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1. 发明授权

US4734198A Dialysis solution mixing system 失效
标题翻译：透析液混合系统
公开(公告)号：US4734198A
公开(公告)日：1988-03-29
申请号：US577387
申请日：1984-02-06
申请人： William H. Harm , Larry E. Fuller , Earnest R. Caine , Raymond F. Cracauer , Louis C. Cosentino , F. Jesus Martinez
发明人： William H. Harm , Larry E. Fuller , Earnest R. Caine , Raymond F. Cracauer , Louis C. Cosentino , F. Jesus Martinez
IPC分类号： A61M1/16 , B01F1/00 , B01F5/10 , B01D13/00
CPC分类号： B01F15/0254 , A61M1/1656 , A61M1/1666 , B01F1/0022 , B01F1/0038 , B01F5/106
摘要： A system and process for preparation of dialysis solution from dry chemicals and water on a large scale batch basis. The required amount of water is metered into a dialysis solution tank. Water from the tank is pumped into a spray head which is positioned above a shipping drum containing predetermined amounts of chemicals. Water rains down on the chemicals dissolving and/or entraining the same and the resulting slurry is returned to the dialysate tank as a slurry by means of a pickup wand and suction source. The liquid and chemicals in the dialysis solution tank are continually cycled until all the chemicals in the drum have been removed. Typically, an additional drum containing other kinds of chemicals is then added to the dialysis solution tank in the same manner. Circulation of the solution is continued within the tank until a fully uniform solution results. Dialysis solution in the tank is then filtered and checked for conductivity prior to its direct use in hemodialysis or dilution in a conventional proportioning system.
摘要翻译：一种大规模批量制备干粉和水的透析液系统和方法。将所需量的水计量到透析溶液罐中。来自罐的水被泵送到喷雾头中，该喷头位于包含预定量化学品的运输滚筒上方。在溶解和/或夹带的化学物质上下沉下来，所得到的浆液通过拾取杆和抽吸源作为浆料返回到透析液罐中。透析溶液罐中的液体和化学物质不断循环，直到滚筒中的所有化学物质被去除。通常，以相同的方式将含有其它种类化学物质的另外的鼓加入到透析溶液罐中。溶液的循环在罐内继续进行，直到得到完全均匀的溶液。然后将透析溶液过滤并检查其电导率，然后直接用于血液透析或常规配比系统中的稀释。

2. 发明授权

US4405320A Septum retaining means for percutaneous device 失效
标题翻译：用于经皮装置的隔垫保持装置
公开(公告)号：US4405320A
公开(公告)日：1983-09-20
申请号：US350574
申请日：1982-02-22
申请人： Raymond F. Cracauer , Larry E. Fuller , Felix J. Martinez , Louis C. Cosentino
发明人： Raymond F. Cracauer , Larry E. Fuller , Felix J. Martinez , Louis C. Cosentino
IPC分类号： A61B17/00 , A61F2/10 , A61M1/00 , A61M5/00
CPC分类号： A61M39/0247 , A61M2039/027
摘要： Septum retaining means for an implantable tubular percutaneous device. The retaining means is a tubular stem insert having an integral pressure plate across an intermediate portion thereof. A modified septum fits into the insert below the pressure plate. Tabs extending outwardly from the upper edge of the insert cooperate with a grooved portion of a body exterior cavity in the T-stem to provide means for holding the insert in the T-stem cavity. Notches in the walls of the insert on either side of the tabs allow the wall portions containing the tabs to be flexed inwardly so as to permit the insert to be passed into and out of the T-stem. The insert is designed to permit a forceps or other crimping tool to obtain access to the tab containing insert wall portions for removal of the insert and septum.
摘要翻译：用于可植入管状经皮装置的隔垫保持装置。保持装置是一个管状杆插入物，其横跨其中间部分具有整体的压力板。改装的隔垫装配在压板下面的插入件中。从插入件的上边缘向外延伸的突出部与T形杆中的主体外部空腔的开槽部分配合，以提供用于将插入件保持在T形杆腔中的装置。在插片的两侧的插入物的壁上的槽口允许包含翼片的壁部向内弯曲，以便允许插入件进入和离开T型杆。插入件被设计成允许镊子或其它压接工具进入到具有用于移除插入物和隔膜的插入壁部分的突片。

3. 发明授权

US4776843A Blood access systems 失效
标题翻译：血液通道系统
公开(公告)号：US4776843A
公开(公告)日：1988-10-11
申请号：US209058
申请日：1980-11-21
申请人： Felix J. Martinez , Louis C. Cosentino , Bruce P. Amiot , Raymond F. Cracauer , Larry E. Fuller
发明人： Felix J. Martinez , Louis C. Cosentino , Bruce P. Amiot , Raymond F. Cracauer , Larry E. Fuller
IPC分类号： A61M1/00 , A61M37/00
CPC分类号： A61M39/0247 , A61M2039/0258 , A61M2039/0264 , A61M2039/027
摘要： Improvements and accessories for a septum closed T-shaped blood access device adapted for implantation into a patient. The implantable device has a stem portion extending above the skin of the patient and defining a septum closed opening into the device. The improvements include an improved septum having a groove in the side thereof encircling the septum and an elastomeric ring carried within the side groove, an improved needle assembly which provides access to the circulatory system through the septum, and a flexible cap for sealing the stem of the implantable device from the outside atmosphere which may be fitted in place or removed without the necessity of specialized tools.
摘要翻译：适于植入患者的隔膜闭合的T形血液进入装置的改进和附件。可植入装置具有延伸在患者皮肤上方的杆部分，并且将隔膜限定在装置中。这些改进包括改进的隔膜，其在其一侧包围隔膜，以及在侧槽内承载的弹性体环，改进的针头组件，其提供通过隔膜进入循环系统;以及柔性帽，来自外部气氛的可植入装置，其可以安装在适当位置或移除而不需要专门的工具。

4. 发明申请

US20080261220A1 Nucleic Acid Detection Assays 审中-公开
标题翻译：核酸检测分析
公开(公告)号：US20080261220A1
公开(公告)日：2008-10-23
申请号：US11927480
申请日：2007-10-29
申请人： Raymond F. Cracauer , Craig Luedtke
发明人： Raymond F. Cracauer , Craig Luedtke
IPC分类号： C12Q1/68 , C07H21/00
CPC分类号： C12P19/34
摘要： The present invention relates to novel methods of producing oligonucleotides. In particular, the present invention provides an efficient, safe, and automated process for the production of large quantities of oligonucleotides.
摘要翻译：本发明涉及生产寡核苷酸的新方法。特别地，本发明提供了用于生产大量寡核苷酸的有效，安全和自动的方法。

5. 发明授权

US5676314A Limited time use sprayer 失效
标题翻译：有限时间使用喷雾器
公开(公告)号：US5676314A
公开(公告)日：1997-10-14
申请号：US416228
申请日：1995-04-04
申请人： Richard Brass , Raymond F. Cracauer , Roland Beihl , Robert C. Hudson, Jr.
发明人： Richard Brass , Raymond F. Cracauer , Roland Beihl , Robert C. Hudson, Jr.
IPC分类号： A61M11/00 , B05B9/08 , A61M11/02
CPC分类号： B05B9/0877
摘要： A sprayer includes a tank having a pump for pressurizing the liquid contents of the pump. The sprayer has a hose extending from the tank for receiving liquid directly from the pump, a spray control valve and discharge nozzle for directing the spray. One or more parts from the pump inlet to the discharge nozzle are adapted to fail after a certain period of time with reuse of the sprayer.
摘要翻译：喷雾器包括具有用于对泵的液体内容物进行加压的泵的罐。喷雾器具有从罐延伸的软管，用于直接从泵接收液体，用于引导喷雾的喷雾控制阀和排出喷嘴。从泵入口到排出喷嘴的一个或多个部件适于在经过一定时间后不经意地重新使用喷雾器。

6. 发明申请

US20090029869A1 SURFACE MODIFICATION, LINKER ATTACHMENT, AND POLYMERIZATION METHODS 审中-公开
标题翻译：表面改性，连接附件和聚合方法
公开(公告)号：US20090029869A1
公开(公告)日：2009-01-29
申请号：US12120912
申请日：2008-05-15
申请人： Zbigniev Skrzypcznski , Raymond F. Cracauer , Jeff G. Hall
发明人： Zbigniev Skrzypcznski , Raymond F. Cracauer , Jeff G. Hall
IPC分类号： C40B30/04 , C40B40/06 , C40B40/08
CPC分类号： G01N33/54353 , C40B40/06
摘要： The present invention relates to surface modifications and linker attachments. For example, the present invention provides surface modification and linker chemistry that facilitates manufacture and use of microarrays, including nucleic acid and protein microarrays. The present invention also relates to array spotting through non-aqueous liquids.
摘要翻译：本发明涉及表面改性和接头附着物。例如，本发明提供了有助于制造和使用包括核酸和蛋白质微阵列在内的微阵列的表面修饰和接头化学。本发明还涉及通过非水性液体的阵列点样。

7. 发明授权

US06932943B1 Nucleic acid synthesizers 失效
标题翻译：核酸合成仪
公开(公告)号：US06932943B1
公开(公告)日：2005-08-23
申请号：US09771332
申请日：2001-01-26
申请人： Raymond F. Cracauer , Zbigniev Skrzypczynski , Ned D. Reimer , Rocky Ganske
发明人： Raymond F. Cracauer , Zbigniev Skrzypczynski , Ned D. Reimer , Rocky Ganske
IPC分类号： G06Q10/00 , G06Q30/00 , B01J19/00
CPC分类号： G06Q10/087 , G06Q30/06
摘要： The present invention relates to nucleic acid synthesizers and methods of using and modifying nucleic acid synthesizers. For example, the present invention provides highly efficient, reliable, and safe synthesizers that find use, for example, in high throughput and automated nucleic acid synthesis, as well as methods of modifying pre-existing synthesizers to improve efficiency, reliability, and safety.
摘要翻译：本发明涉及核酸合成仪和使用和修饰核酸合成仪的方法。例如，本发明提供了高效，可靠和安全的合成器，其可用于例如高通量和自动化核酸合成，以及修改预先存在的合成器以提高效率，可靠性和安全性的方法。

8. 发明授权

US6039714A Collapsible retention bolster for gastrostomy and other ostomy tubes 失效
标题翻译：用于胃造口术和其他造口管的可折叠固定支架
公开(公告)号：US6039714A
公开(公告)日：2000-03-21
申请号：US76443
申请日：1998-05-12
申请人： Raymond F. Cracauer , Lester D. Michels
发明人： Raymond F. Cracauer , Lester D. Michels
IPC分类号： A61M25/04 , A61J15/00 , A61M25/00 , A61M37/00 , A61M5/32 , A61M11/00
CPC分类号： A61J15/0038 , A61J15/0034 , A61J15/0015 , A61J15/0061 , A61M2025/0233 , A61M25/04
摘要： The present invention is an improved ostomy fluid tube and method for its use comprising a collapsible retention bolster for securing the tube to the inner stomach wall and fascia. The retention means comprise several resilient leaf or petal-shaped flanges circumferentially arranged about the feeding tube at a distal point thereon. The otherwise flat, circumferentially arranged flanges possess notches or grooves which facilitate collapse or folding of the retention means for easier removal through an ostomy or other internal cavity.
摘要翻译：本发明是一种改进的造口液管及其使用方法，包括用于将管固定到内胃壁和筋膜的可折叠保持枕。保持装置包括在其上的远端处围绕进料管圆周布置的几个弹性叶片或花瓣形凸缘。否则平坦的周向布置的凸缘具有凹口或凹槽，其有助于保持装置的折叠或折叠，以便通过造口术或其它内部空腔更容易地移除。

9. 发明授权

US5628753A Gastrostomy tube removal tool 失效
标题翻译：胃造口管清除工具
公开(公告)号：US5628753A
公开(公告)日：1997-05-13
申请号：US457641
申请日：1995-06-01
申请人： Raymond F. Cracauer , Lester D. Michels
发明人： Raymond F. Cracauer , Lester D. Michels
IPC分类号： A61B17/34 , A61J15/00 , A61F11/00 , A61M5/00 , A61M5/178
CPC分类号： A61J15/0038 , A61B17/3415 , A61B17/3468 , A61J15/0023
摘要： A gastrostomy feeding tube removal device is comprised of a hollow cylindrical body, a conical head formed at one end and preferably a cap or top at the other to assist in grasping the tool during use. A sheath covers the remaining body portion and is slideably moveable thereon. In use, the gastrostomy tube is pulled through the device which enters the stomach through an ostomy of the patient. Upon contacting the retention bolster means proximate the inner stomach lining, the plastic sheath is pressed forward against the extended members of the retention means thereby collapsing them and withdrawing them into the sheath. The device is then withdrawn from the patient's body simultaneously removing the tube as well.
摘要翻译：胃造口术送料管去除装置由中空圆柱体，一端形成的锥形头组成，最好是另一端的帽或顶部，以在使用过程中帮助抓住该工具。护套覆盖剩余的主体部分并且可滑动地在其上移动。在使用中，胃造口术管被穿过通过患者的造口术进入胃的装置。在靠近内部胃衬里接触保持垫片装置时，塑料护套向前压靠在保持装置的延伸构件上，从而使它们收缩并将其抽回到护套中。然后将装置从患者身体中取出，同时移除管子。

10. 发明授权

US07435390B2 Nucleic acid synthesizers 失效
标题翻译：核酸合成仪
公开(公告)号：US07435390B2
公开(公告)日：2008-10-14
申请号：US10054023
申请日：2001-11-13
申请人： Raymond F. Cracauer , Witold A. Ziarno
发明人： Raymond F. Cracauer , Witold A. Ziarno
IPC分类号： B01J19/00
CPC分类号： B01J19/0046 , G06Q10/087 , G06Q30/06
摘要： The present invention relates to nucleic acid synthesizers and methods of using and modifying nucleic acid synthesizers. For example, the present invention provides highly efficient, reliable, and safe synthesizers that find use, for example, in high throughput and automated nucleic acid synthesis, as well as methods of modifying pre-existing synthesizers to improve efficiency, reliability, and safety.
摘要翻译：本发明涉及核酸合成仪和使用和修饰核酸合成仪的方法。例如，本发明提供了高效，可靠和安全的合成器，其可用于例如高通量和自动化核酸合成，以及修改预先存在的合成器以提高效率，可靠性和安全性的方法。

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