781693A Insulin dispenser for peritoneal cavity 失效
标题翻译：胰岛素分配器用于腹膜腔
公开(公告)号：US4781693A
公开(公告)日：1988-11-01
申请号：US529048
申请日：1983-09-02
申请人： Felix J. Martinez , Larry E. Fuller , Louis C. Cosentino
发明人： Felix J. Martinez , Larry E. Fuller , Louis C. Cosentino
IPC分类号： A61M1/36 , A61M1/00 , A61M39/06 , A61F1/00
CPC分类号： A61M39/0247 , A61M39/06 , A61M2039/0255 , A61M2039/0273 , A61M2039/0282 , A61M2039/062 , A61M2039/0633 , A61M2039/0653 , A61M2039/066 , A61M2039/0686
摘要： An implant device for introduction of insulin into the peritoneal cavity which permits a flexible catheter to be removed and replaced without invasive surgery. The catheter is passed through a substantially rigid percutaneous body and a distally extending catheter conduit which together form a continuous conduit from the body exterior through the peritoneal wall. A polytetrafluoroethylene polymer sleeve allows tissue ingrowth to secure the body to the epidermis. A polyethylene terephthalate portion of the sleeve provides tissue ingrowth to stabilize the implant and prevent extrusion from the dermis. The catheter is associated with the percutaneous tubular body so as to be removable and replaceable through the conduit thereformed after implantation. The catheter preferably terminates within the interior cavity of the percutaneous body and is sealed from the environment by means of a septum closure within the device cavity. A sponge saturated with antiseptic is fitted in the body recess above the septum and is closed off from the environment by a penetrable cap member. The saturated sponge prevents the introduction of bacteria into the peritoneum.
摘要翻译：用于将胰岛素引入腹膜腔的植入装置，其允许在不进行侵入性手术的情况下移除和替换柔性导管。导管通过基本上刚性的经皮体和远侧延伸的导管导管，其一起形成从身体外部穿过腹膜壁的连续导管。聚四氟乙烯聚合物套筒允许组织向内生长以将身体固定在表皮上。套管的聚对苯二甲酸乙二酯部分提供组织向内生长以稳定植入物并防止从真皮挤出。导管与经皮管状体相关联，以便可以通过植入后的导管移除和更换。导管优选地终止于经皮体的内腔内，并且通过在装置腔内的隔膜封闭件与环境密封。用防腐剂饱和的海绵装配在隔膜上方的身体凹陷中，并通过可穿透的帽构件与环境封闭。饱和海绵防止细菌进入腹膜。

6. 发明授权

US4645645A Oxygenator having an improved heat exchanger 失效
标题翻译：具有改进的热交换器的氧化器
公开(公告)号：US4645645A
公开(公告)日：1987-02-24
申请号：US719999
申请日：1985-04-04
申请人： Felix J. Martinez , Larry E. Fuller , Richard J. Irmiter
发明人： Felix J. Martinez , Larry E. Fuller , Richard J. Irmiter
IPC分类号： A61M5/44 , F28D7/02 , F28F21/06 , A61M1/16
CPC分类号： F28F21/062 , A61M5/44 , F28D7/028 , A61M2205/366
摘要： A hollow fiber type blood oxygenator having an integrated and improved heat exchanger having a generally conical housing and core member between which a helically wrapped conduit is situated. The conduit has a plurality of parallel flutes. A housing and core member are formed with helical recessed regions which conform to the conical helix defined by the tubing or conduit. The tubing is formed with flattened opposing surfaces which mate with the corresponding recesses in the housing and core member. The mating on the flats on the tube or conduit to the corresponding flats in the recessed regions of the housing and core member allows a substantially tighter and more uniform fit which minimizes the dynamic blood priming volume.
摘要翻译：一种中空纤维型血液充氧器，其具有整体和改进的热交换器，其具有大致圆锥形的壳体和芯部构件，螺旋形缠绕导管位于该中心构件之间。导管具有多个平行的槽纹。壳体和芯构件形成有螺旋凹陷区域，其符合由管道或管道限定的锥形螺旋。管道形成有平坦的相对表面，其与壳体和芯部构件中的相应凹部配合。在管或导管上的平面上的配合到壳体和芯构件的凹陷区域中的相应平面允许基本上更紧密和更均匀的配合，其使动态吸气体积最小化。

7. 发明授权

US4405320A Septum retaining means for percutaneous device 失效
标题翻译：用于经皮装置的隔垫保持装置
公开(公告)号：US4405320A
公开(公告)日：1983-09-20
申请号：US350574
申请日：1982-02-22
申请人： Raymond F. Cracauer , Larry E. Fuller , Felix J. Martinez , Louis C. Cosentino
发明人： Raymond F. Cracauer , Larry E. Fuller , Felix J. Martinez , Louis C. Cosentino
IPC分类号： A61B17/00 , A61F2/10 , A61M1/00 , A61M5/00
CPC分类号： A61M39/0247 , A61M2039/027
摘要： Septum retaining means for an implantable tubular percutaneous device. The retaining means is a tubular stem insert having an integral pressure plate across an intermediate portion thereof. A modified septum fits into the insert below the pressure plate. Tabs extending outwardly from the upper edge of the insert cooperate with a grooved portion of a body exterior cavity in the T-stem to provide means for holding the insert in the T-stem cavity. Notches in the walls of the insert on either side of the tabs allow the wall portions containing the tabs to be flexed inwardly so as to permit the insert to be passed into and out of the T-stem. The insert is designed to permit a forceps or other crimping tool to obtain access to the tab containing insert wall portions for removal of the insert and septum.
摘要翻译：用于可植入管状经皮装置的隔垫保持装置。保持装置是一个管状杆插入物，其横跨其中间部分具有整体的压力板。改装的隔垫装配在压板下面的插入件中。从插入件的上边缘向外延伸的突出部与T形杆中的主体外部空腔的开槽部分配合，以提供用于将插入件保持在T形杆腔中的装置。在插片的两侧的插入物的壁上的槽口允许包含翼片的壁部向内弯曲，以便允许插入件进入和离开T型杆。插入件被设计成允许镊子或其它压接工具进入到具有用于移除插入物和隔膜的插入壁部分的突片。

8. 发明授权

US4863452A Venous reservoir 失效
标题翻译：静脉水库
公开(公告)号：US4863452A
公开(公告)日：1989-09-05
申请号：US828951
申请日：1986-02-12
申请人： Richard J. Irmiter , Larry E. Fuller , Felix J. Martinez
发明人： Richard J. Irmiter , Larry E. Fuller , Felix J. Martinez
IPC分类号： A61M1/36
CPC分类号： A61M1/3627
摘要： A venous reservoir for use in cardiotomy bypasses comprising a flexible, variable capacity bag having a vertical seal positioned between the outlets and inlets along the lower seal line. The vertical seal line is positioned off-center such that the velocity of blood decreases as it passes the top of said seal line and towards the lower outlet to increase the removal of bubbles from the blood. All ports serving the reservoir are constructed without internal projections into the reservoir to decrease the possibility of thrombosis. The upper and lower edges of the reservoir are looped to receive horizontal rods slidably attached to a vertical support. Adjustment of the distance between the rods varies the volume possible within the reservoir.
摘要翻译：一种用于心切开路旁路的静脉储存器，包括一个柔性可变容量的袋子，该袋子具有位于出口之间的垂直密封件和沿着下部密封线的入口。垂直密封线位于离心位置，使得当血液通过所述密封线的顶部并朝向下部出口时血液的速度降低以增加从血液中除去气泡。用于储层的所有端口都没有内部突出物进入储层，以减少血栓形成的可能性。储存器的上边缘和下边缘环绕以接收可滑动地附接到垂直支撑件的水平杆。杆之间距离的调整可改变储存器内的体积。

9. 发明授权

US4734198A Dialysis solution mixing system 失效
标题翻译：透析液混合系统
公开(公告)号：US4734198A
公开(公告)日：1988-03-29
申请号：US577387
申请日：1984-02-06
申请人： William H. Harm , Larry E. Fuller , Earnest R. Caine , Raymond F. Cracauer , Louis C. Cosentino , F. Jesus Martinez
发明人： William H. Harm , Larry E. Fuller , Earnest R. Caine , Raymond F. Cracauer , Louis C. Cosentino , F. Jesus Martinez
IPC分类号： A61M1/16 , B01F1/00 , B01F5/10 , B01D13/00
CPC分类号： B01F15/0254 , A61M1/1656 , A61M1/1666 , B01F1/0022 , B01F1/0038 , B01F5/106
摘要： A system and process for preparation of dialysis solution from dry chemicals and water on a large scale batch basis. The required amount of water is metered into a dialysis solution tank. Water from the tank is pumped into a spray head which is positioned above a shipping drum containing predetermined amounts of chemicals. Water rains down on the chemicals dissolving and/or entraining the same and the resulting slurry is returned to the dialysate tank as a slurry by means of a pickup wand and suction source. The liquid and chemicals in the dialysis solution tank are continually cycled until all the chemicals in the drum have been removed. Typically, an additional drum containing other kinds of chemicals is then added to the dialysis solution tank in the same manner. Circulation of the solution is continued within the tank until a fully uniform solution results. Dialysis solution in the tank is then filtered and checked for conductivity prior to its direct use in hemodialysis or dilution in a conventional proportioning system.
摘要翻译：一种大规模批量制备干粉和水的透析液系统和方法。将所需量的水计量到透析溶液罐中。来自罐的水被泵送到喷雾头中，该喷头位于包含预定量化学品的运输滚筒上方。在溶解和/或夹带的化学物质上下沉下来，所得到的浆液通过拾取杆和抽吸源作为浆料返回到透析液罐中。透析溶液罐中的液体和化学物质不断循环，直到滚筒中的所有化学物质被去除。通常，以相同的方式将含有其它种类化学物质的另外的鼓加入到透析溶液罐中。溶液的循环在罐内继续进行，直到得到完全均匀的溶液。然后将透析溶液过滤并检查其电导率，然后直接用于血液透析或常规配比系统中的稀释。

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